Attention: World-2DPAGE is no longer maintained.

World-2DPAGE Repository  Search by  [accession number]  [description, ID or gene]  [author names]  [spot ID / serial number]  [identification methods]  [pI / Mw range]  [combined fields]  Maps  [experimental info]  [protein list]  [graphical interface]      Databases 0001 0002 0003 0004 0005 0006 0007 0008 0009 0010 0011 0012 0014 0017 0018 0019 0020 0021 0022 0023 0024 0026 0027 0029 0030 0031 0032 0034 0035 0036 0037 0038 0039 0040 0042 0043 0044 0046 0047 0050 0051 0053 0054 0056 0059 0061 0062 0063 0066 0068 0069 0076 0077 0080 0084 0085 0088 use 'Ctrl' to select several databases Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal Exclude local DBs has only effect if a remote interface is selected

Searching in 'World-2DPAGE Repository [0054]' for entry matching: P55072 World-2DPAGE Repository (0054):  P55072 P55072 General information about the entry View entry in simple text format Entry name TERA_HUMAN Primary accession number P55072 integrated into World-2DPAGE Repository (0054) on  November 28, 2012 (release 1) 2D Annotations were last modified on November 28, 2012 (version 1) General Annotations were last modified on  October 23, 2014 (version 2) Name and origin of the protein Description RecName: Full=Transitional endoplasmic reticulum ATPase; Short=TER ATPase; EC=3.6.4.6; AltName: Full=15S Mg(2+)-ATPase p97 subunit; AltName: Full=Valosin-containing protein; Short=VCP;. Gene name Name=VCP Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION DOI=10.1074/mcp.M112.022947; Vernocchi S., Battello N., Schmitz S., Revets D., Billing A.M., Turner J.D., Muller C.P. ''Membrane glucocorticoid receptor activation induces proteomic changes aligning with classical glucocorticoid-effects'' Molecular & Cellular Proteomics 12(7):1764-1779 (2013) 2D PAGE maps for identified proteins How to interpret a protein HSAPIENS_CCRF-CEM_3-10 {CCRF-CEM cells stimulated with Cort-BSA (internal standard)} Homo sapiens (Human)   map experimental info   HSAPIENS_CCRF-CEM_3-10 MAP LOCATIONS: SPOT 1539: pI=5.14; Mw=89191   [identification data] %COV: SPOT 1539: 69 [1]. SCORE: SPOT 1539: 999 [1]. SEARCH ENGINE: SPOT 1539: Mascot [1]. MAPPING (identification): SPOT 1539: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Claude P. Muller, Centre de Recherche Public de la Sante / National Public Health Laboratory, Luxembourg Cross-references UniProtKB/Swiss-Prot P55072; TERA_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name TERA_HUMAN Primary accession number P55072 Secondary accession number(s) B2R5T8 Q0V924 Q2TAI5 Q969G7 Q9UCD5 Sequence was last modified on  January 23, 2007 (version 4) Annotations were last modified on  October 1, 2014 (version 160) Name and origin of the protein Description RecName: Full=Transitional endoplasmic reticulum ATPase; Short=TER ATPase; EC=3.6.4.6; AltName: Full=15S Mg(2+)-ATPase p97 subunit; AltName: Full=Valosin-containing protein; Short=VCP; Gene name Name=VCP Encoded on Name=VCP Keywords 3D-structure; Acetylation; Amyotrophic lateral sclerosis; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; DNA damage; DNA repair; Endoplasmic reticulum; Hydrolase; Lipid-binding; Methylation; Neurodegeneration; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Transport; Ubl conjugation; Ubl conjugation pathway. