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Searching in 'World-2DPAGE Repository [0054]' for entry matching: P62993 World-2DPAGE Repository (0054):  P62993 P62993 General information about the entry View entry in simple text format Entry name GRB2_HUMAN Primary accession number P62993 integrated into World-2DPAGE Repository (0054) on  November 28, 2012 (release 1) 2D Annotations were last modified on November 28, 2012 (version 1) General Annotations were last modified on  October 23, 2014 (version 2) Name and origin of the protein Description RecName: Full=Growth factor receptor-bound protein 2; AltName: Full=Adapter protein GRB2; AltName: Full=Protein Ash; AltName: Full=SH2/SH3 adapter GRB2;. Gene name Name=GRB2 Synonyms=ASH Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION DOI=10.1074/mcp.M112.022947; Vernocchi S., Battello N., Schmitz S., Revets D., Billing A.M., Turner J.D., Muller C.P. ''Membrane glucocorticoid receptor activation induces proteomic changes aligning with classical glucocorticoid-effects'' Molecular & Cellular Proteomics 12(7):1764-1779 (2013) 2D PAGE maps for identified proteins How to interpret a protein HSAPIENS_CCRF-CEM_3-10 {CCRF-CEM cells stimulated with Cort-BSA (internal standard)} Homo sapiens (Human)   map experimental info   HSAPIENS_CCRF-CEM_3-10 MAP LOCATIONS: SPOT 1077: pI=7.87; Mw=26792   [identification data] %COV: SPOT 1077: 92 [1]. SCORE: SPOT 1077: 500 [1]. SEARCH ENGINE: SPOT 1077: Mascot [1]. MAPPING (identification): SPOT 1077: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Claude P. Muller, Centre de Recherche Public de la Sante / National Public Health Laboratory, Luxembourg Cross-references UniProtKB/Swiss-Prot P62993; GRB2_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name GRB2_HUMAN Primary accession number P62993 Secondary accession number(s) P29354 Q14450 Q63057 Q63059 Sequence was last modified on  August 31, 2004 (version 1) Annotations were last modified on  October 1, 2014 (version 140) Name and origin of the protein Description RecName: Full=Growth factor receptor-bound protein 2; AltName: Full=Adapter protein GRB2; AltName: Full=Protein Ash; AltName: Full=SH2/SH3 adapter GRB2; Gene name Name=GRB2 Synonyms=ASH Encoded on Name=GRB2; Synonyms=ASH Keywords 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Endosome; Golgi apparatus; Host-virus interaction; Nucleus; Phosphoprotein; Reference proteome; Repeat; SH2 domain; SH3 domain. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M96995; AAA58448.1; -; mRNA EMBL X62852; CAA44664.1; -; mRNA EMBL L29511; AAC37549.1; -; mRNA EMBL AF063618; AAC72075.1; -; Genomic_DNA EMBL AF063614; AAC72075.1; JOINED; Genomic_DNA EMBL AF063615; AAC72075.1; JOINED; Genomic_DNA EMBL AF063616; AAC72075.1; JOINED; Genomic_DNA EMBL AF063617; AAC72075.1; JOINED; Genomic_DNA EMBL AF498925; AAM21073.1; -; mRNA EMBL CR541942; CAG46740.1; -; mRNA EMBL AC011933; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL BC000631; AAH00631.1; -; mRNA CCDS CCDS11721.1; -; . CCDS CCDS11722.1; -. [P62993-2]; . PIR A43321; A43321; . RefSeq NP_002077.1; NM_002086.4. [P62993-1]; . RefSeq NP_987102.1; NM_203506.2. [P62993-2]; . UniGene