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SWISS-2DPAGE 
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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P27169




SWISS-2DPAGE:  P27169


P27169


General information about the entry
View entry in simple text format
Entry namePON1_HUMAN
Primary accession numberP27169
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onMarch 31, 2004 (version 1)
General Annotations were last modified on May 19, 2011 (version 13)
Name and origin of the protein
DescriptionRecName: Full=Serum paraoxonase/arylesterase 1; Short=PON 1; EC=3.1.1.2; EC=3.1.1.81; EC=3.1.8.1; AltName: Full=Aromatic esterase 1; Short=A-esterase 1; AltName: Full=K-45; AltName: Full=Serum aryldialkylphosphatase 1;.
Gene nameName=PON1
Synonyms=PON
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=93170324; PubMed=8382160; [NCBI, ExPASy, EBI, Israel, Japan]
Blatter M.-C., James R.W., Messmer S., Barja F., Pometta D.
''''''Identification of a distinct human high-density lipoprotein subspecies defined by a lipoprotein-associated protein, K-45. Identity of K-45 with paraoxonase'';'';''
Eur. J. Biochem. 211(1):871-879(1993)
Comments
  • SUBUNIT: SINGLE CHAIN
2D PAGE maps for identified proteins
How to interpret a protein

PLASMA_HUMAN {Plasma}
Homo sapiens (Human)
Tissue: Plasma
PLASMA_HUMAN
  map experimental info
  protein estimated location
 
