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SWISS-2DPAGE 
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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P00738




SWISS-2DPAGE: P00738



P00738:

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ID   HPT_HUMAN; STANDARD; 2DG.
AC   P00738; P00737;
DT   01-AUG-1993, integrated into SWISS-2DPAGE (release 0).
DT   31-MAR-2004, 2D annotation version 4.
DT   19-MAY-2011, general annotation version 15.
DE   RecName: Full=Haptoglobin; Contains: RecName: Full=Haptoglobin alpha
DE   chain; Contains: RecName: Full=Haptoglobin beta chain; Flags: Precursor;.
GN   Name=HP;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Hominidae; Homo.
OX   NCBI_TaxID=9606;
MT   CSF_HUMAN, HEPG2SP_HUMAN, LIVER_HUMAN, LYMPHOMA_HUMAN, PLASMA_HUMAN.
IM   CSF_HUMAN, HEPG2SP_HUMAN, LIVER_HUMAN, LYMPHOMA_HUMAN, PLASMA_HUMAN.
RN   [1]
RP   MAPPING ON GEL.
RX   MEDLINE=93162045; PubMed=1286669; [NCBI, ExPASy, EBI, Israel, Japan]
RA   Hochstrasser D.F., Frutiger S., Paquet N., Bairoch A., Ravier F.,
RA   Pasquali C., Sanchez J.-C., Tissot J.-D., Bjellqvist B., Vargas R., Appel
RA   R.D., Hughes G.J.;
RT   ''''''Human liver protein map: a reference database established by
RT   microsequencing and gel comparison'';'';'';
RL   Electrophoresis 13(1):992-1001(1992).
RN   [2]
RP   GENETIC VARIANTS.
RX   MEDLINE=83019292; PubMed=6751044; [NCBI, ExPASy, EBI, Israel, Japan]
RA   Bowman B.H., Kurosky A.;
RT   ''''''Haptoglobin: the evolutionary product of duplication, unequal
RT   crossing over, and point mutation'';'';'';
RL   Adv. Hum. Genet. 12(1):189-261(1982).
RN   [3]
RP   MAPPING ON GEL.
RX   MEDLINE=78094420; PubMed=271964; [NCBI, ExPASy, EBI, Israel, Japan]
RA   Anderson N.L., Anderson N.G.;
RT   ''''''High resolution two-dimensional electrophoresis of human plasma proteins'';'';'';
RL   Proc. Natl. Acad. Sci. U.S.A. 74(1):5421-5425(1977).
RN   [4]
RP   MAPPING ON GEL.
RX   MEDLINE=96007934; PubMed=7498157; [NCBI, ExPASy, EBI, Israel, Japan]
RA   Sanchez J.-C., Appel R.D., Golaz O.G., Pasquali C., Ravier F., Bairoch
RA   A., Hochstrasser D.F.;
RT   ''''''Inside SWISS-2DPAGE database'';'';'';
RL   Electrophoresis 16(1):1131-1151(1995).
RN   [5]
RP   MAPPING ON GEL.
RX   MEDLINE=93092937; PubMed=1459097; [NCBI, ExPASy, EBI, Israel, Japan]
RA   Hughes G.J., Frutiger S., Paquet N., Ravier F., Pasquali C., Sanchez
RA   J.-C., James R.W., Tissot J.-D., Bjellqvist B., Hochstrasser D.F.;
RT   ''''''Plasma protein map: an update by microsequencing'';'';'';
RL   Electrophoresis 13(1):707-714(1992).
RN   [6]
RP   MAPPING ON GEL.
RX   MEDLINE=97397181; PubMed=9253242; [NCBI, ExPASy, EBI, Israel, Japan]