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL AC004472; AAC07984.1; -; Genomic_DNA EMBL AF100752; AAD43016.1; -; mRNA EMBL AK312310; BAG35235.1; -; mRNA EMBL AL353795; CAH70993.1; -; Genomic_DNA EMBL CH471071; EAW58404.1; -; Genomic_DNA EMBL BC110913; AAI10914.1; -; mRNA EMBL BC121794; AAI21795.1; -; mRNA EMBL Z70768; CAA94809.1; -; mRNA CCDS CCDS6573.1; -; . PIR T02243; T02243; . RefSeq NP_009057.1; NM_007126.3; . UniGene Hs.529782; -; . PDB 3EBB; X-ray; 1.90 A; E/F/G/H=797-806 PDB 3HU1; X-ray; 2.81 A; A/B/C/D/E/F=1-481 PDB 3HU2; X-ray; 2.85 A; A/B/C/D/E/F=1-481 PDB 3HU3; X-ray; 2.20 A; A/B=1-481 PDB 3QC8; X-ray; 2.20 A; A=21-196 PDB 3QQ7; X-ray; 2.65 A; A=2-187 PDB 3QQ8; X-ray; 2.00 A; A=2-187 PDB 3QWZ; X-ray; 2.00 A; A=1-208 PDB 3TIW; X-ray; 1.80 A; A/B=1-187 PDB 4KDI; X-ray; 1.86 A; A/B=21-196 PDB 4KDL; X-ray; 1.81 A; A=21-196 PDB 4KLN; X-ray; 2.62 A; A/B/C/D/E/F=1-481 PDB 4KO8; X-ray; 1.98 A; A/B=1-481 PDB 4KOD; X-ray; 2.96 A; A/B/C/D/E/F/G/H/I/J/K/L=1-481 PDB 4P0A; X-ray; 2.30 A; B/D=797-806 PDBsum 3EBB; -; . PDBsum 3HU1; -; . PDBsum 3HU2; -; . PDBsum 3HU3; -; . PDBsum 3QC8; -; . PDBsum 3QQ7; -; . PDBsum 3QQ8; -; . PDBsum 3QWZ; -; . PDBsum 3TIW; -; . PDBsum 4KDI; -; . PDBsum 4KDL; -; . PDBsum 4KLN; -; . PDBsum 4KO8; -; . PDBsum 4KOD; -; . PDBsum 4P0A; -; . ProteinModelPortal P55072; -; . SMR P55072; 14-763; . BioGrid 113258; 460; . DIP DIP-33543N; -; . IntAct P55072; 57; . MINT MINT-272884; -; . STRING 9606.ENSP00000351777; -; . BindingDB P55072; -; . ChEMBL CHEMBL1075145; -; . TCDB 3.A.16.1.1; the endoplasmic reticular retrotranslocon (er-rt) family; . PhosphoSite P55072; -; . DMDM 6094447; -; . DOSAC-COBS-2DPAGE P55072; -; . OGP P55072; -; . REPRODUCTION-2DPAGE IPI00022774; -; . REPRODUCTION-2DPAGE P55072; -; . MaxQB P55072; -; . PaxDb P55072; -; . PRIDE P55072; -; . Ensembl ENST00000358901; ENSP00000351777; ENSG00000165280; . GeneID 7415; -; . KEGG hsa:7415; -; . UCSC uc003zvy.2; human; . CTD 7415; -; . GeneCards GC09M035056; -; . GeneReviews VCP; -; . HGNC HGNC:12666; VCP; . HPA CAB005593; -; . HPA HPA012728; -; . HPA HPA012814; -; . MIM 167320; phenotype; . MIM 601023; gene; . MIM 613954; phenotype; . neXtProt NX_P55072; -; . Orphanet 329478; Adult-onset distal myopathy due to VCP mutation; . Orphanet 803; Amyotrophic lateral sclerosis; . Orphanet 275864; Behavioral variant of frontotemporal dementia; . Orphanet 52430; Inclusion body myopathy with Paget disease of bone and frontotemporal dementia; . Orphanet 100070; Progressive non-fluent aphasia; . Orphanet 100069; Semantic dementia; . Orphanet 329475; Spastic paraplegia - Paget disease of bone; . PharmGKB PA37289; -; . eggNOG COG0464; -; . HOGENOM HOG000223224; -; . HOVERGEN HBG001226; -; . InParanoid P55072; -; . KO K13525; -; . OMA HKKVNLT; -; . OrthoDB EOG7H4DSW; -; . PhylomeDB P55072; -; . TreeFam TF300542; -; . Reactome REACT_200744; HSF1 activation; . SignaLink P55072; -; . ChiTaRS VCP; human; . EvolutionaryTrace P55072; -; . GeneWiki Valosin-containing_protein; -; . GenomeRNAi 7415; -; . NextBio 29034; -; . PRO PR:P55072; -; . ArrayExpress P55072; -; . Bgee P55072; -; . CleanEx HS_VCP; -; . Genevestigator P55072; -; . GO GO:0005737; C:cytoplasm; IDA:HPA; . GO GO:0005829; C:cytosol; IDA:UniProtKB; . GO GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB; . GO GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProt; . GO GO:0070062; C:extracellular vesicular exosome; IDA:UniProt; . GO GO:0000836; C:Hrd1p