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SWISS-2DPAGE 
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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P08697




SWISS-2DPAGE:  P08697


P08697


General information about the entry
View entry in simple text format
Entry nameA2AP_HUMAN
Primary accession numberP08697
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onOctober 1, 2001 (version 1)
General Annotations were last modified on May 19, 2011 (version 12)
Name and origin of the protein
DescriptionRecName: Full=Alpha-2-antiplasmin; Short=Alpha-2-AP; AltName: Full=Alpha-2-plasmin inhibitor; Short=Alpha-2-PI; AltName: Full=Serpin F2; Flags: Precursor;.
Gene nameName=SERPINF2
Synonyms=AAP, PLI
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=93092937; PubMed=1459097; [NCBI, ExPASy, EBI, Israel, Japan]
Hughes G.J., Frutiger S., Paquet N., Ravier F., Pasquali C., Sanchez J.-C., James R.W., Tissot J.-D., Bjellqvist B., Hochstrasser D.F.
''''''Plasma protein map: an update by microsequencing'';'';''
Electrophoresis 13(1):707-714(1992)
[2]   MAPPING ON GEL
MEDLINE=96007934; PubMed=7498157; [NCBI, ExPASy, EBI, Israel, Japan]
Sanchez J.-C., Appel R.D., Golaz O.G., Pasquali C., Ravier F., Bairoch A., Hochstrasser D.F.
''''''Inside SWISS-2DPAGE database'';'';''
Electrophoresis 16(1):1131-1151(1995)
Comments
  • SUBUNIT: SINGLE CHAIN
2D PAGE maps for identified proteins
How to interpret a protein

HEPG2SP_HUMAN {HepG2 Secreted Proteins}
Homo sapiens (Human)
Tissue: Hepatoblastoma
HEPG2SP_HUMAN
  map experimental info
  protein estimated location
 
HEPG2SP_HUMAN

MAP LOCATIONS:
pI=4.61; Mw=77713
pI=4.66; Mw=77138
pI=4.72; Mw=76285
pI=4.78; Mw=74884
pI=4.85; Mw=74330
pI=4.93; Mw=73236

MAPPING (identification):
MATCHING WITH THE PLASMA MASTER GEL [2].



PLASMA_HUMAN {Plasma}
Homo sapiens (Human)
Tissue: Plasma
PLASMA_HUMAN
  map experimental info
  protein estimated location
 
PLASMA_HUMAN

MAP LOCATIONS:
pI=4.87; Mw=73985
pI=4.94; Mw=72036
pI=4.98; Mw=70675
pI=5.04; Mw=69076
pI=5.08; Mw=68030
pI=5.10; Mw=67771
pI=5.17; Mw=66097

NORMAL LEVEL:
70 MG/L.

PATHOLOGICAL LEVEL:
DECREASED DURING HYPERFIBRINOLYSIS.

MAPPING (identification):
MICROSEQUENCING [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).
Cross-references
Siena-2DPAGEP08697; A2AP_HUMAN.
UniProtKB/Swiss-ProtP08697; A2AP_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameA2AP_HUMAN
Primary accession numberP08697
Secondary accession number(s) Q8N5U7 Q9UCG2 Q9UCG3
Sequence was last modified on November 1, 1990 (version 3)
Annotations were last modified on September 21, 2011 (version 132)
Name and origin of the protein
DescriptionRecName: Full=Alpha-2-antiplasmin; Short=Alpha-2-AP; AltName: Full=Alpha-2-plasmin inhibitor; Short=Alpha-2-PI; AltName: Full=Serpin F2; Flags: Precursor;
Gene nameName=SERPINF2
Synonyms=AAP, PLI
Encoded onName=SERPINF2; Synonyms=AAP, PLI
KeywordsAcute phase; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Glycoprotein; Isopeptide bond; Polymorphism; Protease inhibitor; Reference proteome; Secreted; Serine protease inhibitor; Signal; Sulfation.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLD00174; BAA00124.1; -; mRNA
EMBLM20786; AAA51554.1; -; Genomic_DNA
EMBLM20782; AAA51554.1; JOINED; Genomic_DNA
EMBLM20783; AAA51554.1; JOINED; Genomic_DNA
EMBLM20784; AAA51554.1; JOINED; Genomic_DNA
EMBLM20785; AAA51554.1; JOINED; Genomic_DNA
EMBLBC031592; AAH31592.1; -; mRNA
EMBLJ02654; AAA35543.1; -; mRNA
EMBLD00116; BAA00070.1; -; mRNA
IPIIPI00879231; -; .
PIRA31402; ITHUA2; .
RefSeqNP_000925.2; NM_000934.3; .
RefSeqNP_001159392.1; NM_001165920.1; .
RefSeqNP_001159393.1; NM_001165921.1; .
UniGeneHs.159509; -; .
ProteinModelPortalP08697; -; .
SMRP08697; 74-446; .
STRINGP08697; -; .
MEROPSI04.023; -; .
SWISS-2DPAGEP08697; -; .
PRIDEP08697; -; .
EnsemblENST00000324015; ENSP00000321853; ENSG00000167711; .
EnsemblENST00000382061; ENSP00000371493; ENSG00000167711; .
GeneID5345; -; .
KEGGhsa:5345; -; .
UCSCuc002ftk.1; human; .
CTD5345; -; .
GeneCardsGC17P001593; -; .
H-InvDBHIX0202497; -; .
HGNCHGNC:9075; SERPINF2; .
HPACAB024863; -; .
HPAHPA001885; -; .
MIM262850; phenotype; .
MIM613168; gene; .
neXtProtNX_P08697; -; .
Orphanet79; Congenital alpha2 antiplasmin deficiency; .
eggNOGprNOG07999; -; .
GeneTreeENSGT00560000076649; -; .
HOGENOMHBG445330; -; .
HOVERGENHBG000043; -; .
InParanoidP08697; -; .
OMALFGAKPM; -; .
PhylomeDBP08697; -; .
ReactomeREACT_604; Hemostasis; .
DrugBankDB00086; Streptokinase; .
NextBio20714; -; .
PMAP-CutDBP08697; -; .
ArrayExpressP08697; -; .
BgeeP08697; -; .
CleanExHS_SERPINF2; -; .
GenevestigatorP08697; -; .
GOGO:0005615; C:extracellular space; IBA:RefGenome; .
GOGO:0031093; C:platelet alpha granule lumen; TAS:Reactome; .
GOGO:0002020; F:protease binding; IPI:UniProtKB; .
GOGO:0004867; F:serine-type endopeptidase inhibitor activity; NAS:UniProtKB; .
GOGO:0006953; P:acute-phase response; IEA:UniProtKB-KW; .
GOGO:0042730; P:fibrinolysis; TAS:Reactome; .
GOGO:0030168; P:platelet activation; TAS:Reactome; .
GOGO:0002576; P:platelet degranulation; TAS:Reactome; .
GOGO:0030162; P:regulation of proteolysis; IBA:RefGenome; .
InterProIPR000215; Protease_inhib_I4_serpin; .
InterProIPR023795; Protease_inhib_I4_serpin_CS; .
InterProIPR023796; Sepin_dom; .
PANTHERPTHR11461; Prot_inh_serpin; 1; .
PfamPF00079; Serpin; 1; .
SMARTSM00093; SERPIN; 1; .
SUPFAMSSF56574; Prot_inh_serpin; 1; .
PROSITEPS00284; SERPIN; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server