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SWISS-2DPAGE 
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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P27773




SWISS-2DPAGE:  P27773


P27773


General information about the entry
View entry in simple text format
Entry namePDIA3_MOUSE
Primary accession numberP27773
integrated into SWISS-2DPAGE on September 1, 1998 (release 7)
2D Annotations were last modified onOctober 1, 2001 (version 2)
General Annotations were last modified on May 19, 2011 (version 10)
Name and origin of the protein
DescriptionRecName: Full=Protein disulfide-isomerase A3; EC=5.3.4.1; AltName: Full=58 kDa glucose-regulated protein; AltName: Full=58 kDa microsomal protein; Short=p58; AltName: Full=Disulfide isomerase ER-60; AltName: Full=Endoplasmic reticulum resident protein 57; Short=ER protein 57; Short=ERp57; AltName: Full=Endoplasmic reticulum resident protein 60; Short=ER protein 60; Short=ERp60; Flags: Precursor;.
Gene nameName=Pdia3
Synonyms=Erp, Erp60, Grp58
Annotated speciesMus musculus (Mouse) [TaxID: 10090]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus.
References
[1]   MAPPING ON GEL
MEDLINE=96154592; PubMed=8586073; [NCBI, ExPASy, EBI, Israel, Japan]
Anderson N.L., Esquer-Blasco R., Hoffmann J.-P., Meheus L., Raymackers J., Steiner S., Witzmann F., Anderson N.G.
''''''An updated two-dimensional gel database of rat liver proteins useful in gene regulation and drug effect studies'';'';''
Electrophoresis 16(1):1977-1981(1995)
[2]   MAPPING ON GEL
PubMed=11680894; [NCBI, ExPASy, EBI, Israel, Japan]
Sanchez J.-C., Chiappe D., Converset V., Hoogland C., Binz P.-A., Paesano S., Appel R.D., Wang S., Sennitt M., Nolan A., Cawthorne M.A., Hochstrasser D.F.
''''''The mouse SWISS-2DPAGE database: a tool for proteomics study of diabetes and obesity'';'';''
Proteomics 1(1):136-163(2001)
2D PAGE maps for identified proteins
How to interpret a protein

ISLETS_MOUSE {Pancreatic islet cells}
Mus musculus (Mouse)
Tissue: Pancreatic islet
ISLETS_MOUSE
  map experimental info
  protein estimated location
 
ISLETS_MOUSE

MAP LOCATIONS:
pI=5.71; Mw=59038  [identification data]
pI=5.51; Mw=45248  [identification data]

MAPPING (identification):
Peptide mass fingerprinting [2].



LIVER_MOUSE {Liver}
Mus musculus (Mouse)
Tissue: Liver
LIVER_MOUSE
  map experimental info
  protein estimated location
 
LIVER_MOUSE

MAP LOCATIONS:
pI=5.71; Mw=56408  [identification data]
pI=5.84; Mw=56408  [identification data]

MAPPING (identification):
MATCHING [2] WITH ANDERSON MOUSE AND RAT LIVER 2-DE MAPS [1], MASS FINGERPRINTING AND MICROSEQUENCING [2].



MUSCLE_MOUSE {Gastrocnemius muscle}
Mus musculus (Mouse)
Tissue: Gastrocnemius
MUSCLE_MOUSE
  map experimental info
  protein estimated location
 
MUSCLE_MOUSE

MAP LOCATIONS:
pI=5.81; Mw=56578
pI=5.68; Mw=56578

MAPPING (identification):
MATCHING WITH THE MOUSE LIVER MASTER GEL [2].



WAT_MOUSE {White adipose tissue}
Mus musculus (Mouse)
Tissue: White adipose tissue
WAT_MOUSE
  map experimental info
  protein estimated location
 
