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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P02656




SWISS-2DPAGE:  P02656


P02656


General information about the entry
View entry in simple text format
Entry nameAPOC3_HUMAN
Primary accession numberP02656
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onDecember 1, 2000 (version 1)
General Annotations were last modified on May 19, 2011 (version 11)
Name and origin of the protein
DescriptionRecName: Full=Apolipoprotein C-III; Short=Apo-CIII; Short=ApoC-III; AltName: Full=Apolipoprotein C3; Flags: Precursor;.
Gene nameName=APOC3
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=81006902; PubMed=7410381; [NCBI, ExPASy, EBI, Israel, Japan]
Zannis V.I., Breslow J.L., Katz A.J.
''''''Isoproteins of human apolipoprotein A-I demonstrated in plasma and intestinal organ culture'';'';''
J. Biol. Chem. 255(1):8612-8617(1980)
[2]   MAPPING ON GEL
MEDLINE=96007934; PubMed=7498157; [NCBI, ExPASy, EBI, Israel, Japan]
Sanchez J.-C., Appel R.D., Golaz O.G., Pasquali C., Ravier F., Bairoch A., Hochstrasser D.F.
''''''Inside SWISS-2DPAGE database'';'';''
Electrophoresis 16(1):1131-1151(1995)
Comments
  • SUBUNIT: SINGLE CHAIN
2D PAGE maps for identified proteins
How to interpret a protein

HEPG2SP_HUMAN {HepG2 Secreted Proteins}
Homo sapiens (Human)
Tissue: Hepatoblastoma
HEPG2SP_HUMAN
  map experimental info
  protein estimated location
 
HEPG2SP_HUMAN

MAP LOCATIONS:
pI=4.45; Mw=8934

MAPPING (identification):
MATCHING WITH THE PLASMA MASTER GEL [2].



PLASMA_HUMAN {Plasma}
Homo sapiens (Human)
Tissue: Plasma
PLASMA_HUMAN
  map experimental info
  protein estimated location
 
PLASMA_HUMAN

MAP LOCATIONS:
pI=4.63; Mw=8528

PATHOLOGICAL LEVEL:
INCREASED DURING TYPE IIB, III, IV AND V HYPERLIPAEMIA.

POSITIONAL VARIANTS:
APO-CIII-0, 1 AND 2.

