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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P32119




SWISS-2DPAGE:  P32119


P32119


General information about the entry
View entry in simple text format
Entry namePRDX2_HUMAN
Primary accession numberP32119
Secondary accession number(s) P32118
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onMarch 31, 2004 (version 3)
General Annotations were last modified on May 19, 2011 (version 10)
Name and origin of the protein
DescriptionRecName: Full=Peroxiredoxin-2; EC=1.11.1.15; AltName: Full=Natural killer cell-enhancing factor B; Short=NKEF-B; AltName: Full=PRP; AltName: Full=Thiol-specific antioxidant protein; Short=TSA; AltName: Full=Thioredoxin peroxidase 1; AltName: Full=Thioredoxin-dependent peroxide reductase 1;.
Gene nameName=PRDX2
Synonyms=NKEFB, TDPX1
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=94147970; PubMed=8313871; [NCBI, ExPASy, EBI, Israel, Japan]
Golaz O., Hughes G.J., Frutiger S., Paquet N., Bairoch A., Pasquali C., Sanchez J.-C., Tissot J.-D., Appel R.D., Walzer C., Balant L.P., Hochstrasser D.F.
''''''Plasma and red blood cell protein maps: update 1993'';'';''
Electrophoresis 14(1):1223-1231(1993)
[2]   MAPPING ON GEL
Demalte-Annessi I., Sanchez J.-C., Hoogland C., Rouge V., Binz P.-A., Appel R.D., Hochstrasser D.F.
Submitted (JAN-1999) to SWISS-2DPAGE
[3]   MAPPING ON GEL
PubMed=12429849; [NCBI, ExPASy, EBI, Israel, Japan]
Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J.
''''''Functional proteomic analysis of human nucleolus'';'';''
Mol. Biol. Cell. 13(1):4100-4109(2002)
[4]   MAPPING ON GEL
Vuadens F., Crettaz D., Telenti A., Quadroni M., Duchosal M.A., Schneider P., Tissot J.-D.
''''''New insights into HIV lymphocyte infection'';'';''
(IN) Sanchez J.-C., Corthals G.L., Hochstrasser D.F. (eds.)Biomedical Application of Proteomics, pp.245-262, Wiley-VCH, Weinheim (2004)
2D PAGE maps for identified proteins
How to interpret a protein

DLD1_HUMAN {Colorectal adenocarcinoma cell line (DL-1)}
Homo sapiens (Human)
Tissue: Colon adenocarcinoma
DLD1_HUMAN
  map experimental info
  protein estimated location
 
DLD1_HUMAN

MAP LOCATIONS:
pI=5.38; Mw=21646  [identification data]

MAPPING (identification):
Peptide mass fingerprinting [2].



LYMPHOCYTE_HUMAN {Lymphocytes}
Homo sapiens (Human)
Tissue: Lymphocyte
LYMPHOCYTE_HUMAN
  map experimental info
  protein estimated location
 
LYMPHOCYTE_HUMAN

MAP LOCATIONS:
pI=5.41; Mw=22317  [identification data]

MAPPING (identification):
Peptide mass fingerprinting [4].



NUCLEOLI_HELA_2D_HUMAN {2D-PAGE of nucleolar proteins from Human HeLa cells}
Homo sapiens (Human)
Tissue: Cervix carcinoma
NUCLEOLI_HELA_2D_HUMAN
  map experimental info
  protein estimated location
 
NUCLEOLI_HELA_2D_HUMAN

MAP LOCATIONS:
pI=5.70; Mw=24026  [identification data]

MAPPING (identification):
Peptide mass fingerprinting and tandem mass spectrometry [3].



RBC_HUMAN {Red blood cells}
Homo sapiens (Human)
Tissue: Erythrocyte
RBC_HUMAN
  map experimental info
  protein estimated location
 
