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World-2DPAGE Repository  Search by  [accession number]  [description, ID or gene]  [author names]  [spot ID / serial number]  [identification methods]  [pI / Mw range]  [combined fields]  Maps  [experimental info]  [protein list]  [graphical interface]      Databases 0001 0002 0003 0004 0005 0006 0007 0008 0009 0010 0011 0012 0014 0017 0018 0019 0020 0021 0022 0023 0024 0026 0027 0029 0030 0031 0032 0034 0035 0036 0037 0038 0039 0040 0042 0043 0044 0046 0047 0050 0051 0053 0054 0056 0059 0061 0062 0063 0066 0068 0069 0076 0077 0080 0084 0085 0088 use 'Ctrl' to select several databases Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal Exclude local DBs has only effect if a remote interface is selected

Searching in 'World-2DPAGE Repository [0054]' for entry matching: PRPS1_HUMAN World-2DPAGE Repository (0054):  PRPS1_HUMAN PRPS1_HUMAN General information about the entry View entry in simple text format Entry name PRPS1_HUMAN Primary accession number P60891 integrated into World-2DPAGE Repository (0054) on  November 28, 2012 (release 1) 2D Annotations were last modified on November 28, 2012 (version 1) General Annotations were last modified on  October 23, 2014 (version 2) Name and origin of the protein Description RecName: Full=Ribose-phosphate pyrophosphokinase 1; EC=2.7.6.1; AltName: Full=PPRibP; AltName: Full=Phosphoribosyl pyrophosphate synthase I; Short=PRS-I;. Gene name Name=PRPS1 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION DOI=10.1074/mcp.M112.022947; Vernocchi S., Battello N., Schmitz S., Revets D., Billing A.M., Turner J.D., Muller C.P. ''Membrane glucocorticoid receptor activation induces proteomic changes aligning with classical glucocorticoid-effects'' Molecular & Cellular Proteomics 12(7):1764-1779 (2013) 2D PAGE maps for identified proteins How to interpret a protein HSAPIENS_CCRF-CEM_3-10 {CCRF-CEM cells stimulated with Cort-BSA (internal standard)} Homo sapiens (Human)   map experimental info   HSAPIENS_CCRF-CEM_3-10 MAP LOCATIONS: SPOT 188203: pI=6.56; Mw=34703   [identification data] %COV: SPOT 188203: 55 [1]. SCORE: SPOT 188203: 501 [1]. SEARCH ENGINE: SPOT 188203: Mascot [1]. MAPPING (identification): SPOT 188203: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Claude P. Muller, Centre de Recherche Public de la Sante / National Public Health Laboratory, Luxembourg Cross-references UniProtKB/Swiss-Prot P60891; PRPS1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PRPS1_HUMAN Primary accession number P60891 Secondary accession number(s) B1ALA8 B2R6T7 B4DNL6 D3DUX6 P09329 Sequence was last modified on  January 23, 2007 (version 2) Annotations were last modified on  October 1, 2014 (version 121) Name and origin of the protein Description RecName: Full=Ribose-phosphate pyrophosphokinase 1; EC=2.7.6.1; AltName: Full=PPRibP; AltName: Full=Phosphoribosyl pyrophosphate synthase I; Short=PRS-I; Gene name Name=PRPS1 Encoded on Name=PRPS1 Keywords 3D-structure; Alternative splicing; ATP-binding; Charcot-Marie-Tooth disease; Complete proteome; Deafness; Direct protein sequencing; Disease mutation; Gout; Kinase; Magnesium; Mental retardation; Metal-binding; Neurodegeneration; Neuropathy; Non-syndromic deafness; Nucleotide biosynthesis; Nucleotide-binding; Polymorphism; Reference proteome; Transferase. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X15331; CAA33386.1; -; mRNA EMBL D00860; BAA00733.1; -; mRNA EMBL AK297968; BAG60278.1; -; mRNA EMBL AK312706; BAG35584.1; -; mRNA EMBL AL137787; CAI42173.1; -; Genomic_DNA EMBL AL772400; CAI42173.1; JOINED; Genomic_DNA EMBL AL772400; CAI41098.1; -; Genomic_DNA EMBL AL137787; CAI41098.1; JOINED; Genomic_DNA EMBL CH471120; EAX02709.1; -; Genomic_DNA EMBL CH471120; EAX02710.1; -; Genomic_DNA EMBL CH471120; EAX02711.1; -; Genomic_DNA EMBL BC001605; AAH01605.1; -; mRNA CCDS CCDS14529.1; -; . PIR JX0159; KIHUR1; . RefSeq NP_001191331.1; NM_001204402.1; . RefSeq NP_002755.1; NM_002764.3; . UniGene Hs.56; -; . PDB 2H06; X-ray; 2.20 A; A/B=1-318 PDB 2H07; X-ray; 2.20 A; A/B=1-318 PDB 2H08; X-ray; 2.50 A; A/B=1-318 PDB 2HCR; X-ray; 2.20 A; A/B=1-318 PDB 3EFH; X-ray; 2.60 A; A/B=1-318 PDB 3S5J; X-ray; 2.02 A; A/B=1-318 PDB 4F8E; X-ray; 2.27 A; A/B=1-318 PDBsum 2H06; -; . PDBsum 2H07; -; . PDBsum 2H08; -; . PDBsum 2HCR; -; . PDBsum 3EFH; -; . PDBsum 3S5J; -; . PDBsum 4F8E; -; . ProteinModelPortal P60891; -; . SMR P60891; 3-317; . BioGrid 111615; 17; . IntAct P60891; 5; . STRING 9606.ENSP00000361512; -; . BindingDB P60891; -; . ChEMBL CHEMBL2638; -; . PhosphoSite P60891; -; . DMDM 46397477; -; . UCD-2DPAGE P60891; -; . MaxQB P60891; -; . PaxDb P60891; -; . PRIDE P60891; -; . DNASU 5631; -; . Ensembl ENST00000372428; ENSP00000361505; ENSG00000147224; . Ensembl ENST00000372435; ENSP00000361512; ENSG00000147224; . GeneID 5631; -; . KEGG hsa:5631; -; . UCSC uc004ene.4; human; . CTD 5631; -; . GeneCards GC0XP106871; -; . GeneReviews PRPS1; -; . HGNC HGNC:9462; PRPS1; . MIM 300661; phenotype; . MIM 301835; phenotype; . MIM 304500; phenotype; . MIM 311070; phenotype; . MIM 311850; gene; . neXtProt NX_P60891; -; . Orphanet 1187; Lethal ataxia with deafness and optic atrophy; . Orphanet 3222; Phosphoribosylpyrophosphate synthetase superactivity; . Orphanet 99014; X-linked Charcot-Marie-Tooth disease type 5; . Orphanet 90625; X-linked nonsyndromic sensorineural deafness type DFN; . PharmGKB PA33817; -; . eggNOG COG0462; -; . HOGENOM HOG000210451; -; . HOVERGEN HBG001520; -; . InParanoid P60891; -; . KO K00948; -; . OMA INERTLP; -; . OrthoDB EOG7G4QG5; -; . PhylomeDB P60891; -; . TreeFam TF106366; -; . BioCyc MetaCyc:HS07410-MONOMER; -; . Reactome REACT_850; 5-Phosphoribose 1-diphosphate biosynthesis; . UniPathway UPA00087; UER00172; . ChiTaRS PRPS1; human; . EvolutionaryTrace P60891; -; . GenomeRNAi 5631; -; . NextBio 21886; -; . PRO PR:P60891; -; . ArrayExpress P60891; -; . Bgee P60891; -; . CleanEx HS_PRPS1; -; . Genevestigator P60891; -; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0002189; C:ribose phosphate diphosphokinase complex; IEA:Ensembl; . GO GO:0043531; F:ADP binding; IEA:Ensembl; . GO GO:0016208; F:AMP binding; IEA:Ensembl; . GO GO:0005524; F:ATP binding; IDA:UniProtKB; . GO GO:0030246; F:carbohydrate binding; IEA:Ensembl; . GO GO:0019003; F:GDP binding; IEA:Ensembl; . GO GO:0016301; F:kinase activity; IEA:UniProtKB-KW; . GO GO:0000287; F:magnesium ion binding; IEA:Ensembl; . GO GO:0042803; F:protein homodimerization activity; IPI:UniProtKB; . GO GO:0004749; F:ribose phosphate diphosphokinase activity; IDA:UniProtKB; . GO GO:0006015; P:5-phosphoribose 1-diphosphate biosynthetic process; TAS:Reactome; . GO GO:0006167; P:AMP biosynthetic process; IEA:Ensembl; . GO GO:0005975; P:carbohydrate metabolic process; TAS:Reactome; . GO GO:0008219; P:cell death; IEA:UniProtKB-KW; . GO GO:0046101; P:hypoxanthine biosynthetic process; IMP:UniProtKB; . GO GO:0007399; P:nervous system development; IMP:UniProtKB; . GO GO:0031100; P:organ regeneration; IEA:Ensembl; . GO GO:0006144; P:purine nucleobase metabolic process; IMP:UniProtKB; . GO GO:0006164; P:purine nucleotide biosynthetic process; IMP:UniProtKB; . GO GO:0006221; P:pyrimidine nucleotide biosynthetic process; NAS:UniProtKB; . GO GO:0044281; P:small molecule metabolic process; TAS:Reactome; . GO GO:0034418; P:urate biosynthetic process; IMP:UniProtKB; . Gene3D 3.40.50.2020; -; 2; . HAMAP MF_00583_B; RibP_PPkinase_B; 1; . InterPro IPR000842; PRib_PP_synth_CS; . InterPro IPR029099; Pribosyltran_N; . InterPro IPR029057; PRTase-like; . InterPro IPR005946; Rib-P_diPkinase; . Pfam PF14572; Pribosyl_synth; 1; . Pfam PF13793; Pribosyltran_N; 1; . SUPFAM SSF53271; SSF53271; 1; . TIGRFAMs TIGR01251; ribP_PPkin; 1; . PROSITE PS00114; PRPP_SYNTHASE; 1; . World-2DPAGE Repository (search AC)