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World-2DPAGE Repository  Search by  [accession number]  [description, ID or gene]  [author names]  [spot ID / serial number]  [identification methods]  [pI / Mw range]  [combined fields]  Maps  [experimental info]  [protein list]  [graphical interface]      Databases 0001 0002 0003 0004 0005 0006 0007 0008 0009 0010 0011 0012 0014 0017 0018 0019 0020 0021 0022 0023 0024 0026 0027 0029 0030 0031 0032 0034 0035 0036 0037 0038 0039 0040 0042 0043 0044 0046 0047 0050 0051 0053 0054 0056 0059 0061 0062 0063 0066 0068 0069 0076 0077 0080 0084 0085 0088 use 'Ctrl' to select several databases Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal Exclude local DBs has only effect if a remote interface is selected

Searching in 'World-2DPAGE Repository [0054]' for entry matching: P61086 World-2DPAGE Repository (0054):  P61086 P61086 General information about the entry View entry in simple text format Entry name UBE2K_HUMAN Primary accession number P61086 integrated into World-2DPAGE Repository (0054) on  November 28, 2012 (release 1) 2D Annotations were last modified on November 28, 2012 (version 1) General Annotations were last modified on  October 23, 2014 (version 2) Name and origin of the protein Description RecName: Full=Ubiquitin-conjugating enzyme E2 K; EC=6.3.2.19; AltName: Full=Huntingtin-interacting protein 2; Short=HIP-2; AltName: Full=Ubiquitin carrier protein; AltName: Full=Ubiquitin-conjugating enzyme E2-25 kDa; Short=Ubiquitin-conjugating enzyme E2(25K); Short=Ubiquitin-conjugating enzyme E2-25K; AltName: Full=Ubiquitin-protein ligase;. Gene name Name=UBE2K Synonyms=HIP2, LIG Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION DOI=10.1074/mcp.M112.022947; Vernocchi S., Battello N., Schmitz S., Revets D., Billing A.M., Turner J.D., Muller C.P. ''Membrane glucocorticoid receptor activation induces proteomic changes aligning with classical glucocorticoid-effects'' Molecular & Cellular Proteomics 12(7):1764-1779 (2013) 2D PAGE maps for identified proteins How to interpret a protein HSAPIENS_CCRF-CEM_3-10 {CCRF-CEM cells stimulated with Cort-BSA (internal standard)} Homo sapiens (Human)   map experimental info   HSAPIENS_CCRF-CEM_3-10 MAP LOCATIONS: SPOT 1101: pI=5.12; Mw=20647   [identification data] %COV: SPOT 1101: 60 [1]. SCORE: SPOT 1101: 452 [1]. SEARCH ENGINE: SPOT 1101: Mascot [1]. MAPPING (identification): SPOT 1101: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Claude P. Muller, Centre de Recherche Public de la Sante / National Public Health Laboratory, Luxembourg Cross-references UniProtKB/Swiss-Prot P61086; UBE2K_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name UBE2K_HUMAN Primary accession number P61086 Secondary accession number(s) A6NJC1 A8K5Y9 B2RDF8 C9JGP1 O54806 P27924 Q16721 Q9CVV9 Q9Y2D3 Sequence was last modified on  January 23, 2007 (version 3) Annotations were last modified on  October 1, 2014 (version 121) Name and origin of the protein Description RecName: Full=Ubiquitin-conjugating enzyme E2 K; EC=6.3.2.19; AltName: Full=Huntingtin-interacting protein 2; Short=HIP-2; AltName: Full=Ubiquitin carrier protein; AltName: Full=Ubiquitin-conjugating enzyme E2-25 kDa; Short=Ubiquitin-conjugating enzyme E2(25K); Short=Ubiquitin-conjugating enzyme E2-25K; AltName: Full=Ubiquitin-protein ligase; Gene name Name=UBE2K Synonyms=HIP2, LIG Encoded on Name=UBE2K; Synonyms=HIP2, LIG Keywords 3D-structure; Acetylation; Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Isopeptide bond; Ligase; Nucleotide-binding; Reference proteome; Ubl conjugation; Ubl conjugation pathway. