Attention: World-2DPAGE is no longer maintained.

World-2DPAGE Repository  Search by  [accession number]  [description, ID or gene]  [author names]  [spot ID / serial number]  [identification methods]  [pI / Mw range]  [combined fields]  Maps  [experimental info]  [protein list]  [graphical interface]      Databases 0001 0002 0003 0004 0005 0006 0007 0008 0009 0010 0011 0012 0014 0017 0018 0019 0020 0021 0022 0023 0024 0026 0027 0029 0030 0031 0032 0034 0035 0036 0037 0038 0039 0040 0042 0043 0044 0046 0047 0050 0051 0053 0054 0056 0059 0061 0062 0063 0066 0068 0069 0076 0077 0080 0084 0085 0088 use 'Ctrl' to select several databases Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal Exclude local DBs has only effect if a remote interface is selected

Searching in 'World-2DPAGE Repository [0054]' for entry matching: P31153 World-2DPAGE Repository (0054):  P31153 P31153 General information about the entry View entry in simple text format Entry name METK2_HUMAN Primary accession number P31153 integrated into World-2DPAGE Repository (0054) on  November 28, 2012 (release 1) 2D Annotations were last modified on November 28, 2012 (version 1) General Annotations were last modified on  October 23, 2014 (version 2) Name and origin of the protein Description RecName: Full=S-adenosylmethionine synthase isoform type-2; Short=AdoMet synthase 2; EC=2.5.1.6; AltName: Full=Methionine adenosyltransferase 2; Short=MAT 2; AltName: Full=Methionine adenosyltransferase II; Short=MAT-II;. Gene name Name=MAT2A Synonyms=AMS2, MATA2 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION DOI=10.1074/mcp.M112.022947; Vernocchi S., Battello N., Schmitz S., Revets D., Billing A.M., Turner J.D., Muller C.P. ''Membrane glucocorticoid receptor activation induces proteomic changes aligning with classical glucocorticoid-effects'' Molecular & Cellular Proteomics 12(7):1764-1779 (2013) 2D PAGE maps for identified proteins How to interpret a protein HSAPIENS_CCRF-CEM_3-10 {CCRF-CEM cells stimulated with Cort-BSA (internal standard)} Homo sapiens (Human)   map experimental info   HSAPIENS_CCRF-CEM_3-10 MAP LOCATIONS: SPOT 14922: pI=6.02; Mw=43661   [identification data] %COV: SPOT 14922: 54 [1]. SCORE: SPOT 14922: 582 [1]. SEARCH ENGINE: SPOT 14922: Mascot [1]. MAPPING (identification): SPOT 14922: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Claude P. Muller, Centre de Recherche Public de la Sante / National Public Health Laboratory, Luxembourg Cross-references UniProtKB/Swiss-Prot P31153; METK2_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name METK2_HUMAN Primary accession number P31153 Secondary accession number(s) A8K511 B4DN45 D6W5L1 Q53SP5 Sequence was last modified on  July 1, 1993 (version 1) Annotations were last modified on  October 1, 2014 (version 151) Name and origin of the protein Description RecName: Full=S-adenosylmethionine synthase isoform type-2; Short=AdoMet synthase 2; EC=2.5.1.6; AltName: Full=Methionine adenosyltransferase 2; Short=MAT 2; AltName: Full=Methionine adenosyltransferase II; Short=MAT-II; Gene name Name=MAT2A Synonyms=AMS2, MATA2 Encoded on Name=MAT2A; Synonyms=AMS2, MATA2 Keywords 3D-structure; Acetylation; Alternative splicing; ATP-binding; Cobalt; Complete proteome; Magnesium; Metal-binding; Nucleotide-binding; One-carbon metabolism; Phosphoprotein; Potassium; Reference proteome; Transferase. