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SWISS-2DPAGE 
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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P06576




SWISS-2DPAGE:  P06576


P06576


General information about the entry
View entry in simple text format
Entry nameATPB_HUMAN
Primary accession numberP06576
integrated into SWISS-2DPAGE on September 1, 1997 (release 6)
2D Annotations were last modified onMarch 31, 2004 (version 4)
General Annotations were last modified on May 19, 2011 (version 12)
Name and origin of the protein
DescriptionRecName: Full=ATP synthase subunit beta, mitochondrial; EC=3.6.3.14; Flags: Precursor;.
Gene nameName=ATP5B
Synonyms=ATPMB, ATPSB
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=97295305; PubMed=9150947; [NCBI, ExPASy, EBI, Israel, Japan]
Sarto C., Marocchi A., Sanchez J.-C., Giannone D., Frutiger S., Golaz O., Wilkins M.R., Doro G., Cappellano F., Hughes G.J., Hochstrasser D.F., Mocarelli P.
''''''Renal cell carcinoma and normal kidney protein expression'';'';''
Electrophoresis 18(1):599-604(1997)
[2]   MAPPING ON GEL
MEDLINE=98163346; PubMed=9504818; [NCBI, ExPASy, EBI, Israel, Japan]
Reymond M.A., Sanchez J.-C., Hughes G.J., Riese J., Tortola S., Peinado M.A., Kirchner T., Hohenberger W., Hochstrasser D.F., Kockerling F.
''''''Standardized characterization of gene expression in human colorectal epithelium by two-dimensional electrophoresis'';'';''
Electrophoresis 18(1):2842-2848(1997)
[3]   MAPPING ON GEL
Demalte-Annessi I., Sanchez J.-C., Hoogland C., Rouge V., Binz P.-A., Appel R.D., Hochstrasser D.F.
Submitted (JAN-1999) to SWISS-2DPAGE
[4]   MAPPING ON GEL
Vuadens F., Crettaz D., Telenti A., Quadroni M., Duchosal M.A., Schneider P., Tissot J.-D.
''''''New insights into HIV lymphocyte infection'';'';''
(IN) Sanchez J.-C., Corthals G.L., Hochstrasser D.F. (eds.)Biomedical Application of Proteomics, pp.245-262, Wiley-VCH, Weinheim (2004)
2D PAGE maps for identified proteins
How to interpret a protein

CEC_HUMAN {Colorectal epithelia cells}
Homo sapiens (Human)
Tissue: Colon epithelium
CEC_HUMAN
  map experimental info
  protein estimated location
 
CEC_HUMAN

MAP LOCATIONS:
pI=4.93; Mw=49174

MAPPING (identification):
MATCHING WITH THE KIDNEY MASTER GEL [2].



DLD1_HUMAN {Colorectal adenocarcinoma cell line (DL-1)}
Homo sapiens (Human)
Tissue: Colon adenocarcinoma
DLD1_HUMAN
  map experimental info
  protein estimated location
 
DLD1_HUMAN

MAP LOCATIONS:
pI=4.99; Mw=48281  [identification data]

MAPPING (identification):
Peptide mass fingerprinting [3].



KIDNEY_HUMAN {Kidney}
Homo sapiens (Human)
Tissue: Kidney
KIDNEY_HUMAN
  map experimental info
  protein estimated location
 
KIDNEY_HUMAN

MAP LOCATIONS:
pI=5.03; Mw=47989  [identification data]
pI=4.99; Mw=48244

MAPPING (identification):
AMINO ACID COMPOSITION ANALYSIS [1].



LYMPHOCYTE_HUMAN {Lymphocytes}
Homo sapiens (Human)
Tissue: Lymphocyte
LYMPHOCYTE_HUMAN
  map experimental info
  protein estimated location
 
LYMPHOCYTE_HUMAN

MAP LOCATIONS:
pI=4.97; Mw=42552  [identification data]