MAPPING (identification):
IMMUNOBLOTTING [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from license@isb-sib.ch).
Cross-references
DOSAC-COBS 2D-PAGEP02656; P02656.
DOSAC-COBS-2DPAGEP02656; APOC3_HUMAN.
UniProtKB/Swiss-ProtP02656; APOC3_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameAPOC3_HUMAN
Primary accession numberP02656
Secondary accession number(s) Q08E83 Q6Q786
Sequence was last modified on July 21, 1986 (version 1)
Annotations were last modified on October 19, 2011 (version 117)
Name and origin of the protein
DescriptionRecName: Full=Apolipoprotein C-III; Short=Apo-CIII; Short=ApoC-III; AltName: Full=Apolipoprotein C3; Flags: Precursor;
Gene nameName=APOC3
Encoded onName=APOC3
Keywords3D-structure; Chylomicron; Complete proteome; Direct protein sequencing; Disease mutation; Glycoprotein; Lipid degradation; Lipid transport; Polymorphism; Reference proteome; Secreted; Signal; Transport; VLDL.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLJ00098; AAB59515.1; -; Genomic_DNA
EMBLM33043; AAB59372.1; -; Genomic_DNA
EMBLM33041; AAB59372.1; JOINED; Genomic_DNA
EMBLM33042; AAB59372.1; JOINED; Genomic_DNA
EMBLX01392; CAA25648.1; -; Genomic_DNA
EMBLX01388; CAA25644.1; -; mRNA
EMBLX03120; CAA26895.1; -; Genomic_DNA
EMBLV01513; CAA24757.1; -; mRNA
EMBLM28613; AAA51760.1; -; mRNA
EMBLM28614; AAA51761.1; -; mRNA
EMBLX00567; CAA25233.1; -; mRNA
EMBLAY422951; AAQ91810.1; -; Genomic_DNA
EMBLAY555191; AAS68230.1; -; Genomic_DNA
EMBLBC027977; AAH27977.1; -; mRNA
EMBLBC121081; AAI21082.1; -; mRNA
IPIIPI00021857; -; .
PIRA90950; LPHUC3; .
RefSeqNP_000031.1; NM_000040.1; .
UniGeneHs.73849; -; .
PDB2JQ3; NMR; -; A=21-99
PDBsum2JQ3; -; .
ProteinModelPortalP02656; -; .
SMRP02656; 21-99; .
IntActP02656; 2; .
STRINGP02656; -; .
GlycoSuiteDBP02656; -; .
SWISS-2DPAGEP02656; -; .
DOSAC-COBS-2DPAGEP02656; -; .
PRIDEP02656; -; .
EnsemblENST00000227667; ENSP00000227667; ENSG00000110245; .
EnsemblENST00000360377; ENSP00000353540; ENSG00000110245; .
EnsemblENST00000375345; ENSP00000364494; ENSG00000110245; .
GeneID345; -; .
KEGGhsa:345; -; .
UCSCuc001ppt.1; human; .
CTD345; -; .
GeneCardsGC11P112632; -; .
H-InvDBHIX0010157; -; .
HGNCHGNC:610; APOC3; .
MIM107720; gene; .
MIM614028; phenotype; .
neXtProtNX_P02656; -; .
Orphanet79506; Cholesterol-ester transfer protein deficiency; .
GeneTreeENSGT00390000015395; -; .
HOVERGENHBG050549; -; .
InParanoidP02656; -; .
PhylomeDBP02656; -; .
ReactomeREACT_22258; Metabolism of lipids and lipoproteins; .
NextBio1423; -; .
ArrayExpressP02656; -; .
BgeeP02656; -; .
CleanExHS_APOC3; -; .
GenevestigatorP02656; -; .
GermOnlineENSG00000110245; Homo sapiens; .
GOGO:0042627; C:chylomicron; IDA:BHF-UCL; .
GOGO:0034363; C:intermediate-density lipoprotein particle; IDA:BHF-UCL; .
GOGO:0034366; C:spherical high-density lipoprotein particle; IDA:BHF-UCL; .
GOGO:0034361; C:very-low-density lipoprotein particle; IDA:BHF-UCL; .
GOGO:0015485; F:cholesterol binding; IC:BHF-UCL; .
GOGO:0070653; F:high-density lipoprotein particle receptor binding; IPI:BHF-UCL; .
GOGO:0055102; F:lipase inhibitor activity; IDA:BHF-UCL; .
GOGO:0005543; F:phospholipid binding; IDA:BHF-UCL; .
GOGO:0032488; P:Cdc42 protein signal transduction; IDA:BHF-UCL; .
GOGO:0033344; P:cholesterol efflux; IDA:BHF-UCL; .
GOGO:0042632; P:cholesterol homeostasis; IMP:BHF-UCL; .
GOGO:0034382; P:chylomicron remnant clearance; IDA:BHF-UCL; .
GOGO:0007186; P:G-protein coupled receptor protein signaling pathway; IDA:BHF-UCL; .
GOGO:0034375; P:high-density lipoprotein particle remodeling; IMP:BHF-UCL; .
GOGO:0042157; P:lipoprotein metabolic process; TAS:Reactome; .
GOGO:0060621; P:negative regulation of cholesterol import; IMP:BHF-UCL; .
GOGO:0045717; P:negative regulation of fatty acid biosynthetic process; IDA:BHF-UCL; .
GOGO:0010987; P:negative regulation of high-density lipoprotein particle clearance; IMP:BHF-UCL; .
GOGO:0051005; P:negative regulation of lipoprotein lipase activity; IDA:BHF-UCL; .
GOGO:0010989; P:negative regulation of low-density lipoprotein particle clearance; IMP:BHF-UCL; .
GOGO:0048261; P:negative regulation of receptor-mediated endocytosis; IDA:BHF-UCL; .
GOGO:0010897; P:negative regulation of triglyceride catabolic process; IDA:BHF-UCL; .
GOGO:0010916; P:negative regulation of very-low-density lipoprotein particle clearance; IDA:BHF-UCL; .
GOGO:0010903; P:negative regulation of very-low-density lipoprotein particle remodeling; IDA:BHF-UCL; .
GOGO:0033700; P:phospholipid efflux; IDA:BHF-UCL; .
GOGO:0043691; P:reverse cholesterol transport; IC:BHF-UCL; .
GOGO:0019433; P:triglyceride catabolic process; IDA:BHF-UCL; .
GOGO:0070328; P:triglyceride homeostasis; IMP:BHF-UCL; .
GOGO:0034379; P:very-low-density lipoprotein particle assembly; TAS:BHF-UCL; .
InterProIPR008403; Apo-CIII; .
PANTHERPTHR14225; Apo-CIII; 1; .
PfamPF05778; Apo-CIII; 1; .
ProDomPD010414; Apo-CIII; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server