RA   Eckerskorn C., Strupat K., Schleuder D., Hochstrasser D.F., Sanchez
RA   J.-C., Lottspeich F., Hillenkamp F.;
RT   ''''''Analysis of proteins by direct-scanning infrared-MALDI mass
RT   spectrometry after 2D-PAGE separation and electroblotting'';'';'';
RL   Anal. Chem. 69(1):2888-2892(1997).
CC   -!- SUBUNIT: TETRAMER OF TWO ALPHA-1 AND TWO BETA CHAINS 
2D   -!- MASTER: CSF_HUMAN;
2D   -!-   PI/MW: SPOT 2D-000C10=4.68/47026;
2D   -!-   PI/MW: SPOT 2D-000C1H=4.80/45624;
2D   -!-   PI/MW: SPOT 2D-000C1K=4.69/45486;
2D   -!-   PI/MW: SPOT 2D-000C1L=4.92/44398;
2D   -!-   PI/MW: SPOT 2D-000C22=4.81/43864;
2D   -!-   PI/MW: SPOT 2D-000C25=5.07/43600;
2D   -!-   PI/MW: SPOT 2D-000C2J=5.20/42428;
2D   -!-   PI/MW: SPOT 2D-000C2M=5.36/42557;
2D   -!-   PI/MW: SPOT 2D-000C2N=5.46/42428;
2D   -!-   PI/MW: SPOT 2D-000C2O=4.93/42557;
2D   -!-   PI/MW: SPOT 2D-000C2P=5.07/42428;
2D   -!-   PI/MW: SPOT 2D-000C36=5.36/40915;
2D   -!-   PI/MW: SPOT 2D-000C38=5.43/41288;
2D   -!-   PI/MW: SPOT 2D-000C3B=5.20/40915;
2D   -!-   PI/MW: SPOT 2D-000C3J=5.52/40112;
2D   -!-   PI/MW: SPOT 2D-000C3K=5.44/40212;
2D   -!-   PI/MW: SPOT 2D-000CEB=5.40/17109;
2D   -!-   PI/MW: SPOT 2D-000CEC=5.67/17109;
2D   -!-   PI/MW: SPOT 2D-000CH4=5.42/9374;
2D   -!-   PI/MW: SPOT 2D-000CH8=5.71/9270;
2D   -!-   MAPPING: MATCHING WITH THE PLASMA MASTER GEL [4].
2D   -!- MASTER: HEPG2SP_HUMAN;
2D   -!-   PI/MW: SPOT 2D-00093R=4.71/41812;
2D   -!-   PI/MW: SPOT 2D-000949=4.99/40598;
2D   -!-   PI/MW: SPOT 2D-00094F=5.33/39290;
2D   -!-   PI/MW: SPOT 2D-00094N=5.44/39162;
2D   -!-   PI/MW: SPOT 2D-00094X=5.58/38400;
2D   -!-   PI/MW: SPOT 2D-0009KM=5.61/15926;
2D   -!-   MAPPING: MATCHING WITH THE PLASMA MASTER GEL [4].
2D   -!- MASTER: LIVER_HUMAN;
2D   -!-   PI/MW: SPOT 2D-0000XL=4.94/40767;
2D   -!-   PI/MW: SPOT 2D-0000XU=5.05/40584;
2D   -!-   PI/MW: SPOT 2D-0000XV=5.05/40037;
2D   -!-   PI/MW: SPOT 2D-0000YJ=5.19/39856;
2D   -!-   PI/MW: SPOT 2D-0000YK=5.19/39320;
2D   -!-   PI/MW: SPOT 2D-0000Z2=5.30/39054;
2D   -!-   PI/MW: SPOT 2D-0001J9=6.30/15953;
2D   -!-   PI/MW: SPOT 2D-0001JC=6.72/15804;
2D   -!-   PI/MW: SPOT 2D-0001NA=5.19/12883;
2D   -!-   NORMAL POSITIONAL VARIANTS: HP1-1; HP2-1; HP2-2; SOME RARE VARIANTS [2].
2D   -!-   PATHOLOGICAL LEVEL: DECREASED DURING LIVER DISEASE AND HAEMOLYTIC
2D         ANAEMIAS; INCREASED DURING ACUTE-PHASE.
2D   -!-   MAPPING: MATCHING WITH A PLASMA GEL [1].
2D   -!- MASTER: LYMPHOMA_HUMAN;
2D   -!-   PI/MW: SPOT 2D-0007QH=4.90/41625;
2D   -!-   PI/MW: SPOT 2D-0007QZ=4.90/40848;
2D   -!-   PI/MW: SPOT 2D-0007RB=5.05/40592;
2D   -!-   PI/MW: SPOT 2D-0007RW=5.06/39918;
2D   -!-   PI/MW: SPOT 2D-0007S2=5.21/39751;
