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World-2DPAGE Repository  Search by  [accession number]  [description, ID or gene]  [author names]  [spot ID / serial number]  [identification methods]  [pI / Mw range]  [combined fields]  Maps  [experimental info]  [protein list]  [graphical interface]      Databases 0001 0002 0003 0004 0005 0006 0007 0008 0009 0010 0011 0012 0014 0017 0018 0019 0020 0021 0022 0023 0024 0026 0027 0029 0030 0031 0032 0034 0035 0036 0037 0038 0039 0040 0042 0043 0044 0046 0047 0050 0051 0053 0054 0056 0059 0061 0062 0063 0066 0068 0069 0076 0077 0080 0084 0085 0088 use 'Ctrl' to select several databases Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal Exclude local DBs has only effect if a remote interface is selected

Searching in 'World-2DPAGE Repository [0054]' for entry matching: XRCC6_HUMAN World-2DPAGE Repository (0054):  XRCC6_HUMAN XRCC6_HUMAN General information about the entry View entry in simple text format Entry name XRCC6_HUMAN Primary accession number P12956 integrated into World-2DPAGE Repository (0054) on  November 28, 2012 (release 1) 2D Annotations were last modified on November 28, 2012 (version 1) General Annotations were last modified on  October 23, 2014 (version 2) Name and origin of the protein Description RecName: Full=X-ray repair cross-complementing protein 6; EC=3.6.4.-; EC=4.2.99.-; AltName: Full=5'-deoxyribose-5-phosphate lyase Ku70; Short=5'-dRP lyase Ku70; AltName: Full=70 kDa subunit of Ku antigen; AltName: Full=ATP-dependent DNA helicase 2 subunit 1; AltName: Full=ATP-dependent DNA helicase II 70 kDa subunit; AltName: Full=CTC box-binding factor 75 kDa subunit; Short=CTC75; Short=CTCBF; AltName: Full=DNA repair protein XRCC6; AltName: Full=Lupus Ku autoantigen protein p70; Short=Ku70; AltName: Full=Thyroid-lupus autoantigen; Short=TLAA; AltName: Full=X-ray repair complementing defective repair in Chinese hamster cells 6;. Gene name Name=XRCC6 Synonyms=G22P1 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION DOI=10.1074/mcp.M112.022947; Vernocchi S., Battello N., Schmitz S., Revets D., Billing A.M., Turner J.D., Muller C.P. ''Membrane glucocorticoid receptor activation induces proteomic changes aligning with classical glucocorticoid-effects'' Molecular & Cellular Proteomics 12(7):1764-1779 (2013) 2D PAGE maps for identified proteins How to interpret a protein HSAPIENS_CCRF-CEM_3-10 {CCRF-CEM cells stimulated with Cort-BSA (internal standard)} Homo sapiens (Human)   map experimental info   HSAPIENS_CCRF-CEM_3-10 MAP LOCATIONS: SPOT 561: pI=6.23; Mw=69712   [identification data] %COV: SPOT 561: 56 [1]. SCORE: SPOT 561: 835 [1]. SEARCH ENGINE: SPOT 561: Mascot [1]. MAPPING (identification): SPOT 561: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Claude P. Muller, Centre de Recherche Public de la Sante / National Public Health Laboratory, Luxembourg Cross-references UniProtKB/Swiss-Prot P12956; XRCC6_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name XRCC6_HUMAN Primary accession number P12956 Secondary accession number(s) B1AHC8 Q6FG89 Q9UCQ2 Q9UCQ3 Sequence was last modified on  January 23, 2007 (version 2) Annotations were last modified on  October 1, 2014 (version 180) Name and origin of the protein Description RecName: Full=X-ray repair cross-complementing protein 6; EC=3.6.4.