World-2DPAGE Constellation: SWISS-2DPAGE

RecName: Full=Hydroxymethylglutaryl-CoA synthase, mitochondrial; Short=HMG-CoA synthase; EC=2.3.3.10; AltName: Full=3-hydroxy-3-methylglutaryl coenzyme A synthase; Flags: Precursor;.

Gene name

Name=Hmgcs2

Annotated species

Mus musculus (Mouse) [TaxID: 10090]

Taxonomy

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus.

References

[1]

MAPPING ON GEL
PubMed=11680894; [NCBI, ExPASy, EBI, Israel, Japan]
Sanchez J.-C., Chiappe D., Converset V., Hoogland C., Binz P.-A., Paesano S., Appel R.D., Wang S., Sennitt M., Nolan A., Cawthorne M.A., Hochstrasser D.F.
''''''The mouse SWISS-2DPAGE database: a tool for proteomics study of diabetes and obesity'';'';''
Proteomics 1(1):136-163(2001)

2D PAGE maps for identified proteins

How to interpret a protein

LIVER_MOUSE {Liver}
Mus musculus (Mouse)
Tissue: Liver

map experimental info
protein estimated location

LIVER_MOUSE

MAP LOCATIONS:

SPOT 2D-0013EK:

pI=7.49; Mw=52180

[identification data]

MAPPING (identification):
Peptide mass fingerprinting [1].

Copyright

This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).

Cross-references

REPRODUCTION-2DPAGE

P54869; P54869.

UniProtKB/Swiss-Prot

P54869; HMCS2_MOUSE.

2D PAGE maps for identified proteins

How to interpret a protein map
You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry name	HMCS2_MOUSE
Primary accession number	P54869
Secondary accession number(s)	Q64740 Q9DBK1 Q9DBM4
Sequence was last modified on	March 15, 2005 (version 2)
Annotations were last modified on	September 21, 2011 (version 99)
Name and origin of the protein
Description	RecName: Full=Hydroxymethylglutaryl-CoA synthase, mitochondrial; Short=HMG-CoA synthase; EC=2.3.3.10; AltName: Full=3-hydroxy-3-methylglutaryl coenzyme A synthase; Flags: Precursor;
Gene name	Name=Hmgcs2
Encoded on	Name=Hmgcs2
Keywords	Acetylation; Cholesterol biosynthesis; Complete proteome; Lipid synthesis; Mitochondrion; Phosphoprotein; Reference proteome; Steroid biosynthesis; Sterol biosynthesis; Transferase; Transit peptide.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBL	AK004865; BAB23626.1; -; mRNA
EMBL	AK004902; BAB23657.1; -; mRNA
EMBL	BC014714; AAH14714.1; -; mRNA
EMBL	BC024744; AAH24744.1; -; mRNA
EMBL	U12790; AAA92675.1; -; Genomic_DNA
EMBL	U12791; AAA92676.1; -; Genomic_DNA
IPI	IPI00420718; -; .
PIR	B55729; B55729; .
RefSeq	NP_032282.2; NM_008256.4; .
UniGene	Mm.289131; -; .
ProteinModelPortal	P54869; -; .
SMR	P54869; 51-508; .
STRING	P54869; -; .
PhosphoSite	P54869; -; .
SWISS-2DPAGE	P54869; -; .
REPRODUCTION-2DPAGE	P54869; -; .
PRIDE	P54869; -; .
Ensembl	ENSMUST00000090746; ENSMUSP00000088249; ENSMUSG00000027875; .
Ensembl	ENSMUST00000120541; ENSMUSP00000113296; ENSMUSG00000027875; .
GeneID	15360; -; .
KEGG	mmu:15360; -; .
UCSC	uc008qpr.2; mouse; .
CTD	3158; -; .
MGI	MGI:101939; Hmgcs2; .
eggNOG	roNOG14554; -; .
HOGENOM	HBG578402; -; .
HOVERGEN	HBG051912; -; .
InParanoid	P54869; -; .
OMA	ESSYWDX; -; .
OrthoDB	EOG4H72B9; -; .
PhylomeDB	P54869; -; .
BRENDA	2.3.3.10; 3474; .
NextBio	287976; -; .
ArrayExpress	P54869; -; .
Bgee	P54869; -; .
CleanEx	MM_HMGCS2; -; .
Genevestigator	P54869; -; .
GermOnline	ENSMUSG00000027875; Mus musculus; .
GO	GO:0005743; C:mitochondrial inner membrane; IDA:MGI; .
GO	GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:EC; .
GO	GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW; .
GO	GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro; .
InterPro	IPR000590; HMG_CoA_synt_AS; .
InterPro	IPR013746; HMG_CoA_synt_C; .
InterPro	IPR013528; HMG_CoA_synth_N; .
InterPro	IPR010122; HMG_CoA_synthase_euk; .
InterPro	IPR016039; Thiolase-like; .
InterPro	IPR016038; Thiolase-like_subgr; .
Gene3D	G3DSA:3.40.47.10; Thiolase-like_subgr; 1; .
Pfam	PF08540; HMG_CoA_synt_C; 1; .
Pfam	PF01154; HMG_CoA_synt_N; 1; .
SUPFAM	SSF53901; Thiolase-like; 2; .
TIGRFAMs	TIGR01833; HMG-CoA-S_euk; 1; .
PROSITE	PS01226; HMG_COA_SYNTHASE; 1; .

SWISS-2DPAGE (search AC)

Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server

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