RBC_HUMAN

MAP LOCATIONS:
pI=5.41; Mw=21321

MAPPING (identification):
INTERNAL SEQUENCE (TDEGIATTGL) [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).
Cross-references
DOSAC-COBS 2D-PAGEP32119; P32119.
DOSAC-COBS-2DPAGEP32119; PRDX2_HUMAN.
OGP-WWWP32119.
REPRODUCTION-2DPAGEIPI00027350; IPI00027350.
UCD-2DPAGEP32119; PRDX2_HUMAN.
UniProtKB/Swiss-ProtP32119; PRDX2_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry namePRDX2_HUMAN
Primary accession numberP32119
Secondary accession number(s) P31945 P32118 P35701 Q6FHG4 Q92763 Q9UC23
Sequence was last modified on January 23, 2007 (version 5)
Annotations were last modified on October 19, 2011 (version 139)
Name and origin of the protein
DescriptionRecName: Full=Peroxiredoxin-2; EC=1.11.1.15; AltName: Full=Natural killer cell-enhancing factor B; Short=NKEF-B; AltName: Full=PRP; AltName: Full=Thiol-specific antioxidant protein; Short=TSA; AltName: Full=Thioredoxin peroxidase 1; AltName: Full=Thioredoxin-dependent peroxide reductase 1;
Gene nameName=PRDX2
Synonyms=NKEFB, TDPX1
Encoded onName=PRDX2; Synonyms=NKEFB, TDPX1
Keywords3D-structure; Acetylation; Antioxidant; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; Oxidoreductase; Peroxidase; Polymorphism; Redox-active center; Reference proteome.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLZ22548; CAA80269.1; -; mRNA
EMBLL19185; AAA50465.1; -; mRNA
EMBLCR450356; CAG29352.1; -; mRNA
EMBLCR541789; CAG46588.1; -; mRNA
EMBLDQ231563; ABB02182.1; -; Genomic_DNA
EMBLBC000452; AAH00452.1; -; mRNA
EMBLBC003022; AAH03022.1; -; mRNA
EMBLBC039428; AAH39428.1; -; mRNA
EMBLX82321; CAA57764.1; -; mRNA
IPIIPI00027350; -; .
PIRI68897; I68897; .
RefSeqNP_005800.3; NM_005809.4; .
UniGeneHs.432121; -; .
PDB1QMV; X-ray; 1.70 A; A/B/C/D/E/F/G/H/I/J=2-198
PDBsum1QMV; -; .
ProteinModelPortalP32119; -; .
SMRP32119; 3-198; .
IntActP32119; 15; .
MINTMINT-3012817; -; .
STRINGP32119; -; .
PeroxiBase4475; Hs2CysPrx02; .
PhosphoSiteP32119; -; .
SWISS-2DPAGEP32119; -; .
Aarhus/Ghent-2DPAGE6116; IEF; .
Cornea-2DPAGEP32119; -; .
DOSAC-COBS-2DPAGEP32119; -; .
OGPP32119; -; .
REPRODUCTION-2DPAGEIPI00027350; -; .
UCD-2DPAGEP32119; -; .
PRIDEP32119; -; .
EnsemblENST00000301522; ENSP00000301522; ENSG00000167815; .
GeneID7001; -; .
KEGGhsa:7001; -; .
NMPDRfig|9606.3.peg.15783; -; .
UCSCuc002mvd.1; human; .
CTD7001; -; .
GeneCardsGC19M012479; -; .
H-InvDBHIX0014805; -; .
HGNCHGNC:9353; PRDX2; .
HPACAB008713; -; .
MIM600538; gene; .
neXtProtNX_P32119; -; .
eggNOGprNOG16631; -; .
GeneTreeENSGT00390000004653; -; .
HOVERGENHBG000286; -; .
InParanoidP32119; -; .
OMAKLNYPLA; -; .
OrthoDBEOG4V6ZHJ; -; .
PhylomeDBP32119; -; .
NextBio27342; -; .
ArrayExpressP32119; -; .
BgeeP32119; -; .
CleanExHS_PRDX2; -; .
GenevestigatorP32119; -; .
GermOnlineENSG00000167815; Homo sapiens; .
GOGO:0008379; F:thioredoxin peroxidase activity; IDA:UniProtKB; .
GOGO:0006916; P:anti-apoptosis; TAS:UniProtKB; .
GOGO:0042744; P:hydrogen peroxide catabolic process; TAS:BHF-UCL; .
GOGO:0019430; P:removal of superoxide radicals; IDA:BHF-UCL; .
InterProIPR000866; AhpC/TSA; .
InterProIPR024706; Peroxiredoxin_AhpC-typ; .
InterProIPR019479; Peroxiredoxin_C; .
InterProIPR012336; Thioredoxin-like_fold; .
Gene3DG3DSA:3.40.30.10; Thioredoxin_fold; 1; .
PfamPF10417; 1-cysPrx_C; 1; .
PfamPF00578; AhpC-TSA; 1; .
PIRSFPIRSF000239; AHPC; 1; .
SUPFAMSSF52833; Thiordxn-like_fd; 1; .
PROSITEPS51352; THIOREDOXIN_2; 1; .



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