-; EC=4.2.99.-; AltName: Full=5'-deoxyribose-5-phosphate lyase Ku70; Short=5'-dRP lyase Ku70; AltName: Full=70 kDa subunit of Ku antigen; AltName: Full=ATP-dependent DNA helicase 2 subunit 1; AltName: Full=ATP-dependent DNA helicase II 70 kDa subunit; AltName: Full=CTC box-binding factor 75 kDa subunit; Short=CTC75; Short=CTCBF; AltName: Full=DNA repair protein XRCC6; AltName: Full=Lupus Ku autoantigen protein p70; Short=Ku70; AltName: Full=Thyroid-lupus autoantigen; Short=TLAA; AltName: Full=X-ray repair complementing defective repair in Chinese hamster cells 6; Gene name Name=XRCC6 Synonyms=G22P1 Encoded on Name=XRCC6; Synonyms=G22P1 Keywords 3D-structure; Acetylation; Activator; Alternative splicing; ATP-binding; Chromosome; Complete proteome; Direct protein sequencing; DNA damage; DNA recombination; DNA repair; DNA-binding; Helicase; Hydrolase; Lyase; Multifunctional enzyme; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Systemic lupus erythematosus; Transcription; Transcription regulation. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL J04607; AAA61177.1; -; mRNA EMBL J04611; AAA51733.1; -; mRNA EMBL M32865; AAA36155.1; -; mRNA EMBL S38729; AAB22381.1; -; mRNA EMBL AK055786; BAG51575.1; -; mRNA EMBL CR542219; CAG47015.1; -; mRNA EMBL AY870329; AAW34364.1; -; Genomic_DNA EMBL Z83840; CAB46206.1; -; Genomic_DNA EMBL CH471095; EAW60448.1; -; Genomic_DNA EMBL BC008343; AAH08343.1; -; mRNA EMBL BC010034; AAH10034.1; -; mRNA EMBL BC012154; AAH12154.1; -; mRNA EMBL BC018259; AAH18259.1; -; mRNA EMBL BC072449; AAH72449.1; -; mRNA CCDS CCDS14021.1; -; . PIR A30299; A30894; . RefSeq NP_001275905.1; NM_001288976.1; . RefSeq NP_001275906.1; NM_001288977.1; . RefSeq NP_001460.1; NM_001469.4; . UniGene Hs.292493; -; . UniGene Hs.730702; -; . PDB 1JEQ; X-ray; 2.70 A; A=1-609 PDB 1JEY; X-ray; 2.50 A; A=1-609 PDB 1JJR; NMR; -; A=556-609 PDB 3RZX; X-ray; 2.61 A; B=537-558 PDBsum 1JEQ; -; . PDBsum 1JEY; -; . PDBsum 1JJR; -; . PDBsum 3RZX; -; . ProteinModelPortal P12956; -; . SMR P12956; 34-609; . BioGrid 108822; 228; . DIP DIP-24188N; -; . IntAct P12956; 121; . MINT MINT-1416738; -; . STRING 9606.ENSP00000352257; -; . PhosphoSite P12956; -; . DMDM 125729; -; . SWISS-2DPAGE P12956; -; . MaxQB P12956; -; . PaxDb P12956; -; . PRIDE P12956; -; . DNASU 2547; -; . Ensembl ENST00000359308; ENSP00000352257; ENSG00000196419; . Ensembl ENST00000360079; ENSP00000353192; ENSG00000196419; . Ensembl ENST00000402580; ENSP00000384941; ENSG00000196419; . Ensembl ENST00000405878; ENSP00000384257; ENSG00000196419; . GeneID 2547; -; . KEGG hsa:2547; -; . UCSC uc003bao.1; human; . CTD 2547; -; . GeneCards GC22P042017; -; . HGNC HGNC:4055; XRCC6; . HPA CAB004254; -; . HPA HPA047549; -; . MIM 152690; gene; . neXtProt NX_P12956; -; . PharmGKB PA28467; -; . eggNOG NOG305318; -; . HOGENOM HOG000006588; -; . HOVERGEN HBG006236; -; . InParanoid P12956; -; . KO K10884; -; . OMA CRYTPRK; -; . OrthoDB EOG7QG43F; -; . PhylomeDB P12956; -; . TreeFam TF315101; -; . Reactome REACT_1022; Nonhomologous End-joining (NHEJ); . Reactome REACT_1201; Processing of DNA ends prior to end rejoining; . Reactome REACT_163993; IRF3-mediated induction of type I IFN; . Reactome REACT_9058; 2-LTR circle formation; . EvolutionaryTrace P12956; -; . GeneWiki Ku70; -; . GenomeRNAi 