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World-2DPAGE Repository  Search by  [accession number]  [description, ID or gene]  [author names]  [spot ID / serial number]  [identification methods]  [pI / Mw range]  [combined fields]  Maps  [experimental info]  [protein list]  [graphical interface]      Databases 0001 0002 0003 0004 0005 0006 0007 0008 0009 0010 0011 0012 0014 0017 0018 0019 0020 0021 0022 0023 0024 0026 0027 0029 0030 0031 0032 0034 0035 0036 0037 0038 0039 0040 0042 0043 0044 0046 0047 0050 0051 0053 0054 0056 0059 0061 0062 0063 0066 0068 0069 0076 0077 0080 0084 0085 0088 use 'Ctrl' to select several databases Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal Exclude local DBs has only effect if a remote interface is selected

Searching in 'World-2DPAGE Repository [0054]' for entry matching: TPIS_HUMAN World-2DPAGE Repository (0054):  TPIS_HUMAN TPIS_HUMAN General information about the entry View entry in simple text format Entry name TPIS_HUMAN Primary accession number P60174 integrated into World-2DPAGE Repository (0054) on  November 28, 2012 (release 1) 2D Annotations were last modified on November 28, 2012 (version 1) General Annotations were last modified on  October 23, 2014 (version 2) Name and origin of the protein Description RecName: Full=Triosephosphate isomerase; Short=TIM; EC=5.3.1.1; AltName: Full=Triose-phosphate isomerase;. Gene name Name=TPI1 Synonyms=TPI Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION DOI=10.1074/mcp.M112.022947; Vernocchi S., Battello N., Schmitz S., Revets D., Billing A.M., Turner J.D., Muller C.P. ''Membrane glucocorticoid receptor activation induces proteomic changes aligning with classical glucocorticoid-effects'' Molecular & Cellular Proteomics 12(7):1764-1779 (2013) 2D PAGE maps for identified proteins How to interpret a protein HSAPIENS_CCRF-CEM_3-10 {CCRF-CEM cells stimulated with Cort-BSA (internal standard)} Homo sapiens (Human)   map experimental info   HSAPIENS_CCRF-CEM_3-10 MAP LOCATIONS: SPOT 1068: pI=5.89; Mw=25206   [identification data] %COV: SPOT 1068: 89 [1]. SCORE: SPOT 1068: 932 [1]. SEARCH ENGINE: SPOT 1068: Mascot [1]. MAPPING (identification): SPOT 1068: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Claude P. Muller, Centre de Recherche Public de la Sante / National Public Health Laboratory, Luxembourg Cross-references UniProtKB/Swiss-Prot P60174; TPIS_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name TPIS_HUMAN Primary accession number P60174 Secondary accession number(s) B7Z5D8 D3DUS9 P00938 Q6FHP9 Q6IS07 Q8WWD0 Q96AG5 Sequence was last modified on  October 19, 2011 (version 3) Annotations were last modified on  October 1, 2014 (version 129) Name and origin of the protein Description RecName: Full=Triosephosphate isomerase; Short=TIM; EC=5.3.1.1; AltName: Full=Triose-phosphate isomerase; Gene name Name=TPI1 Synonyms=TPI Encoded on Name=TPI1; Synonyms=TPI Keywords 3D-structure; Acetylation; Alternative promoter usage; Alternative splicing; Complete proteome; Direct protein sequencing; Disease mutation; Gluconeogenesis; Glycolysis; Hereditary hemolytic anemia; Isomerase; Nitration; Pentose shunt; Phosphoprotein; Polymorphism; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M10036; AAB59511.1; ALT_INIT; mRNA EMBL X69723; CAA49379.1; ALT_INIT; Genomic_DNA EMBL AK298809; BAH12874.1; -; mRNA EMBL U47924; AAB51316.1; ALT_INIT; Genomic_DNA EMBL CH471116; EAW88722.1; -; Genomic_DNA EMBL CH471116; EAW88723.1; -; Genomic_DNA EMBL J04603; AAN86636.1; ALT_FRAME; Genomic_DNA EMBL BC007086; AAH07086.1; ALT_INIT; mRNA EMBL BC007812; AAH07812.1; ALT_INIT; mRNA EMBL BC009329; AAH09329.1; ALT_INIT; mRNA EMBL BC011611; AAH11611.1; ALT_INIT; mRNA EMBL BC015100; AAH15100.1; ALT_INIT; mRNA EMBL BC017165; AAH17165.1; -; mRNA EMBL BC017917; AAH17917.1; ALT_INIT; mRNA EMBL BC070129; AAH70129.1; ALT_SEQ; mRNA EMBL