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World-2DPAGE Repository  Search by  [accession number]  [description, ID or gene]  [author names]  [spot ID / serial number]  [identification methods]  [pI / Mw range]  [combined fields]  Maps  [experimental info]  [protein list]  [graphical interface]      Databases 0001 0002 0003 0004 0005 0006 0007 0008 0009 0010 0011 0012 0014 0017 0018 0019 0020 0021 0022 0023 0024 0026 0027 0029 0030 0031 0032 0034 0035 0036 0037 0038 0039 0040 0042 0043 0044 0046 0047 0050 0051 0053 0054 0056 0059 0061 0062 0063 0066 0068 0069 0076 0077 0080 0084 0085 0088 use 'Ctrl' to select several databases Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal Exclude local DBs has only effect if a remote interface is selected

Searching in 'World-2DPAGE Repository [0054]' for entry matching: P33316 World-2DPAGE Repository (0054):  P33316 P33316 General information about the entry View entry in simple text format Entry name DUT_HUMAN Primary accession number P33316 integrated into World-2DPAGE Repository (0054) on  November 28, 2012 (release 1) 2D Annotations were last modified on November 28, 2012 (version 1) General Annotations were last modified on  October 23, 2014 (version 2) Name and origin of the protein Description RecName: Full=Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial; Short=dUTPase; EC=3.6.1.23; AltName: Full=dUTP pyrophosphatase; Flags: Precursor;. Gene name Name=DUT Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION DOI=10.1074/mcp.M112.022947; Vernocchi S., Battello N., Schmitz S., Revets D., Billing A.M., Turner J.D., Muller C.P. ''Membrane glucocorticoid receptor activation induces proteomic changes aligning with classical glucocorticoid-effects'' Molecular & Cellular Proteomics 12(7):1764-1779 (2013) 2D PAGE maps for identified proteins How to interpret a protein HSAPIENS_CCRF-CEM_3-10 {CCRF-CEM cells stimulated with Cort-BSA (internal standard)} Homo sapiens (Human)   map experimental info   HSAPIENS_CCRF-CEM_3-10 MAP LOCATIONS: SPOT 1188: pI=7.96; Mw=19346   [identification data] %COV: SPOT 1188: 60 [1]. SCORE: SPOT 1188: 839 [1]. SEARCH ENGINE: SPOT 1188: Mascot [1]. MAPPING (identification): SPOT 1188: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Claude P. Muller, Centre de Recherche Public de la Sante / National Public Health Laboratory, Luxembourg Cross-references UniProtKB/Swiss-Prot P33316; DUT_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name DUT_HUMAN Primary accession number P33316 Secondary accession number(s) A8K650 B4DPR5 O14785 Q16708 Q16860 Q6FHN1 Q6NSA3 Q96Q81 Sequence was last modified on  September 21, 2011 (version 4) Annotations were last modified on  October 1, 2014 (version 154) Name and origin of the protein Description RecName: Full=Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial; Short=dUTPase; EC=3.6.1.23; AltName: Full=dUTP pyrophosphatase; Flags: Precursor; Gene name Name=DUT Encoded on Name=DUT Keywords 3D-structure; Alternative splicing; Complete proteome; Direct protein sequencing; Hydrolase; Magnesium; Mitochondrion; Nucleotide metabolism; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transit peptide. