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World-2DPAGE Repository  Search by  [accession number]  [description, ID or gene]  [author names]  [spot ID / serial number]  [identification methods]  [pI / Mw range]  [combined fields]  Maps  [experimental info]  [protein list]  [graphical interface]      Databases 0001 0002 0003 0004 0005 0006 0007 0008 0009 0010 0011 0012 0014 0017 0018 0019 0020 0021 0022 0023 0024 0026 0027 0029 0030 0031 0032 0034 0035 0036 0037 0038 0039 0040 0042 0043 0044 0046 0047 0050 0051 0053 0054 0056 0059 0061 0062 0063 0066 0068 0069 0076 0077 0080 0084 0085 0088 use 'Ctrl' to select several databases Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal Exclude local DBs has only effect if a remote interface is selected

Searching in 'World-2DPAGE Repository [0054]' for entry matching: P31939 World-2DPAGE Repository (0054):  P31939 P31939 General information about the entry View entry in simple text format Entry name PUR9_HUMAN Primary accession number P31939 integrated into World-2DPAGE Repository (0054) on  November 28, 2012 (release 1) 2D Annotations were last modified on November 28, 2012 (version 1) General Annotations were last modified on  October 23, 2014 (version 2) Name and origin of the protein Description RecName: Full=Bifunctional purine biosynthesis protein PURH; Includes: RecName: Full=Phosphoribosylaminoimidazolecarboxamide formyltransferase; EC=2.1.2.3; AltName: Full=5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase; AltName: Full=AICAR transformylase; Includes: RecName: Full=IMP cyclohydrolase; EC=3.5.4.10; AltName: Full=ATIC; AltName: Full=IMP synthase; AltName: Full=Inosinicase;. Gene name Name=ATIC Synonyms=PURH ORFNames=OK/SW-cl.86 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION DOI=10.1074/mcp.M112.022947; Vernocchi S., Battello N., Schmitz S., Revets D., Billing A.M., Turner J.D., Muller C.P. ''Membrane glucocorticoid receptor activation induces proteomic changes aligning with classical glucocorticoid-effects'' Molecular & Cellular Proteomics 12(7):1764-1779 (2013) 2D PAGE maps for identified proteins How to interpret a protein HSAPIENS_CCRF-CEM_3-10 {CCRF-CEM cells stimulated with Cort-BSA (internal standard)} Homo sapiens (Human)   map experimental info   HSAPIENS_CCRF-CEM_3-10 MAP LOCATIONS: SPOT 592: pI=6.27; Mw=64616   [identification data] %COV: SPOT 592: 34 [1]. SCORE: SPOT 592: 239 [1]. SEARCH ENGINE: SPOT 592: Mascot [1]. MAPPING (identification): SPOT 592: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Claude P. Muller, Centre de Recherche Public de la Sante / National Public Health Laboratory, Luxembourg Cross-references UniProtKB/Swiss-Prot P31939; PUR9_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PUR9_HUMAN Primary accession number P31939 Secondary accession number(s) A8K202 E9PBU3 Q13856 Q53S28 Sequence was last modified on  October 10, 2002 (version 3) Annotations were last modified on  October 1, 2014 (version 152) Name and origin of the protein Description RecName: Full=Bifunctional purine biosynthesis protein PURH; Includes: RecName: Full=Phosphoribosylaminoimidazolecarboxamide formyltransferase; EC=2.1.2.3; AltName: Full=5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase; AltName: Full=AICAR transformylase; Includes: RecName: Full=IMP cyclohydrolase; EC=3.5.4.10; AltName: Full=ATIC; AltName: Full=IMP synthase; AltName: Full=Inosinicase; Gene name Name=ATIC Synonyms=PURH ORFNames=OK/SW-cl.86 Encoded on Name=ATIC; Synonyms=PURH; ORFNames=OK/SW-cl.86 Keywords 3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Disease mutation; Epilepsy; Hydrolase; Multifunctional enzyme; Polymorphism; Purine biosynthesis; Reference proteome; Transferase. