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World-2DPAGE Repository  Search by  [accession number]  [description, ID or gene]  [author names]  [spot ID / serial number]  [identification methods]  [pI / Mw range]  [combined fields]  Maps  [experimental info]  [protein list]  [graphical interface]      Databases 0001 0002 0003 0004 0005 0006 0007 0008 0009 0010 0011 0012 0014 0017 0018 0019 0020 0021 0022 0023 0024 0026 0027 0029 0030 0031 0032 0034 0035 0036 0037 0038 0039 0040 0042 0043 0044 0046 0047 0050 0051 0053 0054 0056 0059 0061 0062 0063 0066 0068 0069 0076 0077 0080 0084 0085 0088 use 'Ctrl' to select several databases Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal Exclude local DBs has only effect if a remote interface is selected

Searching in 'World-2DPAGE Repository [0054]' for entry matching: TPR_HUMAN World-2DPAGE Repository (0054):  TPR_HUMAN TPR_HUMAN General information about the entry View entry in simple text format Entry name TPR_HUMAN Primary accession number P12270 integrated into World-2DPAGE Repository (0054) on  November 28, 2012 (release 1) 2D Annotations were last modified on November 28, 2012 (version 1) General Annotations were last modified on  October 23, 2014 (version 2) Name and origin of the protein Description RecName: Full=Nucleoprotein TPR; AltName: Full=Megator; AltName: Full=NPC-associated intranuclear protein; AltName: Full=Translocated promoter region protein;. Gene name Name=TPR Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION DOI=10.1074/mcp.M112.022947; Vernocchi S., Battello N., Schmitz S., Revets D., Billing A.M., Turner J.D., Muller C.P. ''Membrane glucocorticoid receptor activation induces proteomic changes aligning with classical glucocorticoid-effects'' Molecular & Cellular Proteomics 12(7):1764-1779 (2013) 2D PAGE maps for identified proteins How to interpret a protein HSAPIENS_CCRF-CEM_3-10 {CCRF-CEM cells stimulated with Cort-BSA (internal standard)} Homo sapiens (Human)   map experimental info   HSAPIENS_CCRF-CEM_3-10 MAP LOCATIONS: SPOT 6283: pI=4.97; Mw=267162   [identification data] %COV: SPOT 6283: 31 [1]. SCORE: SPOT 6283: 886 [1]. SEARCH ENGINE: SPOT 6283: Mascot [1]. MAPPING (identification): SPOT 6283: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Claude P. Muller, Centre de Recherche Public de la Sante / National Public Health Laboratory, Luxembourg Cross-references UniProtKB/Swiss-Prot P12270; TPR_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name TPR_HUMAN Primary accession number P12270 Secondary accession number(s) Q15655 Q5SWY0 Q99968 Sequence was last modified on  November 25, 2008 (version 3) Annotations were last modified on  October 1, 2014 (version 149) Name and origin of the protein Description RecName: Full=Nucleoprotein TPR; AltName: Full=Megator; AltName: Full=NPC-associated intranuclear protein; AltName: Full=Translocated promoter region protein; Gene name Name=TPR Encoded on Name=TPR Keywords Acetylation; Cell cycle; Cell division; Centromere; Chromosomal rearrangement; Chromosome; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Kinetochore; Membrane; Mitosis; mRNA transport; Nuclear pore complex; Nucleus; Phosphoprotein; Polymorphism; Protein transport; Proto-oncogene; Reference proteome; Translocation; Transport. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X66397; CAA47021.1; -; mRNA EMBL U69668; AAB48030.1; -; mRNA EMBL AL596220; CAI13119.1; -; Genomic_DNA EMBL AL133553; CAI13119.1; JOINED; Genomic_DNA EMBL AL133553; CAI17859.1; -; Genomic_DNA EMBL AL596220; CAI17859.1; JOINED; Genomic_DNA EMBL CH471067; EAW91205.1; -; Genomic_DNA EMBL X62947; CAA44719.1; ALT_TERM; mRNA EMBL Y00672; CAA68681.1; -; mRNA CCDS CCDS41446.1; -; . PIR S23741; S23741; . RefSeq NP_003283.2; NM_003292.2; . UniGene Hs.279640; -; . ProteinModelPortal P12270; -; . BioGrid 113028; 67; . IntAct P12270; 13; . MINT MINT-4993169; -; . STRING 9606.ENSP00000356448; -; . PhosphoSite P12270; -; . DMDM 215274208; -; . MaxQB P12270; -; . PaxDb P12270; -; . PRIDE P12270; -; . Ensembl ENST00000367478; ENSP00000356448; ENSG00000047410; . GeneID 7175; -; . KEGG hsa:7175; -; . UCSC uc001grv.3; human; . CTD 7175; -; . GeneCards GC01M186282; -; . HGNC HGNC:12017; TPR; . HPA HPA019661; -; . HPA HPA019663; -; . HPA HPA024336; -; . MIM 188550; phenotype; . MIM 189940; gene; . neXtProt NX_P12270; -; . Orphanet 146; Papillary or follicular thyroid