Hs.444356; -; . PDB 1AZE; NMR; -; A=1-56 PDB 1BM2; X-ray; 2.10 A; A=49-163 PDB 1BMB; X-ray; 1.80 A; A=49-168 PDB 1CJ1; X-ray; 3.00 A; A/B/C/D/E/F/G/H/I/J/K/L=57-152 PDB 1FHS; NMR; -; A=53-163 PDB 1FYR; X-ray; 2.40 A; A/B/C/D=50-161 PDB 1GCQ; X-ray; 1.68 A; A/B=159-217 PDB 1GFC; NMR; -; A=159-215 PDB 1GFD; NMR; -; A=159-215 PDB 1GHU; NMR; -; A=60-158 PDB 1GRI; X-ray; 3.10 A; A/B=1-217 PDB 1IO6; NMR; -; A=159-215 PDB 1JYQ; X-ray; 2.00 A; A/B=60-151 PDB 1JYR; X-ray; 1.55 A; A=60-151 PDB 1JYU; X-ray; 2.75 A; A=60-151 PDB 1QG1; NMR; -; E=58-159 PDB 1TZE; X-ray; 2.10 A; E=55-152 PDB 1X0N; NMR; -; A=58-159 PDB 1ZFP; X-ray; 1.80 A; E=56-153 PDB 2AOA; X-ray; 1.99 A; A/B=55-153 PDB 2AOB; X-ray; 1.80 A; A/B/C/D=55-153 PDB 2H46; X-ray; 1.90 A; E=53-162 PDB 2H5K; X-ray; 3.25 A; A/B=53-162 PDB 2HUW; X-ray; 1.90 A; A/B=53-162 PDB 2VVK; X-ray; 1.60 A; A=161-214 PDB 2VWF; X-ray; 1.58 A; A=159-214 PDB 2W0Z; X-ray; 1.70 A; A=159-214 PDB 3C7I; X-ray; 1.70 A; A=53-162 PDB 3IMD; X-ray; 2.00 A; A/B=53-163 PDB 3IMJ; X-ray; 2.02 A; A/B=53-163 PDB 3IN7; X-ray; 2.00 A; A/C=53-163 PDB 3IN8; X-ray; 1.70 A; A=53-163 PDB 3KFJ; X-ray; 2.02 A; A=53-163 PDB 3MXC; X-ray; 2.00 A; A=55-152 PDB 3MXY; X-ray; 2.30 A; A=55-152 PDB 3N7Y; X-ray; 2.02 A; A/B/C=55-152 PDB 3N84; X-ray; 2.00 A; A/B/C/D/E/F=53-163 PDB 3N8M; X-ray; 2.00 A; A=53-163 PDB 3OV1; X-ray; 1.60 A; A=53-163 PDB 3OVE; X-ray; 1.82 A; A=53-163 PDB 3S8L; X-ray; 1.71 A; A=53-163 PDB 3S8N; X-ray; 1.71 A; A=53-163 PDB 3S8O; X-ray; 1.85 A; A=53-163 PDB 3WA4; X-ray; 1.35 A; A=60-152 PDB 4P9V; X-ray; 1.64 A; A=53-163 PDB 4P9Z; X-ray; 1.80 A; A=53-163 PDBsum 1AZE; -; . PDBsum 1BM2; -; . PDBsum 1BMB; -; . PDBsum 1CJ1; -; . PDBsum 1FHS; -; . PDBsum 1FYR; -; . PDBsum 1GCQ; -; . PDBsum 1GFC; -; . PDBsum 1GFD; -; . PDBsum 1GHU; -; . PDBsum 1GRI; -; . PDBsum 1IO6; -; . PDBsum 1JYQ; -; . PDBsum 1JYR; -; . PDBsum 1JYU; -; . PDBsum 1QG1; -; . PDBsum 1TZE; -; . PDBsum 1X0N; -; . PDBsum 1ZFP; -; . PDBsum 2AOA; -; . PDBsum 2AOB; -; . PDBsum 2H46; -; . PDBsum 2H5K; -; . PDBsum 2HUW; -; . PDBsum 2VVK; -; . PDBsum 2VWF; -; . PDBsum 2W0Z; -; . PDBsum 3C7I; -; . PDBsum 3IMD; -; . PDBsum 3IMJ; -; . PDBsum 3IN7; -; . PDBsum 3IN8; -; . PDBsum 3KFJ; -; . PDBsum 3MXC; -; . PDBsum 3MXY; -; . PDBsum 3N7Y; -; . PDBsum 3N84; -; . PDBsum 3N8M; -; . PDBsum 3OV1; -; . PDBsum 3OVE; -; . PDBsum 3S8L; -; . PDBsum 3S8N; -; . PDBsum 3S8O; -; . PDBsum 3WA4; -; . PDBsum 4P9V; -; . PDBsum 4P9Z; -; . DisProt DP00210; -; . ProteinModelPortal P62993; -; . SMR P62993; 1-217; . BioGrid 109142; 456; . DIP DIP-29229N; -; . IntAct P62993; 695; . MINT MINT-91952; -; . STRING 9606.ENSP00000339007; -; . BindingDB P62993; -; . ChEMBL CHEMBL3663; -; . DrugBank DB00061; Pegademase bovine; . PhosphoSite P62993; -; . DMDM 51702266; -; . OGP P62993; -; . SWISS-2DPAGE P62993; -; . MaxQB P62993; -; . PaxDb P62993; -; . PRIDE P62993; -; . DNASU 2885; -; . Ensembl ENST00000316615; ENSP00000317360; ENSG00000177885. [P62993-2]; . Ensembl ENST00000316804; ENSP00000339007; ENSG00000177885. [P62993-1]; . Ensembl ENST00000392562; ENSP00000376345; ENSG00000177885. [P62993-1]; . Ensembl ENST00000392563; ENSP00000376346; ENSG00000177885. [P62993-2]; . Ensembl