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World-2DPAGE Repository  Search by  [accession number]  [description, ID or gene]  [author names]  [spot ID / serial number]  [identification methods]  [pI / Mw range]  [combined fields]  Maps  [experimental info]  [protein list]  [graphical interface]      Databases 0001 0002 0003 0004 0005 0006 0007 0008 0009 0010 0011 0012 0014 0017 0018 0019 0020 0021 0022 0023 0024 0026 0027 0029 0030 0031 0032 0034 0035 0036 0037 0038 0039 0040 0042 0043 0044 0046 0047 0050 0051 0053 0054 0056 0059 0061 0062 0063 0066 0068 0069 0076 0077 0080 0084 0085 0088 use 'Ctrl' to select several databases Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal Exclude local DBs has only effect if a remote interface is selected

Searching in 'World-2DPAGE Repository [0054]' for entry matching: PRDX2_HUMAN World-2DPAGE Repository (0054):  PRDX2_HUMAN PRDX2_HUMAN General information about the entry View entry in simple text format Entry name PRDX2_HUMAN Primary accession number P32119 integrated into World-2DPAGE Repository (0054) on  November 28, 2012 (release 1) 2D Annotations were last modified on November 28, 2012 (version 1) General Annotations were last modified on  October 23, 2014 (version 2) Name and origin of the protein Description RecName: Full=Peroxiredoxin-2; EC=1.11.1.15; AltName: Full=Natural killer cell-enhancing factor B; Short=NKEF-B; AltName: Full=PRP; AltName: Full=Thiol-specific antioxidant protein; Short=TSA; AltName: Full=Thioredoxin peroxidase 1; AltName: Full=Thioredoxin-dependent peroxide reductase 1;. Gene name Name=PRDX2 Synonyms=NKEFB, TDPX1 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION DOI=10.1074/mcp.M112.022947; Vernocchi S., Battello N., Schmitz S., Revets D., Billing A.M., Turner J.D., Muller C.P. ''Membrane glucocorticoid receptor activation induces proteomic changes aligning with classical glucocorticoid-effects'' Molecular & Cellular Proteomics 12(7):1764-1779 (2013) 2D PAGE maps for identified proteins How to interpret a protein HSAPIENS_CCRF-CEM_3-10 {CCRF-CEM cells stimulated with Cort-BSA (internal standard)} Homo sapiens (Human)   map experimental info   HSAPIENS_CCRF-CEM_3-10 MAP LOCATIONS: SPOT 1147: pI=5.67; Mw=21761   [identification data] %COV: SPOT 1147: 56 [1]. SCORE: SPOT 1147: 825 [1]. SEARCH ENGINE: SPOT 1147: Mascot [1]. MAPPING (identification): SPOT 1147: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Claude P. Muller, Centre de Recherche Public de la Sante / National Public Health Laboratory, Luxembourg Cross-references UniProtKB/Swiss-Prot P32119; PRDX2_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PRDX2_HUMAN Primary accession number P32119 Secondary accession number(s) A8K0C0 P31945 P32118 P35701 Q6FHG4 Q92763 Q9UC23 Sequence was last modified on  January 23, 2007 (version 5) Annotations were last modified on  October 1, 2014 (version 170) Name and origin of the protein Description RecName: Full=Peroxiredoxin-2; EC=1.11.1.15; AltName: Full=Natural killer cell-enhancing factor B; Short=NKEF-B; AltName: Full=PRP; AltName: Full=Thiol-specific antioxidant protein; Short=TSA; AltName: Full=Thioredoxin peroxidase 1; AltName: Full=Thioredoxin-dependent peroxide reductase 1; Gene name Name=PRDX2 Synonyms=NKEFB, TDPX1 Encoded on