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World-2DPAGE Repository  Search by  [accession number]  [description, ID or gene]  [author names]  [spot ID / serial number]  [identification methods]  [pI / Mw range]  [combined fields]  Maps  [experimental info]  [protein list]  [graphical interface]      Databases 0001 0002 0003 0004 0005 0006 0007 0008 0009 0010 0011 0012 0014 0017 0018 0019 0020 0021 0022 0023 0024 0026 0027 0029 0030 0031 0032 0034 0035 0036 0037 0038 0039 0040 0042 0043 0044 0046 0047 0050 0051 0053 0054 0056 0059 0061 0062 0063 0066 0068 0069 0076 0077 0080 0084 0085 0088 use 'Ctrl' to select several databases Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal Exclude local DBs has only effect if a remote interface is selected

Searching in 'World-2DPAGE Repository [0054]' for entry matching: XRCC5_HUMAN World-2DPAGE Repository (0054):  XRCC5_HUMAN XRCC5_HUMAN General information about the entry View entry in simple text format Entry name XRCC5_HUMAN Primary accession number P13010 integrated into World-2DPAGE Repository (0054) on  November 28, 2012 (release 1) 2D Annotations were last modified on November 28, 2012 (version 1) General Annotations were last modified on  October 23, 2014 (version 2) Name and origin of the protein Description RecName: Full=X-ray repair cross-complementing protein 5; EC=3.6.4.-; AltName: Full=86 kDa subunit of Ku antigen; AltName: Full=ATP-dependent DNA helicase 2 subunit 2; AltName: Full=ATP-dependent DNA helicase II 80 kDa subunit; AltName: Full=CTC box-binding factor 85 kDa subunit; Short=CTC85; Short=CTCBF; AltName: Full=DNA repair protein XRCC5; AltName: Full=Ku80; AltName: Full=Ku86; AltName: Full=Lupus Ku autoantigen protein p86; AltName: Full=Nuclear factor IV; AltName: Full=Thyroid-lupus autoantigen; Short=TLAA; AltName: Full=X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining);. Gene name Name=XRCC5 Synonyms=G22P2 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION DOI=10.1074/mcp.M112.022947; Vernocchi S., Battello N., Schmitz S., Revets D., Billing A.M., Turner J.D., Muller C.P. ''Membrane glucocorticoid receptor activation induces proteomic changes aligning with classical glucocorticoid-effects'' Molecular & Cellular Proteomics 12(7):1764-1779 (2013) 2D PAGE maps for identified proteins How to interpret a protein HSAPIENS_CCRF-CEM_3-10 {CCRF-CEM cells stimulated with Cort-BSA (internal standard)} Homo sapiens (Human)   map experimental info   HSAPIENS_CCRF-CEM_3-10 MAP LOCATIONS: SPOT 464: pI=5.55; Mw=82573   [identification data] %COV: SPOT 464: 50 [1]. SCORE: SPOT 464: 849 [1]. SEARCH ENGINE: SPOT 464: Mascot [1]. MAPPING (identification): SPOT 464: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Claude P. Muller, Centre de Recherche Public de la Sante / National Public Health Laboratory, Luxembourg Cross-references UniProtKB/Swiss-Prot P13010; XRCC5_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name XRCC5_HUMAN Primary accession number P13010 Secondary accession number(s) A8K3X5 Q0Z7V0 Q4VBQ5 Q53HH7 Q7M4N0 Q9UCQ0 Q9UCQ1 Sequence was last modified on  January 23, 2007 (version 3) Annotations were last modified on  October 1, 2014 (version 169) Name and origin of the protein Description RecName: Full=X-ray repair cross-complementing protein 5; EC=3.6.4.