carcinoma; . PharmGKB PA36696; -; . eggNOG NOG12793; -; . HOGENOM HOG000139431; -; . HOVERGEN HBG009158; -; . InParanoid P12270; -; . KO K09291; -; . OMA ECKASWE; -; . OrthoDB EOG7JQBMF; -; . PhylomeDB P12270; -; . TreeFam TF350364; -; . Reactome REACT_115831; ISG15 antiviral mechanism; . Reactome REACT_163931; Nuclear Pore Complex (NPC) Disassembly; . Reactome REACT_6190; Rev-mediated nuclear export of HIV RNA; . Reactome REACT_6804; Regulation of Glucokinase by Glucokinase Regulatory Protein; . Reactome REACT_7991; Vpr-mediated nuclear import of PICs; . Reactome REACT_9395; Nuclear import of Rev protein; . GenomeRNAi 7175; -; . NextBio 18907; -; . PMAP-CutDB P12270; -; . PRO PR:P12270; -; . ArrayExpress P12270; -; . Bgee P12270; -; . CleanEx HS_TPR; -; . Genevestigator P12270; -; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0005868; C:cytoplasmic dynein complex; IDA:UniProtKB; . GO GO:0019898; C:extrinsic component of membrane; IDA:UniProtKB; . GO GO:0000776; C:kinetochore; IDA:UniProtKB; . GO GO:0072686; C:mitotic spindle; IDA:UniProtKB; . GO GO:0005635; C:nuclear envelope; IDA:UniProtKB; . GO GO:0042405; C:nuclear inclusion body; IDA:UniProtKB; . GO GO:0031965; C:nuclear membrane; IDA:UniProtKB; . GO GO:0034399; C:nuclear periphery; IDA:UniProtKB; . GO GO:0005643; C:nuclear pore; IDA:UniProtKB; . GO GO:0044615; C:nuclear pore nuclear basket; IDA:UniProtKB; . GO GO:0005654; C:nucleoplasm; TAS:Reactome; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0003682; F:chromatin binding; IDA:UniProtKB; . GO GO:0070840; F:dynein complex binding; IDA:UniProtKB; . GO GO:0031072; F:heat shock protein binding; IDA:UniProtKB; . GO GO:0051019; F:mitogen-activated protein kinase binding; IDA:UniProtKB; . GO GO:0003729; F:mRNA binding; IDA:UniProtKB; . GO GO:0005487; F:nucleocytoplasmic transporter activity; IDA:UniProtKB; . GO GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB; . GO GO:0005515; F:protein binding; IPI:UniProtKB; . GO GO:0042803; F:protein homodimerization activity; IDA:UniProtKB; . GO GO:0015631; F:tubulin binding; IDA:UniProtKB; . GO GO:0005975; P:carbohydrate metabolic process; TAS:Reactome; . GO GO:0034605; P:cellular response to heat; IDA:UniProtKB; . GO GO:0035457; P:cellular response to interferon-alpha; ISS:UniProtKB; . GO GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome; . GO GO:0015758; P:glucose transport; TAS:Reactome; . GO GO:0008645; P:hexose transport; TAS:Reactome; . GO GO:0000189; P:MAPK import into nucleus; IMP:UniProtKB; . GO GO:0000278; P:mitotic cell cycle; TAS:Reactome; . GO GO:0007067; P:mitotic nuclear division; IEA:UniProtKB-KW; . GO GO:0007077; P:mitotic nuclear envelope disassembly; TAS:Reactome; . GO GO:0007094; P:mitotic spindle assembly checkpoint; IMP:UniProtKB; . GO GO:0031990; P:mRNA export from nucleus in response to heat stress; IDA:UniProtKB; . GO GO:0046832; P:negative regulation of RNA export from nucleus; IDA:UniProtKB; . GO GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB; . GO GO:0045947; P:negative regulation of translational initiation; IMP:UniProtKB; . GO GO:0006999; P:nuclear pore organization; IMP:UniProtKB; . GO GO:0031453; P:positive regulation of heterochromatin assembly; IMP:UniProtKB; . GO GO:0090316; P:positive regulation of intracellular protein transport; IMP:UniProtKB; . GO GO:0090267; P:positive regulation of mitotic cell cycle spindle assembly checkpoint; IMP:UniProtKB; . GO GO:0046827; P:positive regulation of protein export from nucleus; ISS:UniProtKB; . GO GO:0042307; P:positive regulation of protein import into nucleus; IMP:UniProtKB; . GO GO:0006606; P:protein import into nucleus; TAS:ProtInc; . GO GO:0010827; P:regulation of glucose transport; TAS:Reactome; . GO GO:0010965; P:regulation of mitotic sister chromatid separation; IMP:UniProtKB; . GO GO:1901673; P:regulation of spindle assembly involved in mitosis; IMP:UniProtKB; . GO GO:0070849; P:response to epidermal growth factor; IDA:UniProtKB; . GO GO:0006405; P:RNA export from nucleus; IMP:UniProtKB; . GO GO:0006404; P:RNA import into nucleus; IDA:UniProtKB; . GO GO:0044281; P:small molecule metabolic process; TAS:Reactome; . GO GO:0055085; P:transmembrane transport; TAS:Reactome; . GO GO:0016032; P:viral process; TAS:Reactome; . Gene3D 1.10.287.40; -; 1; . InterPro IPR015866; Ser-tRNA-synth_1_N; . InterPro IPR012929; TPR_MLP1_2; . Pfam PF07926; TPR_MLP1_2; 1; . World-2DPAGE Repository (search AC)