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL U37436; AAA97405.1; -; mRNA EMBL D82348; BAA11559.1; -; mRNA EMBL D89976; BAA21762.1; -; mRNA EMBL AB062403; BAB93490.1; -; mRNA EMBL AK290067; BAF82756.1; -; mRNA EMBL AC073284; AAY24062.1; -; Genomic_DNA EMBL CH471063; EAW70529.1; -; Genomic_DNA EMBL BC008879; AAH08879.1; -; mRNA CCDS CCDS2398.1; -. [P31939-1]; . PIR JC4642; JC4642; . RefSeq NP_004035.2; NM_004044.6. [P31939-1]; . UniGene Hs.90280; -; . PDB 1P4R; X-ray; 2.55 A; A/B=1-592 PDB 1PKX; X-ray; 1.90 A; A/B/C/D=1-592 PDB 1PL0; X-ray; 2.60 A; A/B/C/D=1-592 PDBsum 1P4R; -; . PDBsum 1PKX; -; . PDBsum 1PL0; -; . ProteinModelPortal P31939; -; . SMR P31939; 4-592; . BioGrid 106961; 48; . IntAct P31939; 4; . MINT MINT-4999053; -; . STRING 9606.ENSP00000236959; -; . BindingDB P31939; -; . ChEMBL CHEMBL2518; -; . DrugBank DB00116; Tetrahydrofolic acid; . PhosphoSite P31939; -; . DMDM 23831360; -; . REPRODUCTION-2DPAGE IPI00289499; -; . UCD-2DPAGE P31939; -; . MaxQB P31939; -; . PaxDb P31939; -; . PeptideAtlas P31939; -; . PRIDE P31939; -; . DNASU 471; -; . Ensembl ENST00000236959; ENSP00000236959; ENSG00000138363. [P31939-1]; . Ensembl ENST00000435675; ENSP00000415935; ENSG00000138363. [P31939-2]; . GeneID 471; -; . KEGG hsa:471; -; . UCSC uc002vex.4; human. [P31939-1]; . CTD 471; -; . GeneCards GC02P216176; -; . HGNC HGNC:794; ATIC; . HPA CAB013462; -; . HPA HPA021012; -; . MIM 601731; gene; . MIM 608688; phenotype; . neXtProt NX_P31939; -; . Orphanet 250977; AICA-ribosiduria; . PharmGKB PA25094; -; . eggNOG COG0138; -; . HOGENOM HOG000230372; -; . HOVERGEN HBG006912; -; . InParanoid P31939; -; . KO K00602; -; . OMA AGDKANC; -; . OrthoDB EOG74N5GD; -; . PhylomeDB P31939; -; . TreeFam TF105642; -; . BioCyc MetaCyc:HS06490-MONOMER; -; . Reactome REACT_1776; Purine ribonucleoside monophosphate biosynthesis; . SABIO-RK P31939; -; . UniPathway UPA00074; UER00133; . UniPathway UPA00074; UER00135; . ChiTaRS ATIC; human; . EvolutionaryTrace P31939; -; . GeneWiki Inosine_monophosphate_synthase; -; . GenomeRNAi 471; -; . NextBio 1945; -; . PRO PR:P31939; -; . ArrayExpress P31939; -; . Bgee P31939; -; . CleanEx HS_ATIC; -; . Genevestigator P31939; -; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0070062; C:extracellular vesicular exosome; IDA:UniProt; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0005739; C:mitochondrion; IEA:Ensembl; . GO GO:0003937; F:IMP cyclohydrolase activity; TAS:Reactome; . GO GO:0004643; F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity; TAS:Reactome; . GO GO:0042803; F:protein homodimerization activity; IPI:UniProtKB; . GO GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway; . GO GO:0003360; P:brainstem development; IEA:Ensembl; . GO GO:0021549; P:cerebellum development; IEA:Ensembl; . GO GO:0021987; P:cerebral cortex development; IEA:Ensembl; . GO GO:0046452; P:dihydrofolate metabolic process; IEA:Ensembl; . GO GO:0006139; P:nucleobase-containing compound metabolic process; TAS:ProtInc; . GO GO:0055086; P:nucleobase-containing small molecule metabolic process; TAS:Reactome; . GO GO:0009116; P:nucleoside metabolic process; IEA:Ensembl; . GO GO:0031100; P:organ regeneration; IEA:Ensembl; . GO GO:0006144; P:purine nucleobase metabolic process; TAS:Reactome; . GO GO:0009168; P:purine ribonucleoside monophosphate biosynthetic process; TAS:Reactome; . GO GO:0010035; P:response to inorganic substance; IEA:Ensembl; . GO GO:0044281; P:small molecule metabolic process; TAS:Reactome; . GO GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:Ensembl; . Gene3D 1.10.287.440; -; 1; . Gene3D 3.40.140.20; -; 3; . Gene3D 3.40.50.1380; -; 1; . HAMAP MF_00139; PurH; 1; . InterPro IPR024051; AICAR_Tfase_dom; . InterPro IPR024050; AICAR_Tfase_insert_dom; . InterPro IPR002695; AICARFT_IMPCHas; . InterPro IPR016193; Cytidine_deaminase-like; . InterPro IPR011607; MGS-like_dom; . PANTHER PTHR11692; PTHR11692; 1; . Pfam PF01808; AICARFT_IMPCHas; 1; . Pfam PF02142; MGS; 1; . PIRSF PIRSF000414; AICARFT_IMPCHas; 1; . SMART SM00798; AICARFT_IMPCHas; 1; . SMART SM00851; MGS; 1; . SUPFAM SSF52335; SSF52335; 1; . SUPFAM SSF53927; SSF53927; 1; . TIGRFAMs TIGR00355; purH; 1; . World-2DPAGE Repository (search AC)