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World-2DPAGE Repository  Search by  [accession number]  [description, ID or gene]  [author names]  [spot ID / serial number]  [identification methods]  [pI / Mw range]  [combined fields]  Maps  [experimental info]  [protein list]  [graphical interface]      Databases 0001 0002 0003 0004 0005 0006 0007 0008 0009 0010 0011 0012 0014 0017 0018 0019 0020 0021 0022 0023 0024 0026 0027 0029 0030 0031 0032 0034 0035 0036 0037 0038 0039 0040 0042 0043 0044 0046 0047 0050 0051 0053 0054 0056 0059 0061 0062 0063 0066 0068 0069 0076 0077 0080 0084 0085 0088 use 'Ctrl' to select several databases Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal Exclude local DBs has only effect if a remote interface is selected

Searching in 'World-2DPAGE Repository [0054]' for entry matching: P61088 World-2DPAGE Repository (0054):  P61088 P61088 General information about the entry View entry in simple text format Entry name UBE2N_HUMAN Primary accession number P61088 integrated into World-2DPAGE Repository (0054) on  November 28, 2012 (release 1) 2D Annotations were last modified on November 28, 2012 (version 1) General Annotations were last modified on  October 23, 2014 (version 2) Name and origin of the protein Description RecName: Full=Ubiquitin-conjugating enzyme E2 N; EC=6.3.2.19; AltName: Full=Bendless-like ubiquitin-conjugating enzyme; AltName: Full=Ubc13; AltName: Full=UbcH13; AltName: Full=Ubiquitin carrier protein N; AltName: Full=Ubiquitin-protein ligase N;. Gene name Name=UBE2N Synonyms=BLU Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION DOI=10.1074/mcp.M112.022947; Vernocchi S., Battello N., Schmitz S., Revets D., Billing A.M., Turner J.D., Muller C.P. ''Membrane glucocorticoid receptor activation induces proteomic changes aligning with classical glucocorticoid-effects'' Molecular & Cellular Proteomics 12(7):1764-1779 (2013) 2D PAGE maps for identified proteins How to interpret a protein HSAPIENS_CCRF-CEM_3-10 {CCRF-CEM cells stimulated with Cort-BSA (internal standard)} Homo sapiens (Human)   map experimental info   HSAPIENS_CCRF-CEM_3-10 MAP LOCATIONS: SPOT 1274: pI=6.18; Mw=17007   [identification data] %COV: SPOT 1274: 63 [1]. SCORE: SPOT 1274: 434 [1]. SEARCH ENGINE: SPOT 1274: Mascot [1]. MAPPING (identification): SPOT 1274: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Claude P. Muller, Centre de Recherche Public de la Sante / National Public Health Laboratory, Luxembourg Cross-references UniProtKB/Swiss-Prot P61088; UBE2N_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name UBE2N_HUMAN Primary accession number P61088 Secondary accession number(s) Q16781 Q53Y81 Sequence was last modified on  April 26, 2004 (version 1) Annotations were last modified on  October 1, 2014 (version 133) Name and origin of the protein Description RecName: Full=Ubiquitin-conjugating enzyme E2 N; EC=6.3.2.19; AltName: Full=Bendless-like ubiquitin-conjugating enzyme; AltName: Full=Ubc13; AltName: Full=UbcH13; AltName: Full=Ubiquitin carrier protein N; AltName: Full=Ubiquitin-protein ligase N; Gene name Name=UBE2N Synonyms=BLU Encoded on Name=UBE2N; Synonyms=BLU Keywords 3D-structure; Acetylation; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; DNA damage; DNA repair; Isopeptide bond; Ligase; Nucleotide-binding; Nucleus; Reference proteome; Ubl conjugation; Ubl conjugation pathway. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL D83004; BAA11675.1; -; mRNA EMBL BT006873; AAP35519.1; -; mRNA EMBL BC000396; AAH00396.1; -; mRNA EMBL BC003365; AAH03365.1; -; mRNA EMBL BC108704; AAI08705.1; -; mRNA CCDS CCDS31875.1; -; . PIR JC4894; JC4894; . RefSeq NP_003339.1; NM_003348.3; . UniGene Hs.524630; -; . PDB 1J7D; X-ray; 1.85 A; B=1-152 PDB 2C2V; X-ray; 2.90 A; B/E/H/K=2-152 PDB 3HCT; X-ray; 2.10 A; B=1-152 PDB 3HCU; X-ray; 2.60 A; B/D=1-152 PDB 3VON; X-ray; 3.15 A; C/E/G/J/L/N/Q/S/U/X/Z/b/e/g/i/l/n/p=3-150 PDB 3W31; X-ray; 2.96 A; B=1-152 PDB 4DHI; X-ray; 1.80 A; D=1-152 PDB 4DHJ; X-ray; 2.35 A; C/G/K/N=1-152 PDB 4DHZ; X-ray; 3.11 A; F=1-152 PDB 4IP3; X-ray; 2.30 A; B=1-152 PDB 4ORH; X-ray; 4.80 A; B/F/J=1-152 PDBsum 1J7D; -; . PDBsum 2C2V; -; . PDBsum 3HCT; -; . PDBsum 3HCU; -; . PDBsum 3VON; -; . PDBsum 3W31; -; . PDBsum 4DHI; -; . PDBsum 4DHJ; -; . PDBsum 4DHZ; -; . PDBsum 4IP3; -; . PDBsum 4ORH; -; . ProteinModelPortal P61088; -; . SMR P61088; 3-152; . BioGrid 113182; 126; . DIP DIP-29829N; -; . IntAct P61088; 57; . MINT MINT-5001139; -; . STRING 9606.ENSP00000316176; -; . BindingDB P61088; -; . ChEMBL CHEMBL6089; -; . PhosphoSite P61088; -; . DMDM 46577660; -; . OGP Q16781; -; . REPRODUCTION-2DPAGE IPI00003949; -; . MaxQB P61088; -; . PaxDb