ENST00000392564; ENSP00000376347; ENSG00000177885. [P62993-1]; . GeneID 2885; -; . KEGG hsa:2885; -; . UCSC uc002jnx.4; human; . UCSC uc002jny.4; human. [P62993-2]; . CTD 2885; -; . GeneCards GC17M073313; -; . HGNC HGNC:4566; GRB2; . HPA CAB002589; -; . MIM 108355; gene; . neXtProt NX_P62993; -; . PharmGKB PA28962; -; . eggNOG NOG298780; -; . HOGENOM HOG000251625; -; . HOVERGEN HBG005404; -; . InParanoid P62993; -; . KO K04364; -; . OMA VETKFVQ; -; . OrthoDB EOG75F4F6; -; . PhylomeDB P62993; -; . TreeFam TF354288; -; . Reactome REACT_111040; Signaling by SCF-KIT; . Reactome REACT_111080; Spry regulation of FGF signaling; . Reactome REACT_111184; Negative regulation of FGFR signaling; . Reactome REACT_111225; Regulation of KIT signaling; . Reactome REACT_115852; Signaling by constitutively active EGFR; . Reactome REACT_115854; GRB2 events in ERBB2 signaling; . Reactome REACT_115993; SHC1 events in ERBB2 signaling; . Reactome REACT_116005; SHC1 events in ERBB4 signaling; . Reactome REACT_116008; PI3K events in ERBB2 signaling; . Reactome REACT_118700; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; . Reactome REACT_12033; Signalling to RAS; . Reactome REACT_121096; EGFR Transactivation by Gastrin; . Reactome REACT_121141; Signaling by FGFR1 fusion mutants; . Reactome REACT_121398; Signaling by FGFR mutants; . Reactome REACT_12484; EGFR downregulation; . Reactome REACT_12578; GAB1 signalosome; . Reactome REACT_12579; SHC1 events in EGFR signaling; . Reactome REACT_12606; GRB2 events in EGFR signaling; . Reactome REACT_12621; Tie2 Signaling; . Reactome REACT_147727; Constitutive PI3K/AKT Signaling in Cancer; . Reactome REACT_147814; DAP12 signaling; . Reactome REACT_160086; Regulation of actin dynamics for phagocytic cup formation; . Reactome REACT_163701; FCERI mediated MAPK activation; . Reactome REACT_163769; Role of LAT2/NTAL/LAB on calcium mobilization; . Reactome REACT_163834; FCERI mediated Ca+2 mobilization; . Reactome REACT_17025; Downstream signal transduction; . Reactome REACT_18334; NCAM signaling for neurite out-growth; . Reactome REACT_19238; CD28 dependent Vav1 pathway; . Reactome REACT_19344; Costimulation by the CD28 family; . Reactome REACT_21247; FRS2-mediated cascade; . Reactome REACT_21270; PI-3K cascade; . Reactome REACT_21374; SHC-mediated cascade; . Reactome REACT_23787; Regulation of signaling by CBL; . Reactome REACT_23837; Interleukin-3; 5 and GM-CSF signaling; . Reactome REACT_23891; Interleukin receptor SHC signaling; . Reactome REACT_23916; Signal regulatory protein (SIRP) family interactions; . Reactome REACT_508; Signal attenuation; . Reactome REACT_524; SOS-mediated signalling; . Reactome REACT_661; SHC-mediated signalling; . Reactome REACT_75829; PIP3 activates AKT signaling; . Reactome REACT_976; PI3K Cascade; . SignaLink P62993; -; . ChiTaRS GRB2; human; . EvolutionaryTrace P62993; -; . GeneWiki GRB2; -; . GenomeRNAi 2885; -; . NextBio 11389; -; . PRO PR:P62993; -; . ArrayExpress P62993; -; . Bgee P62993; -; . CleanEx HS_GRB2; -; . Genevestigator P62993; -; . GO GO:0008180; C:COP9 signalosome; IDA:UniProtKB; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0005829; C:cytosol; TAS:HGNC; . GO GO:0005768; C:endosome; IDA:UniProtKB; . GO