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Searching in 'World-2DPAGE Repository [0030]' for entry matching: Q9Z110




World-2DPAGE Repository (0030):  Q9Z110


Q9Z110


General information about the entry
View entry in simple text format
Entry nameP5CS_MOUSE
Primary accession numberQ9Z110
integrated into World-2DPAGE Repository (0030) on November 9, 2010 (release 1)
2D Annotations were last modified onJune 21, 2011 (version 2)
General Annotations were last modified on November 23, 2011 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Delta-1-pyrroline-5-carboxylate synthase; Short=P5CS; AltName: Full=Aldehyde dehydrogenase family 18 member A1; Includes: RecName: Full=Glutamate 5-kinase; Short=GK; EC=2.7.2.11; AltName: Full=Gamma-glutamyl kinase; Includes: RecName: Full=Gamma-glutamyl phosphate reductase; Short=GPR; EC=1.2.1.41; AltName: Full=Glutamate-5-semialdehyde dehydrogenase; AltName: Full=Glutamyl-gamma-semialdehyde dehydrogenase;.
Gene nameName=Aldh18a1
Synonyms=P5cs, Pycs
Annotated speciesRattus norvegicus (Rat) [TaxID: 10116]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
References
[1]   2D-PAGE GEL CHARACTERIZATION
DOI=10.1002/pmic.201000006;
D'Hertog W., Maris M., Thorrez L., Waelkens E., Overbergh L., Mathieu C.
''Two-dimensional gel proteome reference map of INS-1E cells''
Proteomics 11(7):1365-1369 (2011)
2D PAGE maps for identified proteins
How to interpret a protein

RAT_INS1E_4-7 {INS-1E cell line, a model rat cell line for pancreatic beta cells, PH4-7}
Rattus norvegicus (Rat)
RAT_INS1E_4-7
  map experimental info
 
RAT_INS1E_4-7

MAP LOCATIONS:
pI=6.70; Mw=86894  [identification data]

IDENTIFICATION: SPOT 400: Mascot protein score=92. Number of peptides=3 [1].
MAPPING (identification):
SPOT 400: Tandem mass spectrometry [1].

Copyright
Data from Dr. Wannes D'Hertog, Catholic University Leuven, Belgium
Cross-references
UniProtKB/Swiss-ProtQ9Z110; P5CS_MOUSE.
World-2DPAGE RepositoryQ9Z110; P5CS_MOUSE.



2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_11
Entry nameP5CS_MOUSE
Primary accession numberQ9Z110
Secondary accession number(s) Q8BGM2 Q9R1P6
Sequence was last modified on July 27, 2011 (version 2)
Annotations were last modified on November 16, 2011 (version 110)
Name and origin of the protein
DescriptionRecName: Full=Delta-1-pyrroline-5-carboxylate synthase; Short=P5CS; AltName: Full=Aldehyde dehydrogenase family 18 member A1; Includes: RecName: Full=Glutamate 5-kinase; Short=GK; EC=2.7.2.11; AltName: Full=Gamma-glutamyl kinase; Includes: RecName: Full=Gamma-glutamyl phosphate reductase; Short=GPR; EC=1.2.1.41; AltName: Full=Glutamate-5-semialdehyde dehydrogenase; AltName: Full=Glutamyl-gamma-semialdehyde dehydrogenase;
Gene nameName=Aldh18a1
Synonyms=P5cs, Pycs
Encoded onName=Aldh18a1; Synonyms=P5cs, Pycs
KeywordsAlternative splicing; Amino-acid biosynthesis; ATP-binding; Complete proteome; Kinase; Membrane; Mitochondrion; Mitochondrion inner membrane; Multifunctional enzyme; NADP; Nucleotide-binding; Oxidoreductase; Proline biosynthesis; Reference proteome; Transferase.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLAF056573; AAD17517.1; -; mRNA
EMBLAF056574; AAD17518.1; -; mRNA
EMBLAK151072; BAE30088.1; -; mRNA
EMBLAK153946; BAE32270.1; -; mRNA
EMBLAK168905; BAE40719.1; -; mRNA
EMBLCH466534; EDL41837.1; -; Genomic_DNA
EMBLBC033427; AAH33427.1; -; mRNA
EMBLBC037699; AAH37699.1; -; mRNA
IPIIPI00129350; -; .
IPIIPI00221398; -; .
RefSeqNP_062672.2; NM_019698.2; .
RefSeqNP_705782.2; NM_153554.2; .
UniGeneMm.233117; -; .
HSSPQ9WYC9; 1O20; .
ProteinModelPortalQ9Z110; -; .
SMRQ9Z110; 69-358; 362-793; .
STRINGQ9Z110; -; .
PhosphoSiteQ9Z110; -; .
PRIDEQ9Z110; -; .
EnsemblENSMUST00000025979; ENSMUSP00000025979; ENSMUSG00000025007; .
GeneID56454; -; .
KEGGmmu:56454; -; .
UCSCuc008hkw.2; mouse; .
MGIMGI:1888908; Aldh18a1; .
GeneTreeENSGT00500000044903; -; .
HOGENOMHBG318080; -; .
HOVERGENHBG007911; -; .
InParanoidQ9Z110; -; .
OrthoDBEOG4ZKJKN; -; .
PhylomeDBQ9Z110; -; .
NextBio312680; -; .
ArrayExpressQ9Z110; -; .
BgeeQ9Z110; -; .
CleanExMM_ALDH18A1; -; .
GenevestigatorQ9Z110; -; .
GermOnlineENSMUSG00000025007; Mus musculus; .
GOGO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell; .
GOGO:0005524; F:ATP binding; IEA:UniProtKB-KW; .
GOGO:0004349; F:glutamate 5-kinase activity; IDA:MGI; .
GOGO:0004350; F:glutamate-5-semialdehyde dehydrogenase activity; IEA:EC; .
GOGO:0006561; P:proline biosynthetic process; IEA:UniProtKB-KW; .
InterProIPR016161; Ald_DH/histidinol_DH; .
InterProIPR016163; Ald_DH_C; .
InterProIPR016162; Ald_DH_N; .
InterProIPR015590; Aldehyde_DH_dom; .
InterProIPR001048; Asp/Glu/Uridylate_kinase; .
InterProIPR000965; G-glutamylP_reductase; .
InterProIPR020593; G-glutamylP_reductase_CS; .
InterProIPR001057; Glu/AcGlu_kinase; .
InterProIPR019797; Glutamate_5-kinase_CS; .
InterProIPR005766; P5_carboxy_syn; .
Gene3DG3DSA:3.40.1160.10; Aa_kinase; 1; .
Gene3DG3DSA:3.40.309.10; Aldehyde_dehydrogenase_C; 1; .
Gene3DG3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 2; .
KOK12657; -; .
PfamPF00696; AA_kinase; 1; .
PfamPF00171; Aldedh; 1; .
PIRSFPIRSF036429; P5C_syn; 1; .
PRINTSPR00474; GLU5KINASE; .
SUPFAMSSF53633; Aa_kinase; 1; .
SUPFAMSSF53720; Aldehyde_DH/Histidinol_DH; 1; .
TIGRFAMsTIGR01092; P5CS; 1; .
TIGRFAMsTIGR00407; ProA; 1; .
PROSITEPS00902; GLUTAMATE_5_KINASE; 1; .
PROSITEPS01223; PROA; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server