WAT_MOUSE

MAP LOCATIONS:
pI=5.74; Mw=56920
pI=5.63; Mw=57098

MAPPING (identification):
MATCHING WITH THE MOUSE LIVER MASTER GEL [2].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).
Cross-references
COMPLUYEAST-2DPAGEP27773; PDIA3_MOUSE.
REPRODUCTION-2DPAGEIPI00230108; IPI00230108.
REPRODUCTION-2DPAGEP27773; P27773.
UniProtKB/Swiss-ProtP27773; PDIA3_MOUSE.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry namePDIA3_MOUSE
Primary accession numberP27773
Secondary accession number(s) Q3TEI9 Q3TIL2 Q3UZK8 Q8C2F4 Q99LF6
Sequence was last modified on May 1, 2007 (version 2)
Annotations were last modified on October 19, 2011 (version 118)
Name and origin of the protein
DescriptionRecName: Full=Protein disulfide-isomerase A3; EC=5.3.4.1; AltName: Full=58 kDa glucose-regulated protein; AltName: Full=58 kDa microsomal protein; Short=p58; AltName: Full=Disulfide isomerase ER-60; AltName: Full=Endoplasmic reticulum resident protein 57; Short=ER protein 57; Short=ERp57; AltName: Full=Endoplasmic reticulum resident protein 60; Short=ER protein 60; Short=ERp60; Flags: Precursor;
Gene nameName=Pdia3
Synonyms=Erp, Erp60, Grp58
Encoded onName=Pdia3; Synonyms=Erp, Erp60, Grp58
KeywordsComplete proteome; Direct protein sequencing; Disulfide bond; Endoplasmic reticulum; Isomerase; Phosphoprotein; Redox-active center; Reference proteome; Repeat; Signal.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLM73329; AAA39944.1; -; mRNA
EMBLDQ000491; AAY16987.1; -; Genomic_DNA
EMBLAK088721; BAC40527.1; -; mRNA
EMBLAK133799; BAE21849.1; -; mRNA
EMBLAK167807; BAE39834.1; -; mRNA
EMBLAK169611; BAE41259.1; -; mRNA
EMBLAL845466; CAM24231.1; -; Genomic_DNA
EMBLBC003285; AAH03285.1; -; mRNA
EMBLBC033439; AAH33439.1; -; mRNA
IPIIPI00230108; -; .
RefSeqNP_031978.2; NM_007952.2; .
UniGeneMm.263177; -; .
ProteinModelPortalP27773; -; .
SMRP27773; 25-493; .
IntActP27773; 3; .
STRINGP27773; -; .
PhosphoSiteP27773; -; .
SWISS-2DPAGEP27773; -; .
REPRODUCTION-2DPAGEIPI00230108; -; .
REPRODUCTION-2DPAGEP27773; -; .
REPRODUCTION-2DPAGEQ3TEI9; -; .
REPRODUCTION-2DPAGEQ8C2F4; -; .
PRIDEP27773; -; .
EnsemblENSMUST00000028683; ENSMUSP00000028683; ENSMUSG00000027248; .
GeneID14827; -; .
KEGGmmu:14827; -; .
UCSCuc008lzb.1; mouse; .
CTD2923; -; .
MGIMGI:95834; Pdia3; .
eggNOGroNOG09779; -; .
GeneTreeENSGT00590000082864; -; .
HOGENOMHBG627841; -; .
HOVERGENHBG005920; -; .
InParanoidP27773; -; .
OMAEGITLFR; -; .
OrthoDBEOG42Z4PX; -; .
PhylomeDBP27773; -; .
NextBio287035; -; .
ArrayExpressP27773; -; .
BgeeP27773; -; .
CleanExMM_PDIA3; -; .
GenevestigatorP27773; -; .
GermOnlineENSMUSG00000027248; Mus musculus; .
GOGO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome; .
GOGO:0042470; C:melanosome; IEA:UniProtKB-SubCell; .
GOGO:0009055; F:electron carrier activity; IEA:InterPro; .
GOGO:0003756; F:protein disulfide isomerase activity; IEA:EC; .
GOGO:0015035; F:protein disulfide oxidoreductase activity; IEA:InterPro; .
GOGO:0045454; P:cell redox homeostasis; IEA:InterPro; .
GOGO:0006662; P:glycerol ether metabolic process; IEA:InterPro; .
GOGO:0043065; P:positive regulation of apoptosis; IMP:MGI; .
InterProIPR005788; Disulphide_isomerase; .
InterProIPR005792; Prot_disulphide_isomerase; .
InterProIPR005746; Thioredoxin; .
InterProIPR012336; Thioredoxin-like_fold; .
InterProIPR017937; Thioredoxin_CS; .
InterProIPR013766; Thioredoxin_domain; .
Gene3DG3DSA:3.40.30.10; Thioredoxin_fold; 3; .
PfamPF00085; Thioredoxin; 2; .
PRINTSPR00421; THIOREDOXIN; .
SUPFAMSSF52833; Thiordxn-like_fd; 4; .
TIGRFAMsTIGR01130; ER_PDI_fam; 1; .
TIGRFAMsTIGR01126; Pdi_dom; 2; .
PROSITEPS00194; THIOREDOXIN_1; 2; .
PROSITEPS51352; THIOREDOXIN_2; 2; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server