Name=PRDX2; Synonyms=NKEFB, TDPX1 Keywords 3D-structure; Acetylation; Alternative splicing; Antioxidant; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; Oxidoreductase; Peroxidase; Polymorphism; Redox-active center; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL Z22548; CAA80269.1; -; mRNA EMBL L19185; AAA50465.1; -; mRNA EMBL CR450356; CAG29352.1; -; mRNA EMBL CR541789; CAG46588.1; -; mRNA EMBL AK289485; BAF82174.1; -; mRNA EMBL DQ231563; ABB02182.1; -; Genomic_DNA EMBL AC018761; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471106; EAW84311.1; -; Genomic_DNA EMBL BC000452; AAH00452.1; -; mRNA EMBL BC003022; AAH03022.1; -; mRNA EMBL BC039428; AAH39428.1; -; mRNA EMBL X82321; CAA57764.1; -; mRNA CCDS CCDS12281.1; -. [P32119-1]; . PIR I68897; I68897; . RefSeq NP_005800.3; NM_005809.5. [P32119-1]; . UniGene Hs.432121; -; . PDB 1QMV; X-ray; 1.70 A; A/B/C/D/E/F/G/H/I/J=2-198 PDBsum 1QMV; -; . ProteinModelPortal P32119; -; . SMR P32119; 3-198; . BioGrid 112860; 57; . IntAct P32119; 27; . MINT MINT-3012817; -; . STRING 9606.ENSP00000301522; -; . PeroxiBase 4475; Hs2CysPrx02; . PhosphoSite P32119; -; . DMDM 2507169; -; . DOSAC-COBS-2DPAGE P32119; -; . OGP P32119; -; . REPRODUCTION-2DPAGE IPI00027350; -; . SWISS-2DPAGE P32119; -; . UCD-2DPAGE P32119; -; . MaxQB P32119; -; . PaxDb P32119; -; . PRIDE P32119; -; . DNASU 7001; -; . Ensembl ENST00000301522; ENSP00000301522; ENSG00000167815. [P32119-1]; . GeneID 7001; -; . KEGG hsa:7001; -; . UCSC uc002mvd.4; human. [P32119-1]; . CTD 7001; -; . GeneCards GC19M012907; -; . HGNC HGNC:9353; PRDX2; . HPA CAB008713; -; . MIM 600538; gene; . neXtProt NX_P32119; -; . PharmGKB PA33723; -; . eggNOG COG0450; -; . HOGENOM HOG000022343; -; . HOVERGEN HBG000286; -; . InParanoid P32119; -; . KO K03386; -; . OMA EGVIQHA; -; . PhylomeDB P32119; -; . TreeFam TF105181; -; . Reactome REACT_172715; Detoxification of Reactive Oxygen Species; . ChiTaRS PRDX2; human; . EvolutionaryTrace P32119; -; . GeneWiki Peroxiredoxin_2; -; . GenomeRNAi 7001; -; . NextBio 27342; -; . PRO PR:P32119; -; . ArrayExpress P32119; -; . Bgee P32119; -; . CleanEx HS_PRDX2; -; . Genevestigator P32119; -; . GO GO:0005737; C:cytoplasm; TAS:UniProtKB; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0070062; C:extracellular vesicular exosome; IDA:UniProt; . GO GO:0016209; F:antioxidant activity; IDA:UniProtKB; . GO GO:0008379; F:thioredoxin peroxidase activity; IDA:UniProtKB; . GO GO:0034599; P:cellular response to oxidative stress; IDA:BHF-UCL; . GO GO:0042744; P:hydrogen peroxide catabolic process; TAS:BHF-UCL; . GO GO:0043066; P:negative regulation of apoptotic process; TAS:UniProtKB; . GO GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl; . GO GO:0042981; P:regulation of apoptotic process; IMP:UniProtKB; . GO GO:0019430; P:removal of superoxide radicals; IDA:BHF-UCL; . GO GO:0006979; P:response to oxidative stress; IMP:UniProtKB; . Gene3D 3.40.30.10; -; 1; . InterPro IPR000866; AhpC/TSA; . InterPro IPR024706; Peroxiredoxin_AhpC-typ; . InterPro IPR019479; Peroxiredoxin_C; . InterPro IPR012336; Thioredoxin-like_fold; . Pfam PF10417; 1-cysPrx_C; 1; . Pfam PF00578; AhpC-TSA; 1; . PIRSF PIRSF000239; AHPC; 1; . SUPFAM SSF52833; SSF52833; 1; . PROSITE PS51352; THIOREDOXIN_2; 1; . World-2DPAGE Repository (search AC)