2547; -; . NextBio 10043; -; . PMAP-CutDB P12956; -; . PRO PR:P12956; -; . ArrayExpress P12956; -; . Bgee P12956; -; . CleanEx HS_XRCC6; -; . Genevestigator P12956; -; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0043564; C:Ku70:Ku80 complex; IDA:UniProtKB; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0070419; C:nonhomologous end joining complex; IDA:UniProtKB; . GO GO:0000783; C:nuclear telomere cap complex; TAS:BHF-UCL; . GO GO:0005730; C:nucleolus; IEA:Ensembl; . GO GO:0005654; C:nucleoplasm; TAS:Reactome; . GO GO:0005634; C:nucleus; IDA:HPA; . GO GO:0005667; C:transcription factor complex; IDA:UniProtKB; . GO GO:0051575; F:5'-deoxyribose-5-phosphate lyase activity; IMP:UniProtKB; . GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0004003; F:ATP-dependent DNA helicase activity; TAS:ProtInc; . GO GO:0003684; F:damaged DNA binding; IEA:InterPro; . GO GO:0003677; F:DNA binding; NAS:UniProtKB; . GO GO:0003690; F:double-stranded DNA binding; TAS:ProtInc; . GO GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB; . GO GO:0005515; F:protein binding; IPI:UniProtKB; . GO GO:0008022; F:protein C-terminus binding; IPI:UniProtKB; . GO GO:0042162; F:telomeric DNA binding; IEA:InterPro; . GO GO:0044212; F:transcription regulatory region DNA binding; IDA:BHF-UCL; . GO GO:0007420; P:brain development; IEA:Ensembl; . GO GO:0071475; P:cellular hyperosmotic salinity response; IEA:Ensembl; . GO GO:0071481; P:cellular response to X-ray; IEA:Ensembl; . GO GO:0032508; P:DNA duplex unwinding; TAS:GOC; . GO GO:0006266; P:DNA ligation; TAS:ProtInc; . GO GO:0006281; P:DNA repair; TAS:Reactome; . GO GO:0006302; P:double-strand break repair; TAS:Reactome; . GO GO:0006303; P:double-strand break repair via nonhomologous end joining; IMP:UniProtKB; . GO GO:0075713; P:establishment of integrated proviral latency; TAS:Reactome; . GO GO:0045087; P:innate immune response; TAS:Reactome; . GO GO:0045892; P:negative regulation of transcription; DNA-templated; IMP:UniProtKB GO GO:0050769; P:positive regulation of neurogenesis; IEA:Ensembl; . GO GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL; . GO GO:0045893; P:positive regulation of transcription; DNA-templated; IDA:UniProtKB GO GO:0032481; P:positive regulation of type I interferon production; TAS:Reactome; . GO GO:0000723; P:telomere maintenance; TAS:BHF-UCL; . GO GO:0006351; P:transcription; DNA-templated; IEA:UniProtKB-KW GO GO:0033151; P:V(D)J recombination; IEA:Ensembl; . GO GO:0016032; P:viral process; TAS:Reactome; . Gene3D 1.10.1600.10; -; 1; . Gene3D 1.10.720.30; -; 1; . Gene3D 2.40.290.10; -; 1; . Gene3D 3.40.50.410; -; 1; . Gene3D 4.10.970.10; -; 1; . InterPro IPR006165; Ku70; . InterPro IPR006164; Ku70/Ku80_beta-barrel_dom; . InterPro IPR027388; Ku70_bridge/pillars_dom; . InterPro IPR005160; Ku_C; . InterPro IPR005161; Ku_N; . InterPro IPR003034; SAP_dom; . InterPro IPR016194; SPOC_like_C_dom; . InterPro IPR002035; VWF_A; . PANTHER PTHR12604:SF2; PTHR12604:SF2; 1; . Pfam PF02735; Ku; 1; . Pfam PF03730; Ku_C; 1; . Pfam PF03731; Ku_N; 1; . Pfam PF02037; SAP; 1; . PIRSF PIRSF003033; Ku70; 1; . SMART SM00559; Ku78; 1; . SMART SM00513; SAP; 1; . SUPFAM SSF100939; SSF100939; 1; . SUPFAM SSF53300; SSF53300; 1; . TIGRFAMs TIGR00578; ku70; 1; . PROSITE PS50800; SAP; 1; . World-2DPAGE Repository (search AC)