Attention: World-2DPAGE is no longer maintained.

World-2DPAGE Repository  Search by  [accession number]  [description, ID or gene]  [author names]  [spot ID / serial number]  [identification methods]  [pI / Mw range]  [combined fields]  Maps  [experimental info]  [protein list]  [graphical interface]      Databases 0001 0002 0003 0004 0005 0006 0007 0008 0009 0010 0011 0012 0014 0017 0018 0019 0020 0021 0022 0023 0024 0026 0027 0029 0030 0031 0032 0034 0035 0036 0037 0038 0039 0040 0042 0043 0044 0046 0047 0050 0051 0053 0054 0056 0059 0061 0062 0063 0066 0068 0069 0076 0077 0080 0084 0085 0088 use 'Ctrl' to select several databases Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal Exclude local DBs has only effect if a remote interface is selected

Searching in 'World-2DPAGE Repository [0054]' for entry matching: TADBP_HUMAN World-2DPAGE Repository (0054):  TADBP_HUMAN TADBP_HUMAN General information about the entry View entry in simple text format Entry name TADBP_HUMAN Primary accession number Q13148 integrated into World-2DPAGE Repository (0054) on  November 28, 2012 (release 1) 2D Annotations were last modified on November 28, 2012 (version 1) General Annotations were last modified on  October 23, 2014 (version 2) Name and origin of the protein Description RecName: Full=TAR DNA-binding protein 43; Short=TDP-43;. Gene name Name=TARDBP Synonyms=TDP43 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION DOI=10.1074/mcp.M112.022947; Vernocchi S., Battello N., Schmitz S., Revets D., Billing A.M., Turner J.D., Muller C.P. ''Membrane glucocorticoid receptor activation induces proteomic changes aligning with classical glucocorticoid-effects'' Molecular & Cellular Proteomics 12(7):1764-1779 (2013) 2D PAGE maps for identified proteins How to interpret a protein HSAPIENS_CCRF-CEM_3-10 {CCRF-CEM cells stimulated with Cort-BSA (internal standard)} Homo sapiens (Human)   map experimental info   HSAPIENS_CCRF-CEM_3-10 MAP LOCATIONS: SPOT 802: pI=5.85; Mw=44740   [identification data] %COV: SPOT 802: 51 [1]. SCORE: SPOT 802: 434 [1]. SEARCH ENGINE: SPOT 802: Mascot [1]. MAPPING (identification): SPOT 802: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Claude P. Muller, Centre de Recherche Public de la Sante / National Public Health Laboratory, Luxembourg Cross-references UniProtKB/Swiss-Prot Q13148; TADBP_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name TADBP_HUMAN Primary accession number Q13148 Secondary accession number(s) A4GUK4 A4GUK5 A4GUK6 B2R629 B4DJ45 E2PU12 Q53H27 Q6FI92 Q96DJ0 Sequence was last modified on  November 1, 1996 (version 1) Annotations were last modified on  October 1, 2014 (version 155) Name and origin of the protein Description RecName: Full=TAR DNA-binding protein 43; Short=TDP-43; Gene name Name=TARDBP Synonyms=TDP43 Encoded on Name=TARDBP; Synonyms=TDP43 Keywords 3D-structure; Alternative splicing; Amyotrophic lateral sclerosis; Complete proteome; Direct protein sequencing; Disease mutation; DNA-binding; mRNA processing; mRNA splicing; Neurodegeneration; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Repressor; RNA-binding; Transcription; Transcription