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SWISS-2DPAGE

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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: AL1A1_HUMAN




SWISS-2DPAGE:  AL1A1_HUMAN


AL1A1_HUMAN


General information about the entry
View entry in simple text format
Entry nameAL1A1_HUMAN
Primary accession numberP00352
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onMarch 31, 2004 (version 1)
General Annotations were last modified on May 19, 2011 (version 14)
Name and origin of the protein
DescriptionRecName: Full=Retinal dehydrogenase 1; Short=RALDH 1; Short=RalDH1; EC=1.2.1.36; AltName: Full=ALDH-E1; AltName: Full=ALHDII; AltName: Full=Aldehyde dehydrogenase family 1 member A1; AltName: Full=Aldehyde dehydrogenase, cytosolic;.
Gene nameName=ALDH1A1
Synonyms=ALDC, ALDH1, PUMB1
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=94147970; PubMed=8313871; [NCBI, Expasy, EBI, Israel, Japan]
Golaz O., Hughes G.J., Frutiger S., Paquet N., Bairoch A., Pasquali C., Sanchez J.-C., Tissot J.-D., Appel R.D., Walzer C., Balant L.P., Hochstrasser D.F.
''''''Plasma and red blood cell protein maps: update 1993'';'';''
Electrophoresis 14(1):1223-1231(1993)
Comments
  • SUBUNIT: HOMOTETRAMER
2D PAGE maps for identified proteins
How to interpret a protein

RBC_HUMAN {Red blood cells}
Homo sapiens (Human)
Tissue: Erythrocyte
RBC_HUMAN
  map experimental info
  protein estimated location
 
