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World-2DPAGE Repository  Search by  [accession number]  [description, ID or gene]  [author names]  [spot ID / serial number]  [identification methods]  [pI / Mw range]  [combined fields]  Maps  [experimental info]  [protein list]  [graphical interface]      Databases 0001 0002 0003 0004 0005 0006 0007 0008 0009 0010 0011 0012 0014 0017 0018 0019 0020 0021 0022 0023 0024 0026 0027 0029 0030 0031 0032 0034 0035 0036 0037 0038 0039 0040 0042 0043 0044 0046 0047 0050 0051 0053 0054 0056 0059 0061 0062 0063 0066 0068 0069 0076 0077 0080 0084 0085 0088 use 'Ctrl' to select several databases Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal Exclude local DBs has only effect if a remote interface is selected

Searching in 'World-2DPAGE Repository [0054]' for entry matching: SYDC_HUMAN World-2DPAGE Repository (0054):  SYDC_HUMAN SYDC_HUMAN General information about the entry View entry in simple text format Entry name SYDC_HUMAN Primary accession number P14868 integrated into World-2DPAGE Repository (0054) on  November 28, 2012 (release 1) 2D Annotations were last modified on November 28, 2012 (version 1) General Annotations were last modified on  October 23, 2014 (version 2) Name and origin of the protein Description RecName: Full=Aspartate--tRNA ligase, cytoplasmic; EC=6.1.1.12; AltName: Full=Aspartyl-tRNA synthetase; Short=AspRS; AltName: Full=Cell proliferation-inducing gene 40 protein;. Gene name Name=DARS ORFNames=PIG40 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION DOI=10.1074/mcp.M112.022947; Vernocchi S., Battello N., Schmitz S., Revets D., Billing A.M., Turner J.D., Muller C.P. ''Membrane glucocorticoid receptor activation induces proteomic changes aligning with classical glucocorticoid-effects'' Molecular & Cellular Proteomics 12(7):1764-1779 (2013) 2D PAGE maps for identified proteins How to interpret a protein HSAPIENS_CCRF-CEM_3-10 {CCRF-CEM cells stimulated with Cort-BSA (internal standard)} Homo sapiens (Human)   map experimental info   HSAPIENS_CCRF-CEM_3-10 MAP LOCATIONS: SPOT 708: pI=6.11; Mw=57136   [identification data] %COV: SPOT 708: 51 [1]. SCORE: SPOT 708: 388 [1]. SEARCH ENGINE: SPOT 708: Mascot [1]. MAPPING (identification): SPOT 708: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Claude P. Muller, Centre de Recherche Public de la Sante / National Public Health Laboratory, Luxembourg Cross-references UniProtKB/Swiss-Prot P14868; SYDC_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name SYDC_HUMAN Primary accession number P14868 Secondary accession number(s) A8K3J2 D3DP77 Q2TNI3 Q32Q69 Q53HV4 Q53YC5 Q68CR9 Q9BW52 Sequence was last modified on  April 16, 2002 (version 2) Annotations were last modified on  October 1, 2014 (version 152) Name and origin of the protein Description RecName: Full=Aspartate--tRNA ligase, cytoplasmic; EC=6.1.1.12; AltName: Full=Aspartyl-tRNA synthetase; Short=AspRS; AltName: Full=Cell proliferation-inducing gene 40 protein; Gene name Name=DARS ORFNames=PIG40 Encoded on Name=DARS; ORFNames=PIG40 Keywords 3D-structure; Acetylation; Alternative splicing; Aminoacyl-tRNA synthetase; ATP-binding; Complete proteome; Cytoplasm; Disease mutation; Ligase; Nucleotide-binding; Phosphoprotein; Polymorphism; Protein biosynthesis; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL J05032; AAA35567.1; -; mRNA EMBL AY762100; AAX07827.1; -; mRNA EMBL BT006710; AAP35356.1; -; mRNA EMBL AK290607; BAF83296.1; -; mRNA EMBL AK222476; BAD96196.1; -; mRNA EMBL CR749809; CAH18669.1; -; mRNA EMBL AC011999; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL AC093391; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471058; EAX11617.1; -; Genomic_DNA EMBL CH471058; EAX11620.1; -; Genomic_DNA EMBL BC000629; AAH00629.1; -; mRNA EMBL BC107749; AAI07750.1; -; mRNA CCDS CCDS2180.1; -; . PIR A34393; SYHUDT; . RefSeq NP_001340.2; NM_001349.3; . UniGene Hs.503787; -; . PDB 4J15; X-ray; 2.24 A; A/B=1-501 PDBsum 4J15; -; . ProteinModelPortal P14868; -; . SMR P14868; 21-495; . BioGrid 107984; 52; . IntAct P14868; 13; . MINT MINT-141082; -; . STRING 9606.ENSP00000264161; -; . DrugBank DB00128; L-Aspartic Acid; . PhosphoSite P14868; -; . DMDM 20178330; -; . OGP P14868; -; . REPRODUCTION-2DPAGE IPI00216951; -; . MaxQB P14868; -; . PaxDb P14868; -; . PeptideAtlas P14868; -; . PRIDE P14868; -; . DNASU 1615; -; . Ensembl ENST00000264161; ENSP00000264161; ENSG00000115866; . Ensembl ENST00000537273; ENSP00000444192; ENSG00000115866; . GeneID 1615; -; . KEGG hsa:1615; -; . UCSC uc002tux.1; human; . CTD 1615; -; . GeneCards GC02M136686; -; . HGNC HGNC:2678; DARS; . HPA HPA020451; -; . HPA HPA029804; -; . HPA HPA029805; -; . MIM 603084; gene; . MIM 615281; phenotype; . neXtProt NX_P14868; -; . Orphanet 363412; Hypomyelination with brain stem and spinal cord involvement and leg spasticity; . PharmGKB PA27146; -; . eggNOG COG0017; -; . HOVERGEN HBG001028; -; . InParanoid P14868; -; . KO K01876; -; . OMA FCVGPVF; -; . OrthoDB EOG7P5T0X; -; . PhylomeDB P14868; -; . TreeFam TF105676; -; . Reactome REACT_15306; Cytosolic tRNA aminoacylation; . ChiTaRS DARS; human; . GeneWiki DARS_(gene); -; . GenomeRNAi 1615; -; . NextBio 6634; -; . PRO PR:P14868; -; . ArrayExpress P14868; -; . Bgee P14868; -; . CleanEx HS_DARS; -; . Genevestigator P14868; -; . GO GO:0005737; C:cytoplasm; IDA:HPA; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0070062; C:extracellular vesicular exosome; IDA:UniProt; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0004046; F:aminoacylase activity; TAS:ProtInc; . GO GO:0004815; F:aspartate-tRNA ligase activity; TAS:ProtInc; . GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB; . GO GO:0005515; F:protein binding; IPI:IntAct; . GO GO:0006422; P:aspartyl-tRNA aminoacylation; TAS:ProtInc; . GO GO:0010467; P:gene expression; TAS:Reactome; . GO GO:0006461; P:protein complex assembly; TAS:ProtInc; . GO GO:0006412; P:translation; TAS:ProtInc; . GO GO:0006418; P:tRNA aminoacylation for protein translation; TAS:Reactome; . Gene3D 2.40.50.140; -; 1; . InterPro IPR004364; aa-tRNA-synt_II; . InterPro IPR018150; aa-tRNA-synt_II-like; . InterPro IPR006195; aa-tRNA-synth_II; . InterPro IPR004523; Asp-tRNA_synthase; . InterPro IPR002312; Asp/Asn-tRNA-synth_IIb; . InterPro IPR012340; NA-bd_OB-fold; . InterPro IPR004365; NA-bd_OB_tRNA; . PANTHER PTHR22594; PTHR22594; 1; . PANTHER PTHR22594:SF10; PTHR22594:SF10; 1; . Pfam PF00152; tRNA-synt_2; 1; . Pfam PF01336; tRNA_anti-codon; 1; . PRINTS PR01042; TRNASYNTHASP; . SUPFAM SSF50249; SSF50249; 1; . TIGRFAMs TIGR00458; aspS_nondisc; 1; . PROSITE PS50862; AA_TRNA_LIGASE_II; 1; . World-2DPAGE Repository (search AC)