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Sample Preparation and Post-separation Analysis

Searching in 'SWISS-2DPAGE' for entry matching: P02545



General information about the entry
View entry in simple text format
Entry nameLMNA_HUMAN
Primary accession numberP02545
Secondary accession number(s) P02546
integrated into SWISS-2DPAGE on April 1, 2000 (release 12)
2D Annotations were last modified onMay 15, 2003 (version 3)
General Annotations were last modified on May 19, 2011 (version 9)
Name and origin of the protein
DescriptionRecName: Full=Prelamin-A/C; Contains: RecName: Full=Lamin-A/C; AltName: Full=70 kDa lamin; AltName: Full=Renal carcinoma antigen NY-REN-32; Flags: Precursor;.
Gene nameName=LMNA
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
MEDLINE=20529951; PubMed=11079567; [NCBI, Expasy, EBI, Israel, Japan]
Jung E., Hoogland C., Chiappe D., Sanchez J.-C., Hochstrasser D.F.
''''''The establishment of a human liver nuclei 2-DE reference map'';'';''
Electrophoresis 21(1):3483-3487(2000)
PubMed=12429849; [NCBI, Expasy, EBI, Israel, Japan]
Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J.
''''''Functional proteomic analysis of human nucleolus'';'';''
Mol. Biol. Cell. 13(1):4100-4109(2002)
2D PAGE maps for identified proteins
How to interpret a protein

NUCLEOLI_HELA_1D_HUMAN {SDS-PAGE of nucleolar proteins from Human HeLa cells}
Homo sapiens (Human)
Tissue: Cervix carcinoma
  map experimental info
  protein estimated location


MAPPING (identification):
Peptide mass fingerprinting [2].

NUCLEI_LIVER_HUMAN {Soluble nuclear proteins and matrix from liver tissue}
Homo sapiens (Human)
Tissue: Liver
  map experimental info
  protein estimated location

pI=7.15; Mw=68933  [identification data]
pI=7.00; Mw=68933  [identification data]
pI=7.11; Mw=68566  [identification data]
pI=7.11; Mw=59687  [identification data]
pI=6.91; Mw=59370  [identification data]
pI=7.04; Mw=59370  [identification data]

MAPPING (identification):
Peptide mass fingerprinting [1].

NUCLEOLI_HELA_2D_HUMAN {2D-PAGE of nucleolar proteins from Human HeLa cells}
Homo sapiens (Human)
Tissue: Cervix carcinoma
  map experimental info
  protein estimated location

pI=6.76; Mw=75283  [identification data]
pI=6.68; Mw=64287  [identification data]

MAPPING (identification):
Peptide mass fingerprinting [2].

