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Searching in 'World-2DPAGE Repository [0022]' for entry matching: TPM1_RAT

World-2DPAGE Repository (0022):  TPM1_RAT


General information about the entry
View entry in simple text format
Entry nameTPM1_RAT
Primary accession numberP04692
integrated into World-2DPAGE Repository (0022) on May 7, 2010 (release 1)
2D Annotations were last modified onJune 22, 2011 (version 2)
General Annotations were last modified on November 24, 2011 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Tropomyosin alpha-1 chain; AltName: Full=Alpha-tropomyosin; AltName: Full=Tropomyosin-1;.
Gene nameName=Tpm1
Synonyms=Alpha-tm, Tpma
Annotated speciesRattus [TaxID: 10114]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae.
Burniston J.G., Kenyani J., Wastling J.M., Burant C.F., Qi N.R., Koch L.G., Britton S.L.
''Proteomic analysis reveals perturbed energy metabolism and elevated oxidative stress in hearts of rats with inborn low aerobic capacity''
Proteomics 11(16):3369-3379 (2011)
2D PAGE maps for identified proteins
How to interpret a protein

Tissue: Heart
  map experimental info

pI=4.69; Mw=32718  [identification data]
pI=4.69; Mw=32718  [identification data]
pI=4.69; Mw=32718  [identification data]
pI=4.69; Mw=32718  [identification data]
pI=4.69; Mw=32718  [identification data]

IDENTIFICATION: SPOT 530: SeqCov=37%. Peptides MS=16/20. Mascot PMF Score=160 [1]
SPOT 546: SeqCov=35.9%. Peptides MS=16/20. Mascot PMF Score=161 [1]; SPOT 631: SeqCov=35.6%. Peptides MS=15/20. Mascot PMF Score=141 [1]; SPOT 876: SeqCov=37%. Peptides MS=16/20. Mascot PMF Score=161 [1]; SPOT 899: SeqCov=30.6%. Peptides MS=13/20. Mascot PMF Score=129 [1].
MAPPING (identification):
SPOT 530: Peptide mass fingerprinting [1];
SPOT 546: Peptide mass fingerprinting [1];
SPOT 631: Peptide mass fingerprinting [1];
SPOT 876: Peptide mass fingerprinting [1];
SPOT 899: Peptide mass fingerprinting [1].

Data from Dr. Jatin Burniston, Liverpool John Moores University, UK
UniProtKB/Swiss-ProtP04692; TPM1_RAT.