GO:0070062; C:extracellular vesicular exosome; IDA:UniProt; . GO GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell; . GO GO:0070436; C:Grb2-EGFR complex; IDA:BHF-UCL; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0005886; C:plasma membrane; TAS:Reactome; . GO GO:0012506; C:vesicle membrane; IEA:Ensembl; . GO GO:0046875; F:ephrin receptor binding; IPI:UniProtKB; . GO GO:0005154; F:epidermal growth factor receptor binding; IPI:UniProtKB; . GO GO:0042802; F:identical protein binding; IPI:IntAct; . GO GO:0043560; F:insulin receptor substrate binding; IPI:UniProtKB; . GO GO:0005168; F:neurotrophin TRKA receptor binding; IPI:UniProtKB; . GO GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB; . GO GO:0005515; F:protein binding; IPI:UniProtKB; . GO GO:0019901; F:protein kinase binding; IPI:BHF-UCL; . GO GO:0017124; F:SH3 domain binding; IDA:UniProtKB; . GO GO:0005070; F:SH3/SH2 adaptor activity; TAS:UniProtKB; . GO GO:0007568; P:aging; IEA:Ensembl; . GO GO:0048646; P:anatomical structure formation involved in morphogenesis; IEA:Ensembl; . GO GO:0007411; P:axon guidance; TAS:Reactome; . GO GO:0007596; P:blood coagulation; TAS:Reactome; . GO GO:0060670; P:branching involved in labyrinthine layer morphogenesis; IEA:Ensembl; . GO GO:0007267; P:cell-cell signaling; TAS:UniProtKB; . GO GO:0071479; P:cellular response to ionizing radiation; IMP:BHF-UCL; . GO GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:UniProtKB; . GO GO:0038095; P:Fc-epsilon receptor signaling pathway; TAS:Reactome; . GO GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; TAS:Reactome; . GO GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome; . GO GO:0045087; P:innate immune response; TAS:Reactome; . GO GO:0008286; P:insulin receptor signaling pathway; IPI:UniProtKB; . GO GO:0050900; P:leukocyte migration; TAS:Reactome; . GO GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; TAS:Reactome; . GO GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome; . GO GO:0048015; P:phosphatidylinositol-mediated signaling; TAS:Reactome; . GO GO:0030168; P:platelet activation; TAS:Reactome; . GO GO:0030838; P:positive regulation of actin filament polymerization; IEA:Ensembl; . GO GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IMP:BHF-UCL; . GO GO:0009967; P:positive regulation of signal transduction; TAS:GOC; . GO GO:0051291; P:protein heterooligomerization; IEA:Ensembl; . GO GO:0007265; P:Ras protein signal transduction; TAS:UniProtKB; . GO GO:0031623; P:receptor internalization; IMP:BHF-UCL; . GO GO:0043408; P:regulation of MAPK cascade; IEA:Ensembl; . GO GO:0042770; P:signal transduction in response to DNA damage; IMP:BHF-UCL; . GO GO:0031295; P:T cell costimulation; TAS:Reactome; . GO GO:0016032; P:viral process; IEA:UniProtKB-KW; . Gene3D 3.30.505.10; -; 1; . InterPro IPR000980; SH2; . InterPro IPR001452; SH3_domain; . Pfam PF00017; SH2; 1; . Pfam PF00018; SH3_1; 2; . PRINTS PR00401; SH2DOMAIN; . PRINTS PR00452; SH3DOMAIN; . SMART SM00252; SH2; 1; . SMART SM00326; SH3; 2; . SUPFAM SSF50044; SSF50044; 2; . SUPFAM SSF55550; SSF55550; 2; . PROSITE PS50001; SH2; 1; . PROSITE PS50002; SH3; 2; . World-2DPAGE Repository (search AC)