This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See or send email from
UniProtKB/Swiss-ProtP02545; LMNA_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameLMNA_HUMAN
Primary accession numberP02545
Secondary accession number(s) D3DVB0 P02546 Q5TCJ2 Q5TCJ3 Q969I8 Q96JA2
Sequence was last modified on March 20, 1987 (version 1)
Annotations were last modified on October 19, 2011 (version 165)
Name and origin of the protein
DescriptionRecName: Full=Prelamin-A/C; Contains: RecName: Full=Lamin-A/C; AltName: Full=70 kDa lamin; AltName: Full=Renal carcinoma antigen NY-REN-32; Flags: Precursor;
Gene nameName=LMNA
Encoded onName=LMNA; Synonyms=LMN1
Keywords3D-structure; Acetylation; Alternative splicing; Cardiomyopathy; Charcot-Marie-Tooth disease; Coiled coil; Complete proteome; Congenital muscular dystrophy; Direct protein sequencing; Disease mutation; Emery-Dreifuss muscular dystrophy; Intermediate filament; Isopeptide bond; Limb-girdle muscular dystrophy; Lipoprotein; Methylation; Neuropathy; Nucleus; Phosphoprotein; Prenylation; Reference proteome; Ubl conjugation.
Copyrighted by the UniProt Consortium, see Distributed under the Creative Commons Attribution-NoDerivs License
EMBLX03444; CAA27173.1; ALT_FRAME; mRNA
EMBLX03445; CAA27174.1; -; mRNA
EMBLM13451; AAA36164.1; -; mRNA
EMBLM13452; AAA36160.1; -; mRNA
EMBLAL135927; CAI15521.1; -; Genomic_DNA
EMBLAL135927; CAI15522.1; -; Genomic_DNA
EMBLCH471121; EAW52997.1; -; Genomic_DNA
EMBLCH471121; EAW52999.1; -; Genomic_DNA
EMBLBC000511; AAH00511.1; -; mRNA
EMBLBC003162; AAH03162.1; -; mRNA
EMBLBC014507; AAH14507.1; -; mRNA
EMBLAF381029; AAK59326.1; -; mRNA
IPIIPI00021405; -; .
IPIIPI00216952; -; .
IPIIPI00216953; -; .
PIRA02961; VEHULA; .
PIRA02962; VEHULC; .
RefSeqNP_005563.1; NM_005572.3; .
RefSeqNP_733821.1; NM_170707.2; .
RefSeqNP_733822.1; NM_170708.2; .
UniGeneHs.594444; -; .
PDB1IFR; X-ray; 1.40 A; A=435-552
PDB1IVT; NMR; -; A=428-549
PDB1X8Y; X-ray; 2.20 A; A=305-387
PDB2XV5; X-ray; 2.40 A; A/B=328-398
PDB3GEF; X-ray; 1.50 A; A/B/C/D=436-552
PDBsum1IFR; -; .
PDBsum1IVT; -; .
PDBsum1X8Y; -; .
PDBsum2XV5; -; .
PDBsum3GEF; -; .
ProteinModelPortalP02545; -; .
SMRP02545; 313-386; 428-549; .
IntActP02545; 23; .
MINTMINT-5003995; -; .
STRINGP02545; -; .
PhosphoSiteP02545; -; .
SWISS-2DPAGEP02545; -; .
PeptideAtlasP02545; -; .
PRIDEP02545; -; .
EnsemblENST00000368300; ENSP00000357283; ENSG00000160789; .
GeneID4000; -; .
KEGGhsa:4000; -; .
UCSCuc001fnh.2; human; .
UCSCuc001fni.2; human; .
CTD4000; -; .
GeneCardsGC01P127446; -; .
HPACAB004022; -; .
HPAHPA006660; -; .
MIM115200; phenotype; .
MIM150330; gene; .
MIM151660; phenotype; .
MIM159001; phenotype; .
MIM176670; phenotype; .
MIM181350; phenotype; .
MIM212112; phenotype; .
MIM248370; phenotype; .
MIM275210; phenotype; .
MIM605588; phenotype; .
MIM610140; phenotype; .
MIM613205; phenotype; .
neXtProtNX_P02545; -; .
Orphanet98853; Autosomal dominant Emery-Dreifuss muscular dystrophy; .
Orphanet264; Autosomal dominant limb-girdle muscular dystrophy type 1B; .
Orphanet98855; Autosomal recessive Emery-dreifuss muscular dystrophy; .
Orphanet98856; Charcot-Marie-Tooth disease type 2B1; .
Orphanet157973; Congenital muscular dystrophy due to lamine A/C deficiency; .
Orphanet154; Familial isolated dilated cardiomyopathy; .
Orphanet2348; Familial partial lipodystrophy; Dunnigan type; .
Orphanet168796; Heart-hand syndrome; Slovenian type; .
Orphanet137871; Laminopathy type Decaudain-Vigouroux; .
Orphanet54260; Left ventricular noncompaction; .
Orphanet1662; Lethal restrictive dermopathy; .
Orphanet90153; Mandibuloacral dysplasia with type A lipodystrophy; .
Orphanet740; Progeria; .
Orphanet83618; Severe dilated cardiomyopathy due to lamin A/C mutation; .
Orphanet902; Werner syndrome; .
PharmGKBPA231; -; .
eggNOGprNOG13164; -; .
HOGENOMHBG716303; -; .
HOVERGENHBG013015; -; .
InParanoidP02545; -; .
OrthoDBEOG4S4PG2; -; .
PhylomeDBP02545; -; .
Pathway_Interaction_DBcaspase_pathway; Caspase cascade in apoptosis; .
Pathway_Interaction_DBfaspathway; FAS signaling pathway (CD95); .
ReactomeREACT_15380; Diabetes pathways; .
ReactomeREACT_578; Apoptosis; .
ReactomeREACT_75792; Meiotic Synapsis; .
NextBio15692; -; .
PMAP-CutDBP02545; -; .
ArrayExpressP02545; -; .
BgeeP02545; -; .
CleanExHS_LMNA; -; .
GenevestigatorP02545; -; .
GermOnlineENSG00000160789; Homo sapiens; .
GOGO:0005737; C:cytoplasm; IDA:HPA; .
GOGO:0005638; C:lamin filament; TAS:UniProtKB; .
GOGO:0005635; C:nuclear envelope; IDA:UniProtKB; .
GOGO:0005654; C:nucleoplasm; TAS:Reactome; .
GOGO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB; .
GOGO:0005515; F:protein binding; IPI:UniProtKB; .
GOGO:0005198; F:structural molecule activity; IEA:InterPro; .
GOGO:0006921; P:cellular component disassembly involved in apoptosis; TAS:Reactome; .
GOGO:0071456; P:cellular response to hypoxia; IEP:UniProtKB; .
GOGO:0030951; P:establishment or maintenance of microtubule cytoskeleton polarity; ISS:BHF-UCL; .
GOGO:0007517; P:muscle organ development; IMP:UniProtKB; .
GOGO:0090343; P:positive regulation of cell aging; IDA:UniProtKB; .
GOGO:0042981; P:regulation of apoptosis; ISS:BHF-UCL; .
GOGO:0030334; P:regulation of cell migration; ISS:BHF-UCL; .
InterProIPR016044; F; .
InterProIPR001664; IF; .
InterProIPR001322; IF_tail_C; .
InterProIPR018039; Intermediate_filament_CS; .
PANTHERPTHR23239; IF; 1; .
PfamPF00038; Filament; 1; .
PfamPF00932; IF_tail; 1; .
PROSITEPS00226; IF; 1; .


SWISS-2DPAGE (search AC)

Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server