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Sample Preparation and Post-separation Analysis

Searching in 'SWISS-2DPAGE' for entry matching: EXOS4_HUMAN



General information about the entry
View entry in simple text format
Entry nameEXOS4_HUMAN
Primary accession numberQ9NPD3
integrated into SWISS-2DPAGE on November 9, 2001 (release 15)
2D Annotations were last modified onDecember 30, 2004 (version 1)
General Annotations were last modified on May 19, 2011 (version 8)
Name and origin of the protein
DescriptionRecName: Full=Exosome complex component RRP41; AltName: Full=Exosome component 4; AltName: Full=Ribosomal RNA-processing protein 41; AltName: Full=p12A;.
Gene nameName=EXOSC4
Synonyms=RRP41, SKI6
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
PubMed=12429849; [NCBI, ExPASy, EBI, Israel, Japan]
Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J.
''''''Functional proteomic analysis of human nucleolus'';'';''
Mol. Biol. Cell. 13(1):4100-4109(2002)
2D PAGE maps for identified proteins
How to interpret a protein

NUCLEOLI_HELA_2D_HUMAN {2D-PAGE of nucleolar proteins from Human HeLa cells}
Homo sapiens (Human)
Tissue: Cervix carcinoma
  map experimental info
  protein estimated location

pI=6.55; Mw=29587  [identification data]

MAPPING (identification):
Peptide mass fingerprinting [1].

This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See or send email from
UniProtKB/Swiss-ProtQ9NPD3; EXOS4_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameEXOS4_HUMAN
Primary accession numberQ9NPD3
Sequence was last modified on January 23, 2007 (version 3)
Annotations were last modified on October 19, 2011 (version 105)
Name and origin of the protein
DescriptionRecName: Full=Exosome complex component RRP41; AltName: Full=Exosome component 4; AltName: Full=Ribosomal RNA-processing protein 41; AltName: Full=p12A;
Gene nameName=EXOSC4
Synonyms=RRP41, SKI6
Encoded onName=EXOSC4; Synonyms=RRP41, SKI6
Keywords3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Exosome; Nucleus; Reference proteome; RNA-binding; rRNA processing.
Copyrighted by the UniProt Consortium, see Distributed under the Creative Commons Attribution-NoDerivs License
EMBLAF281133; AAF82134.1; -; mRNA
EMBLAK000598; BAA91279.1; -; mRNA
EMBLBC002777; AAH02777.1; -; mRNA
IPIIPI00745613; -; .
RefSeqNP_061910.1; NM_019037.2; .
UniGeneHs.632041; -; .
PDB2NN6; X-ray; 3.35 A; B=2-244
PDBsum2NN6; -; .
ProteinModelPortalQ9NPD3; -; .
SMRQ9NPD3; 7-241; .
IntActQ9NPD3; 26; .
EnsemblENST00000316052; ENSP00000315476; ENSG00000178896; .
GeneID54512; -; .
KEGGhsa:54512; -; .
NMPDRfig|9606.3.peg.30882; -; .
UCSCuc003zau.1; human; .
CTD54512; -; .
GeneCardsGC08P140409; -; .
H-InvDBHIX0020970; -; .
HPAHPA024792; -; .
MIM606491; gene; .
neXtProtNX_Q9NPD3; -; .
PharmGKBPA134867931; -; .
eggNOGprNOG09362; -; .
GeneTreeENSGT00550000074804; -; .
HOGENOMHBG737187; -; .
HOVERGENHBG051519; -; .
InParanoidQ9NPD3; -; .
OrthoDBEOG4PC9T0; -; .
PhylomeDBQ9NPD3; -; .
ReactomeREACT_21257; Metabolism of RNA; .
NextBio56896; -; .
ArrayExpressQ9NPD3; -; .
BgeeQ9NPD3; -; .
CleanExHS_EXOSC4; -; .
GenevestigatorQ9NPD3; -; .
GermOnlineENSG00000178896; Homo sapiens; .
GOGO:0005829; C:cytosol; TAS:Reactome; .
GOGO:0000178; C:exosome (RNase complex); IDA:UniProtKB; .
GOGO:0005730; C:nucleolus; NAS:UniProtKB; .
GOGO:0035327; C:transcriptionally active chromatin; IMP:UniProtKB; .
GOGO:0000175; F:3'-5'-exoribonuclease activity; NAS:UniProtKB; .
GOGO:0017091; F:AU-rich element binding; IDA:UniProtKB; .
GOGO:0005515; F:protein binding; IPI:UniProtKB; .
GOGO:0045006; P:DNA deamination; IDA:UniProtKB; .
GOGO:0043928; P:exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay; TAS:Reactome; .
GOGO:0071044; P:histone mRNA catabolic process; IMP:UniProtKB; .
GOGO:0000460; P:maturation of 5.8S rRNA; IMP:UniProtKB; .
GOGO:0071028; P:nuclear mRNA surveillance; IMP:UniProtKB; .
GOGO:0030307; P:positive regulation of cell growth; IMP:UniProtKB; .
InterProIPR001247; ExoRNase_PH_dom1; .
InterProIPR015847; ExoRNase_PH_dom2; .
InterProIPR020568; Ribosomal_S5_D2-typ_fold; .
PfamPF01138; RNase_PH; 1; .
PfamPF03725; RNase_PH_C; 1; .
SUPFAMSSF55666; 3_ExoRNase; 1; .
SUPFAMSSF54211; Ribosomal_S5_D2-typ_fold; 1; .


SWISS-2DPAGE (search AC)

Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server