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World-2DPAGE Repository  Search by  [accession number]  [description, ID or gene]  [author names]  [spot ID / serial number]  [identification methods]  [pI / Mw range]  [combined fields]  Maps  [experimental info]  [protein list]  [graphical interface]      Databases 0001 0002 0003 0004 0005 0006 0007 0008 0009 0010 0011 0012 0014 0017 0018 0019 0020 0021 0022 0023 0024 0026 0027 0029 0030 0031 0032 0034 0035 0036 0037 0038 0039 0040 0042 0043 0044 0046 0047 0050 0051 0053 0054 0056 0059 0061 0062 0063 0066 0068 0069 0076 0077 0080 0084 0085 0088 use 'Ctrl' to select several databases Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal Exclude local DBs has only effect if a remote interface is selected

Searching in 'World-2DPAGE Repository [0054]' for entry matching: Q6NVY1 World-2DPAGE Repository (0054):  Q6NVY1 Q6NVY1 General information about the entry View entry in simple text format Entry name HIBCH_HUMAN Primary accession number Q6NVY1 integrated into World-2DPAGE Repository (0054) on  November 28, 2012 (release 1) 2D Annotations were last modified on November 28, 2012 (version 1) General Annotations were last modified on  October 23, 2014 (version 2) Name and origin of the protein Description RecName: Full=3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; EC=3.1.2.4; AltName: Full=3-hydroxyisobutyryl-coenzyme A hydrolase; Short=HIB-CoA hydrolase; Short=HIBYL-CoA-H; Flags: Precursor;. Gene name Name=HIBCH Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION DOI=10.1074/mcp.M112.022947; Vernocchi S., Battello N., Schmitz S., Revets D., Billing A.M., Turner J.D., Muller C.P. ''Membrane glucocorticoid receptor activation induces proteomic changes aligning with classical glucocorticoid-effects'' Molecular & Cellular Proteomics 12(7):1764-1779 (2013) 2D PAGE maps for identified proteins How to interpret a protein HSAPIENS_CCRF-CEM_3-10 {CCRF-CEM cells stimulated with Cort-BSA (internal standard)} Homo sapiens (Human)   map experimental info   HSAPIENS_CCRF-CEM_3-10 MAP LOCATIONS: SPOT 881: pI=6.30; Mw=39485   [identification data] %COV: SPOT 881: 31 [1]. SCORE: SPOT 881: 148 [1]. SEARCH ENGINE: SPOT 881: Mascot [1]. MAPPING (identification): SPOT 881: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Claude P. Muller, Centre de Recherche Public de la Sante / National Public Health Laboratory, Luxembourg Cross-references UniProtKB/Swiss-Prot Q6NVY1; HIBCH_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name HIBCH_HUMAN Primary accession number Q6NVY1 Secondary accession number(s) D3DPI4 Q53GA8 Q53GF2 Q53RF7 Q53TC6 Q92931 Q9BS94 Sequence was last modified on  May 1, 2007 (version 2) Annotations were last modified on  October 1, 2014 (version 98) Name and origin of the protein Description RecName: Full=3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; EC=3.1.2.4; AltName: Full=3-hydroxyisobutyryl-coenzyme A hydrolase; Short=HIB-CoA hydrolase; Short=HIBYL-CoA-H; Flags: Precursor; Gene name Name=HIBCH Encoded on Name=HIBCH Keywords 3D-structure; Acetylation; Alternative splicing; Branched-chain amino acid catabolism; Complete proteome; Disease mutation; Hydrolase; Mitochondrion; Polymorphism; Reference proteome; Transit peptide. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL U66669; AAC52114.1; ALT_INIT; mRNA EMBL AK222979; BAD96699.1; ALT_INIT; mRNA EMBL AK223023; BAD96743.1; ALT_INIT; mRNA EMBL AC092178; AAY24178.1; ALT_INIT; Genomic_DNA EMBL AC010679; AAX93234.1; -; Genomic_DNA EMBL CH471058; EAX10873.1; -; Genomic_DNA EMBL CH471058; EAX10875.1; -; Genomic_DNA EMBL BC005190; AAH05190.2; ALT_INIT; mRNA EMBL BC067822; AAH67822.1; -; mRNA CCDS CCDS2304.1; -. [Q6NVY1-1]; . CCDS CCDS46475.1; -. [Q6NVY1-2]; . RefSeq NP_055177.2; NM_014362.3. [Q6NVY1-1]; . RefSeq NP_932164.1; NM_198047.2. [Q6NVY1-2]; . UniGene Hs.656685; -; . PDB 3BPT; X-ray; 1.50 A; A=32-386 PDBsum 3BPT; -; . ProteinModelPortal Q6NVY1; -; . SMR Q6NVY1; 32-386; . BioGrid 117658; 4; . IntAct Q6NVY1; 2; . STRING 9606.ENSP00000352706; -; . PhosphoSite Q6NVY1; -; . DMDM 146324905; -; . REPRODUCTION-2DPAGE IPI00419802; -; . MaxQB Q6NVY1; -; . PaxDb Q6NVY1; -; . PeptideAtlas Q6NVY1; -; . PRIDE Q6NVY1; -; . Ensembl ENST00000359678; ENSP00000352706; ENSG00000198130. [Q6NVY1-1]; . Ensembl ENST00000392332; ENSP00000376144; ENSG00000198130. [Q6NVY1-2]; . GeneID 26275; -; . KEGG hsa:26275; -; . UCSC uc002uru.3; human. [Q6NVY1-1]; . UCSC uc002urv.3; human. [Q6NVY1-2]; . CTD 26275; -; . GeneCards GC02M191054; -; . HGNC HGNC:4908; HIBCH; . HPA HPA036540; -; . HPA HPA036541; -; . MIM 250620; phenotype; . MIM 610690; gene; . neXtProt NX_Q6NVY1; -; . Orphanet 88639; Neurodegeneration due to 3-hydroxyisobutyryl-CoA hydrolase deficiency; . PharmGKB PA29281; -; . eggNOG COG1024; -; . HOVERGEN HBG054809; -; . InParanoid Q6NVY1; -; . KO K05605; -; . OMA VASLCHA; -; . PhylomeDB Q6NVY1; -; . TreeFam TF314329; -; . BRENDA 3.1.2.4; 2681; . Reactome REACT_197; Branched-chain amino acid catabolism; . SABIO-RK Q6NVY1; -; . UniPathway UPA00362; -; . EvolutionaryTrace Q6NVY1; -; . GenomeRNAi 26275; -; . NextBio 48577; -; . PRO PR:Q6NVY1; -; . ArrayExpress Q6NVY1; -; . Bgee Q6NVY1; -; . CleanEx HS_HIBCH; -; . Genevestigator Q6NVY1; -; . GO GO:0070062; C:extracellular vesicular exosome; IDA:UniProt; . GO GO:0005759; C:mitochondrial matrix; TAS:Reactome; . GO GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IDA:UniProtKB; . GO GO:0009083; P:branched-chain amino acid catabolic process; TAS:Reactome; . GO GO:0034641; P:cellular nitrogen compound metabolic process; TAS:Reactome; . GO GO:0044281; P:small molecule metabolic process; TAS:Reactome; . GO GO:0006574; P:valine catabolic process; IEA:UniProtKB-UniPathway; . Gene3D 1.10.12.10; -; 1; . Gene3D 3.90.226.10; -; 1; . InterPro IPR029045; ClpP/crotonase-like_dom; . InterPro IPR014748; Crontonase_C; . SUPFAM SSF52096; SSF52096; 2; . World-2DPAGE Repository (search AC)