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Sample Preparation and Post-separation Analysis

Searching in 'SWISS-2DPAGE' for entry matching: P58771



General information about the entry
View entry in simple text format
Entry nameTPM1_MOUSE
Primary accession numberP58771
Secondary accession number(s) P02558 P19354 P99034
integrated into SWISS-2DPAGE on April 1, 2000 (release 12)
2D Annotations were last modified onMay 15, 2003 (version 3)
General Annotations were last modified on May 19, 2011 (version 12)
Name and origin of the protein
DescriptionRecName: Full=Tropomyosin alpha-1 chain; AltName: Full=Alpha-tropomyosin; AltName: Full=Tropomyosin-1;.
Gene nameName=Tpm1
Synonyms=Tpm-1, Tpma
Annotated speciesMus musculus (Mouse) [TaxID: 10090]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus.
PubMed=11680894; [NCBI, Expasy, EBI, Israel, Japan]
Sanchez J.-C., Chiappe D., Converset V., Hoogland C., Binz P.-A., Paesano S., Appel R.D., Wang S., Sennitt M., Nolan A., Cawthorne M.A., Hochstrasser D.F.
''''''The mouse SWISS-2DPAGE database: a tool for proteomics study of diabetes and obesity'';'';''
Proteomics 1(1):136-163(2001)
MEDLINE=96089471; PubMed=8529625; [NCBI, Expasy, EBI, Israel, Japan]
Corbett J.M., Wheeler C.H., Dunn M.J.
''''''Coelectrophoresis of cardiac tissue from human, dog, rat and mouse: towards the establishment of an integrated two-dimensional protein database'';'';''
Electrophoresis 16(1):1524-1529(1995)
2D PAGE maps for identified proteins
How to interpret a protein

ISLETS_MOUSE {Pancreatic islet cells}
Mus musculus (Mouse)
Tissue: Pancreatic islet
  map experimental info
  protein estimated location

pI=4.73; Mw=40803  [identification data]

MAPPING (identification):
Peptide mass fingerprinting [1].

MUSCLE_MOUSE {Gastrocnemius muscle}
Mus musculus (Mouse)
Tissue: Gastrocnemius
  map experimental info
  protein estimated location

pI=4.74; Mw=33929  [identification data]
pI=4.81; Mw=33858  [identification data]
pI=4.87; Mw=33929
pI=4.82; Mw=32330  [identification data]

MAPPING (identification):
SPOTS 2D-00179*, 2D-0017A0: MATCHING [2] WITH THE MOUSE CARDIAC 2-DE GEL [2]; SPOTS 2D-00179*, 2D-0017BM: Peptide mass fingerprinting [1].

This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See or send email from
UniProtKB/Swiss-ProtP58771; TPM1_MOUSE.
World-2DPAGE RepositoryP58771; TPM1_MOUSE.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameTPM1_MOUSE
Primary accession numberP58771
Secondary accession number(s) P02558 P19354 P46902 P99034
Sequence was last modified on July 21, 1986 (version 1)
Annotations were last modified on September 21, 2011 (version 80)
Name and origin of the protein
DescriptionRecName: Full=Tropomyosin alpha-1 chain; AltName: Full=Alpha-tropomyosin; AltName: Full=Tropomyosin-1;
Gene nameName=Tpm1
Synonyms=Tpm-1, Tpma
Encoded onName=Tpm1; Synonyms=Tpm-1, Tpma
KeywordsAcetylation; Actin-binding; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Isopeptide bond; Muscle protein; Phosphoprotein; Reference proteome; Ubl conjugation.
Copyrighted by the UniProt Consortium, see Distributed under the Creative Commons Attribution-NoDerivs License
EMBLX64831; CAA46043.1; -; mRNA
EMBLM22479; AAA40483.1; -; mRNA
IPIIPI00123316; -; .
IPIIPI00227835; -; .
PIRA31380; A60597; .
RefSeqNP_001157720.1; NM_001164248.1; .
RefSeqNP_077745.2; NM_024427.4; .
UniGeneMm.121878; -; .
ProteinModelPortalP58771; -; .
SMRP58771; 8-284; .
DIPDIP-300N; -; .
IntActP58771; 5; .
STRINGP58771; -; .
PhosphoSiteP58771; -; .
SWISS-2DPAGEP58771; -; .
PRIDEP58771; -; .
EnsemblENSMUST00000113685; ENSMUSP00000109315; ENSMUSG00000032366; .
EnsemblENSMUST00000113707; ENSMUSP00000109337; ENSMUSG00000032366; .
GeneID22003; -; .
KEGGmmu:22003; -; .
CTD7168; -; .
MGIMGI:98809; Tpm1; .
HOVERGENHBG107404; -; .
OrthoDBEOG4TXBSM; -; .
ArrayExpressP58771; -; .
BgeeP58771; -; .
CleanExMM_TPM1; -; .
GenevestigatorP58771; -; .
GermOnlineENSMUSG00000032366; Mus musculus; .
GOGO:0005862; C:muscle thin filament tropomyosin; TAS:MGI; .
GOGO:0003779; F:actin binding; IEA:UniProtKB-KW; .
GOGO:0005200; F:structural constituent of cytoskeleton; TAS:MGI; .
GOGO:0060048; P:cardiac muscle contraction; IMP:BHF-UCL; .
GOGO:0001701; P:in utero embryonic development; IMP:MGI; .
GOGO:0003065; P:positive regulation of heart rate by epinephrine; IMP:BHF-UCL; .
GOGO:0055010; P:ventricular cardiac muscle tissue morphogenesis; IMP:BHF-UCL; .
InterProIPR000533; Tropomyosin; .
PfamPF00261; Tropomyosin; 1; .


SWISS-2DPAGE (search AC)

Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server