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SWISS-2DPAGE 
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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P00450




SWISS-2DPAGE:  P00450


P00450


General information about the entry
View entry in simple text format
Entry nameCERU_HUMAN
Primary accession numberP00450
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onDecember 1, 2000 (version 1)
General Annotations were last modified on May 19, 2011 (version 12)
Name and origin of the protein
DescriptionRecName: Full=Ceruloplasmin; EC=1.16.3.1; AltName: Full=Ferroxidase; Flags: Precursor;.
Gene nameName=CP
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=78094420; PubMed=271964; [NCBI, ExPASy, EBI, Israel, Japan]
Anderson N.L., Anderson N.G.
''''''High resolution two-dimensional electrophoresis of human plasma proteins'';'';''
Proc. Natl. Acad. Sci. U.S.A. 74(1):5421-5425(1977)
[2]   MAPPING ON GEL
MEDLINE=96007934; PubMed=7498157; [NCBI, ExPASy, EBI, Israel, Japan]
Sanchez J.-C., Appel R.D., Golaz O.G., Pasquali C., Ravier F., Bairoch A., Hochstrasser D.F.
''''''Inside SWISS-2DPAGE database'';'';''
Electrophoresis 16(1):1131-1151(1995)
Comments
  • SUBUNIT: MONOMER
2D PAGE maps for identified proteins
How to interpret a protein

CSF_HUMAN {Cerebrospinal Fluid}
Homo sapiens (Human)
Tissue: Cerebrospinal fluid
CSF_HUMAN
  map experimental info
  protein estimated location
 
CSF_HUMAN

MAP LOCATIONS:
pI=5.15; Mw=152053
pI=5.17; Mw=151291
pI=5.20; Mw=150533
pI=5.22; Mw=150533
pI=5.26; Mw=149779
pI=5.28; Mw=149779
pI=4.83; Mw=146064
pI=5.32; Mw=146800
pI=4.91; Mw=145333
pI=4.95; Mw=143880
pI=5.03; Mw=143159
pI=5.08; Mw=141728
pI=5.10; Mw=141728
pI=5.14; Mw=139609
pI=5.17; Mw=138213
pI=5.21; Mw=137521
pI=5.25; Mw=137521
pI=5.29; Mw=137521
pI=5.12; Mw=132770
pI=5.29; Mw=132770
pI=5.14; Mw=132121
pI=5.17; Mw=131475
pI=5.21; Mw=130832
pI=5.25; Mw=130193

MAPPING (identification):
MATCHING WITH THE PLASMA MASTER GEL [2].



HEPG2SP_HUMAN {HepG2 Secreted Proteins}
Homo sapiens (Human)
Tissue: Hepatoblastoma
HEPG2SP_HUMAN
  map experimental info
  protein estimated location
 
HEPG2SP_HUMAN

MAP LOCATIONS:
pI=4.70; Mw=135572
pI=4.75; Mw=133299
pI=4.81; Mw=131064
pI=4.88; Mw=129595
pI=4.96; Mw=128867

MAPPING (identification):
MATCHING WITH THE PLASMA MASTER GEL [2].



PLASMA_HUMAN {Plasma}
Homo sapiens (Human)
Tissue: Plasma
PLASMA_HUMAN
  map experimental info
  protein estimated location
 
PLASMA_HUMAN

MAP LOCATIONS:
pI=5.14; Mw=161288
pI=5.17; Mw=161288
pI=5.19; Mw=160170
pI=5.22; Mw=159059
pI=5.24; Mw=157957
pI=5.27; Mw=157957
pI=5.30; Mw=156862
pI=5.33; Mw=155774
pI=5.36; Mw=153622
pI=4.96; Mw=136487
pI=5.00; Mw=133668
pI=5.05; Mw=131821
pI=5.10; Mw=133668
pI=5.14; Mw=131821
pI=5.17; Mw=130908
pI=5.20; Mw=130000
pI=4.96; Mw=129081
pI=5.24; Mw=129081
pI=4.98; Mw=128169
pI=5.09; Mw=126365
pI=5.00; Mw=127264
pI=5.03; Mw=126365
pI=5.06; Mw=125472
pI=5.12; Mw=125472
pI=5.16; Mw=124585
pI=5.20; Mw=123705
pI=5.24; Mw=123705

NORMAL LEVEL:
150-600 MG/L.

PATHOLOGICAL LEVEL:
DECREASED DURING WILSONS DISEASE; INCREASED DURING INFLAMMATORY DISEASES, RETICULOENDOTHELIAL DISEASE, BILE DUCT OBSTRUCTION AND OESTROGEN ADMINISTRATION.

POSITIONAL VARIANTS:
CPA, CPB, CPC, CPNH, CPBPT AND CPTH VARIANTS.

