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World-2DPAGE Repository  Search by  [accession number]  [description, ID or gene]  [author names]  [spot ID / serial number]  [identification methods]  [pI / Mw range]  [combined fields]  Maps  [experimental info]  [protein list]  [graphical interface]      Databases 0001 0002 0003 0004 0005 0006 0007 0008 0009 0010 0011 0012 0014 0017 0018 0019 0020 0021 0022 0023 0024 0026 0027 0029 0030 0031 0032 0034 0035 0036 0037 0038 0039 0040 0042 0043 0044 0046 0047 0050 0051 0053 0054 0056 0059 0061 0062 0063 0066 0068 0069 0076 0077 0080 0084 0085 0088 use 'Ctrl' to select several databases Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal Exclude local DBs has only effect if a remote interface is selected

Searching in 'World-2DPAGE Repository [0054]' for entry matching: LASP1_HUMAN World-2DPAGE Repository (0054):  LASP1_HUMAN LASP1_HUMAN General information about the entry View entry in simple text format Entry name LASP1_HUMAN Primary accession number Q14847 integrated into World-2DPAGE Repository (0054) on  November 28, 2012 (release 1) 2D Annotations were last modified on November 28, 2012 (version 1) General Annotations were last modified on  October 23, 2014 (version 2) Name and origin of the protein Description RecName: Full=LIM and SH3 domain protein 1; Short=LASP-1; AltName: Full=Metastatic lymph node gene 50 protein; Short=MLN 50;. Gene name Name=LASP1 Synonyms=MLN50 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION DOI=10.1074/mcp.M112.022947; Vernocchi S., Battello N., Schmitz S., Revets D., Billing A.M., Turner J.D., Muller C.P. ''Membrane glucocorticoid receptor activation induces proteomic changes aligning with classical glucocorticoid-effects'' Molecular & Cellular Proteomics 12(7):1764-1779 (2013) 2D PAGE maps for identified proteins How to interpret a protein HSAPIENS_CCRF-CEM_3-10 {CCRF-CEM cells stimulated with Cort-BSA (internal standard)} Homo sapiens (Human)   map experimental info   HSAPIENS_CCRF-CEM_3-10 MAP LOCATIONS: SPOT 925: pI=6.61; Mw=29717   [identification data] %COV: SPOT 925: 42 [1]. SCORE: SPOT 925: 562 [1]. SEARCH ENGINE: SPOT 925: Mascot [1]. MAPPING (identification): SPOT 925: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Claude P. Muller, Centre de Recherche Public de la Sante / National Public Health Laboratory, Luxembourg Cross-references UniProtKB/Swiss-Prot Q14847; LASP1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name LASP1_HUMAN Primary accession number Q14847 Secondary accession number(s) B4DGQ0 Q96ED2 Q96IG0 Sequence was last modified on  January 1, 1998 (version 2) Annotations were last modified on  October 1, 2014 (version 144) Name and origin of the protein Description RecName: Full=LIM and SH3 domain protein 1; Short=LASP-1; AltName: Full=Metastatic lymph node gene 50 protein; Short=MLN 50; Gene name Name=LASP1 Synonyms=MLN50 Encoded on Name=LASP1; Synonyms=MLN50 Keywords 3D-structure; Acetylation; Actin-binding; Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Ion transport; LIM domain; Metal-binding; Phosphoprotein; Reference proteome; Repeat; SH3 domain; Transport; Zinc. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X82456; CAA57833.1; -; mRNA EMBL AK294704; BAG57861.1; -; mRNA EMBL AC006441; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL AC110749; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL BC007560; AAH07560.1; -; mRNA EMBL BC012460; AAH12460.1; -; mRNA CCDS CCDS11331.1; -. [Q14847-1]; . CCDS CCDS62164.1; -. [Q14847-3]; . PIR S68234; S68234; . RefSeq NP_001258537.1; NM_001271608.1. [Q14847-3]; . RefSeq NP_006139.1; NM_006148.3. [Q14847-1]; . UniGene Hs.741156; -; . PDB 3I35; X-ray; 1.40 A; A=202-261 PDBsum 3I35; -; . ProteinModelPortal Q14847; -; . SMR Q14847; 1-54; 205-261; . BioGrid 110120; 17; . IntAct Q14847; 15; . MINT MINT-5001286; -; . STRING 9606.ENSP00000325240; -; . PhosphoSite Q14847; -; . DMDM 3122342; -; . OGP Q14847; -; . SWISS-2DPAGE Q14847; -; . MaxQB Q14847; -; . PaxDb Q14847; -; . PRIDE Q14847; -; . DNASU 3927; -; . Ensembl ENST00000318008; ENSP00000325240; ENSG00000002834. [Q14847-1]; . Ensembl ENST00000433206; ENSP00000401048; ENSG00000002834. [Q14847-3]; . Ensembl ENST00000435347; ENSP00000392853; ENSG00000002834. [Q14847-1]; . GeneID 3927; -; . KEGG hsa:3927; -; . UCSC uc002hra.3; human. [Q14847-1]; . CTD 3927; -; . GeneCards GC17P037026; -; . HGNC HGNC:6513; LASP1; . HPA CAB022049; -; . HPA HPA012072; -; . MIM 602920; gene; . neXtProt NX_Q14847; -; . PharmGKB PA30298; -; . eggNOG NOG259964; -; . HOGENOM HOG000006616; -; . HOVERGEN HBG054636; -; . InParanoid Q14847; -; . OMA YWHKACF; -; . OrthoDB EOG771280; -; . PhylomeDB Q14847; -; . TreeFam TF319104; -; . ChiTaRS LASP1; human; . EvolutionaryTrace Q14847; -; . GeneWiki LASP1; -; . GenomeRNAi 3927; -; . NextBio 15423; -; . PRO PR:Q14847; -; . ArrayExpress Q14847; -; . Bgee Q14847; -; . CleanEx HS_LASP1; -; . Genevestigator Q14847; -; . GO GO:0030864; C:cortical actin cytoskeleton; ISS:UniProtKB; . GO GO:0070062; C:extracellular vesicular exosome; IDA:UniProt; . GO GO:0005925; C:focal adhesion; IEA:Ensembl; . GO GO:0015075; F:ion transmembrane transporter activity; ISS:UniProtKB; . GO GO:0005515; F:protein binding; IPI:IntAct; . GO GO:0005070; F:SH3/SH2 adaptor activity; TAS:ProtInc; . GO GO:0008270; F:zinc ion binding; IEA:InterPro; . GO GO:0006811; P:ion transport; ISS:UniProtKB; . GO GO:0009967; P:positive regulation of signal transduction; TAS:GOC; . Gene3D 2.10.110.10; -; 1; . InterPro IPR000900; Nebulin_repeat; . InterPro IPR001452; SH3_domain; . InterPro IPR001781; Znf_LIM; . Pfam PF00412; LIM; 1; . Pfam PF00880; Nebulin; 2; . Pfam PF14604; SH3_9; 1; . PRINTS PR00452; SH3DOMAIN; . SMART SM00132; LIM; 1; . SMART SM00227; NEBU; 2; . SMART SM00326; SH3; 1; . SUPFAM SSF50044; SSF50044; 1; . PROSITE PS00478; LIM_DOMAIN_1; 1; . PROSITE PS50023; LIM_DOMAIN_2; 1; . PROSITE PS51216; NEBULIN; 2; . PROSITE PS50002; SH3; 1; . World-2DPAGE Repository (search AC)