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World-2DPAGE Repository  Search by  [accession number]  [description, ID or gene]  [author names]  [spot ID / serial number]  [identification methods]  [pI / Mw range]  [combined fields]  Maps  [experimental info]  [protein list]  [graphical interface]      Databases 0001 0002 0003 0004 0005 0006 0007 0008 0009 0010 0011 0012 0014 0017 0018 0019 0020 0021 0022 0023 0024 0026 0027 0029 0030 0031 0032 0034 0035 0036 0037 0038 0039 0040 0042 0043 0044 0046 0047 0050 0051 0053 0054 0056 0059 0061 0062 0063 0066 0068 0069 0076 0077 0080 0084 0085 0088 use 'Ctrl' to select several databases Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal Exclude local DBs has only effect if a remote interface is selected

Searching in 'World-2DPAGE Repository [0054]' for entry matching: SYYC_HUMAN World-2DPAGE Repository (0054):  SYYC_HUMAN SYYC_HUMAN General information about the entry View entry in simple text format Entry name SYYC_HUMAN Primary accession number P54577 integrated into World-2DPAGE Repository (0054) on  November 28, 2012 (release 1) 2D Annotations were last modified on November 28, 2012 (version 1) General Annotations were last modified on  October 23, 2014 (version 2) Name and origin of the protein Description RecName: Full=Tyrosine--tRNA ligase, cytoplasmic; EC=6.1.1.1; AltName: Full=Tyrosyl-tRNA synthetase; Short=TyrRS; Contains: RecName: Full=Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed;. Gene name Name=YARS Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION DOI=10.1074/mcp.M112.022947; Vernocchi S., Battello N., Schmitz S., Revets D., Billing A.M., Turner J.D., Muller C.P. ''Membrane glucocorticoid receptor activation induces proteomic changes aligning with classical glucocorticoid-effects'' Molecular & Cellular Proteomics 12(7):1764-1779 (2013) 2D PAGE maps for identified proteins How to interpret a protein HSAPIENS_CCRF-CEM_3-10 {CCRF-CEM cells stimulated with Cort-BSA (internal standard)} Homo sapiens (Human)   map experimental info   HSAPIENS_CCRF-CEM_3-10 MAP LOCATIONS: SPOT 650: pI=6.64; Mw=59012   [identification data] %COV: SPOT 650: 56 [1]. SCORE: SPOT 650: 457 [1]. SEARCH ENGINE: SPOT 650: Mascot [1]. MAPPING (identification): SPOT 650: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Claude P. Muller, Centre de Recherche Public de la Sante / National Public Health Laboratory, Luxembourg Cross-references UniProtKB/Swiss-Prot P54577; SYYC_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name SYYC_HUMAN Primary accession number P54577 Secondary accession number(s) B3KWK4 D3DPQ4 O43276 Q53EN1 Sequence was last modified on  January 23, 2007 (version 4) Annotations were last modified on  October 1, 2014 (version 157) Name and origin of the protein Description RecName: Full=Tyrosine--tRNA ligase, cytoplasmic; EC=6.1.1.1; AltName: Full=Tyrosyl-tRNA synthetase; Short=TyrRS; Contains: RecName: Full=Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed; Gene name Name=YARS Encoded on Name=YARS Keywords 3D-structure; Acetylation; Aminoacyl-tRNA synthetase; ATP-binding; Charcot-Marie-Tooth disease; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Ligase; Neurodegeneration; Neuropathy; Nucleotide-binding; Polymorphism; Protein biosynthesis; Reference proteome; RNA-binding; tRNA-binding. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL U40714; AAB39406.1; ALT_FRAME; mRNA EMBL U89436; AAB88409.1; -; mRNA EMBL AK125213; BAG54166.1; -; mRNA EMBL AK223608; BAD97328.1; -; mRNA EMBL CH471059; EAX07506.1; -; Genomic_DNA EMBL CH471059; EAX07507.1; -; Genomic_DNA EMBL BC001933; AAH01933.1; -; mRNA EMBL BC004151; AAH04151.1; -; mRNA EMBL BC016689; AAH16689.1; -; mRNA CCDS CCDS368.1; -; . RefSeq NP_003671.1; NM_003680.3; . UniGene Hs.213264; -; . PDB 1N3L; X-ray; 1.18 A; A=1-364 PDB 1NTG; X-ray; 2.21 A; A/B/C/D=359-528 PDB 1Q11; X-ray; 1.60 A; A=1-364 PDBsum 1N3L; -; . PDBsum 1NTG; -; . PDBsum 1Q11; -; . ProteinModelPortal P54577; -; . SMR P54577; 4-342; 360-528; . BioGrid 114134; 15; . IntAct P54577; 1; . STRING 9606.ENSP00000362576; -; . BindingDB P54577; -; . ChEMBL CHEMBL3179; -; . DrugBank DB00135; L-Tyrosine; . PhosphoSite P54577; -; . DMDM 13638438; -; . REPRODUCTION-2DPAGE IPI00007074; -; . MaxQB P54577; -; . PaxDb P54577; -; . PeptideAtlas P54577; -; . PRIDE P54577; -; . DNASU 8565; -; . Ensembl ENST00000373477; ENSP00000362576; ENSG00000134684; . GeneID 8565; -; . KEGG hsa:8565; -; . UCSC uc001bvy.1; human; . CTD 8565; -; . GeneCards GC01M033240; -; . HGNC HGNC:12840; YARS; . HPA HPA017936; -; . HPA HPA018950; -; . HPA HPA018954; -; . MIM 603623; gene; . MIM 608323; phenotype; . neXtProt NX_P54577; -; . Orphanet 100045; Autosomal dominant intermediate Charcot-Marie-Tooth disease type C; . PharmGKB PA37431; -; . eggNOG COG0162; -; . HOGENOM HOG000228237; -; . HOVERGEN HBG080113; -; . InParanoid P54577; -; . KO K01866; -; . OMA NRQVEPL; -; . OrthoDB EOG79CXZ2; -; . PhylomeDB P54577; -; . TreeFam TF300898; -; . Reactome REACT_15306; Cytosolic tRNA aminoacylation; . ChiTaRS YARS; human; . EvolutionaryTrace P54577; -; . GeneWiki YARS; -; . GenomeRNAi 8565; -; . NextBio 32113; -; . PMAP-CutDB P54577; -; . PRO PR:P54577; -; . Bgee P54577; -; . CleanEx HS_YARS; -; . Genevestigator P54577; -; . GO GO:0005737; C:cytoplasm; IDA:HPA; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0005615; C:extracellular space; TAS:ProtInc; . GO GO:0005634; C:nucleus; IDA:HPA; . GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0005153; F:interleukin-8 receptor binding; TAS:ProtInc; . GO GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB; . GO GO:0004871; F:signal transducer activity; NAS:ProtInc; . GO GO:0000049; F:tRNA binding; IEA:UniProtKB-KW; . GO GO:0004831; F:tyrosine-tRNA ligase activity; TAS:Reactome; . GO GO:0006915; P:apoptotic process; TAS:ProtInc; . GO GO:0010467; P:gene expression; TAS:Reactome; . GO GO:0007165; P:signal transduction; NAS:GOC; . GO GO:0006418; P:tRNA aminoacylation for protein translation; TAS:Reactome; . GO GO:0006437; P:tyrosyl-tRNA aminoacylation; TAS:ProtInc; . Gene3D 2.40.50.140; -; 1; . Gene3D 3.40.50.620; -; 1; . InterPro IPR002305; aa-tRNA-synth_Ic; . InterPro IPR012340; NA-bd_OB-fold; . InterPro IPR014729; Rossmann-like_a/b/a_fold; . InterPro IPR002547; tRNA-bd_dom; . InterPro IPR002307; Tyr-tRNA-ligase; . Pfam PF00579; tRNA-synt_1b; 1; . Pfam PF01588; tRNA_bind; 1; . PRINTS PR01040; TRNASYNTHTYR; . SUPFAM SSF50249; SSF50249; 1; . TIGRFAMs TIGR00234; tyrS; 1; . PROSITE PS50886; TRBD; 1; . World-2DPAGE Repository (search AC)