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X68836; CAA48726.1; -; mRNA EMBL DQ083239; AAY85355.1; -; mRNA EMBL AK291126; BAF83815.1; -; mRNA EMBL AK297758; BAG60107.1; -; mRNA EMBL AK316411; BAH14782.1; -; mRNA EMBL AC016753; AAY24339.1; -; Genomic_DNA EMBL CH471053; EAW99511.1; -; Genomic_DNA EMBL CH471053; EAW99513.1; -; Genomic_DNA EMBL BC001686; AAH01686.1; -; mRNA EMBL BC001854; AAH01854.1; -; mRNA CCDS CCDS1977.1; -; . PIR S27257; S27257; . RefSeq NP_005902.1; NM_005911.5; . UniGene Hs.516157; -; . PDB 2P02; X-ray; 1.21 A; A=1-395 PDBsum 2P02; -; . ProteinModelPortal P31153; -; . SMR P31153; 16-395; . BioGrid 110314; 22; . IntAct P31153; 17; . STRING 9606.ENSP00000303147; -; . DrugBank DB00134; L-Methionine; . DrugBank DB00118; S-Adenosylmethionine; . PhosphoSite P31153; -; . DMDM 400245; -; . REPRODUCTION-2DPAGE IPI00010157; -; . MaxQB P31153; -; . PaxDb P31153; -; . PeptideAtlas P31153; -; . PRIDE P31153; -; . DNASU 4144; -; . Ensembl ENST00000306434; ENSP00000303147; ENSG00000168906; . Ensembl ENST00000409017; ENSP00000386353; ENSG00000168906; . GeneID 4144; -; . KEGG hsa:4144; -; . UCSC uc002spr.3; human; . CTD 4144; -; . GeneCards GC02P085766; -; . H-InvDB HIX0117562; -; . HGNC HGNC:6904; MAT2A; . HPA CAB009968; -; . HPA HPA043028; -; . MIM 601468; gene; . neXtProt NX_P31153; -; . PharmGKB PA30647; -; . eggNOG COG0192; -; . HOGENOM HOG000245710; -; . HOVERGEN HBG001562; -; . InParanoid P31153; -; . KO K00789; -; . OMA DETEESM; -; . PhylomeDB P31153; -; . TreeFam TF300511; -; . Reactome REACT_115639; Sulfur amino acid metabolism; . Reactome REACT_6946; Methylation; . UniPathway UPA00315; UER00080; . ChiTaRS MAT2A; human; . EvolutionaryTrace P31153; -; . GenomeRNAi 4144; -; . NextBio 16276; -; . PRO PR:P31153; -; . ArrayExpress P31153; -; . Bgee P31153; -; . CleanEx HS_MAT2A; -; . Genevestigator P31153; -; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0048269; C:methionine adenosyltransferase complex; IDA:UniProt; . GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0046872; F:metal ion binding; IEA:UniProtKB-KW; . GO GO:0004478; F:methionine adenosyltransferase activity; IDA:UniProt; . GO GO:0005515; F:protein binding; IPI:UniProtKB; . GO GO:0034641; P:cellular nitrogen compound metabolic process; TAS:Reactome; . GO GO:0032259; P:methylation; TAS:Reactome; . GO GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW; . GO GO:0006556; P:S-adenosylmethionine biosynthetic process; IDA:UniProt; . GO GO:0044281; P:small molecule metabolic process; TAS:Reactome; . GO GO:0000096; P:sulfur amino acid metabolic process; TAS:Reactome; . GO GO:0006805; P:xenobiotic metabolic process; TAS:Reactome; . HAMAP MF_00086; S_AdoMet_synth1; 1; . InterPro IPR022631; ADOMET_SYNTHASE_CS; . InterPro IPR022630; S-AdoMet_synt_C; . InterPro IPR022629; S-AdoMet_synt_central; . InterPro IPR022628; S-AdoMet_synt_N; . InterPro IPR002133; S-AdoMet_synthetase; . InterPro IPR022636; S-AdoMet_synthetase_sfam; . PANTHER PTHR11964; PTHR11964; 1; . Pfam PF02773; S-AdoMet_synt_C; 1; . Pfam PF02772; S-AdoMet_synt_M; 1; . Pfam PF00438; S-AdoMet_synt_N; 1; . PIRSF PIRSF000497; MAT; 1; . SUPFAM SSF55973; SSF55973; 3; . TIGRFAMs TIGR01034; metK; 1; . PROSITE PS00376; ADOMET_SYNTHASE_1; 1; . PROSITE PS00377; ADOMET_SYNTHASE_2; 1; . World-2DPAGE Repository (search AC)