regulation; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL U23731; AAA70033.1; -; mRNA EMBL EF434181; ABO32290.1; ALT_SEQ; mRNA EMBL EF434182; ABO32291.1; -; mRNA EMBL EF434183; ABO32292.1; ALT_SEQ; mRNA EMBL AK295920; BAG58707.1; -; mRNA EMBL AK312416; BAG35326.1; -; mRNA EMBL CR533534; CAG38565.1; -; mRNA EMBL AK222754; BAD96474.1; -; mRNA EMBL AL050265; CAB43367.1; -; mRNA EMBL AL109811; CAI22098.1; -; Genomic_DNA EMBL CH471130; EAW71670.1; -; Genomic_DNA EMBL BC071657; AAH71657.1; -; mRNA EMBL BC095435; AAH95435.1; -; mRNA CCDS CCDS122.1; -; . PIR I38977; I38977; . RefSeq NP_031401.1; NM_007375.3; . UniGene Hs.300624; -; . PDB 1WF0; NMR; -; A=193-267 PDB 2CQG; NMR; -; A=96-185 PDB 4BS2; NMR; -; A=102-269 PDB 4IUF; X-ray; 2.75 A; A=103-179 PDBsum 1WF0; -; . PDBsum 2CQG; -; . PDBsum 4BS2; -; . PDBsum 4IUF; -; . ProteinModelPortal Q13148; -; . SMR Q13148; 67-269; . BioGrid 117003; 284; . DIP DIP-31167N; -; . IntAct Q13148; 23; . MINT MINT-5002768; -; . STRING 9606.ENSP00000240185; -; . ChEMBL CHEMBL2362981; -; . PhosphoSite Q13148; -; . DMDM 20140568; -; . MaxQB Q13148; -; . PaxDb Q13148; -; . PRIDE Q13148; -; . DNASU 23435; -; . Ensembl ENST00000240185; ENSP00000240185; ENSG00000120948; . Ensembl ENST00000439080; ENSP00000404666; ENSG00000120948; . GeneID 23435; -; . KEGG hsa:23435; -; . UCSC uc001art.3; human; . CTD 23435; -; . GeneCards GC01P011006; -; . GeneReviews TARDBP; -; . HGNC HGNC:11571; TARDBP; . HPA CAB003703; -; . HPA HPA017284; -; . MIM 605078; gene; . MIM 612069; phenotype; . neXtProt NX_Q13148; -; . Orphanet 803; Amyotrophic lateral sclerosis; . Orphanet 275872; Frontotemporal dementia with motor neuron disease; . PharmGKB PA36336; -; . eggNOG COG0724; -; . HOVERGEN HBG058671; -; . InParanoid Q13148; -; . OMA KHNSSRQ; -; . PhylomeDB Q13148; -; . TreeFam TF315657; -; . ChiTaRS TARDBP; human; . EvolutionaryTrace Q13148; -; . GeneWiki TARDBP; -; . GenomeRNAi 23435; -; . NextBio 45695; -; . PRO PR:Q13148; -; . ArrayExpress Q13148; -; . Bgee Q13148; -; . CleanEx HS_TARDBP; -; . Genevestigator Q13148; -; . GO GO:0005634; C:nucleus; IDA:BHF-UCL; . GO GO:0003690; F:double-stranded DNA binding; IDA:BHF-UCL; . GO GO:0042802; F:identical protein binding; IPI:IntAct; . GO GO:0003730; F:mRNA 3'-UTR binding; IDA:BHF-UCL; . GO GO:0000166; F:nucleotide binding; IEA:InterPro; . GO GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB; . GO GO:0005515; F:protein binding; IPI:UniProtKB; . GO GO:0003723; F:RNA binding; IDA:BHF-UCL; . GO GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc; . GO GO:0070935; P:3'-UTR-mediated mRNA stabilization; IDA:BHF-UCL; . GO GO:0008219; P:cell death; IEA:UniProtKB-KW; . GO GO:0006397; P:mRNA processing; IEA:UniProtKB-KW; . GO GO:0043922; P:negative regulation by host of viral transcription; IDA:BHF-UCL; . GO GO:0008380; P:RNA splicing; IDA:BHF-UCL; . GO GO:0006366; P:transcription from RNA polymerase II promoter; TAS:ProtInc; . Gene3D 3.30.70.330; -; 2; . InterPro IPR012677; Nucleotide-bd_a/b_plait; . InterPro IPR000504; RRM_dom; . Pfam PF00076; RRM_1; 2; . SMART SM00360; RRM; 2; . PROSITE PS50102; RRM; 2; . World-2DPAGE Repository (search AC)