MAPPING (identification):
Peptide mass fingerprinting [4].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).
Cross-references
DOSAC-COBS 2D-PAGEP06576; P06576.
DOSAC-COBS-2DPAGEP06576; ATPB_HUMAN.
HSC-2DPAGEP06576; HUMAN.
OGP-WWWP06576.
REPRODUCTION-2DPAGEIPI00303476; IPI00303476.
REPRODUCTION-2DPAGEP06576; P06576.
Siena-2DPAGEP06576; ATPB_HUMAN.
UCD-2DPAGEP06576; ATPB_HUMAN.
UniProtKB/Swiss-ProtP06576; ATPB_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameATPB_HUMAN
Primary accession numberP06576
Secondary accession number(s) A8K4X0 Q14283
Sequence was last modified on April 1, 1990 (version 3)
Annotations were last modified on October 19, 2011 (version 146)
Name and origin of the protein
DescriptionRecName: Full=ATP synthase subunit beta, mitochondrial; EC=3.6.3.14; Flags: Precursor;
Gene nameName=ATP5B
Synonyms=ATPMB, ATPSB
Encoded onName=ATP5B; Synonyms=ATPMB, ATPSB
KeywordsAcetylation; ATP synthesis; ATP-binding; CF(1); Complete proteome; Direct protein sequencing; Hydrogen ion transport; Hydrolase; Ion transport; Membrane; Mitochondrion; Mitochondrion inner membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Transit peptide; Transport.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLM27132; AAA51809.1; -; Genomic_DNA
EMBLM19483; AAA51808.1; -; Genomic_DNA
EMBLM19482; AAA51808.1; JOINED; Genomic_DNA
EMBLX03559; CAA27246.1; -; mRNA
EMBLD00022; BAA00016.1; -; mRNA
EMBLAK291085; BAF83774.1; -; mRNA
EMBLCH471054; EAW96952.1; -; Genomic_DNA
EMBLBC016512; AAH16512.1; -; mRNA
EMBLX05606; CAA29095.1; -; mRNA
IPIIPI00303476; -; .
PIRA33370; A33370; .
RefSeqNP_001677.2; NM_001686.3; .
UniGeneHs.406510; -; .
ProteinModelPortalP06576; -; .
SMRP06576; 60-525; .
IntActP06576; 13; .
MINTMINT-5004016; -; .
STRINGP06576; -; .
PhosphoSiteP06576; -; .
SWISS-2DPAGEP06576; -; .
Cornea-2DPAGEP06576; -; .
DOSAC-COBS-2DPAGEP06576; -; .
OGPP06576; -; .
REPRODUCTION-2DPAGEIPI00303476; -; .
REPRODUCTION-2DPAGEP06576; -; .
UCD-2DPAGEP06576; -; .
PRIDEP06576; -; .
EnsemblENST00000262030; ENSP00000262030; ENSG00000110955; .
GeneID506; -; .
KEGGhsa:506; -; .
NMPDRfig|9606.3.peg.7763; -; .
UCSCuc001slr.1; human; .
CTD506; -; .
GeneCardsGC12M054071; -; .
H-InvDBHIX0019097; -; .
HGNCHGNC:830; ATP5B; .
HPACAB017527; -; .
HPAHPA001520; -; .
HPAHPA001528; -; .
MIM102910; gene; .
neXtProtNX_P06576; -; .
PharmGKBPA25122; -; .
eggNOGprNOG14264; -; .
HOGENOMHBG565875; -; .
HOVERGENHBG004307; -; .
InParanoidP06576; -; .
OMAIGQEHYD; -; .
OrthoDBEOG4ZCT4C; -; .
PhylomeDBP06576; -; .
ReactomeREACT_6305; Respiratory electron transport; ATP synthesis by chemiosmotic coupling; and heat production by uncoupling proteins
NextBio2109; -; .
ArrayExpressP06576; -; .
BgeeP06576; -; .
CleanExHS_ATP5B; -; .
GenevestigatorP06576; -; .
GermOnlineENSG00000110955; Homo sapiens; .
GOGO:0009986; C:cell surface; IDA:UniProtKB; .
GOGO:0042645; C:mitochondrial nucleoid; IDA:BHF-UCL; .
GOGO:0005754; C:mitochondrial proton-transporting ATP synthase; catalytic core; NAS:UniProtKB
GOGO:0005886; C:plasma membrane; IDA:UniProtKB; .
GOGO:0005524; F:ATP binding; IEA:UniProtKB-KW; .
GOGO:0043499; F:eukaryotic cell surface binding; IDA:UniProtKB; .
GOGO:0046933; F:hydrogen ion transporting ATP synthase activity; rotational mechanism; IEA:InterPro
GOGO:0008553; F:hydrogen-exporting ATPase activity; phosphorylative mechanism; IEA:InterPro
GOGO:0042288; F:MHC class I protein binding; IDA:UniProtKB; .
GOGO:0046961; F:proton-transporting ATPase activity; rotational mechanism; IMP:UniProtKB
GOGO:0001525; P:angiogenesis; IMP:UniProtKB; .
GOGO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro; .
GOGO:0042776; P:mitochondrial ATP synthesis coupled proton transport; IC:UniProtKB; .
GOGO:0051453; P:regulation of intracellular pH; IMP:UniProtKB; .
GOGO:0022904; P:respiratory electron transport chain; TAS:Reactome; .
InterProIPR020003; ATPase_a/bsu_AS; .
InterProIPR003593; ATPase_AAA+_core; .
InterProIPR005722; ATPase_F1-cplx_bsu; .
InterProIPR018118; ATPase_F1/A1-cplx_a/bsu_N; .
InterProIPR000793; ATPase_F1/V1/A1-cplx_a/bsu_C; .
InterProIPR004100; ATPase_F1/V1/A1-cplx_a/bsu_N; .
InterProIPR000194; ATPase_F1/V1/A1_a/bsu_nucl-bd; .
InterProIPR024034; ATPase_F1_bsu/V1_C; .
Gene3DG3DSA:1.10.1140.10; G3DSA:1.10.1140.10; 1; .
PANTHERPTHR15184:SF8; ATPase_F1_b; 1; .
PfamPF00006; ATP-synt_ab; 1; .
PfamPF00306; ATP-synt_ab_C; 1; .
PfamPF02874; ATP-synt_ab_N; 1; .
SMARTSM00382; AAA; 1; .
SUPFAMSSF47917; ATPase_a/b_C; 1; .
SUPFAMSSF50615; ATPase_a/b_N; 1; .
TIGRFAMsTIGR01039; AtpD; 1; .
PROSITEPS00152; ATPASE_ALPHA_BETA; 1; .



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SWISS-2DPAGE (search AC)


Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server