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL U31930; AAC50418.1; -; mRNA EMBL U62891; AAC51123.1; -; mRNA EMBL AF018432; AAB71393.1; ALT_FRAME; Genomic_DNA EMBL AF018429; AAB71393.1; JOINED; Genomic_DNA EMBL AF018430; AAB71393.1; JOINED; Genomic_DNA EMBL AF018431; AAB71393.1; JOINED; Genomic_DNA EMBL AF018432; AAB71394.1; -; Genomic_DNA EMBL AF018429; AAB71394.1; JOINED; Genomic_DNA EMBL AF018430; AAB71394.1; JOINED; Genomic_DNA EMBL AF018431; AAB71394.1; JOINED; Genomic_DNA EMBL U90223; AAB94642.1; ALT_FRAME; mRNA EMBL U90224; AAB93866.1; ALT_FRAME; Genomic_DNA EMBL U90224; AAB93867.1; -; Genomic_DNA EMBL AB049113; BAB13724.1; -; mRNA EMBL AY935242; AAX14045.1; -; Genomic_DNA EMBL AK291515; BAF84204.1; -; mRNA EMBL AK312122; BAG35058.1; -; mRNA EMBL CR541720; CAG46521.1; -; mRNA EMBL CR541781; CAG46580.1; -; mRNA EMBL CH471082; EAW77350.1; -; Genomic_DNA EMBL AK298464; BAG60677.1; -; mRNA EMBL BC033645; AAH33645.1; -; mRNA EMBL BC070339; AAH70339.1; -; mRNA EMBL BC110377; AAI10378.1; -; mRNA EMBL M89913; AAA58444.1; -; mRNA EMBL L11877; AAA36801.1; -; mRNA CCDS CCDS32231.1; -. [P33316-3]; . CCDS CCDS45255.1; -. [P33316-2]; . PIR A46256; A46256; . PIR G02777; G02777; . RefSeq NP_001020419.1; NM_001025248.1. [P33316-3]; . RefSeq NP_001020420.1; NM_001025249.1; . RefSeq NP_001939.1; NM_001948.3. [P33316-2]; . UniGene Hs.527980; -; . PDB 1Q5H; X-ray; 2.00 A; A/B/C=112-252 PDB 1Q5U; X-ray; 2.00 A; X/Y/Z=112-252 PDB 2HQU; X-ray; 2.20 A; A/B/C=94-252 PDB 3ARA; X-ray; 1.70 A; A/B/C=94-252 PDB 3ARN; X-ray; 1.80 A; A/B/C=94-252 PDB 3EHW; X-ray; 1.80 A; A/B/C/X/Y/Z=94-252 PDB 4MZ5; X-ray; 2.10 A; A/C=97-109 PDB 4MZ6; X-ray; 1.88 A; A/C=97-109 PDBsum 1Q5H; -; . PDBsum 1Q5U; -; . PDBsum 2HQU; -; . PDBsum 3ARA; -; . PDBsum 3ARN; -; . PDBsum 3EHW; -; . PDBsum 4MZ5; -; . PDBsum 4MZ6; -; . ProteinModelPortal P33316; -; . SMR P33316; 112-236; . BioGrid 108187; 14; . IntAct P33316; 21; . MINT MINT-1436411; -; . BindingDB P33316; -; . ChEMBL CHEMBL5203; -; . PhosphoSite P33316; -; . DMDM 347595814; -; . MaxQB P33316; -; . PaxDb P33316; -; . PeptideAtlas P33316; -; . PRIDE P33316; -; . DNASU 1854; -; . Ensembl ENST00000331200; ENSP00000370376; ENSG00000128951. [P33316-3]; . Ensembl ENST00000455976; ENSP00000405160; ENSG00000128951. [P33316-2]; . Ensembl ENST00000558813; ENSP00000453717; ENSG00000128951; . GeneID 1854; -; . KEGG hsa:1854; -; . UCSC uc001zws.3; human. [P33316-3]; . UCSC uc001zww.3; human. [P33316-2]; . CTD 1854; -; . GeneCards GC15P048623; -; . HGNC HGNC:3078; DUT; . HPA HPA054422; -; . MIM 601266; gene; . neXtProt NX_P33316; -; . PharmGKB PA151; -; . eggNOG COG0756; -; . KO K01520; -; . OMA MIEDENE; -; . PhylomeDB P33316; -; . TreeFam TF105416; -; . BioCyc MetaCyc:HS05235-MONOMER; -; . BRENDA 3.6.1.23; 2681; . Reactome REACT_21376; Pyrimidine biosynthesis; . SABIO-RK P33316; -; . UniPathway UPA00610; UER00666; . EvolutionaryTrace P33316; -; . GeneWiki DUT_(gene); -; . GenomeRNAi 1854; -; . NextBio 7591; -; . PRO PR:P33316; -; . ArrayExpress P33316; -; . Bgee P33316; -; . CleanEx HS_DUT; -; . Genevestigator P33316; -; . GO GO:0070062; C:extracellular vesicular exosome; IDA:UniProt; . GO GO:0005739; C:mitochondrion; TAS:ProtInc; . GO GO:0005654; C:nucleoplasm; TAS:Reactome; . GO GO:0005634; C:nucleus; IDA:HPA; . GO GO:0004170; F:dUTP diphosphatase activity; EXP:Reactome; . GO GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB; . GO GO:0005515; F:protein binding; IPI:IntAct; . GO GO:0006260; P:DNA replication; TAS:ProtInc; . GO GO:0006226; P:dUMP biosynthetic process; IEA:UniProtKB-UniPathway; . GO GO:0046080; P:dUTP metabolic process; IEA:InterPro; . GO GO:0006139; P:nucleobase-containing compound metabolic process; TAS:ProtInc; . GO GO:0055086; P:nucleobase-containing small molecule metabolic process; TAS:Reactome; . GO GO:0006206; P:pyrimidine nucleobase metabolic process; TAS:Reactome; . GO GO:0046134; P:pyrimidine nucleoside biosynthetic process; TAS:Reactome; . GO GO:0044281; P:small molecule metabolic process; TAS:Reactome; . Gene3D 2.70.40.10; -; 1; . InterPro IPR029054; dUTPase-like; . InterPro IPR008180; dUTPase/dCTP_deaminase; . InterPro IPR008181; dUTPase_1; . Pfam PF00692; dUTPase; 1; . SUPFAM SSF51283; SSF51283; 1; . TIGRFAMs TIGR00576; dut; 1; . World-2DPAGE Repository (search AC)