2D   -!-   PI/MW: SPOT 2D-0007ST=5.22/39009;
2D   -!-   PI/MW: SPOT 2D-0007T4=5.34/38683;
2D   -!-   MAPPING: MATCHING WITH THE LIVER MASTER GEL [4].
2D   -!- MASTER: PLASMA_HUMAN;
2D   -!-   PI/MW: SPOT 2D-0004ZV=4.88/44344;
2D   -!-   PI/MW: SPOT 2D-0004ZX=4.81/44464;
2D   -!-   PI/MW: SPOT 2D-00050A=4.97/43391;
2D   -!-   PI/MW: SPOT 2D-00050U=4.88/43156;
2D   -!-   PI/MW: SPOT 2D-000510=5.21/42229;
2D   -!-   PI/MW: SPOT 2D-000519=5.08/42114;
2D   -!-   PI/MW: SPOT 2D-00051D=4.97/42114;
2D   -!-   PI/MW: SPOT 2D-00051I=5.37/42000;
2D   -!-   PI/MW: SPOT 2D-00051W=5.08/41412;
2D   -!-   PI/MW: SPOT 2D-000523=5.21/41329;
2D   -!-   PI/MW: SPOT 2D-000524=5.36/40832;
2D   -!-   PI/MW: SPOT 2D-00052N=5.21/40668;
2D   -!-   PI/MW: SPOT 2D-00052T=5.69/40342;
2D   -!-   PI/MW: SPOT 2D-00052Y=5.55/40423;
2D   -!-   PI/MW: SPOT 2D-00053S=5.21/39141;
2D   -!-   PI/MW: SPOT 2D-00053Y=5.38/38749;
2D   -!-   PI/MW: SPOT 2D-000547=5.56/38516;
2D   -!-   PI/MW: SPOT 2D-00054K=5.69/38206;
2D   -!-   PI/MW: SPOT 2D-00055F=5.86/37294;
2D   -!-   PI/MW: SPOT 2D-0005G9=5.68/17069;
2D   -!-   PI/MW: SPOT 2D-0005GC=5.40/16882;
2D   -!-   PI/MW: SPOT 2D-0005GD=6.07/16882;
2D   -!-   PI/MW: SPOT 2D-0012J8=5.37/11990;
2D   -!-   PI/MW: SPOT 2D-0012J9=5.13/11861;
2D   -!-   NORMAL LEVEL: 1000-3000 MG/L.
2D   -!-   PATHOLOGICAL LEVEL: DECREASED DURING LIVER DISEASE AND HAEMOLYTIC
2D         ANAEMIAS; INCREASED DURING ACUTE-PHASE.
2D   -!-   POSITIONAL VARIANTS: HP1-1; HP2-1; HP2-2; SOME RARE VARIANTS [2].
2D   -!-   MAPPING: SPOTS 2D-00*: IMMUNOBLOTTING [3]; SPOTS 2D-0005G*:
2D         MICROSEQUENCING [5] AND MASS spectrometry [6].
CC   ---------------------------------------------------------------------------
CC   This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics.
CC   There are no restrictions on its use by non-profit institutions as long as
CC   its content is in no way modified and this statement is not removed.
CC   Usage by and for commercial entities requires a license agreement (See
CC   http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).
CC   ---------------------------------------------------------------------------
DR   DOSAC-COBS 2D-PAGE; P00738; P00738.
DR   DOSAC-COBS-2DPAGE; P00738; HPT_HUMAN.
DR   HSC-2DPAGE; P00737; HUMAN.
DR   Siena-2DPAGE; P00738; HPT_HUMAN.
DR   UCD-2DPAGE; P00737; HPT_HUMAN.
DR   UniProtKB/Swiss-Prot; P00738; HPT_HUMAN.
//


The following 2-D maps are available for this protein:
Cerebrospinal Fluid
CSF_HUMAN
HepG2 Secreted Proteins
HEPG2SP_HUMAN
Liver
LIVER_HUMAN
Lymphoma
LYMPHOMA_HUMAN
Plasma
PLASMA_HUMAN
 


SWISS-2DPAGE image

SWISS-2DPAGE (search AC)


Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server