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Sample Preparation and Post-separation Analysis

Searching in 'SWISS-2DPAGE' for entry matching: O75367



General information about the entry
View entry in simple text format
Entry nameH2AY_HUMAN
Primary accession numberO75367
integrated into SWISS-2DPAGE on May 15, 2003 (release 16)
2D Annotations were last modified onMay 15, 2003 (version 1)
General Annotations were last modified on May 19, 2011 (version 6)
Name and origin of the protein
DescriptionRecName: Full=Core histone macro-H2A.1; Short=Histone macroH2A1; Short=mH2A1; AltName: Full=Histone H2A.y; Short=H2A/y; AltName: Full=Medulloblastoma antigen MU-MB-50.205;.
Gene nameName=H2AFY
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
PubMed=12429849; [NCBI, Expasy, EBI, Israel, Japan]
Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J.
''''''Functional proteomic analysis of human nucleolus'';'';''
Mol. Biol. Cell. 13(1):4100-4109(2002)
2D PAGE maps for identified proteins
How to interpret a protein

NUCLEOLI_HELA_1D_HUMAN {SDS-PAGE of nucleolar proteins from Human HeLa cells}
Homo sapiens (Human)
Tissue: Cervix carcinoma
  map experimental info
  protein estimated location

Mw=41199  [identification data]

MAPPING (identification):
Tandem mass spectrometry [1].

This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See or send email from
UniProtKB/Swiss-ProtO75367; H2AY_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameH2AY_HUMAN
Primary accession numberO75367
Secondary accession number(s) O75377 Q503A8 Q7Z5E3 Q96D41 Q9H8P3 Q9UP96
Sequence was last modified on January 23, 2007 (version 4)
Annotations were last modified on September 21, 2011 (version 120)
Name and origin of the protein
DescriptionRecName: Full=Core histone macro-H2A.1; Short=Histone macroH2A1; Short=mH2A1; AltName: Full=Histone H2A.y; Short=H2A/y; AltName: Full=Medulloblastoma antigen MU-MB-50.205;
Gene nameName=H2AFY
Encoded onName=H2AFY; Synonyms=MACROH2A1
Keywords3D-structure; Alternative splicing; Chromatin regulator; Chromosome; Complete proteome; DNA-binding; Isopeptide bond; Methylation; Nucleosome core; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation.
Copyrighted by the UniProt Consortium, see Distributed under the Creative Commons Attribution-NoDerivs License
EMBLAF041483; AAC33433.1; -; mRNA
EMBLAF044286; AAC33434.1; -; mRNA
EMBLAF054174; AAC39908.1; -; mRNA
EMBLAK023409; BAB14565.1; -; mRNA
EMBLBC013331; AAH13331.1; -; mRNA
EMBLBC095406; AAH95406.1; -; mRNA
EMBLAY134746; AAN08620.1; -; mRNA
IPIIPI00059366; -; .
IPIIPI00304171; -; .
IPIIPI00744148; -; .
RefSeqNP_001035248.1; NM_001040158.1; .
RefSeqNP_004884.1; NM_004893.2; .
RefSeqNP_613075.1; NM_138609.2; .
RefSeqNP_613258.2; NM_138610.2; .
UniGeneHs.420272; -; .
UniGeneHs.599225; -; .
PDB1U35; X-ray; 3.00 A; C/G=1-120
PDB1ZR3; X-ray; 1.66 A; A/B/C/D=162-372
PDB1ZR5; X-ray; 2.92 A; A/B=161-372
PDB2F8N; X-ray; 2.90 A; G=1-119
PDB2FXK; X-ray; 2.54 A; A/B=162-372
PDB3HSV; X-ray; 1.43 A; M=172-186
PDB3IID; X-ray; 1.90 A; A=162-372
PDB3IIF; X-ray; 2.10 A; A/B/C=162-372
PDB3IVB; X-ray; 1.75 A; M=167-181
PDBsum1U35; -; .
PDBsum1ZR3; -; .
PDBsum1ZR5; -; .
PDBsum2F8N; -; .
PDBsum2FXK; -; .
PDBsum3HSV; -; .
PDBsum3IID; -; .
PDBsum3IIF; -; .
PDBsum3IVB; -; .
ProteinModelPortalO75367; -; .
SMRO75367; 10-117; 181-369; .
DIPDIP-44283N; -; .
IntActO75367; 2; .
MINTMINT-2866965; -; .
STRINGO75367; -; .
PhosphoSiteO75367; -; .
SWISS-2DPAGEO75367; -; .
PRIDEO75367; -; .
EnsemblENST00000510038; ENSP00000424971; ENSG00000113648; .
EnsemblENST00000511689; ENSP00000423563; ENSG00000113648; .
GeneID9555; -; .
KEGGhsa:9555; -; .
UCSCuc003lam.1; human; .
UCSCuc003lan.1; human; .
CTD9555; -; .
GeneCardsGC05M129857; -; .
MIM610054; gene; .
neXtProtNX_O75367; -; .
PharmGKBPA29117; -; .
eggNOGprNOG11347; -; .
HOVERGENHBG009342; -; .
InParanoidO75367; -; .
OrthoDBEOG4XH00N; -; .
PhylomeDBO75367; -; .
NextBio35835; -; .
PMAP-CutDBO75367; -; .
ArrayExpressO75367; -; .
BgeeO75367; -; .
CleanExHS_H2AFY; -; .
GenevestigatorO75367; -; .
GermOnlineENSG00000113648; Homo sapiens; .
GOGO:0001740; C:Barr body; IDA:MGI; .
GOGO:0000786; C:nucleosome; NAS:UniProtKB; .
GOGO:0003677; F:DNA binding; NAS:UniProtKB; .
GOGO:0016568; P:chromatin modification; IEA:UniProtKB-KW; .
GOGO:0007549; P:dosage compensation; IDA:MGI; .
GOGO:0006334; P:nucleosome assembly; NAS:UniProtKB; .
InterProIPR002589; A1pp; .
InterProIPR021171; Core_histone_macro-H2A; .
InterProIPR009072; Histone-fold; .
InterProIPR007125; Histone_core_D; .
InterProIPR002119; Histone_H2A; .
Gene3DG3DSA:; Histone-fold; 1; .
PfamPF00125; Histone; 1; .
PfamPF01661; Macro; 1; .
PIRSFPIRSF037942; Core_histone_macro-H2A; 1; .
SMARTSM00506; A1pp; 1; .
SMARTSM00414; H2A; 1; .
SUPFAMSSF47113; Histone-fold; 1; .


SWISS-2DPAGE (search AC)

Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server