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Sample Preparation and Post-separation Analysis

Searching in 'SWISS-2DPAGE' for entry matching: P54869



General information about the entry
View entry in simple text format
Entry nameHMCS2_MOUSE
Primary accession numberP54869
integrated into SWISS-2DPAGE on June 30, 1999 (release 10)
2D Annotations were last modified onMay 15, 2003 (version 1)
General Annotations were last modified on May 19, 2011 (version 12)
Name and origin of the protein
DescriptionRecName: Full=Hydroxymethylglutaryl-CoA synthase, mitochondrial; Short=HMG-CoA synthase; EC=; AltName: Full=3-hydroxy-3-methylglutaryl coenzyme A synthase; Flags: Precursor;.
Gene nameName=Hmgcs2
Annotated speciesMus musculus (Mouse) [TaxID: 10090]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus.
PubMed=11680894; [NCBI, ExPASy, EBI, Israel, Japan]
Sanchez J.-C., Chiappe D., Converset V., Hoogland C., Binz P.-A., Paesano S., Appel R.D., Wang S., Sennitt M., Nolan A., Cawthorne M.A., Hochstrasser D.F.
''''''The mouse SWISS-2DPAGE database: a tool for proteomics study of diabetes and obesity'';'';''
Proteomics 1(1):136-163(2001)
2D PAGE maps for identified proteins
How to interpret a protein

Mus musculus (Mouse)
Tissue: Liver
  map experimental info
  protein estimated location

pI=7.49; Mw=52180  [identification data]

MAPPING (identification):
Peptide mass fingerprinting [1].

This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See or send email from
UniProtKB/Swiss-ProtP54869; HMCS2_MOUSE.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameHMCS2_MOUSE
Primary accession numberP54869
Secondary accession number(s) Q64740 Q9DBK1 Q9DBM4
Sequence was last modified on March 15, 2005 (version 2)
Annotations were last modified on September 21, 2011 (version 99)
Name and origin of the protein
DescriptionRecName: Full=Hydroxymethylglutaryl-CoA synthase, mitochondrial; Short=HMG-CoA synthase; EC=; AltName: Full=3-hydroxy-3-methylglutaryl coenzyme A synthase; Flags: Precursor;
Gene nameName=Hmgcs2
Encoded onName=Hmgcs2
KeywordsAcetylation; Cholesterol biosynthesis; Complete proteome; Lipid synthesis; Mitochondrion; Phosphoprotein; Reference proteome; Steroid biosynthesis; Sterol biosynthesis; Transferase; Transit peptide.
Copyrighted by the UniProt Consortium, see Distributed under the Creative Commons Attribution-NoDerivs License
EMBLAK004865; BAB23626.1; -; mRNA
EMBLAK004902; BAB23657.1; -; mRNA
EMBLBC014714; AAH14714.1; -; mRNA
EMBLBC024744; AAH24744.1; -; mRNA
EMBLU12790; AAA92675.1; -; Genomic_DNA
EMBLU12791; AAA92676.1; -; Genomic_DNA
IPIIPI00420718; -; .
PIRB55729; B55729; .
RefSeqNP_032282.2; NM_008256.4; .
UniGeneMm.289131; -; .
ProteinModelPortalP54869; -; .
SMRP54869; 51-508; .
STRINGP54869; -; .
PhosphoSiteP54869; -; .
SWISS-2DPAGEP54869; -; .
PRIDEP54869; -; .
EnsemblENSMUST00000090746; ENSMUSP00000088249; ENSMUSG00000027875; .
EnsemblENSMUST00000120541; ENSMUSP00000113296; ENSMUSG00000027875; .
GeneID15360; -; .
KEGGmmu:15360; -; .
UCSCuc008qpr.2; mouse; .
CTD3158; -; .
MGIMGI:101939; Hmgcs2; .
eggNOGroNOG14554; -; .
HOGENOMHBG578402; -; .
HOVERGENHBG051912; -; .
InParanoidP54869; -; .
OrthoDBEOG4H72B9; -; .
PhylomeDBP54869; -; .
BRENDA2.3.3.10; 3474; .
NextBio287976; -; .
ArrayExpressP54869; -; .
BgeeP54869; -; .
CleanExMM_HMGCS2; -; .
GenevestigatorP54869; -; .
GermOnlineENSMUSG00000027875; Mus musculus; .
GOGO:0005743; C:mitochondrial inner membrane; IDA:MGI; .
GOGO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:EC; .
GOGO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW; .
GOGO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro; .
InterProIPR000590; HMG_CoA_synt_AS; .
InterProIPR013746; HMG_CoA_synt_C; .
InterProIPR013528; HMG_CoA_synth_N; .
InterProIPR010122; HMG_CoA_synthase_euk; .
InterProIPR016039; Thiolase-like; .
InterProIPR016038; Thiolase-like_subgr; .
Gene3DG3DSA:; Thiolase-like_subgr; 1; .
PfamPF08540; HMG_CoA_synt_C; 1; .
PfamPF01154; HMG_CoA_synt_N; 1; .
SUPFAMSSF53901; Thiolase-like; 2; .
TIGRFAMsTIGR01833; HMG-CoA-S_euk; 1; .


SWISS-2DPAGE (search AC)

Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server