P61088; -; . PeptideAtlas P61088; -; . PRIDE P61088; -; . DNASU 7334; -; . Ensembl ENST00000318066; ENSP00000316176; ENSG00000177889; . GeneID 7334; -; . KEGG hsa:7334; -; . UCSC uc001tcp.3; human; . CTD 7334; -; . GeneCards GC12M093735; -; . HGNC HGNC:12492; UBE2N; . HPA HPA003962; -; . HPA HPA044976; -; . MIM 603679; gene; . neXtProt NX_P61088; -; . PharmGKB PA37141; -; . eggNOG COG5078; -; . HOGENOM HOG000233455; -; . HOVERGEN HBG063308; -; . InParanoid P61088; -; . KO K10580; -; . OMA YSTHTHI; -; . OrthoDB EOG7XWPQB; -; . PhylomeDB P61088; -; . TreeFam TF101126; -; . Reactome REACT_115831; ISG15 antiviral mechanism; . Reactome REACT_12555; Downstream TCR signaling; . Reactome REACT_163994; FCERI mediated NF-kB activation; . Reactome REACT_22442; Interleukin-1 signaling; . Reactome REACT_24918; IRAK1 recruits IKK complex; . Reactome REACT_25120; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling; . Reactome REACT_25354; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; . Reactome REACT_25374; IKK complex recruitment mediated by RIP1; . Reactome REACT_75776; NOD1/2 Signaling Pathway; . Reactome REACT_75842; Antigen processing: Ubiquitination & Proteasome degradation; . SignaLink P61088; -; . UniPathway UPA00143; -; . ChiTaRS UBE2N; human; . EvolutionaryTrace P61088; -; . GeneWiki UBE2N; -; . GenomeRNAi 7334; -; . NextBio 28704; -; . PRO PR:P61088; -; . ArrayExpress P61088; -; . Bgee P61088; -; . CleanEx HS_UBE2N; -; . Genevestigator P61088; -; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0070062; C:extracellular vesicular exosome; IDA:UniProt; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0043234; C:protein complex; IDA:MGI; . GO GO:0031372; C:UBC13-MMS2 complex; IDA:HGNC; . GO GO:0035370; C:UBC13-UEV1A complex; IDA:UniProtKB; . GO GO:0000151; C:ubiquitin ligase complex; IDA:UniProtKB; . GO GO:0016881; F:acid-amino acid ligase activity; IEA:InterPro; . GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB; . GO GO:0005515; F:protein binding; IPI:UniProtKB; . GO GO:0043130; F:ubiquitin binding; IDA:HGNC; . GO GO:0004842; F:ubiquitin-protein transferase activity; IDA:UniProtKB; . GO GO:0006464; P:cellular protein modification process; TAS:ProtInc; . GO GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome; . GO GO:0000729; P:DNA double-strand break processing; IMP:HGNC; . GO GO:0000724; P:double-strand break repair via homologous recombination; IMP:HGNC; . GO GO:0038095; P:Fc-epsilon receptor signaling pathway; TAS:Reactome; . GO GO:0016574; P:histone ubiquitination; IMP:HGNC; . GO GO:0045087; P:innate immune response; TAS:Reactome; . GO GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:Reactome; . GO GO:0035872; P:nucleotide-binding domain; leucine rich repeat containing receptor signaling pathway; TAS:Reactome GO GO:0070423; P:nucleotide-binding oligomerization domain containing signaling pathway; TAS:Reactome; . GO GO:0045739; P:positive regulation of DNA repair; IMP:HGNC; . GO GO:0031058; P:positive regulation of histone modification; IMP:HGNC; . GO GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IMP:HGNC; . GO GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IMP:UniProtKB; . GO GO:0051443; P:positive regulation of ubiquitin-protein transferase activity; IMP:HGNC; . GO GO:0006301; P:postreplication repair; IMP:HGNC; . GO GO:0070534; P:protein K63-linked ubiquitination; IDA:UniProtKB; . GO GO:0016567; P:protein ubiquitination; IMP:HGNC; . GO GO:0006508; P:proteolysis; TAS:ProtInc; . GO GO:0006282; P:regulation of DNA repair; TAS:ProtInc; . GO GO:0033182; P:regulation of histone ubiquitination; IMP:HGNC; . GO GO:0050852; P:T cell receptor signaling pathway; IMP:UniProtKB; . GO GO:0034166; P:toll-like receptor 10 signaling pathway; TAS:Reactome; . GO GO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome; . GO GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome; . GO GO:0034146; P:toll-like receptor 5 signaling pathway; TAS:Reactome; . GO GO:0034162; P:toll-like receptor 9 signaling pathway; TAS:Reactome; . GO GO:0002224; P:toll-like receptor signaling pathway; TAS:Reactome; . GO GO:0038123; P:toll-like receptor TLR1:TLR2 signaling pathway; TAS:Reactome; . GO GO:0038124; P:toll-like receptor TLR6:TLR2 signaling pathway; TAS:Reactome; . GO GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:Ensembl; . Gene3D 3.10.110.10; -; 1; . InterPro IPR000608; UBQ-conjugat_E2; . InterPro IPR023313; UBQ-conjugating_AS; . InterPro IPR016135; UBQ-conjugating_enzyme/RWD; . Pfam PF00179; UQ_con; 1; . SUPFAM SSF54495; SSF54495; 1; . PROSITE PS00183; UBIQUITIN_CONJUGAT_1; 1; . PROSITE PS50127; UBIQUITIN_CONJUGAT_2; 1; . World-2DPAGE Repository (search AC)