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SWISS-2DPAGE 
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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: VTDB_HUMAN




SWISS-2DPAGE:  VTDB_HUMAN


VTDB_HUMAN


General information about the entry
View entry in simple text format
Entry nameVTDB_HUMAN
Primary accession numberP02774
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onDecember 1, 2000 (version 1)
General Annotations were last modified on May 19, 2011 (version 11)
Name and origin of the protein
DescriptionRecName: Full=Vitamin D-binding protein; Short=DBP; Short=VDB; AltName: Full=Gc-globulin; AltName: Full=Group-specific component; Flags: Precursor;.
Gene nameName=GC
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=93092937; PubMed=1459097; [NCBI, ExPASy, EBI, Israel, Japan]
Hughes G.J., Frutiger S., Paquet N., Ravier F., Pasquali C., Sanchez J.-C., James R.W., Tissot J.-D., Bjellqvist B., Hochstrasser D.F.
''''''Plasma protein map: an update by microsequencing'';'';''
Electrophoresis 13(1):707-714(1992)
[2]   MAPPING ON GEL
MEDLINE=96007934; PubMed=7498157; [NCBI, ExPASy, EBI, Israel, Japan]
Sanchez J.-C., Appel R.D., Golaz O.G., Pasquali C., Ravier F., Bairoch A., Hochstrasser D.F.
''''''Inside SWISS-2DPAGE database'';'';''
Electrophoresis 16(1):1131-1151(1995)
Comments
  • SUBUNIT: SINGLE CHAIN
2D PAGE maps for identified proteins
How to interpret a protein

CSF_HUMAN {Cerebrospinal Fluid}
Homo sapiens (Human)
Tissue: Cerebrospinal fluid
CSF_HUMAN
  map experimental info
  protein estimated location
 
CSF_HUMAN

MAP LOCATIONS:
pI=5.17; Mw=56617
pI=5.24; Mw=56617

MAPPING (identification):
MATCHING WITH THE PLASMA MASTER GEL [2].



PLASMA_HUMAN {Plasma}
Homo sapiens (Human)
Tissue: Plasma
PLASMA_HUMAN
  map experimental info
  protein estimated location
 
PLASMA_HUMAN

MAP LOCATIONS:
pI=5.16; Mw=53772
pI=5.24; Mw=53918

NORMAL LEVEL:
200-550 MG/L.

PATHOLOGICAL LEVEL:
DECREASED DURING SEVERE LIVER DISEASE; INCREASED DURING PREGNANCY.

POSITIONAL VARIANTS:
MORE THAN 80 VARIANTS.

