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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P62993




SWISS-2DPAGE:  P62993


P62993


General information about the entry
View entry in simple text format
Entry nameGRB2_HUMAN
Primary accession numberP62993
Secondary accession number(s) P29354
integrated into SWISS-2DPAGE on March 31, 2004 (release 17)
2D Annotations were last modified onMarch 31, 2004 (version 1)
General Annotations were last modified on May 19, 2011 (version 7)
Name and origin of the protein
DescriptionRecName: Full=Growth factor receptor-bound protein 2; AltName: Full=Adapter protein GRB2; AltName: Full=Protein Ash; AltName: Full=SH2/SH3 adapter GRB2;.
Gene nameName=GRB2
Synonyms=ASH
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
Vuadens F., Crettaz D., Telenti A., Quadroni M., Duchosal M.A., Schneider P., Tissot J.-D.
''''''New insights into HIV lymphocyte infection'';'';''
(IN) Sanchez J.-C., Corthals G.L., Hochstrasser D.F. (eds.)Biomedical Application of Proteomics, pp.245-262, Wiley-VCH, Weinheim (2004)
Comments
  • SUBUNIT: Interacts with phosphorylated TOM1L1. Interacts with the phosphorylated C-terminus of APS. Interacts with PTPNS1, REPS2 and the syntrophin SNTA1. Interacts with REPS1 via its SH3 domain
2D PAGE maps for identified proteins
How to interpret a protein

LYMPHOCYTE_HUMAN {Lymphocytes}
Homo sapiens (Human)
Tissue: Lymphocyte
LYMPHOCYTE_HUMAN
  map experimental info
  protein estimated location
 
LYMPHOCYTE_HUMAN

MAP LOCATIONS:
pI=6.00; Mw=24400  [identification data]

