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World-2DPAGE Repository  Search by  [accession number]  [description, ID or gene]  [author names]  [spot ID / serial number]  [identification methods]  [pI / Mw range]  [combined fields]  Maps  [experimental info]  [protein list]  [graphical interface]      Databases 0001 0002 0003 0004 0005 0006 0007 0008 0009 0010 0011 0012 0014 0017 0018 0019 0020 0021 0022 0023 0024 0026 0027 0029 0030 0031 0032 0034 0035 0036 0037 0038 0039 0040 0042 0043 0044 0046 0047 0050 0051 0053 0054 0056 0059 0061 0062 0063 0066 0068 0069 0076 0077 0080 0084 0085 0088 use 'Ctrl' to select several databases Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal Exclude local DBs has only effect if a remote interface is selected

Searching in 'World-2DPAGE Repository [0054]' for entry matching: P60709 World-2DPAGE Repository (0054):  P60709 P60709 General information about the entry View entry in simple text format Entry name ACTB_HUMAN Primary accession number P60709 integrated into World-2DPAGE Repository (0054) on  November 28, 2012 (release 1) 2D Annotations were last modified on November 28, 2012 (version 1) General Annotations were last modified on  October 23, 2014 (version 2) Name and origin of the protein Description RecName: Full=Actin, cytoplasmic 1; AltName: Full=Beta-actin; Contains: RecName: Full=Actin, cytoplasmic 1, N-terminally processed;. Gene name Name=ACTB Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION DOI=10.1074/mcp.M112.022947; Vernocchi S., Battello N., Schmitz S., Revets D., Billing A.M., Turner J.D., Muller C.P. ''Membrane glucocorticoid receptor activation induces proteomic changes aligning with classical glucocorticoid-effects'' Molecular & Cellular Proteomics 12(7):1764-1779 (2013) 2D PAGE maps for identified proteins How to interpret a protein HSAPIENS_CCRF-CEM_3-10 {CCRF-CEM cells stimulated with Cort-BSA (internal standard)} Homo sapiens (Human)   map experimental info   HSAPIENS_CCRF-CEM_3-10 MAP LOCATIONS: SPOT 786: pI=5.29; Mw=41737   [identification data] %COV: SPOT 786: 70 [1]. SCORE: SPOT 786: 650 [1]. SEARCH ENGINE: SPOT 786: Mascot [1]. MAPPING (identification): SPOT 786: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Claude P. Muller, Centre de Recherche Public de la Sante / National Public Health Laboratory, Luxembourg Cross-references UniProtKB/Swiss-Prot P60709; ACTB_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name ACTB_HUMAN Primary accession number P60709 Secondary accession number(s) P02570 P70514 P99021 Q11211 Q64316 Q75MN2 Q96B34 Q96HG5 Sequence was last modified on  April 1, 1988 (version 1) Annotations were last modified on  October 1, 2014 (version 133) Name and origin of the protein Description RecName: Full=Actin, cytoplasmic 1; AltName: Full=Beta-actin; Contains: RecName: Full=Actin, cytoplasmic 1, N-terminally processed; Gene name Name=ACTB Encoded on Name=ACTB Keywords 3D-structure; Acetylation; ATP-binding; Complete proteome; Cytoplasm; Cytoskeleton; Deafness; Direct protein sequencing; Disease mutation; Dystonia; Mental retardation; Methylation; Nucleotide-binding; Oxidation; Polymorphism; Reference proteome; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X00351; CAA25099.1; -; mRNA EMBL M10277; AAA51567.1; -; Genomic_DNA EMBL X63432; CAA45026.1; -; mRNA EMBL AY582799; AAS79319.1; -; Genomic_DNA EMBL AC006483; AAP22343.1; -; Genomic_DNA EMBL BC001301; AAH01301.1; -; mRNA EMBL BC002409; AAH02409.1; -; mRNA EMBL BC004251; AAH04251.1; -; mRNA EMBL BC008633; AAH08633.1; -; mRNA EMBL BC012854; AAH12854.1; -; mRNA EMBL BC013380; AAH13380.1; -; mRNA EMBL BC014861; AAH14861.1; -; mRNA EMBL BC016045; AAH16045.1; -; mRNA EMBL V00478; CAA23745.1; -; mRNA CCDS CCDS5341.1; -; . PIR A25168; ATHUB; . RefSeq NP_001092.1; NM_001101.3; . UniGene Hs.520640; -; . PDB 3BYH; EM; 12.00 A; A=2-375 PDB 3D2U; X-ray; 2.21 A; C/G=170-178 PDB 3LUE; EM; -; A/B/C/D/E/F/G/H/I/J=2-375 PDBsum 3BYH; -; . PDBsum 3D2U; -; . PDBsum 3LUE; -; . ProteinModelPortal P60709; -; . SMR P60709; 6-375; . BioGrid 106575; 193; . DIP DIP-29686N; -; . IntAct P60709; 165; . MINT MINT-220312; -; . ChEMBL CHEMBL2062353; -; . PhosphoSite P60709; -; . DMDM 46397333; -; . DOSAC-COBS-2DPAGE P60709; -; . DOSAC-COBS-2DPAGE P60709_OR_P63261; -; . REPRODUCTION-2DPAGE P60709; -; . SWISS-2DPAGE P60709; -; . UCD-2DPAGE P60709; -; . MaxQB