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL U58522; AAC50633.1; -; mRNA EMBL AB022435; BAA78555.1; -; mRNA EMBL AB022436; BAA78556.1; -; mRNA EMBL BX339118; -; NOT_ANNOTATED_CDS; mRNA EMBL AK291454; BAF84143.1; -; mRNA EMBL AK315524; BAG37905.1; -; mRNA EMBL AC105287; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL AC108471; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471069; EAW92948.1; -; Genomic_DNA EMBL BC022804; AAH22804.1; -; mRNA EMBL BC050600; AAH50600.1; -; mRNA CCDS CCDS33976.1; -. [P61086-1]; . CCDS CCDS47043.1; -. [P61086-3]; . CCDS CCDS47044.1; -. [P61086-2]; . RefSeq NP_001104582.1; NM_001111112.1. [P61086-3]; . RefSeq NP_001104583.1; NM_001111113.1. [P61086-2]; . RefSeq NP_005330.1; NM_005339.4. [P61086-1]; . UniGene Hs.50308; -; . PDB 1YLA; X-ray; 2.40 A; A/B=1-200 PDB 2O25; X-ray; 2.60 A; A/B=1-200 PDB 3E46; X-ray; 1.86 A; A=1-200 PDB 3F92; X-ray; 2.23 A; A=13-200 PDB 3K9O; X-ray; 1.80 A; A=1-200 PDB 3K9P; X-ray; 2.80 A; A=1-200 PDBsum 1YLA; -; . PDBsum 2O25; -; . PDBsum 3E46; -; . PDBsum 3F92; -; . PDBsum 3K9O; -; . PDBsum 3K9P; -; . ProteinModelPortal P61086; -; . SMR P61086; 3-200; . BioGrid 109340; 77; . DIP DIP-32524N; -; . IntAct P61086; 12; . MINT MINT-5000019; -; . PhosphoSite P61086; -; . DMDM 46577658; -; . OGP P27924; -; . MaxQB P61086; -; . PaxDb P61086; -; . PeptideAtlas P61086; -; . PRIDE P61086; -; . DNASU 3093; -; . Ensembl ENST00000261427; ENSP00000261427; ENSG00000078140. [P61086-1]; . Ensembl ENST00000445950; ENSP00000390483; ENSG00000078140. [P61086-3]; . Ensembl ENST00000503368; ENSP00000421203; ENSG00000078140. [P61086-2]; . GeneID 3093; -; . KEGG hsa:3093; -; . UCSC uc003gut.4; human. [P61086-2]; . UCSC uc003guu.4; human. [P61086-1]; . CTD 3093; -; . GeneCards GC04P039700; -; . HGNC HGNC:4914; UBE2K; . HPA CAB033212; -; . HPA CAB033515; -; . HPA HPA028869; -; . MIM 602846; gene; . neXtProt NX_P61086; -; . PharmGKB PA162407874; -; . eggNOG COG5078; -; . HOVERGEN HBG063308; -; . InParanoid P61086; -; . KO K04649; -; . OMA KHWTNAY; -; . OrthoDB EOG7F513F; -; . PhylomeDB P61086; -; . TreeFam TF101127; -; . Reactome REACT_198532; Negative regulators of RIG-I/MDA5 signaling; . Reactome REACT_25271; Negative regulators of RIG-I/MDA5 signaling; . Reactome REACT_75842; Antigen processing: Ubiquitination & Proteasome degradation; . SignaLink P61086; -; . UniPathway UPA00143; -; . EvolutionaryTrace P61086; -; . GeneWiki HIP2; -; . GenomeRNAi 3093; -; . NextBio 12275; -; . PRO PR:P61086; -; . ArrayExpress P61086; -; . Bgee P61086; -; . CleanEx HS_UBE2K; -; . Genevestigator P61086; -; . GO GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell; . GO GO:0070062; C:extracellular vesicular exosome; IDA:UniProt; . GO GO:0016881; F:acid-amino acid ligase activity; IEA:InterPro; . GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0005515; F:protein binding; IPI:IntAct; . GO GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB; . GO GO:0004842; F:ubiquitin-protein transferase activity; IDA:UniProtKB; . GO GO:0034450; F:ubiquitin-ubiquitin ligase activity; IDA:UniProtKB; . GO GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IEA:Ensembl; . GO GO:0070936; P:protein K48-linked ubiquitination; IDA:UniProtKB; . GO GO:0032434; P:regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl; . GO GO:0006511; P:ubiquitin-dependent protein catabolic process; TAS:ProtInc; . Gene3D 3.10.110.10; -; 1; . InterPro IPR009060; UBA-like; . InterPro IPR015940; UBA/transl_elong_EF1B_N_euk; . InterPro IPR000449; UBA/Ts_N; . InterPro IPR000608; UBQ-conjugat_E2; . InterPro IPR023313; UBQ-conjugating_AS; . InterPro IPR016135; UBQ-conjugating_enzyme/RWD; . Pfam PF00627; UBA; 1; . Pfam PF00179; UQ_con; 1; . SMART SM00165; UBA; 1; . SUPFAM SSF46934; SSF46934; 1; . SUPFAM SSF54495; SSF54495; 1; . PROSITE PS50030; UBA; 1; . PROSITE PS00183; UBIQUITIN_CONJUGAT_1; 1; . PROSITE PS50127; UBIQUITIN_CONJUGAT_2; 1; . World-2DPAGE Repository (search AC)