MAPPING (identification):
MICROSEQUENCING [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).
Cross-references
DOSAC-COBS 2D-PAGEP02774; P02774.
DOSAC-COBS-2DPAGEP02774; VTDB_HUMAN.
REPRODUCTION-2DPAGEP02774; P02774.
REPRODUCTION-2DPAGEIPI00555812; IPI00555812.
Siena-2DPAGEP02774; VTDB_HUMAN.
UniProtKB/Swiss-ProtP02774; VTDB_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameVTDB_HUMAN
Primary accession numberP02774
Secondary accession number(s) B4DPP2 Q16309 Q16310 Q53F31 Q6GTG1
Sequence was last modified on July 21, 1986 (version 1)
Annotations were last modified on October 19, 2011 (version 140)
Name and origin of the protein
DescriptionRecName: Full=Vitamin D-binding protein; Short=DBP; Short=VDB; AltName: Full=Gc-globulin; AltName: Full=Group-specific component; Flags: Precursor;
Gene nameName=GC
Encoded onName=GC
Keywords3D-structure; Actin-binding; Alternative splicing; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Polymorphism; Reference proteome; Repeat; Secreted; Signal; Transport; Vitamin D.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLM12654; AAA52173.1; -; mRNA
EMBLX03178; CAA26938.1; -; mRNA
EMBLS67480; AAB29423.1; -; Genomic_DNA
EMBLS67474; AAB29423.1; JOINED; Genomic_DNA
EMBLS67476; AAB29423.1; JOINED; Genomic_DNA
EMBLS67478; AAB29423.1; JOINED; Genomic_DNA
EMBLS67479; AAB29423.1; JOINED; Genomic_DNA
EMBLS67526; AAB29423.1; JOINED; Genomic_DNA
EMBLL10641; AAA61704.1; -; Genomic_DNA
EMBLAK290827; BAF83516.1; -; mRNA
EMBLAK298433; BAG60654.1; ALT_SEQ; mRNA
EMBLAK315853; BAF98744.1; -; mRNA
EMBLAK223458; BAD97178.1; -; mRNA
EMBLAC024722; -; NOT_ANNOTATED_CDS; Genomic_DNA
EMBLCH471057; EAX05645.1; -; Genomic_DNA
EMBLBC057228; AAH57228.1; -; mRNA
EMBLM17156; AAA19662.2; -; Genomic_DNA
EMBLS77129; AAD14249.1; ALT_SEQ; Genomic_DNA
EMBLS77130; AAD14250.1; ALT_SEQ; Genomic_DNA
IPIIPI00555812; -; .
IPIIPI00968027; -; .
PIRA94076; VYHUD; .
RefSeqNP_000574.2; NM_000583.3; .
RefSeqNP_001191235.1; NM_001204306.1; .
RefSeqNP_001191236.1; NM_001204307.1; .
UniGeneHs.418497; -; .
PDB1J78; X-ray; 2.31 A; A/B=17-474
PDB1J7E; X-ray; 2.55 A; A/B=17-474
PDB1KW2; X-ray; 2.15 A; A/B=17-474
PDB1KXP; X-ray; 2.10 A; D=17-474
PDB1LOT; X-ray; 2.50 A; A=17-474
PDB1MA9; X-ray; 2.40 A; A=17-474
PDBsum1J78; -; .
PDBsum1J7E; -; .
PDBsum1KW2; -; .
PDBsum1KXP; -; .
PDBsum1LOT; -; .
PDBsum1MA9; -; .
ProteinModelPortalP02774; -; .
SMRP02774; 20-474; .
DIPDIP-17038N; -; .
IntActP02774; 5; .
MINTMINT-239255; -; .
STRINGP02774; -; .
GlycoSuiteDBP02774; -; .
SWISS-2DPAGEP02774; -; .
Cornea-2DPAGEP02774; -; .
DOSAC-COBS-2DPAGEP02774; -; .
REPRODUCTION-2DPAGEIPI00555812; -; .
REPRODUCTION-2DPAGEP02774; -; .
Siena-2DPAGEP02774; -; .
PeptideAtlasP02774; -; .
PRIDEP02774; -; .
EnsemblENST00000273951; ENSP00000273951; ENSG00000145321; .
GeneID2638; -; .
KEGGhsa:2638; -; .
CTD2638; -; .
GeneCardsGC04M068412; -; .
HGNCHGNC:4187; GC; .
HPACAB008596; -; .
HPAHPA001526; -; .
HPAHPA019855; -; .
MIM139200; gene+phenotype; .
neXtProtNX_P02774; -; .
PharmGKBPA28601; -; .
eggNOGprNOG04170; -; .
GeneTreeENSGT00390000000113; -; .
HOGENOMHBG269172; -; .
HOVERGENHBG009729; -; .
InParanoidP02774; -; .
OrthoDBEOG4MKNG5; -; .
ReactomeREACT_11193; Metabolism of vitamins and cofactors; .
ReactomeREACT_15493; Steroid hormones; .
ReactomeREACT_22258; Metabolism of lipids and lipoproteins; .
DrugBankDB00169; Cholecalciferol; .
NextBio10400; -; .
ArrayExpressP02774; -; .
BgeeP02774; -; .
CleanExHS_GC; -; .
GenevestigatorP02774; -; .
GermOnlineENSG00000145321; Homo sapiens; .
GOGO:0005829; C:cytosol; TAS:Reactome; .
GOGO:0043202; C:lysosomal lumen; TAS:Reactome; .
GOGO:0003779; F:actin binding; IPI:UniProtKB; .
GOGO:0005499; F:vitamin D binding; TAS:ProtInc; .
GOGO:0051183; F:vitamin transporter activity; IEA:InterPro; .
GOGO:0042359; P:vitamin D metabolic process; TAS:Reactome; .
InterProIPR000264; Serum_albumin; .
InterProIPR020858; Serum_albumin-like; .
InterProIPR020857; Serum_albumin_CS; .
InterProIPR014760; Serum_albumin_N; .
InterProIPR000213; VitD-bd; .
InterProIPR015247; VitD-bind_III; .
PfamPF00273; Serum_albumin; 2; .
PfamPF09164; VitD-bind_III; 1; .
PRINTSPR00802; SERUMALBUMIN; .
PRINTSPR00804; VITAMNDBNDNG; .
SMARTSM00103; ALBUMIN; 2; .
SUPFAMSSF48552; Serum_albumin; 3; .
PROSITEPS00212; ALBUMIN_1; 1; .
PROSITEPS51438; ALBUMIN_2; 2; .



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SWISS-2DPAGE (search AC)


Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server