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World-2DPAGE Repository  Search by  [accession number]  [description, ID or gene]  [author names]  [spot ID / serial number]  [identification methods]  [pI / Mw range]  [combined fields]  Maps  [experimental info]  [protein list]  [graphical interface]      Databases 0001 0002 0003 0004 0005 0006 0007 0008 0009 0010 0011 0012 0014 0017 0018 0019 0020 0021 0022 0023 0024 0026 0027 0029 0030 0031 0032 0034 0035 0036 0037 0038 0039 0040 0042 0043 0044 0046 0047 0050 0051 0053 0054 0056 0059 0061 0062 0063 0066 0068 0069 0076 0077 0080 0084 0085 0088 use 'Ctrl' to select several databases Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal Exclude local DBs has only effect if a remote interface is selected

Searching in 'World-2DPAGE Repository [0054]' for entry matching: P62258 World-2DPAGE Repository (0054):  P62258 P62258 General information about the entry View entry in simple text format Entry name 1433E_HUMAN Primary accession number P62258 integrated into World-2DPAGE Repository (0054) on  November 28, 2012 (release 1) 2D Annotations were last modified on November 28, 2012 (version 1) General Annotations were last modified on  October 23, 2014 (version 2) Name and origin of the protein Description RecName: Full=14-3-3 protein epsilon; Short=14-3-3E;. Gene name Name=YWHAE Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION DOI=10.1074/mcp.M112.022947; Vernocchi S., Battello N., Schmitz S., Revets D., Billing A.M., Turner J.D., Muller C.P. ''Membrane glucocorticoid receptor activation induces proteomic changes aligning with classical glucocorticoid-effects'' Molecular & Cellular Proteomics 12(7):1764-1779 (2013) 2D PAGE maps for identified proteins How to interpret a protein HSAPIENS_CCRF-CEM_3-10 {CCRF-CEM cells stimulated with Cort-BSA (internal standard)} Homo sapiens (Human)   map experimental info   HSAPIENS_CCRF-CEM_3-10 MAP LOCATIONS: SPOT 1001: pI=4.68; Mw=32819   [identification data] %COV: SPOT 1001: 50 [1]. SCORE: SPOT 1001: 413 [1]. SEARCH ENGINE: SPOT 1001: Mascot [1]. MAPPING (identification): SPOT 1001: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Claude P. Muller, Centre de Recherche Public de la Sante / National Public Health Laboratory, Luxembourg Cross-references UniProtKB/Swiss-Prot P62258; 1433E_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name 1433E_HUMAN Primary accession number P62258 Secondary accession number(s) B3KY71 D3DTH5 P29360 P42655 Q4VJB6 Q53XZ5 Q63631 Q7M4R4 Sequence was last modified on  July 5, 2004 (version 1) Annotations were last modified on  October 1, 2014 (version 126) Name and origin of the protein Description RecName: Full=14-3-3 protein epsilon; Short=14-3-3E; Gene name Name=YWHAE Encoded on Name=YWHAE Keywords 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Host-virus interaction; Phosphoprotein; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL U20972; AAC50175.1; -; mRNA EMBL U54778; AAC50710.1; -; mRNA EMBL U43399; AAC50625.1; -; mRNA EMBL U43430; AAD00026.1; -; mRNA EMBL U28936; AAA75301.1; -; mRNA EMBL AB017103; BAA32538.1; -; Genomic_DNA EMBL AY883089; AAX68683.1; -; mRNA EMBL AK128785; BAG54733.1; -; mRNA EMBL AK295260; BAG58249.1; -; mRNA EMBL AK316185; BAH14556.1; -; mRNA EMBL BT007161; AAP35825.1; -; mRNA EMBL CH471108; EAW90628.1; -; Genomic_DNA EMBL CH471108; EAW90629.1; -; Genomic_DNA EMBL BC000179; AAH00179.1; -; mRNA EMBL BC001440; AAH01440.1; -; mRNA CCDS CCDS11001.1; -. [P62258-1]; . PIR A61235; A61235; . PIR I38947; I38947; . RefSeq NP_006752.1; NM_006761.4. [P62258-1]; . UniGene Hs.513851; -; . PDB 2BR9; X-ray; 1.75 A; A=1-233 PDB 3UAL; X-ray; 1.80 A; A=1-232 PDB 3UBW; X-ray; 1.90 A; A=1-234 PDBsum 2BR9; -; . PDBsum 3UAL; -; . PDBsum 3UBW; -; . ProteinModelPortal P62258; -; . SMR P62258; 3-232; . BioGrid 113363; 305; . DIP DIP-36676N; -; . IntAct P62258; 149; . MINT MINT-4998623; -; . STRING 9606.ENSP00000264335; -; . PhosphoSite P62258; -; . DMDM 51702210; -; . OGP P42655; -; . UCD-2DPAGE P62258; -; . MaxQB P62258; -; . PaxDb P62258; -; . PeptideAtlas P62258; -; . PRIDE P62258; -; . DNASU 7531; -; . Ensembl ENST00000264335; ENSP00000264335; ENSG00000108953. [P62258-1]; . Ensembl ENST00000571732; ENSP00000461762; ENSG00000108953. [P62258-2]; . GeneID 7531; -; . KEGG hsa:7531; -; . UCSC uc002fsj.3; human. [P62258-1]; . CTD 7531; -; . GeneCards