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Searching in 'World-2DPAGE Repository [0022]' for entry matching: P67779

World-2DPAGE Repository (0022):  P67779


General information about the entry
View entry in simple text format
Entry namePHB_RAT
Primary accession numberP67779
integrated into World-2DPAGE Repository (0022) on May 7, 2010 (release 1)
2D Annotations were last modified onJune 22, 2011 (version 2)
General Annotations were last modified on November 24, 2011 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Prohibitin;.
Gene nameName=Phb
Annotated speciesRattus [TaxID: 10114]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae.
Burniston J.G., Kenyani J., Wastling J.M., Burant C.F., Qi N.R., Koch L.G., Britton S.L.
''Proteomic analysis reveals perturbed energy metabolism and elevated oxidative stress in hearts of rats with inborn low aerobic capacity''
Proteomics 11(16):3369-3379 (2011)
2D PAGE maps for identified proteins
How to interpret a protein

Tissue: Heart
  map experimental info

pI=5.57; Mw=29859  [identification data]
pI=5.57; Mw=29859  [identification data]

IDENTIFICATION: SPOT 370: SeqCov=63.2%. Peptides MS=13/20. Mascot PMF Score=162 [1]
SPOT 383: SeqCov=50.4%. Peptides MS=10/20. Mascot PMF Score=111 [1].
PEPTIDE EVIDENCE: SPOT 370: 456-MHPELGSFYDSR-467 (47) / 456-MHPELGSFYDSR-467 Oxidation (M) (53) / 73-GLIDEANQDFTNR-85 (56) [1]
SPOT 383: 134-FDAGELITQR-143 (71) / 94-ILFRPVASQLPR-105 (83) / 106-IYTSIGEDYDER-117 (104) [1].
MAPPING (identification):
SPOT 370: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1];
SPOT 383: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1].

Data from Dr. Jatin Burniston, Liverpool John Moores University, UK
UniProtKB/Swiss-ProtP67779; PHB_RAT.

2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_11
Entry namePHB_RAT
Primary accession numberP67779
Secondary accession number(s) P24142 Q4V8M6
Sequence was last modified on October 11, 2004 (version 1)
Annotations were last modified on September 21, 2011 (version 45)
Name and origin of the protein
DescriptionRecName: Full=Prohibitin;
Gene nameName=Phb
Encoded onName=Phb
KeywordsAcetylation; Coiled coil; Complete proteome; Direct protein sequencing; DNA synthesis; Membrane; Mitochondrion; Mitochondrion inner membrane; Phosphoprotein; Reference proteome.
Copyrighted by the UniProt Consortium, see Distributed under the Creative Commons Attribution-NoDerivs License
EMBLM61219; AAA63500.1; -; mRNA
EMBLBC072518; AAH72518.1; -; mRNA
EMBLBC097304; AAH97304.1; -; mRNA
IPIIPI00211756; -; .
PIRA39682; A39682; .
RefSeqNP_114039.1; NM_031851.2; .
UniGeneRn.29754; -; .
ProteinModelPortalP67779; -; .
IntActP67779; 1; .
PhosphoSiteP67779; -; .
World-2DPAGE0004:P67779; -; .
PRIDEP67779; -; .
GeneID25344; -; .
KEGGrno:25344; -; .
CTD5245; -; .
RGD3322; Phb; .
eggNOGmaNOG05553; -; .
HOVERGENHBG004457; -; .
PhylomeDBP67779; -; .
NextBio606263; -; .
GenevestigatorP67779; -; .
GOGO:0031315; C:extrinsic to mitochondrial outer membrane; IDA:RGD; .
GOGO:0030061; C:mitochondrial crista; IDA:RGD; .
GOGO:0005634; C:nucleus; IDA:RGD; .
GOGO:0006260; P:DNA replication; IEA:UniProtKB-KW; .
GOGO:0043066; P:negative regulation of apoptosis; IMP:RGD; .
GOGO:0008285; P:negative regulation of cell proliferation; IMP:RGD; .
GOGO:0031100; P:organ regeneration; IEP:RGD; .
GOGO:0001552; P:ovarian follicle atresia; IEP:RGD; .
GOGO:0001541; P:ovarian follicle development; IEP:RGD; .
GOGO:0034097; P:response to cytokine stimulus; IEP:RGD; .
GOGO:0042493; P:response to drug; IEP:RGD; .
GOGO:0045471; P:response to ethanol; IEP:RGD; .
GOGO:0043434; P:response to peptide hormone stimulus; IEP:RGD; .
GOGO:0006950; P:response to stress; IEP:RGD; .
InterProIPR001107; Band_7; .
InterProIPR000163; Prohibitin; .
PANTHERPTHR23222; Prohibitin; 1; .
PfamPF01145; Band_7; 1; .
SMARTSM00244; PHB; 1; .

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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server