ubiquitin ligase complex; IDA:UniProt; . GO GO:0043231; C:intracellular membrane-bounded organelle; ISS:UniProtKB; . GO GO:0005811; C:lipid particle; IDA:MGI; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0048471; C:perinuclear region of cytoplasm; IDA:ParkinsonsUK-UCL; . GO GO:0000502; C:proteasome complex; IDA:BHF-UCL; . GO GO:0035861; C:site of double-strand break; IDA:UniProtKB; . GO GO:0043531; F:ADP binding; IEA:Ensembl; . GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0016887; F:ATPase activity; TAS:UniProtKB; . GO GO:0035800; F:deubiquitinase activator activity; IDA:ParkinsonsUK-UCL; . GO GO:0008289; F:lipid binding; IEA:UniProtKB-KW; . GO GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB; . GO GO:0031593; F:polyubiquitin binding; IDA:BHF-UCL; . GO GO:0005515; F:protein binding; IPI:UniProtKB; . GO GO:0019904; F:protein domain specific binding; IPI:UniProtKB; . GO GO:0019903; F:protein phosphatase binding; IPI:BHF-UCL; . GO GO:1990381; F:ubiquitin-specific protease binding; IPI:ParkinsonsUK-UCL; . GO GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB; . GO GO:0070842; P:aggresome assembly; IEA:Ensembl; . GO GO:0006974; P:cellular response to DNA damage stimulus; IDA:UniProtKB; . GO GO:0006281; P:DNA repair; NAS:UniProtKB; . GO GO:0006302; P:double-strand break repair; IDA:UniProtKB; . GO GO:0030968; P:endoplasmic reticulum unfolded protein response; TAS:UniProtKB; . GO GO:0006888; P:ER to Golgi vesicle-mediated transport; IEA:Ensembl; . GO GO:0030433; P:ER-associated ubiquitin-dependent protein catabolic process; IMP:UniProtKB; . GO GO:0045184; P:establishment of protein localization; TAS:UniProtKB; . GO GO:1903007; P:positive regulation of Lys63-specific deubiquitinase activity; IDA:ParkinsonsUK-UCL; . GO GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IDA:BHF-UCL; . GO GO:0045732; P:positive regulation of protein catabolic process; IDA:BHF-UCL; . GO GO:0031334; P:positive regulation of protein complex assembly; IDA:BHF-UCL; . GO GO:1903006; P:positive regulation of protein K63-linked deubiquitination; IDA:ParkinsonsUK-UCL; . GO GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; NAS:UniProtKB; . GO GO:0051260; P:protein homooligomerization; IEA:Ensembl; . GO GO:0018279; P:protein N-linked glycosylation via asparagine; IMP:UniProtKB; . GO GO:0016567; P:protein ubiquitination; IDA:UniProtKB; . GO GO:0042981; P:regulation of apoptotic process; TAS:UniProtKB; . GO GO:0030970; P:retrograde protein transport; ER to cytosol; IDA:UniProtKB GO GO:0019985; P:translesion synthesis; IMP:UniProtKB; . Gene3D 3.10.330.10; -; 1; . Gene3D 3.40.50.300; -; 2; . InterPro IPR003593; AAA+_ATPase; . InterPro IPR005938; AAA_ATPase_CDC48; . InterPro IPR009010; Asp_de-COase-like_dom; . InterPro IPR003959; ATPase_AAA_core; . InterPro IPR003960; ATPase_AAA_CS; . InterPro IPR004201; Cdc48_dom2; . InterPro IPR029067; CDC48_domain_2-like; . InterPro IPR003338; CDC4_N-term_subdom; . InterPro IPR027417; P-loop_NTPase; . InterPro IPR015415; Vps4_C; . Pfam PF00004; AAA; 2; . Pfam PF02933; CDC48_2; 1; . Pfam PF02359; CDC48_N; 1; . Pfam PF09336; Vps4_C; 1; . SMART SM00382; AAA; 2; . SMART SM01072; CDC48_2; 1; . SMART SM01073; CDC48_N; 1; . SUPFAM SSF50692; SSF50692; 1; . SUPFAM SSF52540; SSF52540; 2; . SUPFAM SSF54585; SSF54585; 1; . TIGRFAMs TIGR01243; CDC48; 1; . PROSITE PS00674; AAA; 2; . World-2DPAGE Repository (search AC)