MAPPING (identification):
Peptide mass fingerprinting [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).
Cross-references
OGP-WWWP29354.
UniProtKB/Swiss-ProtP62993; GRB2_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameGRB2_HUMAN
Primary accession numberP62993
Secondary accession number(s) P29354 Q14450 Q63057 Q63059
Sequence was last modified on August 31, 2004 (version 1)
Annotations were last modified on October 19, 2011 (version 107)
Name and origin of the protein
DescriptionRecName: Full=Growth factor receptor-bound protein 2; AltName: Full=Adapter protein GRB2; AltName: Full=Protein Ash; AltName: Full=SH2/SH3 adapter GRB2;
Gene nameName=GRB2
Synonyms=ASH
Encoded onName=GRB2; Synonyms=ASH
Keywords3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Golgi apparatus; Host-virus interaction; Phosphoprotein; Reference proteome; Repeat; SH2 domain; SH3 domain.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLM96995; AAA58448.1; -; mRNA
EMBLX62852; CAA44664.1; -; mRNA
EMBLL29511; AAC37549.1; -; mRNA
EMBLAF063618; AAC72075.1; -; Genomic_DNA
EMBLAF063614; AAC72075.1; JOINED; Genomic_DNA
EMBLAF063615; AAC72075.1; JOINED; Genomic_DNA
EMBLAF063616; AAC72075.1; JOINED; Genomic_DNA
EMBLAF063617; AAC72075.1; JOINED; Genomic_DNA
EMBLAF498925; AAM21073.1; -; mRNA
EMBLCR541942; CAG46740.1; -; mRNA
EMBLAC011933; -; NOT_ANNOTATED_CDS; Genomic_DNA
EMBLBC000631; AAH00631.1; -; mRNA
IPIIPI00021327; -; .
IPIIPI00218070; -; .
PIRA43321; A43321; .
RefSeqNP_002077.1; NM_002086.4; .
RefSeqNP_987102.1; NM_203506.2; .
UniGeneHs.444356; -; .
PDB1AZE; NMR; -; A=1-56
PDB1BM2; X-ray; 2.10 A; A=49-163
PDB1BMB; X-ray; 1.80 A; A=49-168
PDB1CJ1; X-ray; 3.00 A; A/B/C/D/E/F/G/H/I/J/K/L=57-152
PDB1FHS; NMR; -; A=53-163
PDB1FYR; X-ray; 2.40 A; A/B/C/D=50-161
PDB1GCQ; X-ray; 1.68 A; A/B=159-217
PDB1GFC; NMR; -; A=159-215
PDB1GFD; NMR; -; A=159-215
PDB1GHU; NMR; -; A=60-158
PDB1GRI; X-ray; 3.10 A; A/B=1-217
PDB1IO6; NMR; -; A=159-215
PDB1JYQ; X-ray; 2.00 A; A/B=60-151
PDB1JYR; X-ray; 1.55 A; A=60-151
PDB1JYU; X-ray; 2.75 A; A=60-151
PDB1QG1; NMR; -; E=58-159
PDB1TZE; X-ray; 2.10 A; E=55-152
PDB1X0N; NMR; -; A=58-159
PDB1ZFP; X-ray; 1.80 A; E=56-153
PDB2AOA; X-ray; 1.99 A; A/B=55-153
PDB2AOB; X-ray; 1.80 A; A/B/C/D=55-153
PDB2H46; X-ray; 1.90 A; E=53-162
PDB2H5K; X-ray; 3.25 A; A/B=53-162
PDB2HUW; X-ray; 1.90 A; A/B=53-162
PDB2VVK; X-ray; 1.60 A; A=161-214
PDB2VWF; X-ray; 1.58 A; A=159-214
PDB2W0Z; X-ray; 1.70 A; A=159-214
PDB3C7I; X-ray; 1.70 A; A=53-162
PDB3IMD; X-ray; 2.00 A; A/B=53-163
PDB3IMJ; X-ray; 2.02 A; A/B=53-163
PDB3IN7; X-ray; 2.00 A; A/C=53-163
PDB3IN8; X-ray; 1.70 A; A=53-163
PDB3KFJ; X-ray; 2.02 A; A=53-163
PDB3MXC; X-ray; 2.00 A; A=55-152
PDB3MXY; X-ray; 2.30 A; A=55-152
PDB3N7Y; X-ray; 2.02 A; A/B/C=55-152
PDB3N84; X-ray; 2.00 A; A/B/C/D/E/F=53-163
PDB3N8M; X-ray; 2.00 A; A=53-163
PDBsum1AZE; -; .
PDBsum1BM2; -; .
PDBsum1BMB; -; .
PDBsum1CJ1; -; .
PDBsum1FHS; -; .
PDBsum1FYR; -; .
PDBsum1GCQ; -; .
PDBsum1GFC; -; .
PDBsum1GFD; -; .
PDBsum1GHU; -; .
PDBsum1GRI; -; .
PDBsum1IO6; -; .
PDBsum1JYQ; -; .
PDBsum1JYR; -; .
PDBsum1JYU; -; .
PDBsum1QG1; -; .
PDBsum1TZE; -; .
PDBsum1X0N; -; .
PDBsum1ZFP; -; .
PDBsum2AOA; -; .
PDBsum2AOB; -; .
PDBsum2H46; -; .
PDBsum2H5K; -; .
PDBsum2HUW; -; .
PDBsum2VVK; -; .
PDBsum2VWF; -; .
PDBsum2W0Z; -; .
PDBsum3C7I; -; .
PDBsum3IMD; -; .
PDBsum3IMJ; -; .
PDBsum3IN7; -; .
PDBsum3IN8; -; .
PDBsum3KFJ; -; .
PDBsum3MXC; -; .
PDBsum3MXY; -; .
PDBsum3N7Y; -; .
PDBsum3N84; -; .
PDBsum3N8M; -; .
ProteinModelPortalP62993; -; .
SMRP62993; 1-217; .
DisProtDP00210; -; .
DIPDIP-29229N; -; .
IntActP62993; 637; .
MINTMINT-91952; -; .
STRINGP62993; -; .
PhosphoSiteP62993; -; .
SWISS-2DPAGEP62993; -; .
OGPP62993; -; .
PRIDEP62993; -; .
EnsemblENST00000316804; ENSP00000339007; ENSG00000177885; .
EnsemblENST00000392562; ENSP00000376345; ENSG00000177885; .
EnsemblENST00000392564; ENSP00000376347; ENSG00000177885; .
GeneID2885; -; .
KEGGhsa:2885; -; .
UCSCuc002jnx.2; human; .
UCSCuc002jny.2; human; .
CTD2885; -; .
GeneCardsGC17M068724; -; .
H-InvDBHIX0014172; -; .
HGNCHGNC:4566; GRB2; .
HPACAB002589; -; .
MIM108355; gene; .
neXtProtNX_P62993; -; .
eggNOGprNOG13884; -; .
HOGENOMHBG715336; -; .
HOVERGENHBG005404; -; .
InParanoidP62993; -; .
OMAGKFFLWV; -; .
OrthoDBEOG4XSKQS; -; .
PhylomeDBP62993; -; .
Pathway_Interaction_DBa6b1_a6b4_integrin_pathway; a6b1 and a6b4 Integrin signaling; .
Pathway_Interaction_DBangiopoietinreceptor_pathway; Angiopoietin receptor Tie2-mediated signaling; .
Pathway_Interaction_DBbcr_5pathway; BCR signaling pathway; .
Pathway_Interaction_DBendothelinpathway; Endothelins; .
