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SWISS-2DPAGE 
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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P60900




SWISS-2DPAGE:  P60900


P60900


General information about the entry
View entry in simple text format
Entry namePSA6_HUMAN
Primary accession numberP60900
Secondary accession number(s) P34062
integrated into SWISS-2DPAGE on March 31, 2004 (release 17)
2D Annotations were last modified onDecember 30, 2004 (version 1)
General Annotations were last modified on May 19, 2011 (version 5)
Name and origin of the protein
DescriptionRecName: Full=Proteasome subunit alpha type-6; EC=3.4.25.1; AltName: Full=27 kDa prosomal protein; Short=PROS-27; Short=p27K; AltName: Full=Macropain iota chain; AltName: Full=Multicatalytic endopeptidase complex iota chain; AltName: Full=Proteasome iota chain;.
Gene nameName=PSMA6
Synonyms=PROS27
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
Vuadens F., Crettaz D., Telenti A., Quadroni M., Duchosal M.A., Schneider P., Tissot J.-D.
''''''New insights into HIV lymphocyte infection'';'';''
(IN) Sanchez J.-C., Corthals G.L., Hochstrasser D.F. (eds.)Biomedical Application of Proteomics, pp.245-262, Wiley-VCH, Weinheim (2004)
Comments
  • SUBUNIT: The proteasome is composed of at least 15 non identical subunits which form a highly ordered ring-shaped structure
2D PAGE maps for identified proteins
How to interpret a protein

LYMPHOCYTE_HUMAN {Lymphocytes}
Homo sapiens (Human)
Tissue: Lymphocyte
LYMPHOCYTE_HUMAN
  map experimental info
  protein estimated location
 
LYMPHOCYTE_HUMAN

MAP LOCATIONS:
pI=6.79; Mw=25871  [identification data]

