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Sample Preparation and Post-separation Analysis

Searching in 'SWISS-2DPAGE' for entry matching: P08249



General information about the entry
View entry in simple text format
Entry nameMDHM_MOUSE
Primary accession numberP08249
integrated into SWISS-2DPAGE on October 31, 1999 (release 11)
2D Annotations were last modified onOctober 1, 2001 (version 1)
General Annotations were last modified on May 19, 2011 (version 9)
Name and origin of the protein
DescriptionRecName: Full=Malate dehydrogenase, mitochondrial; EC=; Flags: Precursor;.
Gene nameName=Mdh2
Annotated speciesMus musculus (Mouse) [TaxID: 10090]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus.
PubMed=11680894; [NCBI, ExPASy, EBI, Israel, Japan]
Sanchez J.-C., Chiappe D., Converset V., Hoogland C., Binz P.-A., Paesano S., Appel R.D., Wang S., Sennitt M., Nolan A., Cawthorne M.A., Hochstrasser D.F.
''''''The mouse SWISS-2DPAGE database: a tool for proteomics study of diabetes and obesity'';'';''
Proteomics 1(1):136-163(2001)
2D PAGE maps for identified proteins
How to interpret a protein

Mus musculus (Mouse)
Tissue: Liver
  map experimental info
  protein estimated location

pI=8.35; Mw=35626  [identification data]

MAPPING (identification):
Peptide mass fingerprinting [1].

This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See or send email from
UniProtKB/Swiss-ProtP08249; MDHM_MOUSE.
World-2DPAGE RepositoryP08249; MDHM_MOUSE.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameMDHM_MOUSE
Primary accession numberP08249
Secondary accession number(s) Q0QF44 Q8CF79 Q8R1P0
Sequence was last modified on May 1, 2007 (version 3)
Annotations were last modified on October 19, 2011 (version 127)
Name and origin of the protein
DescriptionRecName: Full=Malate dehydrogenase, mitochondrial; EC=; Flags: Precursor;
Gene nameName=Mdh2
Encoded onName=Mdh2; Synonyms=Mor1
KeywordsAcetylation; Complete proteome; Direct protein sequencing; Mitochondrion; NAD; Oxidoreductase; Phosphoprotein; Reference proteome; Transit peptide; Tricarboxylic acid cycle.
Copyrighted by the UniProt Consortium, see Distributed under the Creative Commons Attribution-NoDerivs License
EMBLM16229; AAA39509.1; -; mRNA
EMBLX07295; CAA30274.1; -; Genomic_DNA
EMBLX07296; CAA30274.1; JOINED; Genomic_DNA
EMBLX07297; CAA30274.1; JOINED; Genomic_DNA
EMBLX07298; CAA30274.1; JOINED; Genomic_DNA
EMBLX07299; CAA30274.1; JOINED; Genomic_DNA
EMBLX07300; CAA30274.1; JOINED; Genomic_DNA
EMBLX07301; CAA30274.1; JOINED; Genomic_DNA
EMBLAK002305; BAC24986.1; ALT_FRAME; mRNA
EMBLAK167809; BAE39836.1; -; mRNA
EMBLAK160553; BAE35869.1; -; mRNA
EMBLAK135162; BAE22447.1; -; mRNA
EMBLBC023482; AAH23482.1; -; mRNA
EMBLDQ402950; ABD77283.1; -; mRNA
IPIIPI00323592; -; .
PIRS01350; DEMSMM; .
RefSeqNP_032643.2; NM_008617.2; .
UniGeneMm.297096; -; .
ProteinModelPortalP08249; -; .
SMRP08249; 25-337; .
IntActP08249; 3; .
STRINGP08249; -; .
PhosphoSiteP08249; -; .
SWISS-2DPAGEP08249; -; .
UCD-2DPAGEP08249; -; .
PRIDEP08249; -; .
EnsemblENSMUST00000019323; ENSMUSP00000019323; ENSMUSG00000019179; .
GeneID17448; -; .
KEGGmmu:17448; -; .
NMPDRfig|10090.3.peg.12582; -; .
UCSCuc008zyz.1; mouse; .
CTD4191; -; .
MGIMGI:97050; Mdh2; .
eggNOGroNOG11242; -; .
GeneTreeENSGT00390000016686; -; .
HOGENOMHBG566126; -; .
HOVERGENHBG001662; -; .
InParanoidP08249; -; .
OrthoDBEOG4MKNGM; -; .
PhylomeDBP08249; -; .
NextBio292084; -; .
ArrayExpressP08249; -; .
BgeeP08249; -; .
CleanExMM_MDH2; -; .
GenevestigatorP08249; -; .
GermOnlineENSMUSG00000019179; Mus musculus; .
GOGO:0005743; C:mitochondrial inner membrane; IDA:MGI; .
GOGO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell; .
GOGO:0030060; F:L-malate dehydrogenase activity; IDA:MGI; .
GOGO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro; .
GOGO:0006475; P:internal protein amino acid acetylation; ISS:UniProtKB; .
GOGO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW; .
InterProIPR001557; L-lactate/malate_DH; .
InterProIPR022383; Lactate/malate_DH_C; .
InterProIPR001236; Lactate/malate_DH_N; .
InterProIPR015955; Lactate_DH/Glyco_Ohase_4_C; .
InterProIPR001252; Malate_DH_AS; .
InterProIPR010097; Malate_DH_type1; .
InterProIPR016040; NAD(P)-bd_dom; .
Gene3DG3DSA:; lact_mal_DH; 1; .
Gene3DG3DSA:; NAD(P)-bd; 1; .
PANTHERPTHR11540:SF1; MDH_euk_g_bac; 1; .
PfamPF02866; Ldh_1_C; 1; .
PfamPF00056; Ldh_1_N; 1; .
PIRSFPIRSF000102; Lac_mal_DH; 1; .
SUPFAMSSF56327; Lactate_DH/Glyco_hydro_4_C; 1; .
TIGRFAMsTIGR01772; MDH_euk_gproteo; 1; .
PROSITEPS00068; MDH; 1; .


SWISS-2DPAGE (search AC)

Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server