-; AltName: Full=86 kDa subunit of Ku antigen; AltName: Full=ATP-dependent DNA helicase 2 subunit 2; AltName: Full=ATP-dependent DNA helicase II 80 kDa subunit; AltName: Full=CTC box-binding factor 85 kDa subunit; Short=CTC85; Short=CTCBF; AltName: Full=DNA repair protein XRCC5; AltName: Full=Ku80; AltName: Full=Ku86; AltName: Full=Lupus Ku autoantigen protein p86; AltName: Full=Nuclear factor IV; AltName: Full=Thyroid-lupus autoantigen; Short=TLAA; AltName: Full=X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining); Gene name Name=XRCC5 Synonyms=G22P2 Encoded on Name=XRCC5; Synonyms=G22P2 Keywords 3D-structure; Acetylation; Activator; ATP-binding; Chromosome; Complete proteome; Direct protein sequencing; DNA damage; DNA recombination; DNA repair; DNA-binding; Helicase; Hydrolase; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Systemic lupus erythematosus; Transcription; Transcription regulation; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL J04977; AAA59475.1; -; mRNA EMBL M30938; AAA36154.1; -; mRNA EMBL AK290740; BAF83429.1; -; mRNA EMBL AK222603; BAD96323.1; -; mRNA EMBL DQ787434; ABG46942.1; -; Genomic_DNA EMBL CH471063; EAW70562.1; -; Genomic_DNA EMBL BC019027; AAH19027.1; -; mRNA EMBL BC095442; AAH95442.1; -; mRNA EMBL X57500; CAA40736.1; -; mRNA CCDS CCDS2402.1; -; . PIR A35051; A32626; . PIR D42397; D42397; . PIR S62889; S62889; . RefSeq NP_066964.1; NM_021141.3; . UniGene Hs.388739; -; . PDB 1JEQ; X-ray; 2.70 A; B=1-565 PDB 1JEY; X-ray; 2.50 A; B=1-565 PDB 1Q2Z; NMR; -; A=590-709 PDB 1RW2; NMR; -; A=566-710 PDB 3RZ9; X-ray; 2.29 A; B=559-571 PDBsum 1JEQ; -; . PDBsum 1JEY; -; . PDBsum 1Q2Z; -; . PDBsum 1RW2; -; . PDBsum 3RZ9; -; . ProteinModelPortal P13010; -; . SMR P13010; 6-545; 566-710; . BioGrid 113353; 168; . DIP DIP-31379N; -; . IntAct P13010; 51; . MINT MINT-131739; -; . STRING 9606.ENSP00000329528; -; . PhosphoSite P13010; -; . DMDM 125731; -; . SWISS-2DPAGE P13010; -; . MaxQB P13010; -; . PaxDb P13010; -; . PRIDE P13010; -; . DNASU 7520; -; . Ensembl ENST00000392132; ENSP00000375977; ENSG00000079246; . Ensembl ENST00000392133; ENSP00000375978; ENSG00000079246; . GeneID 7520; -; . KEGG hsa:7520; -; . UCSC uc002vfy.3; human; . CTD 7520; -; . GeneCards GC02P216972; -; . HGNC HGNC:12833; XRCC5; . HPA CAB004468; -; . HPA HPA025813; -; . MIM 194364; gene; . neXtProt NX_P13010; -; . PharmGKB PA37425; -; . eggNOG NOG299744; -; . HOVERGEN HBG006237; -; . InParanoid P13010; -; . KO K10885; -; . OMA FLPFPIG; -; . OrthoDB EOG7DVD9X; -; . PhylomeDB P13010; -; . TreeFam TF101205; -; . Reactome REACT_1022; Nonhomologous End-joining (NHEJ); . Reactome REACT_1201; Processing of DNA ends prior to end rejoining; . Reactome REACT_163993; IRF3-mediated induction of type I IFN; . Reactome REACT_9058; 2-LTR circle formation; . ChiTaRS XRCC5; human; . EvolutionaryTrace P13010; -; . GeneWiki Ku80; -; . GenomeRNAi 7520; -; . NextBio 29431; -; . PMAP-CutDB P13010; -; . PRO PR:P13010; -; . ArrayExpress