Pathway_Interaction_DBepha2_fwdpathway; EPHA2 forward signaling; .
Pathway_Interaction_DBephbfwdpathway; EPHB forward signaling; .
Pathway_Interaction_DBepopathway; EPO signaling pathway; .
Pathway_Interaction_DBfcer1pathway; Fc-epsilon receptor I signaling in mast cells; .
Pathway_Interaction_DBfgf_pathway; FGF signaling pathway; .
Pathway_Interaction_DBigf1_pathway; IGF1 pathway; .
Pathway_Interaction_DBil2_pi3kpathway; IL2 signaling events mediated by PI3K; .
Pathway_Interaction_DBil2_stat5pathway; IL2 signaling events mediated by STAT5; .
Pathway_Interaction_DBil2_1pathway; IL2-mediated signaling events; .
Pathway_Interaction_DBil4_2pathway; IL4-mediated signaling events; .
Pathway_Interaction_DBil6_7pathway; IL6-mediated signaling events; .
Pathway_Interaction_DBinsulin_pathway; Insulin Pathway; .
Pathway_Interaction_DBtrkrpathway; Neurotrophic factor-mediated Trk receptor signaling; .
Pathway_Interaction_DBpdgfrapathway; PDGFR-alpha signaling pathway; .
Pathway_Interaction_DBpdgfrbpathway; PDGFR-beta signaling pathway; .
Pathway_Interaction_DBer_nongenomic_pathway; Plasma membrane estrogen receptor signaling; .
Pathway_Interaction_DBmet_pathway; Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met); .
Pathway_Interaction_DBptp1bpathway; Signaling events mediated by PTP1B; .
Pathway_Interaction_DBkitpathway; Signaling events mediated by Stem cell factor receptor (c-Kit); .
Pathway_Interaction_DBvegfr1_2_pathway; Signaling events mediated by VEGFR1 and VEGFR2; .
Pathway_Interaction_DBret_pathway; Signaling events regulated by Ret tyrosine kinase; .
Pathway_Interaction_DBtcrpathway; TCR signaling in naive CD4+ T cells; .
Pathway_Interaction_DBcd8tcrpathway; TCR signaling in naive CD8+ T cells; .
Pathway_Interaction_DBtgfbrpathway; TGF-beta receptor signaling; .
Pathway_Interaction_DBpi3kplctrkpathway; Trk receptor signaling mediated by PI3K and PLC-gamma; .
Pathway_Interaction_DBlymphangiogenesis_pathway; VEGFR3 signaling in lymphatic endothelium; .
ReactomeREACT_11061; Signalling by NGF; .
ReactomeREACT_13552; Integrin cell surface interactions; .
ReactomeREACT_16888; Signaling by PDGF; .
ReactomeREACT_18266; Axon guidance; .
ReactomeREACT_20676; Cell junction organization; .
ReactomeREACT_23853; Interactions of the immunoglobulin superfamily (IgSF) member proteins; .
ReactomeREACT_498; Signaling by Insulin receptor; .
ReactomeREACT_604; Hemostasis; .
ReactomeREACT_6900; Immune System; .
ReactomeREACT_9417; Signaling by EGFR; .
ReactomeREACT_9470; Signaling by FGFR; .
BindingDBP62993; -; .
DrugBankDB00061; Pegademase bovine; .
NextBio11389; -; .
ArrayExpressP62993; -; .
BgeeP62993; -; .
CleanExHS_GRB2; -; .
GenevestigatorP62993; -; .
GermOnlineENSG00000177885; Homo sapiens; .
GOGO:0005829; C:cytosol; TAS:HGNC; .
GOGO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell; .
GOGO:0005154; F:epidermal growth factor receptor binding; IPI:UniProtKB; .
GOGO:0043560; F:insulin receptor substrate binding; IPI:UniProtKB; .
GOGO:0005070; F:SH3/SH2 adaptor activity; TAS:UniProtKB; .
GOGO:0007411; P:axon guidance; TAS:Reactome; .
GOGO:0007596; P:blood coagulation; TAS:Reactome; .
GOGO:0034329; P:cell junction assembly; TAS:Reactome; .
GOGO:0007267; P:cell-cell signaling; TAS:UniProtKB; .
GOGO:0071479; P:cellular response to ionizing radiation; IMP:BHF-UCL; .
GOGO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:UniProtKB; .
GOGO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome; .
GOGO:0008286; P:insulin receptor signaling pathway; IPI:UniProtKB; .
GOGO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW; .
GOGO:0050900; P:leukocyte migration; TAS:Reactome; .
GOGO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; TAS:Reactome; .
GOGO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome; .
GOGO:2000379; P:positive regulation of reactive oxygen species metabolic process; IMP:BHF-UCL; .
GOGO:0007265; P:Ras protein signal transduction; TAS:UniProtKB; .
GOGO:0031623; P:receptor internalization; IMP:BHF-UCL; .
GOGO:0042770; P:signal transduction in response to DNA damage; IMP:BHF-UCL; .
GOGO:0031295; P:T cell costimulation; TAS:Reactome; .
InterProIPR000108; p67phox; .
InterProIPR000980; SH2; .
InterProIPR001452; SH3_domain; .
Gene3DG3DSA:3.30.505.10; SH2; 1; .
PfamPF00017; SH2; 1; .
PfamPF00018; SH3_1; 2; .
PRINTSPR00499; P67PHOX; .
PRINTSPR00401; SH2DOMAIN; .
PRINTSPR00452; SH3DOMAIN; .
SMARTSM00252; SH2; 1; .
SMARTSM00326; SH3; 2; .
SUPFAMSSF50044; SH3; 1; .
PROSITEPS50001; SH2; 1; .
PROSITEPS50002; SH3; 2; .



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SWISS-2DPAGE (search AC)


Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server