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World-2DPAGE Repository  Search by  [accession number]  [description, ID or gene]  [author names]  [spot ID / serial number]  [identification methods]  [pI / Mw range]  [combined fields]  Maps  [experimental info]  [protein list]  [graphical interface]      Databases 0001 0002 0003 0004 0005 0006 0007 0008 0009 0010 0011 0012 0014 0017 0018 0019 0020 0021 0022 0023 0024 0026 0027 0029 0030 0031 0032 0034 0035 0036 0037 0038 0039 0040 0042 0043 0044 0046 0047 0050 0051 0053 0054 0056 0059 0061 0062 0063 0066 0068 0069 0076 0077 0080 0084 0085 0088 use 'Ctrl' to select several databases Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal Exclude local DBs has only effect if a remote interface is selected

Searching in 'World-2DPAGE Repository [0054]' for entry matching: VATB2_HUMAN World-2DPAGE Repository (0054):  VATB2_HUMAN VATB2_HUMAN General information about the entry View entry in simple text format Entry name VATB2_HUMAN Primary accession number P21281 integrated into World-2DPAGE Repository (0054) on  November 28, 2012 (release 1) 2D Annotations were last modified on November 28, 2012 (version 1) General Annotations were last modified on  October 23, 2014 (version 2) Name and origin of the protein Description RecName: Full=V-type proton ATPase subunit B, brain isoform; Short=V-ATPase subunit B 2; AltName: Full=Endomembrane proton pump 58 kDa subunit; AltName: Full=HO57; AltName: Full=Vacuolar proton pump subunit B 2;. Gene name Name=ATP6V1B2 Synonyms=ATP6B2, VPP3 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION DOI=10.1074/mcp.M112.022947; Vernocchi S., Battello N., Schmitz S., Revets D., Billing A.M., Turner J.D., Muller C.P. ''Membrane glucocorticoid receptor activation induces proteomic changes aligning with classical glucocorticoid-effects'' Molecular & Cellular Proteomics 12(7):1764-1779 (2013) 2D PAGE maps for identified proteins How to interpret a protein HSAPIENS_CCRF-CEM_3-10 {CCRF-CEM cells stimulated with Cort-BSA (internal standard)} Homo sapiens (Human)   map experimental info   HSAPIENS_CCRF-CEM_3-10 MAP LOCATIONS: SPOT 11050: pI=5.57; Mw=56501   [identification data] %COV: SPOT 11050: 52 [1]. SCORE: SPOT 11050: 668 [1]. SEARCH ENGINE: SPOT 11050: Mascot [1]. MAPPING (identification): SPOT 11050: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Claude P. Muller, Centre de Recherche Public de la Sante / National Public Health Laboratory, Luxembourg Cross-references UniProtKB/Swiss-Prot P21281; VATB2_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name VATB2_HUMAN Primary accession number P21281 Secondary accession number(s) B2R5Z3 D3DSQ5 Q14544 Q15859 Q96IR0 Sequence was last modified on  December 1, 2000 (version 3) Annotations were last modified on  October 1, 2014 (version 155) Name and origin of the protein Description RecName: Full=V-type proton ATPase subunit B, brain isoform; Short=V-ATPase subunit B 2; AltName: Full=Endomembrane proton pump 58 kDa subunit; AltName: Full=HO57; AltName: Full=Vacuolar proton pump subunit B 2; Gene name Name=ATP6V1B2 Synonyms=ATP6B2, VPP3 Encoded on Name=ATP6V1B2; Synonyms=ATP6B2, VPP3 Keywords Complete proteome; Hydrogen ion transport; Hydrolase; Ion transport; Membrane; Reference proteome; Transport. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M60346; AAA35610.1; -; mRNA EMBL L35249; AAA58661.1; -; mRNA EMBL AK312372; BAG35290.1; -; mRNA EMBL CH471080; EAW63758.1; -; Genomic_DNA EMBL CH471080; EAW63759.1; -; Genomic_DNA EMBL BC003100; AAH03100.1; -; mRNA EMBL BC007309; AAH07309.1; -; mRNA EMBL BC030640; AAH30640.1; -; mRNA EMBL Z37165; CAA85522.1; -; Genomic_DNA EMBL X62949; CAA44721.1; -; mRNA CCDS CCDS6014.1; -; . PIR B44138; B44138; . PIR I39208; I39208; . RefSeq NP_001684.2; NM_001693.3; . UniGene Hs.295917; -; . ProteinModelPortal P21281; -; . SMR P21281; 55-505; . BioGrid 107009; 65; . IntAct P21281; 4; . MINT MINT-5004128; -; . STRING 9606.ENSP00000276390; -; . BindingDB P21281; -; . ChEMBL CHEMBL5641; -; . DrugBank DB05260; Gallium nitrate; . TCDB 3.A.2.2.4; the h(+)- or na(+)-translocating f-type; v-type and a-type atpase (f-atpase) superfamily; . PhosphoSite P21281; -; . DMDM 12643271; -; . REPRODUCTION-2DPAGE IPI00007812; -; . MaxQB P21281; -; . PaxDb P21281; -; . PeptideAtlas P21281; -; . PRIDE P21281; -; . DNASU 526; -; . Ensembl ENST00000276390; ENSP00000276390; ENSG00000147416; . GeneID 526; -; . KEGG hsa:526; -; . UCSC uc003wzp.3; human; . CTD 526; -; . GeneCards GC08P020054; -; . HGNC HGNC:854; ATP6V1B2; . HPA HPA008147; -; . MIM 606939; gene; . neXtProt NX_P21281; -; . PharmGKB PA25155; -; . eggNOG COG1156; -; . HOGENOM HOG000165320; -; . HOVERGEN HBG002176; -; . InParanoid P21281; -; . KO K02147; -; . OMA TVCEFTG; -; . OrthoDB EOG7NW68Q; -; . PhylomeDB P21281; -; . TreeFam TF300313; -; . BioCyc MetaCyc:HS07429-MONOMER; -; . Reactome REACT_1109; Insulin receptor recycling; . Reactome REACT_121256; Phagosomal maturation (early endosomal stage); . Reactome REACT_25283; Transferrin endocytosis and recycling; . GeneWiki ATP6V1B2; -; . GenomeRNAi 526; -; . NextBio 2183; -; . PRO PR:P21281; -; . ArrayExpress P21281; -; . Bgee P21281; -; . CleanEx HS_ATP6V1B2; -; . Genevestigator P21281; -; . GO GO:0005829; C:cytosol; ISS:UniProtKB; . GO GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell; . GO GO:0070062; C:extracellular vesicular exosome; IDA:UniProt; . GO GO:0016021; C:integral component of membrane; IEA:Ensembl; . GO GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA; . GO GO:0005765; C:lysosomal membrane; IDA:UniProtKB; . GO GO:0042470; C:melanosome; IEA:UniProtKB-SubCell; . GO GO:0005902; C:microvillus; IEA:Ensembl; . GO GO:0005886; C:plasma membrane; ISS:UniProtKB; . GO GO:0033180; C:proton-transporting V-type ATPase; V1 domain; IEA:InterPro GO GO:0005524; F:ATP binding; IEA:InterPro; . GO GO:0015078; F:hydrogen ion transmembrane transporter activity; TAS:ProtInc; . GO GO:0046961; F:proton-transporting ATPase activity; rotational mechanism; TAS:ProtInc GO GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro; . GO GO:0006879; P:cellular iron ion homeostasis; TAS:Reactome; . GO GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome; . GO GO:0051701; P:interaction with host; TAS:Reactome; . GO GO:0090382; P:phagosome maturation; TAS:Reactome; . GO GO:0015992; P:proton transport; TAS:ProtInc; . GO GO:0033572; P:transferrin transport; TAS:Reactome; . GO GO:0055085; P:transmembrane transport; TAS:Reactome; . Gene3D 3.40.50.300; -; 1; . HAMAP MF_00310; ATP_synth_B_arch; 1; . InterPro IPR020003; ATPase_a/bsu_AS; . InterPro IPR000793; ATPase_F1/V1/A1-cplx_a/bsu_C; . InterPro IPR000194; ATPase_F1/V1/A1_a/bsu_nucl-bd; . InterPro IPR004100; ATPase_F1_a/bsu_N; . InterPro IPR005723; ATPase_V1-cplx_bsu; . InterPro IPR027417; P-loop_NTPase; . InterPro IPR022879; V-ATPase_su_B/beta; . Pfam PF00006; ATP-synt_ab; 1; . Pfam PF00306; ATP-synt_ab_C; 1; . Pfam PF02874; ATP-synt_ab_N; 1; . SUPFAM SSF52540; SSF52540; 1; . TIGRFAMs TIGR01040; V-ATPase_V1_B; 1; . PROSITE PS00152; ATPASE_ALPHA_BETA; 1; . World-2DPAGE Repository (search AC)