2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_11
Entry nameTPM1_RAT
Primary accession numberP04692
Secondary accession number(s) P06469 P18342 P18343 P18344 P19354 Q53X09 Q63582 Q63608 Q63609
Sequence was last modified on April 4, 2006 (version 3)
Annotations were last modified on November 16, 2011 (version 108)
Name and origin of the protein
DescriptionRecName: Full=Tropomyosin alpha-1 chain; AltName: Full=Alpha-tropomyosin; AltName: Full=Tropomyosin-1;
Gene nameName=Tpm1
Synonyms=Alpha-tm, Tpma
Encoded onName=Tpm1; Synonyms=Alpha-tm, Tpma
Keywords3D-structure; Acetylation; Actin-binding; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Isopeptide bond; Muscle protein; Phosphoprotein; Reference proteome; Ubl conjugation.
Copyrighted by the UniProt Consortium, see Distributed under the Creative Commons Attribution-NoDerivs License
EMBLM15474; AAA21801.1; -; Genomic_DNA
EMBLM15472; AAA21801.1; JOINED; Genomic_DNA
EMBLM15473; AAA21801.1; JOINED; Genomic_DNA
EMBLM16432; AAA21801.1; JOINED; Genomic_DNA
EMBLM16433; AAA21801.1; JOINED; Genomic_DNA
EMBLM18135; AAA21803.1; ALT_TERM; Genomic_DNA
EMBLM16432; AAA21803.1; JOINED; Genomic_DNA
EMBLM15472; AAA21803.1; JOINED; Genomic_DNA
EMBLM16433; AAA21803.1; JOINED; Genomic_DNA
EMBLM15473; AAA21803.1; JOINED; Genomic_DNA
EMBLM18135; AAA21804.1; -; Genomic_DNA
EMBLM16432; AAA21804.1; JOINED; Genomic_DNA
EMBLM16433; AAA21804.1; JOINED; Genomic_DNA
EMBLM18135; AAA21805.1; -; Genomic_DNA
EMBLM16432; AAA21805.1; JOINED; Genomic_DNA
EMBLM15472; AAA21805.1; JOINED; Genomic_DNA
EMBLM16433; AAA21805.1; JOINED; Genomic_DNA
EMBLX02411; CAA26258.1; ALT_SEQ; mRNA
EMBLM34135; AAA42252.1; -; mRNA
EMBLM34134; AAA42253.1; -; mRNA
EMBLM34136; AAA42254.1; -; mRNA
EMBLM34137; AAA40773.1; -; Genomic_DNA
EMBLM34138; AAA40774.1; -; Genomic_DNA
EMBLM60666; AAA42290.1; -; mRNA
EMBLM60668; AAA18098.1; -; mRNA
EMBLM60669; AAA18099.1; -; mRNA
EMBLX02412; CAA26259.1; -; mRNA
IPIIPI00197888; -; .
IPIIPI00207964; -; .
IPIIPI00231563; -; .
IPIIPI00231566; -; .
IPIIPI00231567; -; .
IPIIPI00231568; -; .
IPIIPI00391995; -; .
IPIIPI00391997; -; .
PIRA34787; A34787; .
PIRA39816; A39816; .
PIRB27407; B27407; .
PIRB34787; B34787; .
PIRC34787; C34787; .
PIRC39816; C39816; .
PIRD39816; D39816; .
RefSeqNP_001029241.1; NM_001034069.1; .
RefSeqNP_001029244.1; NM_001034072.1; .
RefSeqNP_001029245.1; NM_001034073.1; .
RefSeqNP_001029246.1; NM_001034074.1; .
RefSeqNP_001029247.1; NM_001034075.1; .
RefSeqNP_062004.1; NM_019131.2; .
UniGeneRn.87540; -; .
PDB1IHQ; NMR; -; A/B=206-209
PDB1MV4; NMR; -; A/B=251-284
PDB1TMZ; NMR; -; A/B=1-14
PDB2B9C; X-ray; 2.30 A; A/B=89-207
PDB2G9J; NMR; -; A/B=1-14
C/D=251-284PDBsum; 1IHQ; -; .
PDBsum1MV4; -; .
PDBsum1TMZ; -; .
PDBsum2B9C; -; .
PDBsum2G9J; -; .
ProteinModelPortalP04692; -; .
SMRP04692; 8-284; .
DIPDIP-29020N; -; .
IntActP04692; 1; .
STRINGP04692; -; .
PhosphoSiteP04692; -; .
Rat-heart-2DPAGEP04692; -; .
PRIDEP04692; -; .
EnsemblENSRNOT00000024493; ENSRNOP00000024493; ENSRNOG00000018184; .
EnsemblENSRNOT00000024575; ENSRNOP00000024575; ENSRNOG00000018184; .
EnsemblENSRNOT00000024617; ENSRNOP00000024617; ENSRNOG00000018184; .
EnsemblENSRNOT00000024721; ENSRNOP00000024721; ENSRNOG00000018184; .
GeneID24851; -; .
KEGGrno:24851; -; .
UCSCNM_001034068; rat; .
CTD7168; -; .
RGD3898; Tpm1; .
eggNOGmaNOG09955; -; .
HOVERGENHBG107404; -; .
NextBio604620; -; .
ArrayExpressP04692; -; .
GenevestigatorP04692; -; .
GermOnlineENSRNOG00000018184; Rattus norvegicus; .
GOGO:0005737; C:cytoplasm; IEA:UniProtKB-KW; .
GOGO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell; .
GOGO:0003779; F:actin binding; IEA:UniProtKB-KW; .
GOGO:0030049; P:muscle filament sliding; IDA:BHF-UCL; .
GOGO:0030336; P:negative regulation of cell migration; IGI:BHF-UCL; .
GOGO:0032781; P:positive regulation of ATPase activity; IDA:BHF-UCL; .
GOGO:0045785; P:positive regulation of cell adhesion; IGI:BHF-UCL; .
GOGO:0051496; P:positive regulation of stress fiber assembly; IGI:BHF-UCL; .
GOGO:0031529; P:ruffle organization; IGI:BHF-UCL; .
GOGO:0042060; P:wound healing; IGI:BHF-UCL; .
InterProIPR000533; Tropomyosin; .
KOK10373; -; .
PfamPF00261; Tropomyosin; 1; .

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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server