PLASMA_HUMAN

MAP LOCATIONS:
pI=4.84; Mw=45937
pI=4.93; Mw=43391

MAPPING (identification):
IMMUNOBLOTTING [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).
Cross-references
Siena-2DPAGEP27169; PON1_HUMAN.
UniProtKB/Swiss-ProtP27169; PON1_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry namePON1_HUMAN
Primary accession numberP27169
Secondary accession number(s) B2RA40 Q16052 Q6B0J6 Q9UCB1
Sequence was last modified on October 5, 2010 (version 3)
Annotations were last modified on September 21, 2011 (version 134)
Name and origin of the protein
DescriptionRecName: Full=Serum paraoxonase/arylesterase 1; Short=PON 1; EC=3.1.1.2; EC=3.1.1.81; EC=3.1.8.1; AltName: Full=Aromatic esterase 1; Short=A-esterase 1; AltName: Full=K-45; AltName: Full=Serum aryldialkylphosphatase 1;
Gene nameName=PON1
Synonyms=PON
Encoded onName=PON1; Synonyms=PON
Keywords3D-structure; Calcium; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; HDL; Hydrolase; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Secreted; Signal.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLM63012; AAB59538.1; -; mRNA
EMBLM63013; AAA60142.1; -; mRNA
EMBLM63014; AAA60143.1; -; mRNA
EMBLS56555; AAB25717.1; -; Genomic_DNA
EMBLS56546; AAB25717.1; JOINED; Genomic_DNA
EMBLS56548; AAB25717.1; JOINED; Genomic_DNA
EMBLS64696; AAB27899.1; -; mRNA
EMBLS64615; AAB27714.2; -; mRNA
EMBLU55885; AAB41835.1; -; Genomic_DNA
EMBLU55877; AAB41835.1; JOINED; Genomic_DNA
EMBLU55878; AAB41835.1; JOINED; Genomic_DNA
EMBLU55879; AAB41835.1; JOINED; Genomic_DNA
EMBLU55880; AAB41835.1; JOINED; Genomic_DNA
EMBLU55881; AAB41835.1; JOINED; Genomic_DNA
EMBLU55882; AAB41835.1; JOINED; Genomic_DNA
EMBLU55883; AAB41835.1; JOINED; Genomic_DNA
EMBLD84371; BAA12327.1; -; mRNA
EMBLU53784; AAA97957.1; -; mRNA
EMBLZ70723; CAA94728.1; -; mRNA
EMBLAK314027; BAG36737.1; -; mRNA
EMBLAF539592; AAM97935.1; -; Genomic_DNA
EMBLAC004022; AAC35293.1; -; Genomic_DNA
EMBLCH236949; EAL24133.1; -; Genomic_DNA
EMBLCH471091; EAW76771.1; -; Genomic_DNA
EMBLBC074719; AAH74719.1; -; mRNA
IPIIPI00218732; -; .
PIRA45451; A45451; .
RefSeqNP_000437.3; NM_000446.5; .
UniGeneHs.370995; -; .
PDB1V04; X-ray; 2.20 A; A=1-353
PDB1XHR; Model; -; A=40-355
PDBsum1V04; -; .
PDBsum1XHR; -; .
ProteinModelPortalP27169; -; .
SMRP27169; 16-355; .
STRINGP27169; -; .
PhosphoSiteP27169; -; .
SWISS-2DPAGEP27169; -; .
PeptideAtlasP27169; -; .
PRIDEP27169; -; .
EnsemblENST00000222381; ENSP00000222381; ENSG00000005421; .
GeneID5444; -; .
KEGGhsa:5444; -; .
CTD5444; -; .
GeneCardsGC07M089534; -; .
H-InvDBHIX0033662; -; .
HGNCHGNC:9204; PON1; .
HPAHPA001610; -; .
MIM168820; gene+phenotype; .
MIM612633; phenotype; .
neXtProtNX_P27169; -; .
Orphanet803; Amyotrophic lateral sclerosis; .
PharmGKBPA33529; -; .
eggNOGprNOG17627; -; .
HOGENOMHBG613410; -; .
HOVERGENHBG003604; -; .
InParanoidP27169; -; .
OMAFFYDSEN; -; .
OrthoDBEOG4XD3RN; -; .
BRENDA3.1.1.2; 2681; .
DrugBankDB01076; Atorvastatin; .
DrugBankDB01327; Cefazolin; .
NextBio21069; -; .
ArrayExpressP27169; -; .
BgeeP27169; -; .
CleanExHS_PON1; -; .
GenevestigatorP27169; -; .
GermOnlineENSG00000005421; Homo sapiens; .
GOGO:0034366; C:spherical high-density lipoprotein particle; IDA:BHF-UCL; .
GOGO:0004063; F:aryldialkylphosphatase activity; IDA:UniProtKB; .
GOGO:0004064; F:arylesterase activity; IDA:UniProtKB; .
GOGO:0005509; F:calcium ion binding; IDA:UniProtKB; .
GOGO:0005543; F:phospholipid binding; IDA:BHF-UCL; .
GOGO:0042803; F:protein homodimerization activity; IDA:BHF-UCL; .
GOGO:0019439; P:aromatic compound catabolic process; IDA:BHF-UCL; .
GOGO:0046395; P:carboxylic acid catabolic process; IDA:BHF-UCL; .
GOGO:0046434; P:organophosphate catabolic process; IDA:BHF-UCL; .
GOGO:0046470; P:phosphatidylcholine metabolic process; IDA:BHF-UCL; .
GOGO:0051099; P:positive regulation of binding; IDA:BHF-UCL; .
GOGO:0010875; P:positive regulation of cholesterol efflux; IDA:BHF-UCL; .
GOGO:0032411; P:positive regulation of transporter activity; IDA:BHF-UCL; .
GOGO:0009605; P:response to external stimulus; NAS:UniProtKB; .
InterProIPR011042; 6-blade_b-propeller_TolB-like; .
InterProIPR002640; Arylesterase; .
InterProIPR008363; Paraoxonase1; .
Gene3DG3DSA:2.120.10.30; 6-blade_b-propeller_TolB-like; 1; .
PfamPF01731; Arylesterase; 1; .
PRINTSPR01785; PARAOXONASE; .
PRINTSPR01786; PARAOXONASE1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server