GC17M001148; -; . H-InvDB HIX0013751; -; . H-InvDB HIX0030006; -; . HGNC HGNC:12851; YWHAE; . HPA CAB016200; -; . HPA CAB021109; -; . HPA CAB047350; -; . HPA HPA008445; -; . MIM 605066; gene; . neXtProt NX_P62258; -; . Orphanet 217385; 17p13.3 microduplication syndrome; . Orphanet 261257; Distal 17p13.3 microdeletion syndrome; . Orphanet 531; Miller-Dieker syndrome; . PharmGKB PA37440; -; . eggNOG COG5040; -; . HOVERGEN HBG050423; -; . InParanoid P62258; -; . KO K06630; -; . OMA MQESDKP; -; . OrthoDB EOG7HHWT3; -; . PhylomeDB P62258; -; . TreeFam TF102003; -; . Reactome REACT_118607; Signaling by Hippo; . Reactome REACT_13526; NADE modulates death signalling; . Reactome REACT_147867; Translocation of GLUT4 to the plasma membrane; . Reactome REACT_15296; Recruitment of mitotic centrosome proteins and complexes; . Reactome REACT_15364; Loss of Nlp from mitotic centrosomes; . Reactome REACT_15451; Loss of proteins required for interphase microtubule organization from the centrosome; . Reactome REACT_160315; Regulation of PLK1 Activity at G2/M Transition; . Reactome REACT_200744; HSF1 activation; . Reactome REACT_200780; Regulation of HSF1-mediated heat shock response; . SignaLink P62258; -; . ChiTaRS YWHAE; human; . EvolutionaryTrace P62258; -; . GeneWiki YWHAE; -; . GenomeRNAi 7531; -; . NextBio 29461; -; . PMAP-CutDB P62258; -; . PRO PR:P62258; -; . ArrayExpress P62258; -; . Bgee P62258; -; . CleanEx HS_YWHAE; -; . Genevestigator P62258; -; . GO GO:0030659; C:cytoplasmic vesicle membrane; TAS:Reactome; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB; . GO GO:0005871; C:kinesin complex; IEA:Ensembl; . GO GO:0042470; C:melanosome; IEA:UniProtKB-SubCell; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0005739; C:mitochondrion; IEA:Ensembl; . GO GO:0019899; F:enzyme binding; IPI:UniProtKB; . GO GO:0042826; F:histone deacetylase binding; IPI:BHF-UCL; . GO GO:0044325; F:ion channel binding; IPI:BHF-UCL; . GO GO:0023026; F:MHC class II protein complex binding; IDA:UniProt; . GO GO:0051219; F:phosphoprotein binding; IPI:BHF-UCL; . GO GO:0050815; F:phosphoserine binding; IPI:BHF-UCL; . GO GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB; . GO GO:0015459; F:potassium channel regulator activity; IDA:BHF-UCL; . GO GO:0005515; F:protein binding; IPI:UniProtKB; . GO GO:0046982; F:protein heterodimerization activity; IPI:BHF-UCL; . GO GO:0006915; P:apoptotic process; TAS:Reactome; . GO GO:0097190; P:apoptotic signaling pathway; TAS:Reactome; . GO GO:0021987; P:cerebral cortex development; IEA:Ensembl; . GO GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome; . GO GO:0035329; P:hippo signaling; TAS:Reactome; . GO GO:0021766; P:hippocampus development; IEA:Ensembl; . GO GO:0035556; P:intracellular signal transduction; TAS:ProtInc; . GO GO:0097193; P:intrinsic apoptotic signaling pathway; TAS:Reactome; . GO GO:0061024; P:membrane organization; TAS:Reactome; . GO GO:0086013; P:membrane repolarization during cardiac muscle cell action potential; IC:BHF-UCL; . GO GO:0000278; P:mitotic cell cycle; TAS:Reactome; . GO GO:1902309; P:negative regulation of peptidyl-serine dephosphorylation; IDA:BHF-UCL; . GO GO:0001764; P:neuron migration; IEA:Ensembl; . GO GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome; . GO GO:1900740; P:positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; TAS:Reactome; . GO GO:0006605; P:protein targeting; IEA:Ensembl; . GO GO:0043281; P:regulation of cysteine-type endopeptidase activity involved in apoptotic process; TAS:Reactome; . GO GO:0086091; P:regulation of heart rate by cardiac conduction; IC:BHF-UCL; . GO GO:0003064; P:regulation of heart rate by hormone; NAS:BHF-UCL; . GO GO:0060306; P:regulation of membrane repolarization; IDA:BHF-UCL; . GO GO:1901016; P:regulation of potassium ion transmembrane transporter activity; IDA:BHF-UCL; . GO GO:0021762; P:substantia nigra development; IEP:UniProt; . GO GO:0016032; P:viral process; IEA:UniProtKB-KW; . Gene3D 1.20.190.20; -; 1; . InterPro IPR000308; 14-3-3; . InterPro IPR023409; 14-3-3_CS; . InterPro IPR023410; 14-3-3_domain; . PANTHER PTHR18860; PTHR18860; 1; . Pfam PF00244; 14-3-3; 1; . PIRSF PIRSF000868; 14-3-3; 1; . PRINTS PR00305; 1433ZETA; . SMART SM00101; 14_3_3; 1; . SUPFAM SSF48445; SSF48445; 1; . PROSITE PS00796; 1433_1; 1; . PROSITE PS00797; 1433_2; 1; . World-2DPAGE Repository (search AC)