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Searching in 'World-2DPAGE Repository [0022]' for entry matching: P63018

World-2DPAGE Repository (0022):  P63018


General information about the entry
View entry in simple text format
Entry nameHSP7C_RAT
Primary accession numberP63018
integrated into World-2DPAGE Repository (0022) on May 7, 2010 (release 1)
2D Annotations were last modified onJune 22, 2011 (version 2)
General Annotations were last modified on November 24, 2011 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Heat shock cognate 71 kDa protein; AltName: Full=Heat shock 70 kDa protein 8;.
Gene nameName=Hspa8
Synonyms=Hsc70, Hsc73
Annotated speciesRattus [TaxID: 10114]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae.
Burniston J.G., Kenyani J., Wastling J.M., Burant C.F., Qi N.R., Koch L.G., Britton S.L.
''Proteomic analysis reveals perturbed energy metabolism and elevated oxidative stress in hearts of rats with inborn low aerobic capacity''
Proteomics 11(16):3369-3379 (2011)
2D PAGE maps for identified proteins
How to interpret a protein

Tissue: Heart
  map experimental info

pI=5.37; Mw=71055  [identification data]
pI=5.37; Mw=71055  [identification data]

IDENTIFICATION: SPOT 698: SeqCov=31.9%. Peptides MS=15/20. Mascot PMF Score=139 [1]
SPOT 764: SeqCov=21.5%. Peptides MS=9/20. Mascot PMF Score=68 [1].
MAPPING (identification):
SPOT 698: Peptide mass fingerprinting [1];
SPOT 764: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1].

Data from Dr. Jatin Burniston, Liverpool John Moores University, UK
UniProtKB/Swiss-ProtP63018; HSP7C_RAT.

2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_11
Entry nameHSP7C_RAT
Primary accession numberP63018
Secondary accession number(s) P08109 P12225 Q4FZY7 Q62373 Q62374 Q62375
Sequence was last modified on August 1, 1988 (version 1)
Annotations were last modified on November 16, 2011 (version 84)
Name and origin of the protein
DescriptionRecName: Full=Heat shock cognate 71 kDa protein; AltName: Full=Heat shock 70 kDa protein 8;
Gene nameName=Hspa8
Synonyms=Hsc70, Hsc73
Encoded onName=Hspa8; Synonyms=Hsc70, Hsc73
Keywords3D-structure; Acetylation; ATP-binding; Chaperone; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleotide-binding; Phosphoprotein; Reference proteome; Repressor; Stress response; Transcription; Transcription regulation; Ubl conjugation.
Copyrighted by the UniProt Consortium, see Distributed under the Creative Commons Attribution-NoDerivs License
EMBLY00054; CAA68265.1; -; Genomic_DNA
EMBLM11942; AAA41354.1; -; mRNA
EMBLBC061547; AAH61547.1; -; mRNA
EMBLBC098914; AAH98914.1; -; mRNA
IPIIPI00208205; -; .
PIRS07197; S07197; .
RefSeqNP_077327.1; NM_024351.2; .
UniGeneRn.120392; -; .
UniGeneRn.201298; -; .
PDB1CKR; NMR; -; A=385-543
PDB1Q2G; Model; -; C=385-543
PDB1UD0; X-ray; 3.45 A; A/B/C/D=542-646
PDB2V7Z; X-ray; 3.50 A; A/B=1-543
PDB7HSC; NMR; -; A=385-543
PDBsum1CKR; -; .
PDBsum1Q2G; -; .
PDBsum1UD0; -; .
PDBsum2V7Z; -; .
PDBsum7HSC; -; .
ProteinModelPortalP63018; -; .
SMRP63018; 1-621; .
IntActP63018; 5; .
MINTMINT-2514077; -; .
STRINGP63018; -; .
PhosphoSiteP63018; -; .
World-2DPAGE0004:P63018; -; .
PRIDEP63018; -; .
GeneID24468; -; .
KEGGrno:24468; -; .
UCSCBC061547; rat; .
CTD3312; -; .
RGD621725; Hspa8; .
eggNOGmaNOG11692; -; .
GeneTreeENSGT00550000074467; -; .
HOVERGENHBG051845; -; .
OrthoDBEOG4W6NVK; -; .
PhylomeDBP63018; -; .
NextBio603401; -; .
GenevestigatorP63018; -; .
GOGO:0070062; C:extracellular vesicular exosome; IDA:RGD; .
GOGO:0042470; C:melanosome; IEA:UniProtKB-SubCell; .
GOGO:0043005; C:neuron projection; IDA:RGD; .
GOGO:0043025; C:neuronal cell body; IDA:RGD; .
GOGO:0043234; C:protein complex; IDA:RGD; .
GOGO:0030529; C:ribonucleoprotein complex; ISS:UniProtKB; .
GOGO:0005625; C:soluble fraction; IDA:RGD; .
GOGO:0008021; C:synaptic vesicle; IDA:RGD; .
GOGO:0043531; F:ADP binding; IDA:RGD; .
GOGO:0005524; F:ATP binding; IDA:RGD; .
GOGO:0042623; F:ATPase activity; coupled; IDA:RGD
GOGO:0005102; F:receptor binding; IPI:RGD; .
GOGO:0051082; F:unfolded protein binding; IMP:RGD; .
GOGO:0051085; P:chaperone mediated protein folding requiring cofactor; IDA:RGD; .
GOGO:0045892; P:negative regulation of transcription; DNA-dependent; ISS:UniProtKB
GOGO:0006950; P:response to stress; IEA:UniProtKB-KW; .
GOGO:0006351; P:transcription; DNA-dependent; IEA:UniProtKB-KW
InterProIPR018181; Heat_shock_70_CS; .
InterProIPR001023; Hsp70; .
InterProIPR013126; Hsp_70; .
KOK03283; -; .
PANTHERPTHR19375; Hsp70; 1; .
PfamPF00012; HSP70; 1; .
PROSITEPS00297; HSP70_1; 1; .
PROSITEPS00329; HSP70_2; 1; .
PROSITEPS01036; HSP70_3; 1; .

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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server