P13010; -; . Bgee P13010; -; . CleanEx HS_XRCC5; -; . Genevestigator P13010; -; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0043564; C:Ku70:Ku80 complex; IDA:UniProtKB; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0070419; C:nonhomologous end joining complex; IDA:UniProtKB; . GO GO:0000784; C:nuclear chromosome; telomeric region; IDA:BHF-UCL GO GO:0000783; C:nuclear telomere cap complex; TAS:BHF-UCL; . GO GO:0005654; C:nucleoplasm; TAS:Reactome; . GO GO:0005634; C:nucleus; IDA:HPA; . GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0004003; F:ATP-dependent DNA helicase activity; TAS:ProtInc; . GO GO:0003684; F:damaged DNA binding; IEA:InterPro; . GO GO:0003677; F:DNA binding; NAS:UniProtKB; . GO GO:0003690; F:double-stranded DNA binding; TAS:ProtInc; . GO GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB; . GO GO:0005515; F:protein binding; IPI:UniProtKB; . GO GO:0008022; F:protein C-terminus binding; IPI:UniProtKB; . GO GO:0042162; F:telomeric DNA binding; IDA:BHF-UCL; . GO GO:0044212; F:transcription regulatory region DNA binding; IDA:BHF-UCL; . GO GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB; . GO GO:0007420; P:brain development; IEA:Ensembl; . GO GO:0008283; P:cell proliferation; IEA:Ensembl; . GO GO:0071475; P:cellular hyperosmotic salinity response; IEA:Ensembl; . GO GO:0071398; P:cellular response to fatty acid; IEA:Ensembl; . GO GO:0071481; P:cellular response to X-ray; IEA:Ensembl; . GO GO:0032508; P:DNA duplex unwinding; TAS:GOC; . GO GO:0006310; P:DNA recombination; TAS:ProtInc; . GO GO:0006281; P:DNA repair; TAS:Reactome; . GO GO:0006302; P:double-strand break repair; TAS:Reactome; . GO GO:0006303; P:double-strand break repair via nonhomologous end joining; IMP:UniProtKB; . GO GO:0075713; P:establishment of integrated proviral latency; TAS:Reactome; . GO GO:0060218; P:hematopoietic stem cell differentiation; IEA:Ensembl; . GO GO:0045087; P:innate immune response; TAS:Reactome; . GO GO:0045892; P:negative regulation of transcription; DNA-templated; IMP:UniProtKB GO GO:0050769; P:positive regulation of neurogenesis; IEA:Ensembl; . GO GO:0032481; P:positive regulation of type I interferon production; TAS:Reactome; . GO GO:0042493; P:response to drug; IEA:Ensembl; . GO GO:0000723; P:telomere maintenance; TAS:BHF-UCL; . GO GO:0006351; P:transcription; DNA-templated; IEA:UniProtKB-KW GO GO:0016032; P:viral process; TAS:Reactome; . Gene3D 1.10.1600.10; -; 1; . Gene3D 1.25.40.240; -; 1; . Gene3D 2.40.290.10; -; 1; . Gene3D 3.40.50.410; -; 1; . InterPro IPR006164; Ku70/Ku80_beta-barrel_dom; . InterPro IPR024193; Ku80; . InterPro IPR005160; Ku_C; . InterPro IPR005161; Ku_N; . InterPro IPR014893; Ku_PK_bind; . InterPro IPR016194; SPOC_like_C_dom; . InterPro IPR002035; VWF_A; . PANTHER PTHR12604:SF3; PTHR12604:SF3; 1; . Pfam PF02735; Ku; 1; . Pfam PF03730; Ku_C; 1; . Pfam PF03731; Ku_N; 1; . Pfam PF08785; Ku_PK_bind; 1; . PIRSF PIRSF016570; Ku80; 1; . SMART SM00559; Ku78; 1; . SMART SM00327; VWA; 1; . SUPFAM SSF100939; SSF100939; 1; . SUPFAM SSF101420; SSF101420; 1; . SUPFAM SSF53300; SSF53300; 1; . World-2DPAGE Repository (search AC)