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SWISS-2DPAGE

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It will be discontinued on 31-May-2024.

Swiss-2DPAGE data (text records and image files) will continue to be available from https://ftp.expasy.org/databases/swiss-2dpage/.


SWISS-2DPAGE 
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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: TBCA_HUMAN




SWISS-2DPAGE:  TBCA_HUMAN


TBCA_HUMAN


General information about the entry
View entry in simple text format
Entry nameTBCA_HUMAN
Primary accession numberO75347
integrated into SWISS-2DPAGE on March 31, 2004 (release 17)
2D Annotations were last modified onMarch 31, 2004 (version 1)
General Annotations were last modified on May 19, 2011 (version 5)
Name and origin of the protein
DescriptionRecName: Full=Tubulin-specific chaperone A; AltName: Full=TCP1-chaperonin cofactor A; AltName: Full=Tubulin-folding cofactor A; Short=CFA;.
Gene nameName=TBCA
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
Vuadens F., Crettaz D., Telenti A., Quadroni M., Duchosal M.A., Schneider P., Tissot J.-D.
''''''New insights into HIV lymphocyte infection'';'';''
(IN) Sanchez J.-C., Corthals G.L., Hochstrasser D.F. (eds.)Biomedical Application of Proteomics, pp.245-262, Wiley-VCH, Weinheim (2004)
Comments
  • SUBUNIT: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state
2D PAGE maps for identified proteins
How to interpret a protein

LYMPHOCYTE_HUMAN {Lymphocytes}
Homo sapiens (Human)
Tissue: Lymphocyte
LYMPHOCYTE_HUMAN
  map experimental info
  protein estimated location
 
LYMPHOCYTE_HUMAN

MAP LOCATIONS:
pI=5.16; Mw=16734  [identification data]

MAPPING (identification):
MALDI tandem mass spectrometry [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).
Cross-references
OGP-WWWO75347.
UniProtKB/Swiss-ProtO75347; TBCA_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameTBCA_HUMAN
Primary accession numberO75347
Sequence was last modified on January 23, 2007 (version 3)
Annotations were last modified on September 21, 2011 (version 100)
Name and origin of the protein
DescriptionRecName: Full=Tubulin-specific chaperone A; AltName: Full=TCP1-chaperonin cofactor A; AltName: Full=Tubulin-folding cofactor A; Short=CFA;
Gene nameName=TBCA
Encoded onName=TBCA
Keywords3D-structure; Acetylation; Chaperone; Complete proteome; Cytoplasm; Cytoskeleton; Microtubule; Reference proteome.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLAF038952; AAC39866.1; -; mRNA
EMBLBT007354; AAP36018.1; -; mRNA
EMBLBC018210; AAH18210.1; -; mRNA
IPIIPI00217236; -; .
RefSeqNP_004598.1; NM_004607.2; .
UniGeneHs.291212; -; .
PDB1H7C; X-ray; 1.80 A; A=1-108
PDBsum1H7C; -; .
ProteinModelPortalO75347; -; .
SMRO75347; 4-106; .
IntActO75347; 3; .
STRINGO75347; -; .
PhosphoSiteO75347; -; .
SWISS-2DPAGEO75347; -; .
OGPO75347; -; .
PeptideAtlasO75347; -; .
PRIDEO75347; -; .
EnsemblENST00000380377; ENSP00000369736; ENSG00000171530; .
GeneID6902; -; .
KEGGhsa:6902; -; .
UCSCuc003kfh.1; human; .
CTD6902; -; .
GeneCardsGC05M072194; -; .
H-InvDBHIX0004973; -; .
HGNCHGNC:11579; TBCA; .
HPAHPA036487; -; .
MIM610058; gene; .
neXtProtNX_O75347; -; .
PharmGKBPA36343; -; .
eggNOGprNOG21342; -; .
HOVERGENHBG004499; -; .
InParanoidO75347; -; .
OMAMMYEKEA; -; .
OrthoDBEOG4W6NXN; -; .
PhylomeDBO75347; -; .
ReactomeREACT_17015; Metabolism of proteins; .
NextBio26989; -; .
ArrayExpressO75347; -; .
BgeeO75347; -; .
CleanExHS_TBCA; -; .
GenevestigatorO75347; -; .
GermOnlineENSG00000171530; Homo sapiens; .
GOGO:0005737; C:cytoplasm; TAS:UniProtKB; .
GOGO:0005874; C:microtubule; IEA:UniProtKB-KW; .
GOGO:0051087; F:chaperone binding; TAS:ProtInc; .
GOGO:0051082; F:unfolded protein binding; IEA:InterPro; .
GOGO:0051084; P:'de novo' posttranslational protein folding; TAS:Reactome; .
GOGO:0007023; P:post-chaperonin tubulin folding pathway; TAS:ProtInc; .
GOGO:0007021; P:tubulin complex assembly; IEA:InterPro; .
InterProIPR004226; CofA_tubulin-bd; .
PANTHERPTHR21500; CofA_tubulin_bd; 1; .
PfamPF02970; TBCA; 1; .
ProDomPD010430; CofA_tubulin_bd; 1; .
SUPFAMSSF46988; Tub_bind_cof_A; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server