MAPPING (identification):
IMMUNOBLOTTING [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).
Cross-references
DOSAC-COBS 2D-PAGEP00450; P00450.
DOSAC-COBS-2DPAGEP00450; CERU_HUMAN.
Siena-2DPAGEP00450; CERU_HUMAN.
UniProtKB/Swiss-ProtP00450; CERU_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameCERU_HUMAN
Primary accession numberP00450
Secondary accession number(s) Q14063 Q2PP18 Q9UKS4
Sequence was last modified on August 13, 1987 (version 1)
Annotations were last modified on October 19, 2011 (version 144)
Name and origin of the protein
DescriptionRecName: Full=Ceruloplasmin; EC=1.16.3.1; AltName: Full=Ferroxidase; Flags: Precursor;
Gene nameName=CP
Encoded onName=CP
Keywords3D-structure; Complete proteome; Copper; Copper transport; Direct protein sequencing; Disulfide bond; Glycoprotein; Ion transport; Metal-binding; Oxidoreductase; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Secreted; Signal; Transport.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLM13699; AAA51976.1; -; mRNA
EMBLDQ314867; ABC40726.1; -; Genomic_DNA
EMBLD45045; BAA08085.1; -; Genomic_DNA
EMBLD00025; BAA00019.1; -; mRNA
EMBLX04135; CAA27752.1; -; mRNA
EMBLX04136; CAA27753.1; -; mRNA
EMBLX04137; CAA27754.1; -; mRNA
EMBLX04138; CAA27755.1; -; mRNA
EMBLAF132978; AAF02483.1; -; Genomic_DNA
EMBLM13536; AAA51975.1; -; mRNA
EMBLJ05506; -; NOT_ANNOTATED_CDS; Genomic_DNA
IPIIPI00017601; -; .
PIRA25443; KUHU; .
RefSeqNP_000087.1; NM_000096.3; .
UniGeneHs.558314; -; .
PDB1KCW; X-ray; 3.00 A; A=20-1065
PDB2J5W; X-ray; 2.80 A; A=1-1065
PDBsum1KCW; -; .
PDBsum2J5W; -; .
ProteinModelPortalP00450; -; .
IntActP00450; 4; .
STRINGP00450; -; .
GlycoSuiteDBP00450; -; .
PhosphoSiteP00450; -; .
SWISS-2DPAGEP00450; -; .
DOSAC-COBS-2DPAGEP00450; -; .
Siena-2DPAGEP00450; -; .
PeptideAtlasP00450; -; .
PRIDEP00450; -; .
EnsemblENST00000264613; ENSP00000264613; ENSG00000047457; .
GeneID1356; -; .
KEGGhsa:1356; -; .
UCSCuc003ewy.2; human; .
CTD1356; -; .
GeneCardsGC03M146261; -; .
H-InvDBHIX0003762; -; .
HGNCHGNC:2295; CP; .
HPACAB008591; -; .
HPAHPA001834; -; .
MIM117700; gene; .
MIM604290; phenotype; .
neXtProtNX_P00450; -; .
Orphanet48818; Aceruloplasminemia; .
eggNOGprNOG19766; -; .
HOGENOMHBG357170; -; .
HOVERGENHBG003674; -; .
InParanoidP00450; -; .
BioCycMetaCyc:HS00590-MONOMER; -; .
Pathway_Interaction_DBhif1_tfpathway; HIF-1-alpha transcription factor network; .
ReactomeREACT_15518; Transmembrane transport of small molecules; .
DrugBankDB00055; Drotrecogin alfa; .
NextBio5493; -; .
PMAP-CutDBP00450; -; .
ArrayExpressP00450; -; .
BgeeP00450; -; .
CleanExHS_CP; -; .
GenevestigatorP00450; -; .
GermOnlineENSG00000047457; Homo sapiens; .
GOGO:0005615; C:extracellular space; IDA:BHF-UCL; .
GOGO:0051087; F:chaperone binding; IPI:BHF-UCL; .
GOGO:0005507; F:copper ion binding; IEA:InterPro; .
GOGO:0004322; F:ferroxidase activity; TAS:ProtInc; .
GOGO:0006879; P:cellular iron ion homeostasis; TAS:Reactome; .
GOGO:0006825; P:copper ion transport; IEA:UniProtKB-KW; .
GOGO:0055085; P:transmembrane transport; TAS:Reactome; .
InterProIPR001117; Cu-oxidase; .
InterProIPR011706; Cu-oxidase_2; .
InterProIPR011707; Cu-oxidase_3; .
InterProIPR002355; Cu_oxidase_Cu_BS; .
InterProIPR008972; Cupredoxin; .
Gene3DG3DSA:2.60.40.420; Cupredoxin; 6; .
PfamPF00394; Cu-oxidase; 1; .
PfamPF07731; Cu-oxidase_2; 1; .
PfamPF07732; Cu-oxidase_3; 2; .
SUPFAMSSF49503; Cupredoxin; 6; .
PROSITEPS00079; MULTICOPPER_OXIDASE1; 3; .
PROSITEPS00080; MULTICOPPER_OXIDASE2; 1; .



SWISS-2DPAGE image

SWISS-2DPAGE (search AC)


Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server