MAPPING (identification):
Peptide mass fingerprinting [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).
Cross-references
OGP-WWWP34062.
REPRODUCTION-2DPAGEIPI00029623; IPI00029623.
UCD-2DPAGEP60900; PSA6_HUMAN.
UniProtKB/Swiss-ProtP60900; PSA6_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry namePSA6_HUMAN
Primary accession numberP60900
Secondary accession number(s) B2R7J9 P34062 Q6IB60
Sequence was last modified on April 13, 2004 (version 1)
Annotations were last modified on October 19, 2011 (version 92)
Name and origin of the protein
DescriptionRecName: Full=Proteasome subunit alpha type-6; EC=3.4.25.1; AltName: Full=27 kDa prosomal protein; Short=PROS-27; Short=p27K; AltName: Full=Macropain iota chain; AltName: Full=Multicatalytic endopeptidase complex iota chain; AltName: Full=Proteasome iota chain;
Gene nameName=PSMA6
Synonyms=PROS27
Encoded onName=PSMA6; Synonyms=PROS27
KeywordsAcetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Isopeptide bond; Nucleus; Phosphoprotein; Polymorphism; Protease; Proteasome; Reference proteome; Threonine protease; Ubl conjugation.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLX59417; CAA42052.1; -; mRNA
EMBLCR456944; CAG33225.1; -; mRNA
EMBLAK313011; BAG35846.1; -; mRNA
EMBLCH471078; EAW65877.1; -; Genomic_DNA
EMBLBC002979; AAH02979.1; -; mRNA
EMBLBC017882; AAH17882.1; -; mRNA
EMBLBC022354; AAH22354.1; -; mRNA
EMBLBC023659; AAH23659.1; -; mRNA
EMBLBC070137; AAH70137.1; -; mRNA
EMBLX61972; CAA43964.1; -; mRNA
IPIIPI00029623; -; .
PIRS30274; S30274; .
RefSeqNP_002782.1; NM_002791.1; .
UniGeneHs.446260; -; .
ProteinModelPortalP60900; -; .
SMRP60900; 2-245; .
DIPDIP-29367N; -; .
IntActP60900; 11; .
MINTMINT-5001118; -; .
STRINGP60900; -; .
MEROPST01.971; -; .
PhosphoSiteP60900; -; .
SWISS-2DPAGEP60900; -; .
REPRODUCTION-2DPAGEIPI00029623; -; .
UCD-2DPAGEP60900; -; .
PeptideAtlasP60900; -; .
PRIDEP60900; -; .
EnsemblENST00000261479; ENSP00000261479; ENSG00000100902; .
GeneID5687; -; .
KEGGhsa:5687; -; .
UCSCuc001wtd.1; human; .
CTD5687; -; .
GeneCardsGC14P015875; -; .
H-InvDBHIX0011598; -; .
H-InvDBHIX0079614; -; .
HGNCHGNC:9535; PSMA6; .
HPAHPA003049; -; .
MIM602855; gene; .
neXtProtNX_P60900; -; .
PharmGKBPA33880; -; .
eggNOGprNOG15104; -; .
HOGENOMHBG499923; -; .
HOVERGENHBG107363; -; .
InParanoidP60900; -; .
OMAGKDCAVV; -; .
OrthoDBEOG4BP1CH; -; .
PhylomeDBP60900; -; .
ReactomeREACT_11045; Signaling by Wnt; .
ReactomeREACT_13; Metabolism of amino acids and derivatives; .
ReactomeREACT_13505; Proteasome mediated degradation of PAK-2p34; .
ReactomeREACT_152; Cell Cycle; Mitotic; .
ReactomeREACT_1538; Cell Cycle Checkpoints; .
ReactomeREACT_21257; Metabolism of RNA; .
ReactomeREACT_383; DNA Replication; .
ReactomeREACT_578; Apoptosis; .
ReactomeREACT_6185; HIV Infection; .
ReactomeREACT_6850; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; .
ReactomeREACT_6900; Immune System; .
NextBio22090; -; .
ArrayExpressP60900; -; .
BgeeP60900; -; .
CleanExHS_PSMA6; -; .
GenevestigatorP60900; -; .
GermOnlineENSG00000100902; Homo sapiens; .
GOGO:0005829; C:cytosol; TAS:Reactome; .
GOGO:0005739; C:mitochondrion; IDA:HPA; .
GOGO:0016363; C:nuclear matrix; ISS:BHF-UCL; .
GOGO:0005654; C:nucleoplasm; TAS:Reactome; .
GOGO:0005844; C:polysome; IDA:BHF-UCL; .
GOGO:0019773; C:proteasome core complex; alpha-subunit complex; IDA:BHF-UCL
GOGO:0030017; C:sarcomere; ISS:BHF-UCL; .
GOGO:0051059; F:NF-kappaB binding; IPI:BHF-UCL; .
GOGO:0035639; F:purine ribonucleoside triphosphate binding; NAS:BHF-UCL; .
GOGO:0003723; F:RNA binding; NAS:UniProtKB; .
GOGO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW; .
GOGO:0031145; P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome; .
GOGO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome; .
GOGO:0006915; P:apoptosis; TAS:Reactome; .
GOGO:0006977; P:DNA damage response; signal transduction by p53 class mediator resulting in cell cycle arrest; TAS:Reactome
GOGO:0000082; P:G1/S transition of mitotic cell cycle; TAS:Reactome; .
GOGO:0000216; P:M/G1 transition of mitotic cell cycle; TAS:Reactome; .
GOGO:0016071; P:mRNA metabolic process; TAS:Reactome; .
GOGO:0051436; P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome; .
GOGO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IMP:BHF-UCL; .
GOGO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome; .
GOGO:0000209; P:protein polyubiquitination; TAS:Reactome; .
GOGO:0042981; P:regulation of apoptosis; TAS:Reactome; .
GOGO:0006521; P:regulation of cellular amino acid metabolic process; TAS:Reactome; .
GOGO:0050727; P:regulation of inflammatory response; IC:BHF-UCL; .
GOGO:0000084; P:S phase of mitotic cell cycle; TAS:Reactome; .
GOGO:0016032; P:viral reproduction; TAS:Reactome; .
InterProIPR000426; Proteasome_asu_CS; .
InterProIPR023332; Proteasome_suA-type; .
InterProIPR001353; Proteasome_sua/b; .
PfamPF00227; Proteasome; 1; .
PfamPF10584; Proteasome_A_N; 1; .
SMARTSM00948; Proteasome_A_N; 1; .
PROSITEPS00388; PROTEASOME_A_1; 1; .
PROSITEPS51475; PROTEASOME_A_2; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server