RBC_HUMAN

MAP LOCATIONS:
pI=6.25; Mw=51518
pI=6.46; Mw=51388
pI=6.61; Mw=51129

MAPPING (identification):
COMIGRATION AND IMMUNOBLOTTING [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).
Cross-references
DOSAC-COBS 2D-PAGEP00352; P00352.
DOSAC-COBS-2DPAGEP00352; AL1A1_HUMAN.
REPRODUCTION-2DPAGEP00352; P00352.
REPRODUCTION-2DPAGEIPI00218914; IPI00218914.
UCD-2DPAGEP00352; AL1A1_HUMAN.
UniProtKB/Swiss-ProtP00352; AL1A1_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameAL1A1_HUMAN
Primary accession numberP00352
Secondary accession number(s) O00768 Q5SYR1
Sequence was last modified on January 23, 2007 (version 2)
Annotations were last modified on October 19, 2011 (version 129)
Name and origin of the protein
DescriptionRecName: Full=Retinal dehydrogenase 1; Short=RALDH 1; Short=RalDH1; EC=1.2.1.36; AltName: Full=ALDH-E1; AltName: Full=ALHDII; AltName: Full=Aldehyde dehydrogenase family 1 member A1; AltName: Full=Aldehyde dehydrogenase, cytosolic;
Gene nameName=ALDH1A1
Synonyms=ALDC, ALDH1, PUMB1
Encoded onName=ALDH1A1; Synonyms=ALDC, ALDH1, PUMB1
KeywordsAcetylation; Complete proteome; Cytoplasm; Direct protein sequencing; NAD; Oxidoreductase; Polymorphism; Reference proteome.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLM31994; AAA51692.1; -; Genomic_DNA
EMBLM31982; AAA51692.1; JOINED; Genomic_DNA
EMBLM31983; AAA51692.1; JOINED; Genomic_DNA
EMBLM31984; AAA51692.1; JOINED; Genomic_DNA
EMBLM31985; AAA51692.1; JOINED; Genomic_DNA
EMBLM31986; AAA51692.1; JOINED; Genomic_DNA
EMBLM31987; AAA51692.1; JOINED; Genomic_DNA
EMBLM31988; AAA51692.1; JOINED; Genomic_DNA
EMBLM31989; AAA51692.1; JOINED; Genomic_DNA
EMBLM31990; AAA51692.1; JOINED; Genomic_DNA
EMBLM31991; AAA51692.1; JOINED; Genomic_DNA
EMBLM31992; AAA51692.1; JOINED; Genomic_DNA
EMBLAF003341; AAC51652.1; -; mRNA
EMBLAY390731; AAR92229.1; -; mRNA
EMBLBT006921; AAP35567.1; -; mRNA
EMBLAY338497; AAP88039.1; -; Genomic_DNA
EMBLAL591031; CAI12257.1; -; Genomic_DNA
EMBLCH471089; EAW62543.1; -; Genomic_DNA
EMBLBC001505; AAH01505.1; -; mRNA
EMBLS61235; AAD13925.1; -; Genomic_DNA
EMBLM26761; AAA35518.1; -; mRNA
EMBLK03000; AAA51695.1; -; mRNA
IPIIPI00218914; -; .
PIRA33371; DEHUE1; .
RefSeqNP_000680.2; NM_000689.4; .
UniGeneHs.76392; -; .
ProteinModelPortalP00352; -; .
SMRP00352; 8-501; .
IntActP00352; 4; .
STRINGP00352; -; .
PhosphoSiteP00352; -; .
SWISS-2DPAGEP00352; -; .
Cornea-2DPAGEP00352; -; .
DOSAC-COBS-2DPAGEP00352; -; .
REPRODUCTION-2DPAGEIPI00218914; -; .
REPRODUCTION-2DPAGEP00352; -; .
UCD-2DPAGEP00352; -; .
PeptideAtlasP00352; -; .
PRIDEP00352; -; .
EnsemblENST00000297785; ENSP00000297785; ENSG00000165092; .
GeneID216; -; .
KEGGhsa:216; -; .
UCSCuc004ajd.1; human; .
CTD216; -; .
GeneCardsGC09M045338; -; .
H-InvDBHIX0008099; -; .
HGNCHGNC:402; ALDH1A1; .
HPACAB020690; -; .
HPAHPA002123; -; .
MIM100640; gene; .
neXtProtNX_P00352; -; .
PharmGKBPA24692; -; .
eggNOGprNOG13758; -; .
HOGENOMHBG752218; -; .
HOVERGENHBG000097; -; .
InParanoidP00352; -; .
OMANFPLVMF; -; .
OrthoDBEOG4Z8XW6; -; .
PhylomeDBP00352; -; .
ReactomeREACT_13433; Biological oxidations; .
DrugBankDB00157; NADH; .
DrugBankDB00755; Tretinoin; .
DrugBankDB00162; Vitamin A; .
NextBio874; -; .
ArrayExpressP00352; -; .
BgeeP00352; -; .
CleanExHS_ALDH1A1; -; .
GenevestigatorP00352; -; .
GermOnlineENSG00000165092; Homo sapiens; .
GOGO:0005829; C:cytosol; TAS:Reactome; .
GOGO:0004029; F:aldehyde dehydrogenase (NAD) activity; EXP:Reactome; .
GOGO:0005497; F:androgen binding; TAS:ProtInc; .
GOGO:0005099; F:Ras GTPase activator activity; TAS:UniProtKB; .
GOGO:0001758; F:retinal dehydrogenase activity; IEA:EC; .
GOGO:0006081; P:cellular aldehyde metabolic process; TAS:ProtInc; .
GOGO:0006069; P:ethanol oxidation; TAS:Reactome; .
GOGO:0006805; P:xenobiotic metabolic process; TAS:Reactome; .
InterProIPR016161; Ald_DH/histidinol_DH; .
InterProIPR016163; Ald_DH_C; .
InterProIPR016160; Ald_DH_CS; .
InterProIPR016162; Ald_DH_N; .
InterProIPR015590; Aldehyde_DH_dom; .
Gene3DG3DSA:3.40.309.10; Aldehyde_dehydrogenase_C; 1; .
Gene3DG3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1; .
PfamPF00171; Aldedh; 1; .
SUPFAMSSF53720; Aldehyde_DH/Histidinol_DH; 1; .
PROSITEPS00070; ALDEHYDE_DEHYDR_CYS; 1; .
PROSITEPS00687; ALDEHYDE_DEHYDR_GLU; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server