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Sample Preparation and Post-separation Analysis Searching in 'SWISS-2DPAGE' for entry matching: P54869 SWISS-2DPAGE:  P54869 P54869 General information about the entry View entry in simple text format Entry name HMCS2_MOUSE Primary accession number P54869 integrated into SWISS-2DPAGE on  June 30, 1999 (release 10) 2D Annotations were last modified on May 15, 2003 (version 1) General Annotations were last modified on  May 19, 2011 (version 12) Name and origin of the protein Description RecName: Full=Hydroxymethylglutaryl-CoA synthase, mitochondrial; Short=HMG-CoA synthase; EC=2.3.3.10; AltName: Full=3-hydroxy-3-methylglutaryl coenzyme A synthase; Flags: Precursor;. Gene name Name=Hmgcs2 Annotated species Mus musculus (Mouse) [TaxID: 10090] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus. References [1]   MAPPING ON GEL PubMed=11680894; [NCBI, ExPASy, EBI, Israel, Japan] Sanchez J.-C., Chiappe D., Converset V., Hoogland C., Binz P.-A., Paesano S., Appel R.D., Wang S., Sennitt M., Nolan A., Cawthorne M.A., Hochstrasser D.F. ''''''The mouse SWISS-2DPAGE database: a tool for proteomics study of diabetes and obesity'';'';'' Proteomics 1(1):136-163(2001) 2D PAGE maps for identified proteins How to interpret a protein LIVER_MOUSE {Liver} Mus musculus (Mouse) Tissue: Liver   map experimental info   protein estimated location   LIVER_MOUSE MAP LOCATIONS: SPOT 2D-0013EK: pI=7.49; Mw=52180   [identification data] MAPPING (identification): Peptide mass fingerprinting [1]. Copyright This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss). Cross-references REPRODUCTION-2DPAGE P54869; P54869. UniProtKB/Swiss-Prot P54869; HMCS2_MOUSE. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 2011_10 Entry name HMCS2_MOUSE Primary accession number P54869 Secondary accession number(s) Q64740 Q9DBK1 Q9DBM4 Sequence was last modified on  March 15, 2005 (version 2) Annotations were last modified on  September 21, 2011 (version 99) Name and origin of the protein Description RecName: Full=Hydroxymethylglutaryl-CoA synthase, mitochondrial; Short=HMG-CoA synthase; EC=2.3.3.10; AltName: Full=3-hydroxy-3-methylglutaryl coenzyme A synthase; Flags: Precursor; Gene name Name=Hmgcs2 Encoded on Name=Hmgcs2 Keywords Acetylation; Cholesterol biosynthesis; Complete proteome; Lipid synthesis; Mitochondrion; Phosphoprotein; Reference proteome; Steroid biosynthesis; Sterol biosynthesis; Transferase; Transit peptide. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL AK004865; BAB23626.1; -; mRNA EMBL AK004902; BAB23657.1; -; mRNA EMBL BC014714; AAH14714.1; -; mRNA EMBL BC024744; AAH24744.1; -; mRNA EMBL U12790; AAA92675.1; -; Genomic_DNA EMBL U12791; AAA92676.1; -; Genomic_DNA IPI IPI00420718; -; . PIR B55729; B55729; . RefSeq NP_032282.2; NM_008256.4; . UniGene Mm.289131; -; . ProteinModelPortal P54869; -; . SMR P54869; 51-508; . STRING P54869; -; . PhosphoSite P54869; -; . SWISS-2DPAGE P54869; -; . REPRODUCTION-2DPAGE P54869; -; . PRIDE P54869; -; . Ensembl ENSMUST00000090746; ENSMUSP00000088249; ENSMUSG00000027875; . Ensembl ENSMUST00000120541; ENSMUSP00000113296; ENSMUSG00000027875; . GeneID 15360; -; . KEGG mmu:15360; -; . UCSC uc008qpr.2; mouse; . CTD 3158; -; . MGI MGI:101939; Hmgcs2; . eggNOG roNOG14554; -; . HOGENOM HBG578402; -; . HOVERGEN HBG051912; -; . InParanoid P54869; -; . OMA ESSYWDX; -; . OrthoDB EOG4H72B9; -; . PhylomeDB P54869; -; . BRENDA 2.3.3.10; 3474; . NextBio 287976; -; . ArrayExpress P54869; -; . Bgee P54869; -; . CleanEx MM_HMGCS2; -; . Genevestigator P54869; -; . GermOnline ENSMUSG00000027875; Mus musculus; . GO GO:0005743; C:mitochondrial inner membrane; IDA:MGI; . GO GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:EC; . GO GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW; . GO GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro; . InterPro IPR000590; HMG_CoA_synt_AS; . InterPro IPR013746; HMG_CoA_synt_C; . InterPro IPR013528; HMG_CoA_synth_N; . InterPro IPR010122; HMG_CoA_synthase_euk; . InterPro IPR016039; Thiolase-like; . InterPro IPR016038; Thiolase-like_subgr; . Gene3D G3DSA:3.40.47.10; Thiolase-like_subgr; 1; . Pfam PF08540; HMG_CoA_synt_C; 1; . Pfam PF01154; HMG_CoA_synt_N; 1; . SUPFAM SSF53901; Thiolase-like; 2; . TIGRFAMs TIGR01833; HMG-CoA-S_euk; 1; . PROSITE PS01226; HMG_COA_SYNTHASE; 1; . SWISS-2DPAGE (search AC)