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World-2DPAGE Repository
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Select Remote Interfaces
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SWISS-2DPAGE
World-2DPAGE Portal
Exclude local DBs
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Searching in 'World-2DPAGE Repository [0019]' for entry
matching:
P63329
World-2DPAGE Repository
(0019):
P63329
P63329
General information about the entry
View entry in simple text format
Entry name
PP2BA_RAT
Primary accession number
P63329
integrated into World-2DPAGE Repository (0019) on
December 9, 2009 (release 1)
2D Annotations were last modified on
May 30, 2011 (version 2)
General Annotations were last modified on
January 13, 2012 (version 2)
Name and origin of the protein
Description
RecName: Full=Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; EC=3.1.3.16; AltName: Full=CAM-PRP catalytic subunit; AltName: Full=Calmodulin-dependent calcineurin A subunit alpha isoform;.
Gene name
Name=Ppp3ca
Synonyms=Calna
Annotated species
Rattus norvegicus (Rat) [TaxID:
10116
]
Taxonomy
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
References
[1]
2D-PAGE GEL CHARACTERIZATION
DOI=
10.1111/j.1471-4159.2010.06719.x
;
VanGuilder H.D., Yan H., Farley J.A., Sonntag W.E., Freeman W.M.
''Aging alters the expression of neurotransmission-regulating proteins in the hippocampal synaptoproteome''
J of Neurochemistry 113(6):1577-1588 (2010)
2D PAGE maps for identified proteins
How to interpret a protein
HIPP_SYNAP
{Rat hippocampal synaptoproteome}
Rattus norvegicus (Rat)
Tissue: Hippocampus
map experimental info
HIPP_SYNAP
MAP LOCATIONS:
SPOT 370
:
pI=5.58; Mw=59290
[identification data]
SPOT 1154
:
pI=5.58; Mw=59290
[identification data]
IDENTIFICATION:
SPOT 370: Peptides number=8. SeqCov=15.4%. MOWSE score=5.97E+7 [
1
]
SPOT 1154: Peptides number=8. SeqCov=15.5%. MOWSE score=2.66E+6 [
1
].
MAPPING (identification):
SPOT
370
:
Peptide mass fingerprinting
[
1
];
Tandem mass spectrometry
[
1
];
SPOT
1154
:
Peptide mass fingerprinting
[
1
];
Tandem mass spectrometry
[
1
].
Copyright
Data from Dr. Willard Freeman, Penn State College of Medicine, USA
Cross-references
UniProtKB/Swiss-Prot
P63329; PP2BA_RAT.
2D PAGE maps for identified proteins
How to interpret a protein map
You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
Warning 1
: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
Warning 2
: the 2D PAGE map is built on demand. This may take some few seconds to be computed.
External data extracted from
UniProtKB/Swiss-Prot
Extracted from
UniProtKB/Swiss-Prot
, release:
2011_12
Entry name
PP2BA_RAT
Primary accession number
P63329
Secondary accession number(s)
P12816 P20652 Q6LDJ8 Q9WUV7 Q9Z1I5
Sequence was last modified on
October 11, 2004 (version 1)
Annotations were last modified on
November 16, 2011 (version 69)
Name and origin of the protein
Description
RecName: Full=Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; EC=3.1.3.16; AltName: Full=CAM-PRP catalytic subunit; AltName: Full=Calmodulin-dependent calcineurin A subunit alpha isoform;
Gene name
Name=Ppp3ca
Synonyms=Calna
Encoded on
Name=Ppp3ca; Synonyms=Calna
Keywords
Alternative splicing
;
Calmodulin-binding
;
Complete proteome
;
Direct protein sequencing
;
Hydrolase
;
Iron
;
Metal-binding
;
Nucleus
;
Phosphoprotein
;
Protein phosphatase
;
Reference proteome
;
Zinc
.
Copyright
Copyrighted by the UniProt Consortium, see
https://www.uniprot.org/help/license
. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBL
D90035; BAA14083.1
; -; mRNA
EMBL
M29275; AAA40940.1
; -; mRNA
EMBL
X57115; CAA40398.2
; -; mRNA
EMBL
D10480; BAA01283.1
; -; Genomic_DNA
EMBL
M58440; AAA41914.1
; -; mRNA
IPI
IPI00201410; -
; .
IPI
IPI00559849; -
; .
PIR
A33264; A33264
; .
RefSeq
NP_058737.1; NM_017041.1
; .
UniGene
Rn.6866; -
; .
ProteinModelPortal
P63329; -
; .
SMR
P63329; 1-372
; .
STRING
P63329; -
; .
PhosphoSite
P63329; -
; .
PRIDE
P63329; -
; .
GeneID
24674; -
; .
KEGG
rno:24674; -
; .
UCSC
NM_017041; rat
; .
CTD
5530; -
; .
RGD
3382; Ppp3ca
; .
eggNOG
roNOG11256; -
; .
GeneTree
ENSGT00530000063087; -
; .
HOVERGEN
HBG002819; -
; .
InParanoid
P63329; -
; .
OrthoDB
EOG4PVNZK; -
; .
PhylomeDB
P63329; -
; .
NextBio
604055; -
; .
ArrayExpress
P63329; -
; .
Genevestigator
P63329; -
; .
GermOnline
ENSRNOG00000009882; Rattus norvegicus
; .
GO
GO:0005955; C:calcineurin complex
; IDA:RGD; .
GO
GO:0005829; C:cytosol
; IDA:RGD; .
GO
GO:0016020; C:membrane
; IDA:RGD; .
GO
GO:0005634; C:nucleus
; IEA:UniProtKB-SubCell; .
GO
GO:0005625; C:soluble fraction
; IDA:RGD; .
GO
GO:0004723; F:calcium-dependent protein serine/threonine phosphatase activity
; IDA:RGD; .
GO
GO:0005516; F:calmodulin binding
; IDA:RGD; .
GO
GO:0046872; F:metal ion binding
; IEA:UniProtKB-KW; .
GO
GO:0046982; F:protein heterodimerization activity
; IDA:RGD; .
GO
GO:0071333; P:cellular response to glucose stimulus
; IMP:BHF-UCL; .
GO
GO:0045955; P:negative regulation of calcium ion-dependent exocytosis
; IC:BHF-UCL; .
GO
GO:0046676; P:negative regulation of insulin secretion
; IMP:BHF-UCL; .
GO
GO:0006470; P:protein dephosphorylation
; IDA:RGD; .
GO
GO:0001975; P:response to amphetamine
; IEP:RGD; .
InterPro
IPR004843; Metallo_PEstase_dom
; .
InterPro
IPR006186; Ser/Thr-sp_prot-phosphatase
; .
KO
K04348; -
; .
Pfam
PF00149; Metallophos
; 1; .
PRINTS
PR00114; STPHPHTASE
; .
SMART
SM00156; PP2Ac
; 1; .
PROSITE
PS00125; SER_THR_PHOSPHATASE
; 1; .
World-2DPAGE Repository (search AC)
Database constructed and maintained by
SIB
, using the
Make2D-DB II
package (
ver. 3.10.2
) from the
World-2DPAGE Constellation
of the
Expasy web server