AK313282; BAG36090.1; ALT_INIT; mRNA EMBL CR541702; CAG46503.1; -; mRNA CCDS CCDS53740.1; -. [P60174-3]; . CCDS CCDS58206.1; -. [P60174-4]; . CCDS CCDS8566.1; -. [P60174-1]; . PIR S29743; ISHUT; . RefSeq NP_000356.1; NM_000365.5. [P60174-1]; . RefSeq NP_001152759.1; NM_001159287.1. [P60174-3]; . RefSeq NP_001244955.1; NM_001258026.1. [P60174-4]; . UniGene Hs.524219; -; . PDB 1HTI; X-ray; 2.80 A; A/B=39-286 PDB 1KLG; X-ray; 2.40 A; C=60-74 PDB 1KLU; X-ray; 1.93 A; C=60-74 PDB 1WYI; X-ray; 2.20 A; A/B=39-286 PDB 2IAM; X-ray; 2.80 A; P=60-74 PDB 2IAN; X-ray; 2.80 A; C/H/M/R=60-74 PDB 2JK2; X-ray; 1.70 A; A/B=39-286 PDB 2VOM; X-ray; 1.85 A; A/B/C/D=39-286 PDB 4BR1; X-ray; 1.90 A; A/B=41-286 PDB 4E41; X-ray; 2.60 A; C/H=60-74 PDBsum 1HTI; -; . PDBsum 1KLG; -; . PDBsum 1KLU; -; . PDBsum 1WYI; -; . PDBsum 2IAM; -; . PDBsum 2IAN; -; . PDBsum 2JK2; -; . PDBsum 2VOM; -; . PDBsum 4BR1; -; . PDBsum 4E41; -; . ProteinModelPortal P60174; -; . SMR P60174; 41-286; . BioGrid 113020; 40; . IntAct P60174; 14; . MINT MINT-1384176; -; . STRING 9606.ENSP00000379933; -; . BindingDB P60174; -; . ChEMBL CHEMBL4880; -; . PhosphoSite P60174; -; . DMDM 353526311; -; . DOSAC-COBS-2DPAGE P60174; -; . REPRODUCTION-2DPAGE IPI00797687; -; . REPRODUCTION-2DPAGE P60174; -; . SWISS-2DPAGE P60174; -; . UCD-2DPAGE P00938; -; . UCD-2DPAGE P60174; -; . MaxQB P60174; -; . PaxDb P60174; -; . PRIDE P60174; -; . DNASU 7167; -; . Ensembl ENST00000229270; ENSP00000229270; ENSG00000111669. [P60174-3]; . Ensembl ENST00000396705; ENSP00000379933; ENSG00000111669. [P60174-1]; . Ensembl ENST00000488464; ENSP00000475620; ENSG00000111669. [P60174-4]; . Ensembl ENST00000535434; ENSP00000443599; ENSG00000111669. [P60174-4]; . GeneID 7167; -; . KEGG hsa:7167; -; . UCSC uc001qrk.4; human. [P60174-3]; . CTD 7167; -; . GeneCards GC12P007112; -; . HGNC HGNC:12009; TPI1; . HPA CAB004675; -; . HPA HPA050924; -; . HPA HPA053568; -; . MIM 190450; gene; . MIM 615512; phenotype; . neXtProt NX_P60174; -; . Orphanet 868; Triose phosphate-isomerase deficiency; . PharmGKB PA36689; -; . eggNOG COG0149; -; . HOGENOM HOG000226413; -; . HOVERGEN HBG002599; -; . InParanoid P60174; -; . KO K01803; -; . OMA PAIYLDQ; -; . OrthoDB EOG76DTT8; -; . PhylomeDB P60174; -; . TreeFam TF300829; -; . BioCyc MetaCyc:HS03441-MONOMER; -; . Reactome REACT_1383; Glycolysis; . Reactome REACT_1520; Gluconeogenesis; . SABIO-RK P60174; -; . UniPathway UPA00109; UER00189; . UniPathway UPA00138; -; . ChiTaRS TPI1; human; . EvolutionaryTrace P60174; -; . GeneWiki TPI1; -; . GenomeRNAi 7167; -; . NextBio 28066; -; . PRO PR:P60174; -; . Bgee P60174; -; . CleanEx HS_TPI1; -; . Genevestigator P60174; -; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0005615; C:extracellular space; IDA:UniProt; . GO GO:0070062; C:extracellular vesicular exosome; IDA:UniProt; . GO GO:0005634; C:nucleus; IDA:UniProt; . GO GO:0005515; F:protein binding; IPI:IntAct; . GO GO:0004807; F:triose-phosphate isomerase activity; NAS:UniProtKB; . GO GO:0005975; P:carbohydrate metabolic process; TAS:Reactome; . GO GO:0009790; P:embryo development; IEA:Ensembl; . GO GO:0006094; P:gluconeogenesis; TAS:Reactome; . GO GO:0006006; P:glucose metabolic process; TAS:Reactome; . GO GO:0019682; P:glyceraldehyde-3-phosphate metabolic process; IEA:Ensembl; . GO GO:0006096; P:glycolytic process; TAS:Reactome; . GO GO:0006098; P:pentose-phosphate shunt; IEA:UniProtKB-KW; . GO GO:0044281; P:small molecule metabolic process; TAS:Reactome; . Gene3D 3.20.20.70; -; 1; . HAMAP MF_00147_B; TIM_B; 1; . InterPro IPR013785; Aldolase_TIM; . InterPro IPR022896; TrioseP_Isoase_bac/euk; . InterPro IPR000652; Triosephosphate_isomerase; . InterPro IPR020861; Triosephosphate_isomerase_AS; . PANTHER PTHR21139; PTHR21139; 1; . Pfam PF00121; TIM; 1; . SUPFAM SSF51351; SSF51351; 1; . TIGRFAMs TIGR00419; tim; 1; . PROSITE PS00171; TIM_1; 1; . PROSITE PS51440; TIM_2; 1; . World-2DPAGE Repository (search AC)