P60709; -; . PaxDb P60709; -; . PeptideAtlas P60709; -; . PRIDE P60709; -; . DNASU 60; -; . Ensembl ENST00000331789; ENSP00000349960; ENSG00000075624; . GeneID 60; -; . KEGG hsa:60; -; . UCSC uc003soq.4; human; . CTD 60; -; . GeneCards GC07M005566; -; . HGNC HGNC:132; ACTB; . HPA CAB002621; -; . HPA HPA041264; -; . HPA HPA041271; -; . MIM 102630; gene; . MIM 243310; phenotype; . MIM 607371; phenotype; . neXtProt NX_P60709; -; . Orphanet 2995; Baraitser-Winter syndrome; . Orphanet 79107; Developmental malformations - deafness - dystonia; . PharmGKB PA24457; -; . eggNOG COG5277; -; . HOVERGEN HBG003771; -; . InParanoid P60709; -; . KO K05692; -; . OMA SIVHLKC; -; . OrthoDB EOG72RMZ1; -; . PhylomeDB P60709; -; . TreeFam TF354237; -; . Reactome REACT_11035; Gap junction degradation; . Reactome REACT_11049; Formation of annular gap junctions; . Reactome REACT_147867; Translocation of GLUT4 to the plasma membrane; . Reactome REACT_160086; Regulation of actin dynamics for phagocytic cup formation; . Reactome REACT_16936; Prefoldin mediated transfer of substrate to CCT/TriC; . Reactome REACT_17050; Folding of actin by CCT/TriC; . Reactome REACT_172610; HATs acetylate histones; . Reactome REACT_19195; Adherens junctions interactions; . Reactome REACT_197820; HATs acetylate histones; . Reactome REACT_20649; Cell-extracellular matrix interactions; . Reactome REACT_22266; Interaction between L1 and Ankyrins; . Reactome REACT_22365; Recycling pathway of L1; . Reactome REACT_24970; Factors involved in megakaryocyte development and platelet production; . SignaLink P60709; -; . ChiTaRS ACTB; human; . EvolutionaryTrace P60709; -; . GeneWiki Beta-actin; -; . GenomeRNAi 60; -; . NextBio 253; -; . PRO PR:P60709; -; . ArrayExpress P60709; -; . Bgee P60709; -; . CleanEx HS_ACTB; -; . Genevestigator P60709; -; . GO GO:0030424; C:axon; IEA:Ensembl; . GO GO:0072562; C:blood microparticle; IDA:UniProt; . GO GO:0030863; C:cortical cytoskeleton; IEA:Ensembl; . GO GO:0005737; C:cytoplasm; TAS:UniProtKB; . GO GO:0036464; C:cytoplasmic ribonucleoprotein granule; IDA:ParkinsonsUK-UCL; . GO GO:0005856; C:cytoskeleton; TAS:UniProtKB; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0005615; C:extracellular space; IDA:UniProt; . GO GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0070688; C:MLL5-L complex; IDA:UniProtKB; . GO GO:0035267; C:NuA4 histone acetyltransferase complex; IDA:UniProtKB; . GO GO:0000790; C:nuclear chromatin; IDA:UniProt; . GO GO:0005654; C:nucleoplasm; TAS:Reactome; . GO GO:0014069; C:postsynaptic density; IEA:Ensembl; . GO GO:0043234; C:protein complex; IDA:UniProt; . GO GO:0030529; C:ribonucleoprotein complex; IDA:UniProtKB; . GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0019894; F:kinesin binding; IPI:UniProtKB; . GO GO:0050998; F:nitric-oxide synthase binding; IPI:BHF-UCL; . GO GO:0005515; F:protein binding; IPI:UniProtKB; . GO GO:0005200; F:structural constituent of cytoskeleton; TAS:UniProtKB; . GO GO:0030957; F:Tat protein binding; IPI:BHF-UCL; . GO GO:0051084; P:'de novo' posttranslational protein folding; TAS:Reactome; . GO GO:0034332; P:adherens junction organization; TAS:Reactome; . GO GO:0043044; P:ATP-dependent chromatin remodeling; IDA:UniProt; . GO GO:0007411; P:axon guidance; TAS:Reactome; . GO GO:0007596; P:blood coagulation; TAS:Reactome; . GO GO:0034329; P:cell junction assembly; TAS:Reactome; . GO GO:0045216; P:cell-cell junction organization; TAS:Reactome; . GO GO:0006928; P:cellular component movement; TAS:UniProtKB; . GO GO:0044267; P:cellular protein metabolic process; TAS:Reactome; . GO GO:0006325; P:chromatin organization; TAS:Reactome; . GO GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; TAS:Reactome; . GO GO:0045087; P:innate immune response; TAS:Reactome; . GO GO:0061024; P:membrane organization; TAS:Reactome; . GO GO:0006457; P:protein folding; TAS:Reactome; . GO GO:0001895; P:retina homeostasis; IEP:UniProt; . GO GO:0021762; P:substantia nigra development; IEP:UniProt; . InterPro IPR004000; Actin-related; . InterPro IPR020902; Actin/actin-like_CS; . InterPro IPR004001; Actin_CS; . PANTHER PTHR11937; PTHR11937; 1; . Pfam PF00022; Actin; 1; . PRINTS PR00190; ACTIN; . SMART SM00268; ACTIN; 1; . PROSITE PS00406; ACTINS_1; 1; . PROSITE PS00432; ACTINS_2; 1; . PROSITE PS01132; ACTINS_ACT_LIKE; 1; . World-2DPAGE Repository (search AC)