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Searching in 'World-2DPAGE Repository [0043]' for entry matching: Q60631

World-2DPAGE Repository (0043):  Q60631


General information about the entry
View entry in simple text format
Entry nameGRB2_MOUSE
Primary accession numberQ60631
integrated into World-2DPAGE Repository (0043) on January 4, 2012 (release 1)
2D Annotations were last modified onJanuary 6, 2012 (version 1)
General Annotations were last modified on April 18, 2012 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Growth factor receptor-bound protein 2; AltName: Full=Adapter protein GRB2; AltName: Full=SH2/SH3 adapter GRB2;.
Gene nameName=Grb2
Annotated speciesMus musculus (Mouse) [TaxID: 10090]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus.
DOI=10.1016/j.jprot.2012.04.001 ;
Sun Z., Biela L.M., Hamilton K.L., Reardon K.F.
''Concentration-dependent effects of the soy phytoestrogen genistein on the proteome of cultured cardiomyocytes''
Journal of Proteomics 0(0):0-0 (2012)
2D PAGE maps for identified proteins
How to interpret a protein

MMUSCULUS_HL-1PHO_4-7 {mouse HL-1 cultured cardiomyocytes hydrophobic extraction}
Mus musculus (Mouse)
Tissue: Cardiac myocyte
  map experimental info

Mw=25336  [identification data]

%COV: BAND pho20: 10.4 [1].
SCORE: BAND pho20: 131 [1].
SEARCH ENGINE: BAND pho20: Mascot [1].
MAPPING (identification):
BAND pho20: Tandem mass spectrometry [1].

Data from Dr. Zeyu Sun, Department of Chemical and Biological Engineering, Colorado State University, Fort Collins, USA
UniProtKB/Swiss-ProtQ60631; GRB2_MOUSE.

2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2012_03
Entry nameGRB2_MOUSE
Primary accession numberQ60631
Secondary accession number(s) Q61240
Sequence was last modified on November 1, 1996 (version 1)
Annotations were last modified on March 21, 2012 (version 133)
Name and origin of the protein
DescriptionRecName: Full=Growth factor receptor-bound protein 2; AltName: Full=Adapter protein GRB2; AltName: Full=SH2/SH3 adapter GRB2;
Gene nameName=Grb2
Encoded onName=Grb2
Keywords3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Endosome; Golgi apparatus; Nucleus; Phosphoprotein; Reference proteome; Repeat; SH2 domain; SH3 domain.
Copyrighted by the UniProt Consortium, see Distributed under the Creative Commons Attribution-NoDerivs License
EMBLU07617; AAB40022.1; -; mRNA
EMBLD85748; BAA12862.1; -; mRNA
EMBLBC052377; AAH52377.1; -; mRNA
EMBLBC085254; AAH85254.1; -; mRNA
IPIIPI00119058; -; .
IPIIPI00230539; -; .
PIRA54688; A54688; .
RefSeqNP_032189.1; NM_008163.3; .
UniGeneMm.439649; -; .
PDB1GBQ; NMR; -; A=1-59
PDB1GBR; NMR; -; A=1-59
PDB2GBQ; NMR; -; A=1-59
PDB3GBQ; NMR; -; A=1-59
PDB4GBQ; NMR; -; A=1-59
PDBsum1GBQ; -; .
PDBsum1GBR; -; .
PDBsum2GBQ; -; .
PDBsum3GBQ; -; .
PDBsum4GBQ; -; .
ProteinModelPortalQ60631; -; .
SMRQ60631; 1-217; .
DIPDIP-259N; -; .
IntActQ60631; 38; .
MINTMINT-84889; -; .
STRINGQ60631; -; .
PhosphoSiteQ60631; -; .
PRIDEQ60631; -; .
EnsemblENSMUST00000021090; ENSMUSP00000021090; ENSMUSG00000059923; .
EnsemblENSMUST00000106497; ENSMUSP00000102106; ENSMUSG00000059923; .
EnsemblENSMUST00000106499; ENSMUSP00000102108; ENSMUSG00000059923; .
EnsemblENSMUST00000106500; ENSMUSP00000102109; ENSMUSG00000059923; .
GeneID14784; -; .
KEGGmmu:14784; -; .
CTD2885; -; .
MGIMGI:95805; Grb2; .
eggNOGNOG298780; -; .
GeneTreeENSGT00550000074482; -; .
HOGENOMHBG715336; -; .
HOVERGENHBG005404; -; .
InParanoidQ60631; -; .
KOK04364; -; .
OrthoDBEOG4XSKQS; -; .
PhylomeDBQ60631; -; .
NextBio286907; -; .
ArrayExpressQ60631; -; .
BgeeQ60631; -; .
CleanExMM_GRB2; -; .
GenevestigatorQ60631; -; .
GermOnlineENSMUSG00000059923; Mus musculus; .
GOGO:0005829; C:cytosol; TAS:Reactome; .
GOGO:0005768; C:endosome; ISS:UniProtKB; .
GOGO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell; .
GOGO:0005634; C:nucleus; ISS:UniProtKB; .
GOGO:0012506; C:vesicle membrane; IDA:MGI; .
GOGO:0046875; F:ephrin receptor binding; IPI:UniProtKB; .
GOGO:0019904; F:protein domain specific binding; IPI:MGI; .
GOGO:0019903; F:protein phosphatase binding; IPI:UniProtKB; .
GOGO:0005070; F:SH3/SH2 adaptor activity; IDA:MGI; .
GOGO:0048646; P:anatomical structure formation involved in morphogenesis; IMP:MGI; .
GOGO:0060670; P:branching involved in embryonic placenta morphogenesis; IMP:MGI; .
GOGO:0030154; P:cell differentiation; IMP:MGI; .
GOGO:0007265; P:Ras protein signal transduction; TAS:MGI; .
GOGO:0043408; P:regulation of MAPK cascade; IGI:MGI; .
InterProIPR000108; p67phox; .
InterProIPR000980; SH2; .
InterProIPR001452; SH3_domain; .
Gene3DG3DSA:3.30.505.10; SH2; 1; .
PfamPF00017; SH2; 1; .
PfamPF00018; SH3_1; 2; .
SMARTSM00252; SH2; 1; .
SMARTSM00326; SH3; 2; .
SUPFAMSSF50044; SH3; 1; .
PROSITEPS50001; SH2; 1; .
PROSITEPS50002; SH3; 2; .

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World-2DPAGE Repository (search AC)

Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server